Toxicological studies of Caesalpinia sappan wood derived dye in Wister albino rats

作     者：G.Athinarayanana A.J.A.Ranjitsingh A.Usha Raja Nanthini C.Padmalatha 

作者机构：Department of ZoologySri Paramakalyani CollegeAlwarkurichiMS UniversityTamil NaduIndia JP College of Arts and ScienceTenkasiMS UniversityTamil NaduIndia Department of BiotechnologyMother Teresa UniversityKodaikanalTamil NaduIndia UGCNew DelhiIndia 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2017年第6卷第1期

页      面：34-38页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：C.sappan Natural dye Dye toxicity Food grade dye Consumer products 

摘      要：Natural dyes taken from the barks of the tree Caesalpinia sappan has been used in many consumer *** it is imperative to test the toxicity of this *** the present study an investigation was conducted to find out the toxic effect of aqueous extract of the dye *** in test animal Wister albino *** oral toxicity showed no clinical signs of toxicity and no mortality even at a dose level of 100–2000 mg/kg in 14 days observation *** a dose level above 2500 mg/kg was given for 28 days,no death was noticed up to the dose level 5000 mg/kg body *** weight of the tested rats was not significantly reduced,when compared with the control *** organ-body weight ratio of kidney,liver and abdomen did not change when compared to the control group in the observation *** less toxicity of the dyes of ***.