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Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.

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Acta Pharmaceutica Sinica B 2013年第5期3卷 328-332页

作者： Ruizhi Men Ning Li Yachao Xing Yingzhan tang chengyu tan Fantong Meng Juan Zhang Hui Ni Xiaoguang Jia Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China Marine Environmental Engineering College Dalian Ocean UniversityDalian 116023China Xinjiang Institute of Chinese Materia Medica and Ethnodrug Urumqi 830002China

Suaeda physophora *** a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous *** order to have a better utilization of halophytes,a screening for ACE inhibitors from halophytes growing in Xinjiang was carried *** result showed that the 70%EtOH extract and n-BuOH extract of *** *** significant ACE inhibitory *** we focused on its biochemical constituents *** new quinazoline alkaloid,namely Suaedine(1),along with six known compounds(2–7)was isolated from the aerial parts of *** *** structure of the new quinazoline alkaloid was established by one-and two-dimensional nuclear magnetic resonance,optical rotation and mass spectrometry *** flavonoid compounds(2–4)and phenolic compound(5)exhibited significant ACE *** was the first time to focus on the chemical constituents and bioactivities of this plant.

关键词： Desert plant Suaeda physophora Pall. Chemical constituents ACE inhibitory activity

Fine-tuning growth in gold nanostructures from achiral 2D to chiral 3D geometries

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Nano Research 2024年第7期17卷 6654-6660页

作者： Lili tan Zhi Chen chengyu Xiao Zhiyong Geng Yinran Jin Chaoyang Wei Fei Teng Wenlong Fu Peng-peng Wang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Enriching the library of chiral plasmonic structures is of significant importance in advancing their applicability across diverse domains such as biosensing,nanophotonics,and ***,employing triangle nanoplates as growth seeds,we synthesized a novel class of chiral-shaped plasmonic nanostructures through a wet chemical strategy with dipeptide as chiral inducers,including chiral tri-blade boomerangs,concave rhombic dodecahedrons,and *** structural diversity in chiral plasmonic nanostructures was elucidated through their continuous morphological evolution from two-dimensional to threedimensional *** fine-tuning of chiroptical properties was achieved by precisely manipulating crucial synthetic parameters such as the amount of chiral molecules,seeds,and gold precursor that significantly influenced chiral structure *** findings provide a promising avenue for enriching chiral materials with highly sophisticated structures,facilitating a fundamental understanding of the relationship between structural nuances and chiroptical properties.

关键词： plasmonic nanostructures geometric chirality circular dichroism fine-tuning

纳米-Al_2O_3颗粒对镍电结晶初期阶段的影响(英文)

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稀有金属材料与工程 2010年第1期39卷 10-16页

作者：谭澄宇崔航胡炜刘宇郑子樵中南大学湖南长沙410083

利用循环伏安(CV)、计时安培(CA)和电化学阻抗(EIS)研究了纳米Al2O3颗粒在不同电位(***)下对Ni自硫酸盐镀液在铜基体上电沉积的影响。结果表明,Ni-Al2O3体系共沉积的起始电位为:–740mV左右;在不同的电位下,纳米-Al2O3颗粒对镍沉积过程... 详细信息

利用循环伏安(CV)、计时安培(CA)和电化学阻抗(EIS)研究了纳米Al2O3颗粒在不同电位(***)下对Ni自硫酸盐镀液在铜基体上电沉积的影响。结果表明,Ni-Al2O3体系共沉积的起始电位为:–740mV左右;在不同的电位下,纳米-Al2O3颗粒对镍沉积过程的影响有所差别;在电位–740～–830mV范围,与纯Ni沉积相比较,Ni-Al2O3体系沉积的峰电流所对应的孕育期tm明显缩短,反映Al2O3颗粒在阴极表面有利于镍沉积成核,且促进了电结晶成核。Al2O3颗粒吸附在阴极表面可能会阻碍部分离子电荷放电和物质传输过程,尤其在电位–250～–650mV范围,致使Ni-Al2O3体系沉积阻抗增加。在较高的过电位下,Al2O3颗粒的促进作用有所减弱,许多颗粒堆积在电极表面上还可能减小Ni-Al2O3沉积的还原反应电流。在电位–890mV,Ni-Al2O3体系电沉积初期阶段的成核过程基本遵循三维的Scharifker-Hill瞬时成核模式。

关键词： Ni-Al2O3 薄膜:电结晶成核共沉积 1-t曲线

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矿用断电控制器的设计

煤矿安全 2015年第10期46卷 117-119页

作者：谭成宇中煤科工集团重庆研究院有限公司重庆400037

结合AQ6201-2006《煤矿安全监控系统通用技术要求》以及MT/T1079-2008《矿用断电控制器》标准,分析了矿用安全监控系统的功能,并针对矿用断电控制系统进行了研究与设计。针对多种类型的馈电传感器,设计了一款矿用断电控制器,包括断电控... 详细信息

结合AQ6201-2006《煤矿安全监控系统通用技术要求》以及MT/T1079-2008《矿用断电控制器》标准,分析了矿用安全监控系统的功能,并针对矿用断电控制系统进行了研究与设计。针对多种类型的馈电传感器,设计了一款矿用断电控制器,包括断电控制电路以及馈电电路,设计能够满足上述2个标准的要求。

