Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs

作     者：Andrea G.Braundmeier-Fleming Cassandra S.Skenandore Lesly Gil Victoria Jacobsen Melissa Cregger Taylor Badger Mallory Karr Guoyao Wu Stephen B.Smith Annie E.Newell-Fugate Andrea G.Braundmeier-Fleming;Cassandra S.Skenandore;Lesly Gil;Victoria Jacobsen;Melissa Cregger;Taylor Badger;Mallory Karr;Guoyao Wu;Stephen B.Smith;Annie E.Newell-Fugate

作者机构：Department of Medical MicrobiologyImmunology and Cell BiologySchool of MedicineSouthern Illinois UniversitySpringfieldIL 62702USA Department of Veterinary Physiology and PharmacologyCollege of Veterinary Medicine and Biomedical SciencesTexas A&M University4466 TAMUCollege StationTX 77843USA Department of Animal ScienceTexas A&M University2471 TAMUCollege StationTX 77843USA 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2020年第11卷第2期

页      面：480-492页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：This study was made possible through the grant USDA Formula Animal Health Fund(NIFA)to A.E.Newell-Fugate The open access publishing fees for this article have been covered by the Texas A&M University Open Access to Knowledge Fund(OAKFund) supported by the University Libraries and the Office of the Vice President for Research 

主　　题：Alternatives Antibiotic supplementation Grower pigs Medium chain fatty acids Nursery pigs Oil 

摘      要：Background:We hypothesized that supplementation of nursery and grower pig diets with coconut oil in the absence of antibiotics would yield maintenance of glucose homeostasis,growth performance,and immune function similar to what is achieved with nursery and grower pig diets containing *** received the same base treatment diets from d24(weaning)to d71 of age and had blood and fecal samples collected on d24,d31,d45 and d71 for measurement of whole blood glucose,serum insulin,cortisol and cytokines,and fecal *** had weekly weights and daily feed consumption measured throughout the *** were euthanized at d71 and subcutaneous fat and ileal contents were collected for assessment for fatty acids and microbiome,*** treatments consisted of 2%soybean oil plus antibiotics(ABX;n=22),2%soybean oil without antibiotics(NABX;n=22),and 2%coconut oil without antibiotics(COC;n=22).Statistical analysis examined the effect of diet within each timepoint using a repeated measures ***:Pigs fed COC diet had decreased serum insulin levels,maintained feed intake,feed conversion and weight gain,and,based on serum cytokines and fecal microbiome,were immunologically similar to ABX-fed ***,NABX-fed pigs performed similarly to the ABX-fed pigs in all parameters except for serum ***,there was no difference in the incidence of diarrhea between any of the diet ***:This study demonstrates that dietary antibiotics are not necessary to maintain growth performance in nursery and grower ***,dietary antibiotics appear to modulate circulating cytokine *** coconut oil is neither harmful nor helpful to growth performance or immune function in nursery and grower pigs but does modulate serum insulin ***,while coconut oil fed at 2%by weight is a suitable substitute for dietary antibiotics,this study suggests that no substitute for dietary antibiotics is needed at all.