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Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft

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World Journal of Gastroenterology 1998年第1期4卷 12-14页

作者： GONG Yi LIU Kang-Da ZHOU Ge XUE Qiong CHEN Shao-Liang tang zhao-you Liver Cancer Institute Zhongshan Hospital Shanghai Medical University Shanghai 200032 China Shanghai Medical University China Institute of Nuclear Medicine Zhongshan Hospital Shanghai Medical University Shanghai 200032 China

IM To study the radioimmunoimaging (RAII) using the human/mouse chimeric Ab to evaluate its targeting activity in animal models.METHODS To chimeric Ab was labeled with 131I. RAII was performed at different intervals after injection of radiolabeled Abs in nude mice with human hepatoma xenograft, and tissue distribution of radioactivity was measured. Comparison was made in the chimeric Ab between the single segment Ab and previous murine mAb against HBxAg.RESULTS The experimental objects developed tumorpositive image after 2 days of radiolabeled Abs injection, and the peak accumulation of radioactivity fell on the 7th day. The tumor/liver ratioactivity of the chimeric Ab, single segment Ab, antiHBx mAb, and the control group was 281±021, 244±016, 460±019, and 096±014, respectively.CONCLUSION The genetic engineering Abs have a considerable targeting activity which can be used as a novel humanized vector in the targeting treatment of liver cancer..

关键词： liver neoplasms, experimental carcinoma, hepatocellular chimeric antibody mice, nude hepatitis B virus disease models, animal radioimmunodetection radioimmunotherapy

Relationship between expression of α fetoprotein messenger RNA and some clinical parameters of human hepatocellular carcinoma

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World Journal of Gastroenterology 1999年第2期5卷 23-27页

作者： HE Ping, tang zhao you, YE Sheng Long and LIU Bin Bin

AIM To certify the relationship between AFP mRNA and some pathological parameters of he-patocellular carcinoma (HCC).METHOD We detected the expression of AFP in mRNA level in tissue samples from 52 patients suffering from HCC by RT-PCR *** The positive rate of AFP mRNA was 76.9% in the HCC tumor tissues, and 69.4% in the paratumor tissues from the HCC patients with severe cirrhosis. However, in HCC patients without cirrhosis, the positive rate reached 50% in tumor tissues, but no AFP mRNA expression was found in the related paratumor *** The AFP protein was specially expressed by HCC cells and mutated hepatocytes. The AFP mRNA was positively related with cirrhosis, but no significant relationship was found between AFP mRNA and tumor size, capsule status and tumor metastasis.

关键词： liver neoplasms carcinoma, hepatocellular AFP mRNA polymerase chain reaction

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从肝癌看癌症临床研究

肿瘤 2009年第1期29卷 1-4页

作者：汤钊猷复旦大学肝癌研究所上海200032 复旦大学中山医院上海200032

不同的癌症固然有其个性,但癌症的共性可能更为重要,肝癌研究与其他许多实体肿瘤研究具有共通性。为此,本文从临床医师角度出发,从重视癌症研究背景的转变、重视癌症是全身性疾病、重视癌症最本质的问题——转移、重视癌生物学特性的可... 详细信息

不同的癌症固然有其个性,但癌症的共性可能更为重要,肝癌研究与其他许多实体肿瘤研究具有共通性。为此,本文从临床医师角度出发,从重视癌症研究背景的转变、重视癌症是全身性疾病、重视癌症最本质的问题——转移、重视癌生物学特性的可逆性、重视癌的个体化治疗以及重视癌症研究必须坚持早期诊断和早期治疗等方面,讨论肝癌的临床研究,反思癌症研究中存在的一些共性问题。

关键词：肝肿瘤生物医学研究肿瘤转移肿瘤治疗方案早期诊断

Crossed renal ectopia with rectal cancer:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2122-2127页

作者： Zhen-Wei tang Hui-Feng Yang zhao-Yu Wu Chang-you Wang Department of General Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Crossed renal ectopia(CRE)occurs when one kidney crosses the midline from the primary side to the contralateral side while the ureter remains on the primary *** cancer,one of the most common malignant tumors of the digestive tract,refers to cancer from the dentate line to the rectosigmoid *** concurrent presentation of CRE alongside rectal cancer is an uncommon clinical *** SUMMARY Herein,we report a 69-year-old male patient with rectal cancer who was diagnosed with CRE via computed tomography during *** thorough preoperative evaluations,the patient underwent Dixon *** We performed laparoscopic radical resection of rectal cancer and adequate lymph node removal in a patient with CRE with no postoperative discomfort.

