Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

作     者：Bo-Tao Duan Xue-Kai Zhao Yang-Yang Cui De-Zheng Liu Lin Wang Lei Zhou Xing-Yuan Zhang 

作者机构：Department of Hepatobiliary SurgeryBinzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of OphthalmologyBinzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第3期

页      面：842-859页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis 

摘      要：BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.