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Updated prevalence of latent prostate cancer in Chinese population and comparison of biopsy results: An autopsy-based study

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The Innovation 2024年第1期5卷 80-87页

作者： Yuliang Chen Zhien Zhou Yi Zhou Zhipeng mai Shijie Jin Zhen Liang Zhiyuan Shang Yuzhi Zuo Yu Xiao Wenze Wang Haibo Wang Weigang Yan Department of Urology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Gynaecology and Obstetrics Beijing HospitalNational Centre of GerontologyBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Peking University Clinical Research Institute Peking University First HospitalBeijing 100034China

Prostate cancer detected by autopsy is named latent prostate *** the repertoire of clinical prostate cancer,latent cancer may better reflect the disease *** clinical prostate specimens,which are obtained exclusively from biopsy-positive cases,prostate specimens obtained through autopsy provide information on biopsy-negative cases,helping calculate the true sensitivity of prostate *** 2014 to 2021,we collected autopsy specimens of the prostate from body donors in China and performed transperineal and transrectal biopsies on specimens before step-sectioning and pathological *** found that the crude prevalence of latent prostate cancer in middle-aged and elderly men was 35.1%(81/231),which was higher than previous estimates for Chinese *** overall per-patient sensitivities of transperineal and transrectal biopsies were not significantly different(33.3%vs.32.1%,p=0.82),but the two approaches differed in preferential sampling area along the proximal-distal axis of the *** biopsy had a higher sensitivity for detecting clinically significant lesions in the distal third(34.7%vs.16.3%,p=0.02)and distal half(30.6%vs.18.1%,p=0.04),while transrectal biopsy had a higher sensitivity for lesions in the proximal half(25.0%vs.13.9%,p=0.046).Both transperineal and transrectal methods of biopsy missed most small lesions(0.5 mL).In conclusion,the prevalence of latent prostate cancer in China has increased over the past 2 *** transperineal and transrectal methods of biopsy had comparable sensitivities but had different preferential sampling *** approaches miss one-third of large lesions.

关键词： biopsy prevalence latent

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Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen Yu Ya-Ping Li Yue-Ming Xin mai Mao Ya-Xin Pan Yi-Xuan Qu Zheng-Dong Luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

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SapBase:A central portal for functional and comparative genomics of Sapindaceae species

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Journal of Integrative Plant Biology 2024年第8期66卷 1561-1570页

作者： Jiawei Li Chengjie Chen Zaohai Zeng Fengqi Wu Junting Feng Bo Liu Yingxiao mai Xinyi Chu Wanchun Wei Xin Li Yanyang Liang YuanLong Liu Jing Xu Rui Xia State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of HorticultureSouth China Agricultural UniversityGuangzhou 510640China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510640China Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in South China at the Ministry of Agriculture and Rural Affairs South China Agricultural UniversityCollege of HorticultureGuangzhou 510640China

The Sapindaceae family,encompassing a wide range of plant forms such as herbs,vines,shrubs,and trees,is widely distributed across tropical and subtropical *** family includes economically important crops like litchi,longan,rambutan,and *** the wide application of genomic technologies in recent years,several Sapindaceae plant genomes have been decoded,leading to an accumulation of substantial omics data in this *** surge in data highlights the pressing need for a unified genomic data center capable of storing,sharing,and analyzing these ***,we introduced SapBase,that is,the Sapindaceae Genome *** houses seven published plant genomes alongside their corresponding gene structure and functional annotations,small RNA annotations,gene expression profiles,gene pathways,and synteny block *** offers user-friendly features for gene information mining,co-expression analysis,and interspecies comparative genomic ***,we showcased SapBase's extensive capacities through a detailed bioinformatic analysis of a MYB gene in ***,Sap Base could serve as an integrative genomic resource and analysis platform for the scientific exploration of Sapinaceae species and their comparative studies with other plants.

