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Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

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Journal of Animal Science and Biotechnology 2020年第2期11卷 480-492页

作者： Andrea g.Braundmeier-Fleming Cassandra S.Skenandore Lesly gil Victoria Jacobsen Melissa Cregger taylor Badger Mallory Karr guoyao Wu Stephen B.Smith Annie E.Newell-Fugate Department of Medical Microbiology Immunology and Cell BiologySchool of MedicineSouthern Illinois UniversitySpringfieldIL 62702USA Department of Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M University4466 TAMUCollege StationTX 77843USA Department of Animal Science Texas A&M University2471 TAMUCollege StationTX 77843USA

Background:We hypothesized that supplementation of nursery and grower pig diets with coconut oil in the absence of antibiotics would yield maintenance of glucose homeostasis,growth performance,and immune function similar to what is achieved with nursery and grower pig diets containing *** received the same base treatment diets from d24(weaning)to d71 of age and had blood and fecal samples collected on d24,d31,d45 and d71 for measurement of whole blood glucose,serum insulin,cortisol and cytokines,and fecal *** had weekly weights and daily feed consumption measured throughout the *** were euthanized at d71 and subcutaneous fat and ileal contents were collected for assessment for fatty acids and microbiome,*** treatments consisted of 2%soybean oil plus antibiotics(ABX;n=22),2%soybean oil without antibiotics(NABX;n=22),and 2%coconut oil without antibiotics(COC;n=22).Statistical analysis examined the effect of diet within each timepoint using a repeated measures ***:Pigs fed COC diet had decreased serum insulin levels,maintained feed intake,feed conversion and weight gain,and,based on serum cytokines and fecal microbiome,were immunologically similar to ABX-fed ***,NABX-fed pigs performed similarly to the ABX-fed pigs in all parameters except for serum ***,there was no difference in the incidence of diarrhea between any of the diet ***:This study demonstrates that dietary antibiotics are not necessary to maintain growth performance in nursery and grower ***,dietary antibiotics appear to modulate circulating cytokine *** coconut oil is neither harmful nor helpful to growth performance or immune function in nursery and grower pigs but does modulate serum insulin ***,while coconut oil fed at 2%by weight is a suitable substitute for dietary antibiotics,this study suggests that no substitute for dietary antibiotics is needed at all.

关键词： Alternatives Antibiotic supplementation grower pigs Medium chain fatty acids Nursery pigs Oil

Methodology of Single Crystal growth and Microstructure Analysis of CoTi(Zr) Intermetallic Compounds

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Journal of Materials Science & Technology 2005年第6期21卷 817-821页

作者： Mike L.JENKINS glyn taylor Department of Materials University of Oxford Parks Road Oxford OX1 3PH UK

The effects of preparation and crystal growth methods on the microstructure, composition, and oxidation of CoTi（Zr） intermetallics were dealt with . A group of methods has been used to produce CoTi and CoTi（Zr） crystals to prevent the formation of titanium oxide particles during melting and crystal growth. The results show that more oxides formed when using powdered starting materials even though the metals handled were and melted under an inert gas atmosphere; using bulk starting materials produced alloys showed less oxidation than powders, but adding a small amount of AI to getter the oxygen was not sufficient to prevent TiO2 formation. However, using a slightly reducing atmosphere during initial melting was highly effective in reducing the formation of oxide. Crystal growth carried out in Ar did not reduce the amount of oxide but only redistributed the particles. TiO2 particles were found only in the grain boundaries after crystal growing, where they obstructed grain growth. Crystal growth in a vacuum was found to be essential in producing oxide free crystals. A seed selection technique was developed and used in growing CoTi single crystals. The microstructures of the samples were determined using optical microscopy, scanning electron microscopy and transmission electron microscopy, including the morphologies, grain sizes, oxide distributions and crystal structure confirmation.

