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Pilot time-varying control behavior modeling in refractory period with aircraft failures

Science China(Technological Sciences) 2023年第7期66卷 2000-2012页

作者： XU ShuTing tan WenQian WANG WeiJun SUN LiGuo School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Nanchang 330000China

Modeling human pilot control behavior aims to understand and describe how humans control aircrafts and devices,to provide a foundation for the study of the dynamic characteristics of the human-vehicle system.In the presence of aircraft failures,the human pilot has a control process of the refractory period,which may cause adverse aircraft-pilot couplings,and even lead to loss-of-control events.This refractory period will make the pilot emerge with time-varying and adaptive features.This paper investigates how pilot control behavior changes to adapt to the aircraft failure situation and develops a time-varying pilot model during the refractory period.Six aviation pilots performed a human-in-the-loop simulation experiment on a ground flight simulator to simulate the failure situations for a pitch-tracking task.To characterize the pilot’s time-varying response mechanism,a time-frequency-spectrum method was used to analyze the pilot control signal.Main innovations in the proposed model can be embodied in the description of the fuzziness,time-varying,and adaptation of the pilot for the failures in the refractory period.Based on fuzzy logic theory,the pilot’s judgment and identification of failures are described.The adaptation of manual control behavior to time-varying aircraft dynamics is depicted by adaptive model theory.Time-domain and time-frequency-spectrum analysis show that the simulation results of the pilot model are consistent with the human-in-the-loop experimental results.The model simulation evaluations are within the range of the experimental evaluation,which shows the rationality of the timevarying behavior model of the human pilot in a failure refractory period.The model has practical values for guiding the pilot to deal with abnormal conditions and predicting nonlinear aircraft-pilot couplings.

关键词： time-varying system human pilot model fuzzy control simulation aircraft-pilot couplings

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An extended numerical model of the first exothermic peak for three dimensional printed cement-based materials

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 80-88页

作者： Wei JIANG wenqian LI Xi CHEN School of Materials Science and Engineering Tongji UniversityShanghai 200092China School of Civil Engineering Tongji UniversityShanghai 200092China

The first exothermic peak of cement-based material occurs a few minutes after mixing,and the properties of three dimensional(3D)printed concrete,such as setting time,are very sensitive to this.Against this background,based on the classical Park cement exothermic model of hydration,we propose and construct a numerical model of the first exothermic peak,taking into account the proportions of C_(3)S,C_(3)A and quicklime in particular.The calculated parameters are calibrated by means of relevant published exothermic test data.It is found that this developed model offers a good simulation of the first exothermic peak of hydration for C_(3)S and C_(3)A proportions from 0 to 100% of cement clinker and reflects the effect of quicklime content at 8%-10%.The unique value of this research is provision of an important computational tool for applications that are sensitive to the first exothermic peak of hydration,such as 3D printing.

关键词： 3D printed cement-based materials cement hydration the first exothermic peak liquid quick-setting agent numerical model

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Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei Guo wenqian Li Ye Guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes.Additionally,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease.Herein,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

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A privacy-preserving method for publishing data with multiple sensitive attributes

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 222-238页

作者： Tong Yi Minyong Shi wenqian Shang Haibin Zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

The overgeneralisation may happen because most studies on data publishing for multiple sensitive attributes(SAs)have not considered the personalised privacy requirement.Furthermore,sensitive information disclosure may also be caused by these personalised requirements.To address the matter,this article develops a personalised data publishing method for multiple SAs.According to the requirements of individuals,the new method partitions SAs values into two categories:private values and public values,and breaks the association between them for privacy guarantees.For the private values,this paper takes the process of anonymisation,while the public values are released without this process.An algorithm is designed to achieve the privacy mode,where the selectivity is determined by the sensitive value frequency and undesirable objects.The experimental results show that the proposed method can provide more information utility when compared with previous methods.The theoretic analyses and experiments also indicate that the privacy can be guaranteed even though the public values are known to an adversary.The overgeneralisation and privacy breach caused by the personalised requirement can be avoided by the new method.