关键词： functional crops unified

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel Ohoud Shagroud mai AAlim A.Sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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多源流理论视角下美国职业生涯教育立法政策的变迁

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职教论坛 2024年第5期40卷 119-128页

作者：买琳燕广州番禺职业技术学院职业教育研究院广东广州511483

多源流理论为解释政策过程和分析政策变迁提供了一种视角和框架。美国职业生涯教育立法政策经历了三个时期:一是以片段化的引导性立法政策支持职业指导和职业生涯发展的探索期;二是以特色化的规制性立法政策推进职业生涯教育实践的确立... 详细信息

多源流理论为解释政策过程和分析政策变迁提供了一种视角和框架。美国职业生涯教育立法政策经历了三个时期:一是以片段化的引导性立法政策支持职业指导和职业生涯发展的探索期;二是以特色化的规制性立法政策推进职业生涯教育实践的确立期;三是以系统化的策略性立法政策深化职业生涯教育改革的深化期。运用多源流理论分析这一变迁历程会发现:美国时代变动引发的失业危机与传统教育效能单一之间的冲突构成了“问题识别”;职业生涯教育思想在政策共同体中的演化促成了“政策阐明”;公众舆论与政党执政理念对职业生涯教育的影响产生了“政治活动”;马兰德的“过程软化”与打开“政策之窗”则最终促成了“政策之窗与溪流的结合”。回顾美国职业生涯教育立法政策的颁布与调整,有两点值得思考和借鉴:一是立法政策在发展趋势、人群面向、目标定位和功能发挥上有明显变化;二是立法政策规范和保障是影响美国职业生涯教育实践的重要推动因素,而职业生涯教育立法政策的颁布又是特定时期多种因素长期共同作用促成的结果。

关键词：多源流理论职业生涯教育政策变迁立法

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数字时代全过程人民民主宪法实现机制研究

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河南社会科学 2024年第6期32卷 43-51页

作者：程迈华东政法大学涉外法治研究院上海200042

全过程人民民主是一种具有全面建构性、以充分实现人民主体地位为目的的民主形态。数字时代的到来正在引发人类社会上层建筑的变动,在给全过程人民民主的实现带来诸多需要认真应对的挑战的同时,也提供了众多机遇。如果对两者关系处理得... 详细信息

全过程人民民主是一种具有全面建构性、以充分实现人民主体地位为目的的民主形态。数字时代的到来正在引发人类社会上层建筑的变动,在给全过程人民民主的实现带来诸多需要认真应对的挑战的同时,也提供了众多机遇。如果对两者关系处理得当的话,会形成促进双方共同发展的合力。全过程人民民主的实现离不开法治的保障。作为根本法的宪法具有制度拱顶石的作用,在数字时代促进全过程人民民主实现的宪法机制具有双重维度,即组织法律维度与权利体系维度。在这两个维度上,宪法机制同时面临着挑战与机遇。在应对这些挑战、利用这些机遇,更好地在数字时代实现全过程人民民主的过程中,数字时代的宪法理论研究和制度实践也获得进一步发展的机遇。

关键词：全过程人民民主数字时代宪法机制数字人权

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Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3253-3258页

作者： Xue-Mei Han Yi-mai Zhou Lu-Sha Cen Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina The First Clinical Medical College Zhejiang Chinese Medicine UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND In addition to the non-specific symptomatology of ocular rosacea,currently,there are no reliable diagnostic tests for the disease,which may lead to its ***,we report a case of ocular rosacea presenting with multiple recurrent chalazion on both *** SUMMARY A 63-year-old female patient presented with multiple chalazion and dry eyes in both eyes,with no facial *** management done were application of steroid eye ointment on both eyelids,hot compresses,and eyelid margin cleaning;noting that there was no relief of *** excision of the chalazion was done on both eyes,however,bilateral recurrence occurred *** pathological studies showed infiltration of a small amount of fibrous tissue with many chronic inflammatory *** studies were positive for *** of the chalazion occurred after oral administration of doxycycline and *** Our findings show that ophthalmologists should recognize the ocular manifestations of skin diseases.

关键词： Ocular rosacea Rosacea Recurrent chalazion Bilateral chalazion Multiple chalazion Case report

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堵塞沉积对波形板汽水分离器运行特性的影响规律及机理

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哈尔滨工程大学学报 2024年第5期45卷 982-988页

作者：买丹婕赵富龙刘庆祝田瑞峰谭思超哈尔滨工程大学核科学与技术学院黑龙江哈尔滨150001 哈尔滨工程大学黑龙江省核动力装置性能与设备重点实验室黑龙江哈尔滨150001

在核电厂装置运行的热态工况下,波形板汽水分离器内高温高压且湿度较大,易出现腐蚀现象,产生沉积物并影响汽水分离性能。为研究沉积堵塞现象对波形板汽水分离器运行特性的影响机理,本文运用CFD软件对不同堵塞程度的波形板建立了经过合... 详细信息

