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Biomaterials for refractive correction:corneal onlays and inlays

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Science China Chemistry 2014年第4期57卷 501-509页

作者： wu Jian FUNDERBURGH James l wagner William R McGowan Institute for Regenerative Medicine University of Pittsburgh Department of Surgery University of Pittsburgh School of Medicine Department of Ophthalmology University of Pittsburgh School of Medicine Department of Bioengineering University of Pittsburgh

Corneal inlays and onlays represent a means of providing patients with permanent refractive error correction. As an alternative to conventional spectacles and contact lens, these techniques are less invasive compared with laser-based refractive surgery and are reversible. In this review, we provide a brief overview of the anatomic microstructure of the human cornea, indicating the primary physiological function for each component. Next, the wide range of biomaterials used as corneal inlays and onlays are considered, from synthetic polymers to biological components derived from the extracellular matrix. The limitations and challenges associated with the most common materials are discussed as is the need to improve their properties to achieve long-term, complication-free intraocular implantation. Finally, the prospect of applying tissue engineering strategies is noted for its potential to generate autologous corneal tissue that could be implanted as the optimal inlay or onlay materials.

关键词： refractive error onlays inlays synthetic polymer biological extracellular matrix refractive surgery

Microbial communities biostimulated by ethanol during uranium （VI） bioremediation in contaminated sediment as shown by stable isotope probing

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Frontiers of Environmental Science & Engineering 2015年第3期9卷 453-464页

作者： Mary Beth lEIGH Wei-Min wu Erick CARDENAS Ondrej UHlIK Sue CARROll Terry GENTRY terence l. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDlE James M. TIEDJE Center for Microbial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA Department of Civil and Environmental Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA Department of Biochemistry and Microbiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environmental Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA Department of Crop and Soil Sciences Texas A&M University College Station TX 77843 USA

Stable isotope probing （SIP） was used to identify microbes stimulated by ethanol addition in microcosms containing two sediments collected from the bioremediation test zone at the US Department of Energy Oak Ridge site, TN, USA. One sample was highly bioreduced with ethanol while another was less reduced. Microcosms with the respective sediments were amended with ^13C labeled ethanol and incubated for 7 days for SIP. Ethanol was rapidly converted to acetate within 24h accompanied with the reduction of nitrate and sulfate. The accumulation of acetate persisted beyond the 7 d period. Aqueous U did not decline in the microcosm with the reduced sediment due to desorption of U but continuously declined in the less reduced sample. Microbial growth and concomitant 13C-DNA production was detected when ethanol was exhausted and abundant acetate had accumulated in both microcosms. This coincided with U（VI） reduction in the less reduced sample. I3C originating from ethanol was ultimately utilized for growth, either directly or indirectly, by the dominant microbial community members within 7 days of incubation. The microbial community was comprised predominantly of known denitrifiers, sulfate-reducing bacteria and iron （Ⅲ） reducing bacteria including Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus and others, including the known U（VI）-redueing bacteria Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobac- ter and Desulfosporosinus. The findings suggest that ethanol biostimulates the U（VI）-reducing microbial com- munity by first serving as an electron donor for nitrate, sulfate, iron （IH） and U（VI） reduction, and acetate which then functions as electron donor for U（VI） reduction and carbon source for microbial growth.

关键词： Stable isotope probing (S/P) ethanol acetate uranium reduction sediment bioremediation

YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn l.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.lam terence wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry l.Miller Kenneth R.Williams W.M.Keck Foundation Biotechnology Resource laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（lC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

Dynamics evolution of γ' precipitates size and composition interface between γ/γ' phases in Ni-Al alloy at different aging temperatures

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Rare Metals 2022年第10期41卷 3552-3559页

作者： Xing-Chao wu Yong-Sheng li Wei liu Zhi-Yuan Hou Meng-Qiong Huang School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

The precipitation dynamics of γ’(l1-NiAl)phase and composition interfacial width between γ(fcc Ni)and γ’ phase were investigated using the phase field simulation linking with CAlPHAD *** coarsening rate and particle size distribution(PSD) of γ’ phase,the temporal composition interfacial width of γ/γ’ in Ni-17 at% Al alloy aged at 923,973 and 1023 K were *** the aging temperature increases,the morphology of γ’ phase changes from the interconnected rectangle shape to the separated cuboidal *** average particle radius() of γ’ phase at coarsening stage follows ∞t^(n) with the exponents n=0.21,0.23 and 0.26,*** peak values of simulated PSDs at 923 K are less than the value calculated by the lifshitz-Slyozov-wagner(lSW) model,and the width of simulated PSD increases at later stage of *** normalized radius(r/)which corresponds to the peak value of PSD moves from1.1 to 1.0 as the aging temperature increases from 923 to1023 K,and they are smaller than that of lSW *** composition interfacial width decreases as the aging progresses and increases as the aging temperature increases.

