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Glassy carbon microneedles-new transdermal drug delivery device derived from a scalable C-MEMS process

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Microsystems & Nanoengineering 2018年第1期4卷 13-23页

作者： Richa Mishra Bidhan Pramanick Tapas Kumar Maiti tarun kanti bhattacharyya Advanced Technology Development Center IIT KharagpurKharagpurWest Bengal 721302India Department of Mechanical Engineering IIT KharagpurKharagpurWest Bengal 721302India Biotechnology Department IIT KharagpurKharagpurWest Bengal 721302India Department of Electronics and Electrical Communication Engineering IIT KharagpurKharagpurWest Bengal 721302India School of Electrical Sciences IIT GoaPondaGoa 403401India

Because carbon is the basic element of all life forms and has been successfully applied as a material for medical applications,it is desirable to investigate carbon for drug delivery applications,as *** this work,we report the fabrication of a hollow carbon microneedle array with flow channels using a conventional carbonmicroelectromechanical system(C-MEMS)*** process utilizes the scalable and irreversible step of pyrolysis,where prepatterned SU-8 microneedles(precursor)are converted to glassy carbon structures in an inert atmosphere at high temperature(900°C)while retaining their original shape upon *** converted to glassy carbon,the microneedles inherit the unique properties of hardness,biocompatibility,and thermal and chemical resistance associated with this material.A comparative study of hardness and Young’s modulus for carbon microneedles and SU-8 microneedles was performed to evaluate the increased strength of the microneedles induced by the C-MEMS process *** shrinkage of the carbon microneedles upon pyrolysis was observed and *** characterizations including energy-dispersive X-ray spectroscopy(EDX)and Raman spectroscopy were carried out to estimate the atomic percentage of carbon in the microneedle structure and its crystalline nature,*** investigations confirm that the microneedles are glassy in *** and bending tests were also performed to determine the maximum forces that the carbon microneedles can withstand,and it was found that these forces were approximately two orders of magnitude higher than the resistive forces presented by skin.A microneedle array was inserted into mouse skin multiple times and was successfully removed without the breakage of any microneedles.

关键词： carbon process needle

Are case reports valuable?Exploring their role in evidence based medicine and patient care

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World Journal of Clinical Cases 2024年第24期12卷 5452-5455页

作者： tarun Kumar Suvvari Department of Clinical Research Squad Medicine and Research(SMR)Amadalavalasa 532185Andhra PradeshIndia Department of Medicine Rangaraya Medical CollegeKakinada 533001Andhra PradeshIndia

Case reports,often overlooked in evidence-based medicine(EBM),play a pivotal role in healthcare *** provide unique insights into rare conditions,novel treatments,and adverse effects,serving as valuable educational tools and generating new *** their limitations in generalizability,case reports contribute significantly to evidence-based practice by offering detailed clinical information and fostering critical thinking among healthcare *** acknowledging their limitations and adhering to reporting guidelines,case reports can contribute significantly to medical knowledge and patient care within the evolving landscape of *** editorial explores the intrinsic value of case reports in EBM and patient care.

关键词： Clinical cases Case reports Evidence based medicine Editorial Healthcare research

Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney tarun Prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

Exploring the association between hypertension and cognitive impairment:Evidence-based insights

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Chronic Diseases and Translational Medicine 2024年第2期10卷 153-155页

作者： tarun Kumar Suvvari Rangaraya Medical College KakinadaAndhra PradeshIndia Squad Medicine and Research VizagAndhra PradeshIndia

To the Editor,Hypertension,also known as high blood pressure(BP),affects millions of people *** its well-documented cardiovascular consequences,hypertension has been uncovered an association with cognitive impairment.1 This is a growing concern,as the number of people with hypertension is expected to increase in the coming years,particularly in developing countries.

关键词： hypertension impairment cardiovascular

Determining the relationship between chemical composition and size, shape and effective density of airborne fine particles through concurrent use of inertial and optical based measurements

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Particuology 2016年第5期14卷 93-101页

作者： Anand Kumar tarun Gupta Environmental Engineering and Management Program Indian Institute of Technology Kanpur Kanpur 208016 India Institute of Atmospheric and Climate Science Swiss Federal Institute of Technology Zurich Zurich 8092 Switzerland Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