在核电厂装置运行的热态工况下,波形板汽水分离器内高温高压且湿度较大,易出现腐蚀现象,产生沉积物并影响汽水分离性能。为研究沉积堵塞现象对波形板汽水分离器运行特性的影响机理,本文运用CFD软件对不同堵塞程度的波形板建立了经过合理简化的二维模型,在不同热态工况下对波形板分离器开展数值计算与分析,得到了堵塞程度对波形板运行特性的影响规律和作用机理。结果表明:堵塞沉积的波形板压降和分离效率随工况的变化趋势均与未堵塞时较为相似;沉积物使实际流通截面变小,从而使波形板的压降增大,且压降增幅随堵塞程度增大而增大;沉积物明显影响了液滴的碰撞分离过程,使分离效率降低;在疏水钩未失效前,波形板分离效率的降幅随堵塞程度增大而增大;在压降、效率增幅方面,沉积物在低流速工况下的影响程度更大。研究结果为波形板的沉积堵塞研究及其运行和设计提供了一定的理论支撑和科学依据。

关键词：波形板汽水分离器堵塞沉积分离效率汽水分离运行特性

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Mitigating the dissolution of V_(2)O_(5) in aqueous ZnSO_(4) electrolyte through Ti-doping for zinc storage

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Chinese Chemical Letters 2024年第1期35卷 558-562页

作者： Zihe Wei Xuehua Wang Ting Zhu Ping Hu Liqiang mai Liang Zhou Hubei Longzhong Laboratory Wuhan University of Technology(Xiangyang Demonstration Zone)Xiangyang 441000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200China

Aqueous zinc-ion batteries(AZIBs)have become a hotspot for electrochemical energy storage owing to the high safety,low cost,environmental friendliness,and favorable rate ***,the serious dissolution of cathode materials in aqueous electrolytes would lead to poor cyclability,which should be addressed before ***,we designed a Ti-doped V_(2)O_(5) with yolk-shell microspherical structure for *** Ti doping stabilizes the crystal structure and relieves the dissolution of V_(2)O_(5) in aqueous ZnSO_(4) *** optimized sample,Ti_(0.2)V_(1.8)O_(4.9),delivers a high capacity(355 mAh/g at 0.05 A/g)as well as good capacity retention(89%after 2500 cycles at 1.0 A/g).This work provides an effective strategy to mitigate the dissolution of cathode material in aqueous ZnSO_(4) electrolyte for cyclability enhancement.

关键词： Aqueous zinc-ion batteries V_(2)O_(5)cathode materials Aqueous ZnSO_(4)electrolyte Yolk-shell structure Ti doping

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新型农业经营主体生存动态演化的时空格局及其影响因素

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地理科学进展 2024年第1期43卷 47-62页

作者：麦强盛李乐西南林业大学会计学院昆明650233 西南林业大学经济管理学院昆明650233

研判新型农业经营主体发展的外部环境、内生动力和演化趋势,增强农业农村发展新动能,是关系中国农业农村现代化的重大战略。论文基于2000—2022年农业农村部公布的农业产业化国家重点龙头企业、全国农民合作社和家庭农场典型案例名单以... 详细信息

研判新型农业经营主体发展的外部环境、内生动力和演化趋势,增强农业农村发展新动能,是关系中国农业农村现代化的重大战略。论文基于2000—2022年农业农村部公布的农业产业化国家重点龙头企业、全国农民合作社和家庭农场典型案例名单以及中国农业企业黄页中的新型农业经营主体相关数据,通过空间计量分析和生存分析,探究其生存的空间格局及其影响因素。研究发现:①新型农业经营主体进入和退出农业市场的数量呈现倒“U”型曲线,实存数量呈逐渐上升的状态。②新型农业经营主体的生存时间在区域间形成差异化格局,高—高集聚区主要集中在中东部地区。③“个体特征和创新能力”因素对新型农业经营主体生存时间有正向影响,“阶段演变”对其生存时间有负向影响。④随着成立阶段的推移,新型农业经营主体资产规模和关联经济组织数量对其生存时间的影响作用逐渐下降,地理区域因素影响作用也逐渐减弱。研究结论可为新型农业经营主体生存分析提供实证依据,为分析其发展演化的地理特征提供借鉴参考。

关键词：新型农业经营主体生存时间时序格局阶段演变

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