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Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

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Journal of Molecular Cell Biology 2016年第6期8卷 530-541页

作者： YouHua Zhang YouDong Pan ChangDong Lin YaJuan Zheng Hao Sun HaiLong Zhang JunLei Wang MengYa Yuan tao duan QiaoLing Du JianFeng Chen State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 200040China

Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder with potentially deleterious consequences for *** a clear correlation between the elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice,the underlying mechanisms remain ***,we report that bile acids induce NF-κB pathway activation via G protein-coupled bile acid receptor 1(Gpbar1),with consequent upregulation of inflammatory genes in trophoblasts,leading to aberrant leukocyte infiltration and inflammation in *** acid(UDCA),a drug used clinically to treat ICP,competes with other bile acids for binding with Gpbar1 and thus inhibits bile acid-induced inflammatory response in trophoblasts and improves fetal survival in pregnant rats with obstructive ***,inhibition of NF-κB by andrographolide is more effective than UDCA in benefiting placentas and ***,anti-inflammation therapy targeting Gpbar1/NF-κB pathway could be effective in suppressing bile acid-induced inflammation and alleviating ICP-associated fetal disorders.

关键词： fetal outcome G protein-coupled receptor maternal cholestasis placental inflammation ursodeoxycholic acid

Flake channels construction of hydroxyapatite/gelatin cryogel with excellent flame retardant properties for enhancing the capturing of iodine

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Collagen and Leather 2024年第1期5卷 101-112页

作者： Yanxia Wei Bo Wang Liyan Cao Xin Cheng Yuhan Qiao tao duan Guiqiang He Pingping Ding Yan Zhou Jian Zhou Engineering Research Center of Biomass Materials School of Life Science and EngineeringMinistry of EducationSouthwest University of Science and TechnologyMianyang 621010SichuanPeople's Republic of China The Collelge of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059SichuanPeople's Republic of China NHC Key Laboratory of Nuclear Technology Medical Transformation Mianyang Central HospitalMianyang 621000SichuanPeople's Republic of China

Safe and efficient capturing of volatile radioiodine is of extremely important significance in the treatment of spent ***,the flake channels in gelatin-hydroxyapatite(HAP@Ge)cryogel with excellent flame retardant properties were constructed by immobilizing hydroxyapatite nanorods(HAP)on Gelatin(Ge)cryogel for enhancing the capturing of *** immobilization of HAP nanorods enhanced thermal stability,provided low rates of dynamic heat transfer and dissipation,and remarkably improved the flame retardant and smoke suppression properties of the Ge cryogel,which can effectively prevent the occurrence of safety incidents caused by further thermal degradation or combustion of this *** importantly,it was effective in improving the rapid enrichment of iodine,resulting in a high adsorption *** maximum adsorption capacity of HAP@Ge cryogel for iodine vapor reached 2693 mg/g at *** high adsorption capacity for iodine was attributed to the multi-scale porous structure in HAP@Ge cryogel,which offered effective channels for iodine diffusion,whereas the numerous complex and irregular flakes provided sufficient number of active sites for iodine *** adsorption process was chemical in nature and involved the-PO_(4)^(3-),-OH,-C=O,and-NHR groups on HAP@Ge ***,the complex porous structure of HAP@Ge cryogel enhanced the physical capturing of *** advantages,such as low-cost raw material,simple preparation method,good flame retardancy,and excellent capturing performance for iodine indicated that HAP@Ge cryogel is a potential candidate for the removal of radioactive iodine in the exhaust gas stream of post-treatment plants.