This study presents the development of a medium flow, multiple slit based PM2.5 （particle aerodynamic diameter 〈2.5 μm） inertial impactor. Its performance was compared with that of a light scattering based optical particle sizer in a field study and in controlled lab based experiments using polydisperse dolomite powder as test aerosol. The impactor＇s optimum nozzle configuration had a cutoff size of 2.51 μm （aero- dynamic diameter） at an operating flow rate of 215 L/rain with a pressure drop of 0.35 kPa across the impactor stage. Because the apparent particle density of an ambient aerosol depends on the physical properties and the chemical composition of the particles, the PM2.5 mass concentration was measured with an optical particle sizer and an inertial impactor over a weekday and a weekend day in a field study during which the effective particle shape factor and density were in tandem modified in order to com- pare the results from the two sampling techniques. The correlation of the two instrument results tended towards 1：1 with increasing values of shape factor （irregular shaped） and effective particle density. This observation was supported through chemical investigations of the collected mass, which showed a higher percentage contribution from elements which are mostly of crustal nature （namely, Ca, Fe, and Mg）.

关键词： lmpactor PM2.5 Optical particle counter Effective particle density Shape factor

Propagation of Rayleigh waves on free surface of transversely isotropic generalized thermoelastic diffusion

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Applied Mathematics and Mechanics(English Edition) 2008年第11期29卷 1451-1462页

作者： Rajneesh Kumar tarun Kansal Department of Mathematics Kurukshetra UniversityKurukshetra-136 119India

The present paper is devoted to the study of Rayleigh wave propagation in a homogeneous, transversely isotropic, thermoelastic diffusive half-space, subject to stress free, thermally insulated/isothermal, and chemical potential boundary conditions in the context of the generalized thermoelastic diffusion theory. The Green-Lindsay（GL） theory is used in the study. In this theory, thermodiffusion and thermodiffusion mechanical relaxations are governed by four different time constants. Secular equations for surface wave propagation in the considered media are derived. Anisotropy and diffusion effects on the phase velocity, attenuation coefficient are graphically presented in order to present the analytical results and make comparison. Some special cases of frequency equations are derived from the present investigation.

关键词： wave propagation transversely isotropic generalized thermoelastic diffusion phase velocity attenuation coefficient

Effect of relaxation times on circular crested waves in thermoelastic diffusive plate

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Applied Mathematics and Mechanics(English Edition) 2010年第4期31卷 493-500页

作者： Rajneesh KUMAR tarun KANSAL Department of Mathematics Kurukshetra University

The propagation of circularly crested thermoelastic diffusive waves in an infinite homogeneous transversely isotropic plate subjected to stress free, isothermal/insulated and chemical potential conditions is investigated in the framework of different thermo- elastic diffusion theories. The dispersion equations of thermoelastic diffusive Lamb type waves are derived. Some special cases of the dispersion equations are also deduced.

关键词： wave propagation transversely generalized thermoelastic diffusion attenuation isotropic crested waves phase velocity coefficient amplitudes

Hybrid Bio-based Composites from Waste Chicken Feather and Betel Nut Fiber: A Study on the Mechanical and Thermal Properties

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Journal of Bionic Engineering 2022年第1期19卷 268-277页

作者： Gitashree Gogoi Chayanika Chowdhury tarun K.Maji Department of Chemical Sciences Tezpur UniversityAssam784028India

The present work is an attempt to develop bio-based hybrid composites by incorporating Betel nut Fiber(BF)and Chicken feather Fiber(CF)at different ratios in modified soybean oil matrix by compression molding *** ratio of the fiber and resin was taken as 30:*** soybean oil(ESO)was modified by using methacrylic acid and methacrylic *** ratio of CF and BF was varied from 2:1 to 1:2 *** influence of hybrid fibers and fiber ratio on various properties of the composites was *** obtained results showed that composites prepared with 1:1 ratio of CF and BF exhibited highest tensile strength compared to the other composites prepared by using different ratios of CF and *** surface morphology of the composites was studied by Scanning Electron Microscopy(SEM),where surface roughness was found to be decreased after incorporation of hybrid *** analysis was carried out to study the behaviour of the composites at high temperature,where thermal stability was found to enhance for hybrid composites compared to the composites prepared with single *** properties like water vapour uptake capacity and volumetric swelling were measured and found to be decreased for the hybrid *** overall improvement in properties was observed for composites having 1:1 ratio of CF:***,it is concluded that 1:1 weight ratio of CF and BF is the optimum mixing ratio to enhance the various properties of the hybrid composites.

关键词： Hybrid composites Betel nut fiber Chicken feather fiber Mechanical properties Thermal properties