关键词： data privacy data publishing

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Enhancing Deep Learning Semantics:The Diffusion Sampling and Label-Driven Co-Attention Approach

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Computers, Materials & Continua 2024年第5期79卷 1939-1956页

作者： ChunhuaWang wenqian Shang Tong Yi Haibin Zhu State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China School of Computer and Cyber Sciences Communication University of ChinaBeijing100024China School of Computer Science and Engineering Guangxi Normal UniversityGuilin541004China Department of Computer Science Nipissing UniversityNorth BayON P1B 8L7Canada

The advent of self-attention mechanisms within Transformer models has significantly propelled the advancement of deep learning algorithms,yielding outstanding achievements across diverse domains.Nonetheless,self-attention mechanisms falter when applied to datasets with intricate semantic content and extensive dependency structures.In response,this paper introduces a Diffusion Sampling and Label-Driven Co-attention Neural Network(DSLD),which adopts a diffusion sampling method to capture more comprehensive semantic information of the data.Additionally,themodel leverages the joint correlation information of labels and data to introduce the computation of text representation,correcting semantic representationbiases in thedata,andincreasing the accuracyof semantic representation.Ultimately,the model computes the corresponding classification results by synthesizing these rich data semantic representations.Experiments on seven benchmark datasets show that our proposed model achieves competitive results compared to state-of-the-art methods.

关键词： Semantic representation sampling attention label-driven co-attention attention mechanisms

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Tb(Ⅲ)functionalized MOF based self-calibrating sensor integrated with logic gate operation for efficient epinephrine detection in serum

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Journal of Rare Earths 2024年第5期42卷 987-994,I0006页

作者： Dongsheng Zhao wenqian Li Rongmei Wen Wencui Li Xin Liu Xiutang Zhang Liming Fan Shanxi Key Laboratory of Advanced Carbon Electrode Materials Shanxi Coal Mine Water Treatment Technology Innovation CenterSchool of Chemistry and Chemical EngineeringNorth University of ChinaTaiyuan030051China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin300071China

By anchoring Tb^(3+)ions on its free carboxyl groups of the nanocaged NiMOF,a dual-emission self-calibrating sensor of Tb^(3+)@NiMOF was fabricated through coordination post-synthetic modification(PSM)strategy.With Tb^(3+)ions as the secondary fluorescent signal and sensing active sites,Tb^(3+)@NiMOF presents great potentials in visually and efficiently monitoring EPI in serum,with high sensitivity and selectivity,fast response,excellent recyclable,and the low detection limit(LOD,3.06 ng/mL).Furthermore,a tandem combinational logic gate based intelligent detection system was constructed to improve the practicability and convenience of epinephrine(EPI)detection in serum by comparing the light emitted colour with the series standard colour cards preset in the smartphone.This work provides a promising approach of developing metal-organic frameworks(MOFs)based self-calibrating sensors for intelligent detection of bioactive molecules.

关键词： Metal-organic framework Post-synthetic modification Self-calibrating sensor Logic gate operation Epinephrine detection Rare earths

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Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2333-2348页

作者： Xiao Liu Yuyu Liu Xiping Xu wenqian Huang Yaru Yan Yingxia Wang Weisheng Tian Ting Mo Xiaoxue Cui Jun Li She-Po Shi Pengfei Tu Modern Research Center for Traditional Chinese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China Modern Research Center for Traditional Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Enzymatic malonylation of natural glycosides provides a promising alternative method for drug-like malonylated glycosides supply.However,the catalytic potential and structural basis of plant malonyltransferase are far from being fully elucidated.This work identified a new malonyltransferase CtMaT1 from Cistanche tubulosa.It displayed unprecedented mono-and/or di-malonylation activity toward diverse glucosides with different aglycons.A“one-pot”system by CtMaT1 and a malonyl-CoA synthetase was established to biosynthesize nine new malonylated glucosides.Structural investigations revealed that CtMaT1 possesses an adequately spacious acyl-acceptor pocket capable of accommodating diverse glucosides.Additionally,it recognizes malonyl-CoA through strong electrotactic and hydrogen interactions.QM/MM calculation revealed the H167-mediated SN2 reaction mechanism of CtMaT1,while dynamic simulations detected the formation of stable hydrogen bonds between the glucose-6-OH group and H167,resulting in its high malonylation regiospecificity.Calculated energy profiles of two isomeric glycosides highlighted lower reaction energy barriers towards glucoside substrates,emphasizing CtMaT1's preference for glucosides.Furthermore,a mutant CtMaT1H36A with notably increased di-malonylation activity was obtained.The underlying molecular mechanism was illuminated through MM/GBSA binding free energy calculation.This study significantly advances the understanding of plant acyltransferases from both functional and protein structural perspectives,while also providing a versatile tool for enzymatic malonylation applications in pharmacology.