关键词： Rectal cancer Crossed renal ectopia Anatomy Laparoscopic surgery Case report

Homological Transfer between Additive Categories and Higher Differential Additive Categories

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1325-1344页

作者： Xi tang zhao Yong HUANG School of Science Guilin University of Aerospace TechnologyGuilin 541004P.R.China Department of Mathematics Nanjing UniversityNanjing 210093P.R.China

Given an additive category C and an integer n≥*** higher differential additive category consists of objects X in C equipped with an endomorphism ϵ_(X)satisfying ϵ_(X)^(n).Let R be a,finite-dimensional basic algebra over an algebraically closed field and T the augmenting functor from the category of finitely generated left R-modules to that of finitely generated left R/(t^(n))-*** is proved that a finitely generated left R-module M isτ-rigid(respectively,(support)τ-tilting,almost completeτ-tilting)if and only if so is T(M)as a left R[t]/(t^(n))-***,R isτm-selfinjective if and only if so is R[t]/(t^(n)).

关键词： Higher differential objects Wakamatsu tilting subcategories G_(ω)-projective modules sup-portτ-tilting modules τ_(m)-selfinjective algebras precluster tilting subcategories

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肝癌临床研究之我见

中华肝脏病杂志 2006年第7期14卷 481-482页

作者：汤钊猷复旦大学肝癌研究所中山医院上海200032

原发性肝癌（大多为肝细胞癌）全球发病率高，我国占第一位，在我国癌症病死率中，肝癌占第二位，在全球占第三位。这个第一、第二和第三，提示我国肝癌研究的重要性和迫切性。

关键词：癌,肝细胞研究

Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice

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World Journal of Gastroenterology 1999年第2期5卷 28-30页

作者： SUN Hui Chuan, LI Xiao Ming, XUE Qiong, CHEN Jun, GAO Dong Mei and tang zhao you

AIM To study the angiogenesis induced by liver cancer with different metastatic potentials using corneal micropocket model in nude *** Corneal micropockets were created in nude mice. Tumor tissues and liver tissues were implanted into the corneal micropockets. Angiogenesis was observed using a digital camera under slit-lamp biomicroscope, and compared among different grafts and incision alone. Vascular responses were recorded in regard to the range, number and length of new blood vessels toward the grafts or *** Vascular responses induced by tumor tissues were greater than those by incision alone and liver tissue grafts. LCI-D20 induced more intensive angiogenesis than *** Highly metastatic liver cancer LCI D20 was more angiogenic than low metastatic cancer LCI D35 and liver tissue. Micropocket was a useful model to study dynamic process of angiogenesis in vivo.

关键词： liver neoplasms angiogenesis corneal micropocket model neoplasms metastasis

Research progress on metal-organic framework compounds(MOFs)in electrocatalysis

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Journal of Environmental Sciences 2024年第7期141卷 261-276页

作者： Yutong Guo Shunzheng zhao Xiaolong tang Honghong Yi Department of Environmental Science and Engineering School of Energy and Environmental EngineeringUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

Metal-organic frameworks(MOFs)have favorable characteristics such as large specific surface area,high porosity,structural diversity,and pore surface modification,giving them great potential for development and attractive prospects in the research area of modern materials ***,unsatisfactory catalytic activity and poor electronic conductivity are the main challenges facing *** review focuses on MOF-based materials used in electrocatalysis,based on the types of catalytic reactions that have used MOF-based materials in recent years along with their applications,and also looks at some new electrocatalytic materials and their future development prospects.

关键词： Metal-organic frame compounds Electrocatalysis Oxidation-reduction Nitrogen fixation to synthesize ammonia Carbon dioxide reduction

Closed-Form Solution for a Circular Nanohole with Surface Effects Under Uniform Heat Flux

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Acta Mechanica Solida Sinica 2024年第1期37卷 43-52页

作者： Jieyao tang Jieyan zhao Haibing Yang Cunfa Gao State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510641China College of Mechanics and Materials Hohai UniversityNanjing 211100China

This paper investigates the steady-state thermoelastic problem of a circular nanohole embedded in an infinitely large elastic plane subjected to a uniform far-field heat flux.A lowly conductive surface model is used to account for the effects of surface phonon scattering,while the complete Gurtin–Murdoch model is utilized to characterize the effects of surface tension and surface *** closed-form solution to the temperature and stress field surrounding the hole is derived in the context of complex variable *** numerical examples are presented to analyze the influence of surface effects on thermal stress *** is shown that surface effects induce notable increases in normal and shear stresses around the ***,all three stress components(hoop,normal,and shear)in the vicinity of the hole exhibit substantial augmentation with increasing surface tension and surface *** particular,it is found that the presence of surface effects amplifies the variation in stress gradients and intensifies stress concentration around the hole.

关键词： Circular nanohole Surface effect Thermal stress Heat flux