关键词： Gelatin Hydroxyapatite nanorod Flake channel Flame retardancy Iodine capture

Novel management indications for conservative treatment of chylous ascites after gastric cancer surgery

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World Journal of Gastroenterology 2022年第42期28卷 6056-6067页

作者： Peng-Fei Kong Yong-Hu Xu Zhi-Hua Lai Ming-Zhe Ma Yan-tao duan Bo Sun Da-Zhi Xu Department of Gastric Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of the General Surgery Suzhou Industrial Park Xinghai HospitalSuzhou 215124Jiangsu ProvinceChina

BACKGROUND Chylous ascites(CA) presents a challenge as a relatively common postoperative complication in gastric cancer(GC). Primary conservative therapy involved total parenteral nutrition, continuous low-pressure drainage, somatostatin, and a lowfat diet. Drainage tube(DT) clamping has been presented as a potential alternative conservative treatment for GC patients with *** To propose novel conservative treatment strategies for CA following GC *** The data of patients with CA after GC surgery performed at the Fudan University Shanghai Cancer Center between 2006 and 2021 were evaluated *** 53 patients underwent surgery for GC and exhibited postoperative CA during the study period. Postoperative hospitalization and time of DT removal showed a significant positive association(R~2 = 0.979, P < 0.001). We further observed that delayed DT removal significantly extended the total and postoperative hospitalization, antibiotic usage duration, and hospitalization cost(postoperative hospitalization: 25.8 d vs 15.5 d, P < 0.001;total hospitalization: 33.2 d vs 24.7 d, P < 0.01;antibiotic usage duration: 10.8 d vs 6.2 d, P < 0.01;hospitalization cost: ￥9.2 × 104vs ￥6.5 × 104, P < 0.01). Multivariate analysis demonstrated that postoperative infection and antibiotic usage were independent factors for delayed DT ***, DT removal times were shorter in seven patients who underwent DT clamping(clamped DT vs normal group, 11.8 d vs 13.6 d, P = 0.047;clamped DT vs delayed group, 13.6 d vs 27.4 d, P < 0.001). In addition, our results indicated that removal of the DT may be possible after three consecutive days of drainage volumes less than 300 mL in GC patients with *** Infection and antibiotic usage were vital independent factors that influenced delayed DT removal in patients with CA. Appropriate standards for DT removal can significantly reduce the duration of hospitalization. Furthermore, DT clamping might be a recommended

关键词： Gastric cancer Chylous ascites Conservative treatment Drainage tube

Nitrogen-rich carbon nitrogen polymers for enhancing the sorption of uranyl

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Chinese Chemical Letters 2022年第7期33卷 3468-3473页

作者： Zeru Wang Wenhao Li Linzhen Wu Zhuang Wang Yalan Cao Jingkai Cheng Guangyuan Chen Qian Zhao Mei Jiang Zhengguo Chen Lin Zhu tao duan National Co-Innovation Center for Nuclear Waste Disposal and Environmental Safety Southwest University of Science and TechnologyMianyang 621010China State Key Laboratory of Environment-friendly Energy Materials School of National Defence Science and TechnologySouthwest University of Science and TechnologyMianyang 621010China College of Chemistry Sichuan UniversityChengdu 610064China School of Physics and Astronomy China West Normal UniversityNanchong 637002China NHC Key Laboratory of Nuclear Technology Medical Transformation Mianyang Central HospitalMianyang 621010China

Nitrogen enrichment and increased nitrogen content is an effective strategy for enhancing adsorption of uranium by carbon nitride ***,we reported the uranium absorption by using a structurally well-defined and nitrogen-rich carbon nitride polymer with C_(3)N_(5) stoichiometry for the first *** comparison with the adsorption performance of g-C_(3)N_(4) for U(Ⅵ),the conjugation system of the material was increased by connecting the heptazine unit through the azo bridge in the structure of C_(3)N_(5),so that C_(3)N_(5) exhibited several times higher adsorption performance than that of g-C_(3)N_(4).The C_(3)N_(5) has high kinetics for uranyl ions,which can adsorb100 mg/g U(Ⅵ)in only 10 min and reach complete adsorption equilibrium in 60 min;the theoretical maximum adsorption capacity is 207 mg/g,meanwhile,the material exhibits high *** results of spectral analysis and theoretical calculations indicate that the process of uranyl ion capture by C3N5is a combination of physical and chemical adsorption,and its higher density of electronic states makes the electrostatic binding ability enhanced,which is favorable to the adsorption of uranyl ions by C_(3)N_(5).This work indicates that C_(3)N_(5) has great promise and application in the separation and enrichment of uranyl ions,and also provides a reference for the systematic investigation of the adsorption ability of nitrogenrich carbon nitrogen polymers on uranyl ions.

关键词： Uranium Nitrogen enrichment Carbon nitride C_(3)N_(5) Adsorption

Preparation, characterization and salt-resistance of a coal based super absorbent composite

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Mining Science and Technology 2010年第6期20卷 864-871页

作者： CHU Mo, HUANG Zhanbin, XU Bang, FANG tao, duan Hui School of Chemical and Environmental Engineering, China University of Mining & Technology, Beijing 100083, China School of Chemical and Environmental Engineering China University of Mining & Technology Beijing 100083 China

Potassium humate was extracted from brown coal. A novel super absorbent composite, poly （acrylic acid-co-acryla- mide）/potassium humate （PAA-AM/KHA）, was prepared by graft polymerization of acrylic acid, acrylamide and coal based potassium humate using N, N＇-methylenebisacrylamide as a crosslinker and potassium peroxydisulfate as an initiator. The effects of reaction temperature, degree of neutralization of the poly （acrylic acid） and the amounts of crosslinker, initiator and potassium humate were investigated. Salt resistance tests were also carded out. The composite prepared under optimal conditions had a potassium bumate content of 10% and exhibited a water absorption of 770 g/g in distilled water, and 349, 286 and 41 gig in 0.5 mol/L KC1, MgC12 and A1CI3 solutions respectively. The results indicate that the salt resistance of PAA-AM/KHA was superior to that of poly （acrylic acid-co-acrylamide） because of the collaborative effect of functional groups of the coal based potassium humate. The PAA-AM/KHA micro powder was characterized by IR spectroscopy and the micrographic surface was characterized by scanning electron microscopy. Introduction of potassium humate into the poly （acrylic acid-co-acrylamide） structure creates a composite more suitable for use as a water-managing material in the renewal of arid and desert environments. The salt resisting property of the composite is improved, production costs are reduced and the growth stimulant effect is still present.

关键词： brown coal coal based potassium humate superabsorbent salt-resistant property

Suppression of Coriolis error in weak equivalence principle test using ^85Rb-^87Rb dual-species atom interferometer

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Chinese Physics B 2020年第7期29卷 77-84页

作者： Wei-tao duan Chuan He Si-Tong Yan Yu-Hang Ji Lin Zhou Xi Chen Jin Wang Ming-Sheng Zhan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China School of Physics University of Chinese Academy of SciencesBeijing 100049China Center for Cold Atoms Physics Chinese Academy of SciencesWuhan 430071China

Coriolis effect is an important error source in the weak equivalence principle(WEP)test using atom *** this paper,the problem of Coriolis error in WEP test is studied theoretically and *** theoretical simulation,the Coriolis effect is analyzed by establishing an error *** measurement errors of Eotvos coefficient(η)in WEP test related to experimental parameters,such as horizontal-velocity difference and horizontal-position difference of atomic clouds,horizontal-position difference of detectors,and rotation compensation of Raman laser’s mirror are *** experimental investigation,the position difference between^85Rb and^87Rb atomic clouds is reduced to 0.1 mm by optimizing the experimental parameters,an alternating detection method is used to suppress the error caused by detection position difference,thus the Coriolis error related to the atomic clouds and detectors is reduced to 1.1 × 10^-*** Coriolis error is further corrected by com pensating the rotation of Raman laser's mirror,and the total uncertainty o f rj measurement related to the Coriolis effect is reduced as δη=4.4 × 10^-11.

