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A polynomial resultant approach to algebraic constructions of extremal graphs

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Science China Mathematics 2024年

作者： tao Zhang Zixiang Xu Gennian Ge Institute of Mathematics and Interdisciplinary Sciences Xidian University School of Mathematical Sciences Capital Normal University

the turan problem asks for the largest number of edges ex（n, H） in an n-vertex graph not containing a fixed forbidden subgraph H, which is one of the most important problems in extremal graph theory. However,the order of magnitude of ex（n, H） for bipartite graphs is known only in a handful of cases. In particular,giving explicit constructions of extremal graphs is very challenging in this field. In this paper, we develop a polynomial resultant approach to the algebraic construction of explicit extremal graphs, which can efficiently decide whether a specified structure exists. A key insight in our approach is the multipolynomial resultant, which is a fundamental tool of computational algebraic geometry. Our main results include the matched lower bounds on the turan number of 1-subdivision of K3,t1and the linear turan number of the Berge theta hypergraphΘ3B,t2, where t1= 25 and t2= 217. Moreover, the constant t1 improves the random algebraic construction of Bukh and Conlon（2018） and makes the known estimation better on the smallest value of t1 concerning a problem posed by Conlon et al.（2021） by reducing the value from a magnitude of 1056 to the number 25, while the constant t2improves a result of He and tait（2019）.

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Promoted catalytic performance of Ag-Mn bimetal catalysts synthesized through reduction route

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Journal of Environmental Sciences 2024年第3期137卷 358-369页

作者： Wenkai Hu tao Guo Kaiyao Ma Xu Li Wangting Luo Mingzhi Wu Hao Guo Yaxin Zhang Wenfeng Shangguan School of Chemical Engineering and technology Xinjiang UniversityUrumchi 830017China Research Center for Combustion and Environmental technology Shanghai Jiao Tong UniversityShanghai 200240China

VOCs can exert great harm to both human and environment,and catalytic oxidation is believed to be an effective technique to eliminate these *** this paper,Ag-Mn bimetal catalysts with 10 wt.%of silver were synthesized using doping,impregnation,and reduction methods respectively,and then they were applied to the catalytic oxidation of *** series of characterizations it showed that the loading of silver using reduction method significantly resulted in improved physico-chemical properties of manganese oxides,such as larger surface area and pore volume,higher proportion of surface Mn~(3+)and Mn~(4+),stronger reducibility and more active of surface oxygen species,which were all beneficial to its catalytic *** a result,the Ag-Mn catalysts synthesized by reduction method showed a lower t_(90)value(equals to the temperature at which 90%of initial benzene was removed)of 203℃.Besides,both the used and fresh Ag-Mn catalysts synthesized by reduction method showed preferable stability in this research.

关键词： Ag-Mn Benzene oxidation Catalytic performance Reduction route

Predict the evolution of mechanical property of Al-Li alloys in a marine environment

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Defence technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei Li Lin Xiang Guang Wu Hongli Si Jinyan Chen Yiming Jin Yan Su Jianquan tao Chunyang Huang State Key Laboratory of Explosion Science and technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest technology and Engineering Research Institute Chongqing400039China

the ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-Li alloys in the marine *** obtained the mechanical properties of Al-Li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).the strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-term Memory(LStM)neural ***,the output data of LStM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-Li *** main conclusions are as follows:*** variation law of mechanical properties of2297-t8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-t8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LStM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-Li alloy Machine learning Corrosion

RNA ac^(4)C modification in cancer biology:from regulatory mechanisms to clinical applications

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Science China(Life Sciences) 2024年第4期67卷 832-835页

作者： Lijun tao Yunqing Lu Zhuojia Chen Lichen Ge Junming He Jianxin Peng Hongsheng Wang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Hepatobiliary Surgery Guangdong Province Traditional Chinese Medical HospitalGuangzhou 510120China

RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since *** these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。

关键词： clinical (4) modification

New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： Wen-Chao Cao Qing-Shan Chen Run Gan tao Huang Xiao-He Yan the Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:to identify a maculopathy patient caused by new recessive compound heterozygous variants in ***:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 *** sequence capture array technique was used to screen potential pathologic *** chain reaction and Sanger sequencing were used to confirm the screening ***:Fundus examination showed round macular lesions appeared in both *** coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right *** autofluorescence showed patchy hyper-autofluorescence in the *** field examination indicates central defects in both ***(ERG)and multifocal ERG showed no obvious *** fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left *** found that the proband carried a missense variant(c.1972C>t)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous *** variants are likely pathogenic according to the ACMG *** imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal ***:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1

Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-Quan Luo Zhi-Jian Wei A-Man Xu tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** to explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** to explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** the expression level of CASC19 is related to the t stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMt conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMt conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMt conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and t stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines

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Green Synthesis and Catalysis 2024年第1期5卷 57-61页

作者： Lesong Li tao Liu Weiwu Ren Yang Wang Molecular Synthesis Center&Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology(QNLM)Qingdao 266237China

A catalyst-free and atom-economical[4+3]cycloaddition of azadienes with C,N-cyclic azomethine imines has been developed,providing an efficient and environmentally benign access to 1,2,4-triazepines with high diastereo... 详细信息

关键词： Catalyst-free Atom-economical[4+3] Cycloaddition C,N-cyclic Azomethine imine Azadiene 1,2,4-triazepine

Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine t.O.nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia the Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

the aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration tau traumatic brain injury

Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

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Asian Pacific Journal of tropical Biomedicine 2024年第6期14卷 253-258页

作者： trinh tat Cuong Duong Duc t.ien Hoang Hai Yen nguyen Anh Duc trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:to evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUt4)were examined in 3t3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(Pth no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(Pthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUt4 in 3t3-L1 cells(Ptone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUt4