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Omics for deciphering oral microecology

International Journal of Oral Science 2024年第2期16卷 197-207页

作者： Yongwang Lin Xiaoyue Liang Zhengyi Li tao gong Biao Ren Yuqing Li Xian Peng State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina

The human oral microbiome harbors one of the most diverse microbial communities in the human body,playing critical roles in oral and systemic *** technological innovations are propelling the characterization and manipulation of oral ***-throughput sequencing enables comprehensive taxonomic and functional profiling of oral *** long-read platforms improve genome assembly from complex ***-cell genomics provides insights into uncultured *** imaging modalities including fluorescence,mass spectrometry,and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing *** techniques link phylogenetic identity with *** spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for *** facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput *** integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly,gene expression,metabolites,microenvironments,virulence mechanisms,and microbe-host interfaces in the context of health and ***,significant knowledge gaps persist regarding community origins,developmental trajectories,homeostasis versus dysbiosis triggers,functional biomarkers,and strategies to deliberately reshape the oral microbiome for therapeutic *** convergence of sequencing,imaging,cultureomics,synthetic systems,and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict,prevent,diagnose,and treat associated oral diseases.

关键词： insight holds oral

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The SLEGS beamline of SSRF

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Nuclear Science and Techniques 2024年第7期35卷 20-30页

作者： Long-Xiang Liu Hong-Wei Wang gong-tao Fan Hang-Hua Xu Yue Zhang Zi-Rui Hao Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The Shanghai Laser Electron Gamma Source(SLEGS,located in BL03SSID)beamline at the Shanghai Synchrotron Radiation Facility(SSRF)is a Laser Compton Scattering(LCS)gamma source used for the investigation of nuclear structure,which is in extensive demand in fields such as nulear astrophysics;nulear cdluster structure,polarization physics;and nulear energy The beamline is based on the inverse Compton scattering of 10640 nm photons on 3.5 GeV electrons and a gamma source with va riable energy by changing the scattering angle frorm 20°to 160°.γrays of 0.25-21.1 MeV can be extracted by the scheme consisting of the interaction chamber,coarse collinator,fine collimator,and *** maximum photon flux for 1800 is approximately 10^(7)photons/s at the target at 21.7 MeV,with a 3-mm-diameter *** beamline was equipped with four types of spectrometers for experiments in(Y,Y'),(7,n),(Y,D),and(7,0).At present,Nuclear Resonance Fluorescence(NRF)spectrometry,Flat-Efficiency neutron Detector(FED)spectrometry,neutron Time-OF Flight(TOF)spectrometry,and Light-Charged Particle(LCP)spectrormetry methods have been developed.

关键词： Shanghai Synchrotron Radiation Facility SLEGS Nuclear astrophysics Nuclear structure

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Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

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Nano Research 2024年第7期17卷 6400-6410页

作者： Hanming Zhang Honglin Gao Yicong Zhang Yikun Han Qing Lin tao gong Xun Sun Zhirong Zhang Ling Zhang Shiqi Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic ***,we constructed TRAIL-[NDHCPT]^(GAC),a synergistic hydroxycamptothecin(HCPT)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)protein co-loaded disk-shaped nanocarrier withγ-glutamyl transpeptidase *** the novel nanodisks extravasated into the tumor interstitium,theγ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved theγ-glutamyl portions of the nanodisk surface to produce positively charged amino *** a result,the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic *** and TRAIL exerted synergistic antitumor effects with better overall therapeutic *** TRAIL-[ND-HCPT]^(GAC)system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.

关键词： tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk

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Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin He Lulu Wang Dongxu Wu Fan Tong Huan Zhao Hanmei Li tao gong Huile Gao Yang Zhou Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key Laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity Inc. WalthamMA 02451USA School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

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Artificial intelligence and evidence-based research will promote the development of traditional medicine

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Acupuncture and Herbal Medicine 2024年第1期4卷 134-135页

作者： Xinran Liu tao gong College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK College of Acupuncture and Chinese Medicine Northwestern Health Sciences UniversityBloomingtonUSA

Traditional medicine(TM)has progressively achieved international *** recent first-ever World Health Organization(WHO)Traditional Medicine Global Summit 2023 has undoubtedly highlighted the significance of TM^([1]).This conference was held in India during August 17–18,2023^([2]),aiming to mobilize political commitment and evidence-based action supporting TM and integrating it to advance the health and well-being of the people and planet.

关键词： integrating doubt planet

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Study of the spatial growth of stimulated Brillouin scattering in a gas-filled hohlraum via detecting the driven ion acoustic wave

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Matter and Radiation at Extremes 2024年第2期9卷 36-49页

作者： Chaoxin Chen tao gong Zhichao Li Liang Hao Yonggang Liu Xiangming Liu Hang Zhao Yaoyuan Liu Kaiqiang Pan Qi Li Sanwei Li Zhijun Li Sai Jin Feng Wang Dong Yang Laser Fusion Research Center China Academy of Engineering PhysicsMianyangSichuan 621900People’s Republic of China Institute of Applied Physics and Computational Mathematics Beijing 100094People’s Republic of China

In an experiment performed on the Shenguang-III prototype laser facility, collective Thomson scattering (TS) is used to study the spatialgrowth of stimulated Brillouin scattering (SBS) in a gas-filled hohlraum by detecting the SBS-driven ion acoustic wave. High-quality timeresolved SBS and TS spectra are obtained simultaneously in the experiment, and these are analyzed by a steady-state code based on theray-tracing model. The analysis indicates that ion–ion collisions may play an important role in suppressing SBS growth in the Au plasma;as aresult, the SBS excited in the filled gas region is dominant. In the early phase of the laser pulse, SBS originates primarily from the high-densityplasma at the edges of the interaction beam channel, which is piled up by the heating of the interaction beam. Throughout the duration of thelaser pulse, the presence of the TS probe beam might mitigate SBS by perturbing the density distribution around the region overlapping withthe interaction beam.

关键词： scattering filled Brillouin

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Fermented defatted rice bran-derived gut Clostridium butyricum improved the gut barrier function by regulating HIF-1 signaling pathway

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Food Science and Human Wellness 2024年

作者： Weifa Su Zipeng Jiang tao gong Man Du Fengqin Wang Zeqing Lu Mingliang Jin Yizhen Wang Key Laboratory of Molecular Animal Nutrition Ministry of Education Zhejiang University Key Laboratory of Animal Nutrition and Feed Ministry of Agricultural and Rural Affairs Zhejiang University National Engineering Research Center of Green Feeds and Healthy Livestock Industry Zhejiang University Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province Zhejiang University College of Animal Science Institute of Feed Science Zhejiang University

Emerging evidence of the beneficial effects of defatted rice bran (DFRB) on gut health has advanced the development of fermented defatted rice bran as a potential functional food. However， less is known about its effects and underlying mechanisms on gut health. In this study， a mouse model together with fecal microbiota transplantation (FMT) was utilized to study the effects and mechanisms of fermented DFRB (FR) on gut barrier function. We found that FR improved the intestinal morphology， gut tight junction proteins， mucin， antimicrobial peptides， and IL-22 and promoted the gut Clostridium butyricum and butyrate. Notably， correlation analysis indicated gut C. butyricum and butyrate were two FR-induced effectors that improved gut health. FMT results suggested that C. butyricum， butyrate， and fecal microbiota from the FR group all reduced PHD2 expression by activating PPAR-γ in the mouse colon. This decrease in gut PHD2 subsequently upregulated the HIF-1α expression， which in turn increased the expression of its targeted downstream tight junction proteins， mucin and antimicrobial peptides， and colonic IL-22 secretion. Overall， FR-derived C. butyricum and butyrate might improve gut barrier function through the HIF-1 signaling pathway， which provides a reference for the application of fermented DFRB as a potential functional food for improving of gut barrier function.

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Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

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Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma tao gong Ling Zhang Zhirong Zhang Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)***,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB ***,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor *** demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell ***,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in *** order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor *** anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

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公平竞争审查制度与备案审查制度的衔接机制研究

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西北大学学报（哲学社会科学版） 2024年第4期54卷 140-153页

作者：宁立志龚涛武汉大学法学院湖北武汉430072

公平竞争审查制度与备案审查制度是我国约束规范性文件制发的两种审查制度,但部门法之间的隔阂导致它们在理论上长期割裂。这两种审查制度在监督机制、审查能力、审查动力等方面具有互补性,使得建立它们之间的衔接机制具有现实可能性和... 详细信息

公平竞争审查制度与备案审查制度是我国约束规范性文件制发的两种审查制度,但部门法之间的隔阂导致它们在理论上长期割裂。这两种审查制度在监督机制、审查能力、审查动力等方面具有互补性,使得建立它们之间的衔接机制具有现实可能性和必要性。在坚持公平竞争审查的事前自我审查这一基本定位的前提下,可以将事后审查部分纳入备案审查制度中,将公平竞争审查结论作为备案审查中合法性与适当性审查的参考文件。还可以适时扩张公平竞争审查对象,将部分涉及市场主体经济活动的党组织规范性文件以及人大及其常委会立法、决议和决定纳入公平竞争审查制度,并建立党委、人大、政府之间的公平竞争审查衔接联动机制。

关键词：公平竞争审查备案审查反垄断法合法性审查适当性审查自我审查

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专利非实施主体的价值评判与法律规制——以网络化开放创新范式为视角

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知识产权 2024年第4期 92-108页

作者：宁立志龚涛武汉大学法学院

在传统视角下,专利非实施主体(NPE)主要产生于知识产权制度的漏洞,它们通过滥诉和滥用禁令救济等方式攫取了不合理的高额利润,会产生阻碍创新、损害消费者利益、破坏市场秩序等消极效果。但实际上,NPE的产生与网络化开放创新密切相关。... 详细信息

在传统视角下,专利非实施主体(NPE)主要产生于知识产权制度的漏洞,它们通过滥诉和滥用禁令救济等方式攫取了不合理的高额利润,会产生阻碍创新、损害消费者利益、破坏市场秩序等消极效果。但实际上,NPE的产生与网络化开放创新密切相关。NPE是知识产权二级市场发展和专业化分工的产物,它在许可谈判中的优势地位很大程度上来自于专利许可模式由事前许可向事后许可的转变。同时,NPE也反过来促进了网络化开放创新。它可以促进技术流动,降低企业获取技术的搜寻成本,提高小企业和个体发明人的创新激励。因此,NPE并没有“原罪”,而是一个中性的市场主体。对NPE的规制思路,应当从基于主体身份的规制路径转变为基于滥用行为及其权利源头的规制路径。

关键词：网络化开放创新非实施主体专利主张实体标准必要专利禁令

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