关键词： atom interferometer weak equivalence principle test Coriolis effect

Identification of novel molecular markers of mastitis caused by Staphylococcus aureus using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle

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Journal of Animal Science and Biotechnology 2021年第1期12卷 155-171页

作者： Di Wang Lei Liu Serafino M.A.Augustino tao duan Thomas J.Hall David E.MacHugh Jinhuan Dou Yi Zhang Yachun Wang Ying Yu Key Laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture&National Engineering Laboratory for Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China UCD School of Agriculture and Food Science University College DublinDublin D04 V1W8Ireland Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China UCD Conway Institute of Biomolecular and Biomedical Research University College DublinDublin D04 V1W8Ireland

Background: Mastitis in dairy cows caused by Staphylococcus aureus is a major problem hindering economic growth in dairy farms worldwide. It is difficult to prevent or eliminate due to its asymptomatic nature and long persistence of infection. Although transcriptomic responses of bovine mammary gland cells to pathogens that cause mastitis have been studied, the common responses of peripheral blood leukocytes to S. aureus infection across two consecutive generations of dairy cattle have not been ***: In the current study, RNA-Seq was used to profile the transcriptomes of peripheral blood leukocytes sampled from S. aureus-infected mothers and their S. aureus-infected daughters, and also healthy non-infected mothers and their healthy daughters. Differential gene expression was evaluated as follows: 1) S. aureus-infected cows versus healthy non-infected cows(S vs. H, which include all the mothers and daughters), 2) S. aureus-infected mothers versus healthy non-infected mothers(SM vs. HM), and 3) S. aureus-infected daughters versus healthy noninfected daughters(SMD vs. HMD).Results: Analysis of all identified expressed genes in the four groups(SM, SMD, HM, and HMD) showed that EPOR,IL9, IFNL3, CCL26, IL26 were exclusively expressed in both the HM and HMD groups, and that they were significantly(P 1.2) were detected in the three comparisons, respectively. DEGs with P 2 were used for functional enrichment analyses. For the S vs. H comparison, DEGs detected included CCL20, IL13 and MMP3, which are associated with the IL-17 signaling pathway. In the SM vs. HM and SMD vs. HMD comparisons, five(BLA-DQB, C1 R, C2, FCGR1 A, and KRT10) and six(BLA-DQB, C3 AR1, CFI, FCAR, FCGR3 A, and LOC10498484) genes, respectively, were involved in the S. aureus infection ***: Our stud

关键词： Dairy cow Disease resistance Mastitis Peripheral blood leukocyte Staphylococcus aureus Transcriptome Two generations

Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 842-859页

作者： Bo-tao duan Xue-Kai Zhao Yang-Yang Cui De-Zheng Liu Lin Wang Lei Zhou Xing-Yuan Zhang Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

关键词： Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis

Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 41-47页

作者： Song Chen Wei Zhang Ji-Ming Wang Hong-tao duan Jia-Hui Kong Yue-Xin Wang Meng Dong Xue Bi Jian Song Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Clinical College of Ophthalmology Tianjin Medical University

AIM：To investigate whether umbilical cord human mesenchymal stem cell（UC-MSC）was able to differentiate into neural stem cell and neuron.·METHODS：The umbilical cords were o btained from pregnant women with their written consent and the approval of the Clinic Ethnics ***-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum（FBS）,then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation *** investigated whether UC-MSC was able to differentiate into neural stem cell and neuron by using flow cytometry,reverse transcriptase-polymerase chain reaction（RT-PCR）and immunofluorescence（IF）analyzes.·R ESULTS：A substantial number of UC-MSC was harvested using the tissue explants adherent method at about *** cytometric study revealed that these cells expressed common markers of MSCs,such as CD105（SH2）,CD73（SH3）and *** induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase（NSE）and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,*** showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger ***-PCR and IF analysis showed that microtubule-associated protein 2（MAP2）and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION：Human umbilical cord derived MSCs can be cultured and proliferated and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases.

关键词： human umbilical cord mesenchymal stemcells neural stem cells neuron neurodegenerative eye diseases