关键词： CoTi CoTi(Zr) Intermetallics Crystal growth Nicrostructure

Mycobacterium avium subspecies paratuberculosis in the causation of Crohn's disease

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World Journal of gastroenterology 2000年第5期6卷 630-632页

作者： John Hermon-taylor Department of Surgery St.George's Hospital Medical SchoolLondon SW17 OREU.K.

Mycobacterium avium subspecies paratuberculosis(MAP),originally called Johne’s bacillus was firstdescribed from germany in 1895 as the cause of achronic inflammatory disease of the intestine in *** the 20th century progressed,clinical andsub-clinical MAP infection in farm animals inWestern Europe appeared to become *** the early reviews available

关键词： mycobacterium avium paratuberculosis Crohn’s disease immunologic tests immunocompetence mycobacterium avium subspecies paratuberculosis

Superplastic forming characteristics of AZ41 magnesium alloy

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Transactions of Nonferrous Metals Society of China 2021年第3期31卷 648-654页

作者： S.taylor g.D.WEST E.MOgIRE F.TANg H.R.KOTADIA WMg the University of WarwickCoventry CV47ALUK Buehler WMG Materials Engineering Centrethe University of WarwickCoventry CV47ALUK

An AZ41 magnesium alloy in the hot-rolled condition without further thermomechanical processing to modify its microstructure was investigated to establish its suitability for use within a superplastic forming process and to establish optimum forming *** was assessed using elevated temperature tensile testing and hot gas bulging,across a range of strain rates(1×10^(−1)−1×10^(−3)s^(−1))and temperatures(350−450℃).Circle grid analysis with gOM Aramis cameras was used to understand peak strains and material thinning in relation to industrial forming *** forming EBSD and STEM analysis was conducted to understand the mechanisms responsible for the materials formability,with dynamic recrystallization being clearly *** elongation of 520%was achieved at 450℃ and 1×10^(−3)s^(−1);industrially relevant elongation was achieved at 1×10^(−2) s^(−1) at both 450℃(195%)and 400℃(170%).

关键词： magnesium superplastic forming superplasticity electron back-scattered diffraction(EBSD) AZ41 magnesium alloy

Virus entry mediated by hepatitis B virus envelope proteins

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World Journal of gastroenterology 2013年第40期19卷 6730-6734页

作者： John M taylor Fox Chase Cancer Center PhiladelphiaPA19111United States

Hepatitis B virus(HBV),a major cause of human liver disease worldwide,encodes three envelope proteins needed for the attachment and entry of the virus into susceptible host cells.A second virus,hepatitis delta virus,which is known to enhance liver disease in HBV infected patients,diverts the same HBV envelope proteins to achieve its own assembly and *** the lab,lentiviral vectors based on human immunodeficiency virus type 1 can be assembled using the HBV envelope proteins,and will similarly infect susceptible *** article provides a partial review and some personal reflections of how these three viruses infect and of how recipient cells become susceptible,along with some consideration of questions that remain to be answered.

关键词： Hepatitis B virus Hepatitis delta virus Receptor Envelope proteins Entry

WJH 6^(th) Anniversary Special Issues(2): Hepatocellular carcinoma Problem of hepatocellular carcinoma in West Africa

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World Journal of Hepatology 2014年第11期6卷 783-792页

作者： Nimzing g Ladep Olufunmilayo A Lesi Pantong Mark Maud Lemoine Charles Onyekwere Mary Afihene Mary ME Crossey Simon D taylor-Robinson Hepatology Unit Imperial College London St Mary’s Hospital Campus Department of Medicine College of Med-icine University of Lagos Department of Medicine Jos University Teach-ing Hospital Department of Medicine Lagos State Uni-versity College of Medicine/Teaching Hospital Department of Medicine Komfo Anokye Teach-ing Hospital