关键词： Ni-Al alloy Precipitation Dynamics Particle size distribution Composition interface Phase field

地下水铀污染的原位微生物还原与固定：在美国能源部田纳西橡树岭放射物污染现场的试验

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环境科学学报 2011年第3期31卷 449-459页

作者：吴唯民 Jack Carley David Watson 顾宝华 Scott Brooks Shelly D.Kelly Kenneth Kemner Joy D.van Nostrand 吴力游许玫英周集中罗剑 Erick Cardenas 黄家琪 Matthew W.Fields terence l.Marsh James M.Tiedje Stefan J.Green Joel E.Kostka Peter K.Kitanidis Philip M.Jardme CraigS.Criddle 美国斯坦福大学土木与环境工程系 StanfordCA94305USA 美国橡树岭国家实验室环境科学部 OakRidgeTN37831USA 美国阿岗国家实验室生物科学部 ArgonneIL60439USA 美国俄克拉荷马大学植物-与微生物学系 NormanOK73019USA 广东省微生物研究所广州510070 美国乔冶亚理工学院土木与环境工程系 AtlantaGA30332USA 美国密歇根州立大学微生物生态中心 EastLansingMI48823USA 美国蒙大拿州立大学生物膜工程中心 BozemanMT59717USA 美国佛罗里达州立大学地球海洋大气科学系 TallahasseeFL32306USA 美国田纳西大学生物系统工程与土壤科学系 KnoxvilleTN37996USA

总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后... 详细信息

总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后通过加入溶解氧和硝酸盐来试验微生物还原后的地下水层中还原固定态铀的稳定性.通过预处理和长期间隔注入乙醇溶液,地下水中铀浓度从40～60mg·l-1降至0.03mg·l-1以下,达到了美国环保署饮用水的标准.还原的四价铀主要以U(Ⅳ)-Fe复合物的形态存在.结果表明,固定化后的四价铀只有在厌氧条件下才是稳定的,溶解氧和硝酸盐侵入地下水层后会使固定化的四价铀重新氧化为溶解态的六价铀.在试验过程中,采用多种分子生物学方法检测了微生物种群的变化和与铀氧化还原反应有关的功能微生物.本研究表明,在维持试验系统无氧和无硝酸盐的条件下,通过添加乙醇为电子供体可有效地促进地下水中土著功能微生物的活性,从而实现铀的原位还原固定与稳定.

关键词：铀污染微生物还原原位生物修复地下水沉积物

IKAP模式用于糖尿病足改良胫骨横向骨搬移术患者疗效分析

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中国基层医药 2023年第9期30卷 1422-1426页

作者：叶颖吴件姿丽水市中心医院修复重建、手外、整形外科丽水323000

目的:观察信息-知识-信念-行为(IKAP)模式用于严重糖尿病足改良胫骨横向骨搬移术患者的临床疗效。方法:选取丽水市中心医院2020年3月至2022年3月拟行改良胫骨横向骨搬移术wagner 3、4级糖尿病足患者86例为研究对象,采用随机数字表法分... 详细信息

目的:观察信息-知识-信念-行为(IKAP)模式用于严重糖尿病足改良胫骨横向骨搬移术患者的临床疗效。方法:选取丽水市中心医院2020年3月至2022年3月拟行改良胫骨横向骨搬移术wagner 3、4级糖尿病足患者86例为研究对象,采用随机数字表法分为对照组、观察组各43例。对照组接受传统健康教育,观察组在对照组基础上给予IKAP模式的健康教育。比较两组自我效能感、自我护理能力、心理状态、生活质量、周围血管与神经恢复情况、血糖控制水平。结果:出院3个月后,观察组患者自我效能感量表、自我护理能力测定量表评分分别为(32.17±5.08)分、(151.32±10.62)分,均明显高于对照组的(29.28±6.12)分、(119.69±10.90)分(t=2.38、13.63,均Pl/l、(6.61±0.47)%,均明显低于对照组的(8.72±0.91)mmol/l、(7.28±0.54)%(t=11.83、6.14,均P<0.001)。结论:IKAP模式可提升严重糖尿病足改良胫骨横向骨搬移术患者遵医依从性,缓解其焦虑或抑郁情绪,改善生活质量,促进周围神经、血管病变恢复,有效控制血糖,有一定的临床应用优势。