关键词： Plant acyltransferase Malonyltransferase Malonylated glycosides Enzymatic catalysis Enzyme promiscuity

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Practical Experience of Management of Urban Parks at Home and Abroad

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Meteorological and Environmental Research 2024年第1期15卷 30-37页

作者： wenqian LING Yong ZHU Qinhuai XU Chengdu Institute of Planning&Design Chengdu 610061China

By systematically reviewing the practical experience of management of urban parks at home and abroad,the advanced experience in organization,management system,operation mechanism and social participation were summarized,and the optimization and improvement measures for the construction and management of urban parks in Chengdu were proposed to provide reference for the high-level construction,high-quality experience and efficient management of urban parks in the construction of park city demonstration zone in Chengdu.

关键词： Urban parks Management and operation Domestic and foreign experience Chengdu Park city

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模仿与转化:明代中晚期国画与瓷画中“士绅出行”图式比较研究

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中国陶瓷 2024年第1期60卷 105-121页

作者：张文倩景德镇陶瓷大学景德镇333403 恩施职业技术学院恩施445000

“士绅出行”图源于明代中晚期社会各阶层普遍参与的旅游活动,是国画与瓷画的重要题材。本文着眼于国画与瓷画中的“士绅出行”图式,比较二者的形式内容以探讨瓷画对国画的图式模仿与转化;并进一步分析瓷画“士绅出行”的元素构成和图... 详细信息

“士绅出行”图源于明代中晚期社会各阶层普遍参与的旅游活动,是国画与瓷画的重要题材。本文着眼于国画与瓷画中的“士绅出行”图式,比较二者的形式内容以探讨瓷画对国画的图式模仿与转化;并进一步分析瓷画“士绅出行”的元素构成和图式结构,寻找瓷画以国画为蓝本进行图式转化的具体方法与路径。同时,将二者置入明代中晚期社会文化环境中进行考察,揭示瓷画在模仿与转化国画“士绅出行”图式过程中日渐趣味化的具体成因。

关键词：士绅出行春游晚归携琴访友图式瓷器纹饰

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钯催化N-磺酰基吲哚衍生物碳氢键芳基化反应

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精细化工 2024年第1期41卷 147-158,232页

作者：谭晶孙美娇吴文倩彭进松陈春霞东北林业大学化学化工与资源利用学院黑龙江哈尔滨150040

以碘代芳烃为芳基化试剂,探讨了N-对甲苯磺酰基吲哚通过磺酰基团导向的钯催化C—H键选择性芳基化反应过程。结果表明,以醋酸钯为催化剂、三苯基膦为配体、碳酸钠为碱、碳酸银为添加剂的条件下,N-对甲苯磺酰基吲哚在1,4-二氧六环溶剂中于... 详细信息

以碘代芳烃为芳基化试剂,探讨了N-对甲苯磺酰基吲哚通过磺酰基团导向的钯催化C—H键选择性芳基化反应过程。结果表明,以醋酸钯为催化剂、三苯基膦为配体、碳酸钠为碱、碳酸银为添加剂的条件下,N-对甲苯磺酰基吲哚在1,4-二氧六环溶剂中于120℃下反应24 h可获得2位和2,7位芳基化的产物,反应总产率可达93%。在该条件下,通过改变底物和碘代芳烃的结构测试了该法的适用范围与局限性,共制备得到28种芳基化吲哚衍生物,总产率为22%~93%,产物经~1HNMR、^(13)CNMR和HRMS表征确定了其化学结构。

关键词：钯催化吲哚骨架 C—H官能化芳基化导向基团催化技术

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