The incidence of hepatocellular carcinoma(HCC) isknown to be high in West Africa with an approximateyearly mortality rate of 200000. Several factors are responsible for this. Early acquisition of risk factors; with vertical or horizontal transmission of hepatitis B(HBV), environmental food contaminants(aflatoxins), poor management of predisposing risk factors and poorlymanaged strategies for health delivery. There has been a low uptake of childhood immunisation for hepatitis B in many West African countries. Owing to late presentations, most sufferers of HCC die within weeks of their diagnosis. Highlighted reasons for the specific disease pattern of HCC in West Africa include:(1) high rate of risk factors;(2) failure to identify at risk populations;(3) lack of effective treatment; and(4) scarce resources for timely diagnosis. This is contrasted to the developed world, which generally has sufficient resources to detect cases early for curative treatment. Provision of palliative care for HCC patients is limited by availability and affordability of potent analgesics. Regional efforts, as well as collaborative networking activities hold promise that could change the epidemiology of HCC in West Africa.

关键词： Liver cancer West Africa Aflatoxin Surveillance Hepatitis B

Short-term Forecasting of Individual Residential Load Based on Deep Learning and K-means Clustering

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CSEE Journal of Power and Energy Systems 2021年第2期7卷 261-269页

作者： Fujia Han Tianjiao Pu Maozhen Li gareth taylor Artificial Intelligence Application Department China Electric Power Research InstituteBeijing 100192China Department of Electronic and Computer Engineering Brunei University LondonUxbridgeUKUB83PH Brunei Institute of Power Systems Brunei University LondonUxbridgeUKUB83PH

In order to currently motivate a wide range of various interactions between power network operators and electricity customers,residential load forecasting plays an increasingly important role in demand side response(DSR).Due to high volatility and uncertainty of residential load,it is significantly challenging to forecast it ***,this paper presents a short-term individual residential load forecasting method based on a combination of deep learning and k-means clustering,which is capable of effectively extracting the similarity of residential load and performing residential load forecasting accurately at the individual *** first makes full use of k-means clustering to extract similarity among residential load and then employs deep learning to extract complicated patterns of residential *** presented method is tested and validated on a real-life Irish residential load dataset,and the experimental results suggest that it can achieve a much higher prediction accuracy,in comparison with a published benchmark method.

关键词： Deep learning demand side response(DSR) interactions k-means clustering residential load forecasting similarity

Non-contact method to reduce contact problems between sample and electrode in dielectric measurements

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High Voltage 2020年第6期5卷 753-761页

作者： Jing Hao Xiangdong Xu Nathaniel taylor Electromagnetic Engineering KTH Royal Institute of Technology10044 StockholmSweden Electric Power Engineering Chalmers University of Technology41296 GothenburgSweden

Dielectric response measurement is a widely used technique for characterising dielectric materials in terms of their capacitance and dielectric loss. However, the widely used approach with contact between samples and electrodes can in some cases limit the accuracy of the measurement. The authors introduce an easily realised electrode arrangement for non-contact measurements, which avoids these contact problems. The performance of the electrode arrangement in terms of the edge effect is assessed. The non-contact and contact methods are compared based on error-sensitivity analysis and experimental results. Differences are studied further, with attention to contact pressure. The non-contact method is also compared experimentally with the one-sided non-contact method. Air-reference measurements, comparing the sample to an air-gap for improved calibration, are used for all measurements. The results show that the non-contact method can be an alternative to reduce contact problems between the sample and electrodes, although error sensitivity can be higher when the non-contact method is used. The non- contact method can decrease the influence of the pressure applied to the sample compared to the contact method, and can also reduce the problem of poor contact that can arise from the absence of pressure in the one-sided non-contact method.

关键词： method. dielectric electrode

Wrapping up the role of pericytes in Parkinson's disease

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Neural Regeneration Research 2023年第11期18卷 2395-2396页

作者： taylor John Stevenson Birger Victor Dieriks Department of Pharmacology University of AucklandAucklandNew Zealand Centre for Brain Research University of AucklandAucklandNew Zealand Department of Anatomy and Medical Imaging University of AucklandAucklandNew Zealand

Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.

关键词： homeostasis pericyte