关键词：糖尿病糖尿病足胫骨横向骨搬移术健康教育诊疗模式护士自我管理心理状态生活质量

Study of the genus Phytobius Schoenherr(Coleoptera:Curculionidae:Ceutorhynchinae) with a newly recorded species from China

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Entomotaxonomia 2018年第1期40卷 46-61页

作者： Jiahuan lU Junhao HUANG lujing YANG Runzhi ZHANG Hong wu Institute of Forestry Protection School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiang 311300China Forestry Bureau of Sanyuan SanmingFujian 365001China CAS Key laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeo'ing 100101China

The genus Phytobius Schoenherr,1833(Ceutorhynchinae:Phytobiini)from China was revised on the basis of morphological observations and barcode *** distribution of the type species ***(Marsham,1802)in China was confirmed for the first time,based on specimens collected from Beijing and *** species,*** wagner,1939 was found widely distributed along the east coast of *** morphologically varied populations from the north(Heilongjiang)and south(Zhejiang)are suggested to be the same species based on the genetic divergence and phylogeny analysis of CO1 *** plant association of the species with Polygonum hydropiper l.(Polygonaceae)was *** photographs,illustrations of important characters,distribution map,and a key to both species are provided.

关键词： Phytobiini taxonomy DNA barcoding

罗望子多糖对冰重结晶、生长习性和量热行为的影响

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食品与发酵工业 2024年第1期50卷 120-126页

作者：孙先保宋红王江梅吴艳周炜扬州市扬大康源乳业有限公司江苏扬州225004 上海交通大学农业与生物学院上海200240 山东省潍坊生态环境监测中心山东潍坊261041

为系统考察罗望子多糖对冰晶生长的抑制效应,采用“蔗糖三明治”冰重结晶试验、lifshitz-Slyozov-wagner(lSW)理论模型、动态冰晶修饰试验和差示扫描量热法研究该多糖溶液的冰重结晶动力学、冰晶生长习性和量热行为。结果表明,罗望子多... 详细信息

为系统考察罗望子多糖对冰晶生长的抑制效应,采用“蔗糖三明治”冰重结晶试验、lifshitz-Slyozov-wagner(lSW)理论模型、动态冰晶修饰试验和差示扫描量热法研究该多糖溶液的冰重结晶动力学、冰晶生长习性和量热行为。结果表明,罗望子多糖在溶液中呈浓度依赖性构象转变,该多糖具有显著的冰重结晶抑制活性,其中添加0.25%(质量分数)的多糖可以使冰晶生长速率降低近10倍。罗望子多糖具有较弱的冰晶形貌修饰活性,暗示其与冰晶表面可能具有较弱的相互作用。此外,罗望子多糖具有一定的冰点抑制活性而对融点没有显著影响。值得注意的是,当多糖浓度超过一定值时,冰重结晶抑制活性和冰点抑制活性略有降低,推测罗望子多糖基于“界面效应”抑制冰晶生长。研究结果表明罗望子多糖具有作为新型天然冷冻食品抑冰剂的潜力,也为理解天然多糖的防冻机理提供了新的思路。

关键词：多糖冰晶冰重结晶抑制量热行为冷冻食品

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(Nb,Al)共掺BaTiO_3陶瓷的巨介电及介电弛豫现象（英文）

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无机材料学报 2017年第2期32卷 219-224页

作者：黄栋吴颖苗纪远刘志甫李永祥中国科学院上海硅酸盐研究所无机功能材料与器件重点实验室上海200050 上海科技大学物质科学与技术学院上海201210

(Nb,Al)共掺的BaTiO_3陶瓷(BaTi_(0.98)(Nb_(0.5)Al_(0.5))_(0.02)O_3)表现出巨介电现象,介电常数可以达到3×105,介电损耗为0.2。在10^(-1)~10~7 Hz范围内,观察到三种介电弛豫现象,并分别对其进行了分析。低频段(10^(-1)~10 Hz)和中频段(10~3~10~5 Hz)属于非德拜弛豫,分别是由于Maxwell-wagner电极界面极化和晶界层电容器效应引起的;相反,高频段(10~5~10~7 Hz)属于德拜弛豫,通过阿伦尼乌斯公式的拟合,得到其激活能E=15 meV和频率因子f_0=7×10~6Hz。较小的激活能和频率因子表明其弛豫过程可能来源于复杂缺陷团簇中的电子的局域运动,被称为钉扎电子–缺陷偶极子效应。本研究显示钉扎电子–缺陷偶极子效应可以作为设计新型巨介电钙钛矿材料的依据。

关键词： (Nb,Al)共掺钙钛矿巨介电常数钉扎电子–缺陷偶极子