关键词：监控系统断电控制馈电电路电路设计常开常闭

miR-181b-5p调控TIMP3对apoE-/-鼠动脉粥样硬化炎症影响及相关因子检验

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基因组学与应用生物学 2018年第5期37卷 2200-2206页

作者：郑莉谭成宇湖北省巴东县人民医院

为探究mi R-181b-5p靶向调控TIMP3对apo E^-/-鼠动脉粥样硬化炎症的影响,本研究基于生物信息学预测筛选,并采用双荧光素酶报告基因系统验证mi R-181b-5p靶基因。同时在ox-LDL刺激THP-1巨噬细胞及apo E^-/-动脉粥样硬化模型小鼠中检测mi ... 详细信息

为探究mi R-181b-5p靶向调控TIMP3对apo E^-/-鼠动脉粥样硬化炎症的影响,本研究基于生物信息学预测筛选,并采用双荧光素酶报告基因系统验证mi R-181b-5p靶基因。同时在ox-LDL刺激THP-1巨噬细胞及apo E^-/-动脉粥样硬化模型小鼠中检测mi R-181b-5p靶基因m RNA及蛋白水平的表达情况,并且检测转染mi R-181b-5p后细胞水平和动物体内炎症因子TNF-α、INF-γ、IL-1β、IL-18、CCL2的表达变化。此外,通过病理切片方法检测转染mi R-181b-5p后小鼠主动脉窦处病变情况。研究通过双荧光素酶报告基因系统验证TIMP3为mi R-181b-5p靶基因,并在ox-LDL刺激THP-1巨噬细胞及apo E^-/-动脉粥样硬化模型小鼠中证明了mi R-181b-5p可以降低TIMP3转录水平从而降低其蛋白水平表达,同时研究发现mi R-181b-5p在细胞水平和动物体内均会增强炎症因子TNF-α、INF-γ、IL-1β、IL-18、CCL2的表达,并可以增加小鼠主动脉窦处病变面积。研究认为在动脉粥样硬化发生中,mi R-181b-5p可以增加病变面积并且提升相关炎症因子的表达、分泌,其作用机理很可能是通过抑制靶基因TIMP3表达,进而降低TIMP3蛋白水平实现的,为研究动脉粥样硬化机制提供了理论依据。

关键词：双荧光素酶报告基因系统动脉粥样硬化 miR-181b-5p TIMP3

The Current Progress and Challenges of Carbonized Polymer Dot-Based Room-Temperature Phosphorescent Materials

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CCS Chemistry 2024年第3期6卷 604-622页

作者： chengyu Zheng Songyuan Tao Bai Yang State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012

Carbonized polymer dots(CPDs)as one type of carbon dots have attracted widespread attention in recent *** proposal of the“shell–core”structure of CPDs leads to further thinking about the association between their special structures and luminescent *** recent years,great progress has been made in the field of CPD-based room-temperature phosphorescent *** review pays particular attention to how the special“core–shell”structure of CPDs influences the activation of roomtemperature phosphorescence(RTP).The strategies and vital factors to activate RTP for CPD-based materials in both solid state and water were reviewed in detail to elaborate on the effect of the special structure on RTP ***,some perspectives on the current challenges were also provided to guide the further development of CPD-based room-temperature phosphorescent materials.

关键词： room-temperature phosphorescent materials carbon dots carbonized polymer dots “core-shell”structure photoluminescent mechanism

Unsupervised Time Series Segmentation: A Survey on Recent Advances

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Computers, Materials & Continua 2024年第8期80卷 2657-2673页

作者： chengyu Wang Xionglve Li Tongqing Zhou Zhiping Cai College of Computer National University of Defense TechnologyChangsha410073China

Time series segmentation has attracted more interests in recent years,which aims to segment time series into different segments,each reflects a state of the monitored *** there have been many surveys on time series segmentation,most of them focus more on change point detection(CPD)methods and overlook the advances in boundary detection(BD)and state detection(SD)*** this paper,we categorize time series segmentation methods into CPD,BD,and SD methods,with a specific focus on recent advances in BD and SD *** the scope of BD and SD,we subdivide the methods based on their underlying models/techniques and focus on the milestones that have shaped the development trajectory of each *** a conclusion,we found that:(1)Existing methods failed to provide sufficient support for online working,with only a few methods supporting online deployment;(2)Most existing methods require the specification of parameters,which hinders their ability to work adaptively;(3)Existing SD methods do not attach importance to accurate detection of boundary points in evaluation,which may lead to limitations in boundary point *** highlight the ability to working online and adaptively as important attributes of segmentation methods,the boundary detection accuracy as a neglected metrics for SD methods.

关键词： Time series segmentation time series state detection boundary detection change point detection

Accelerating BERT inference with GPU-efficient exit prediction

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Frontiers of Computer Science 2024年第3期18卷 31-42页

作者： Lei LI chengyu WANG Minghui QIU Cen CHEN Ming GAO Aoying ZHOU Shanghai Engineering Research Center of Big Data Management School of Data Science and EngineeringEast China Normal UniversityShanghai 200062China Alibaba Group Hangzhou 311121China KLATASDS-MOE School of StatisticsEast China Normal UniversityShanghai 200062China

BERT is a representative pre-trained language model that has drawn extensive attention for significant improvements in downstream Natural Language Processing(NLP)*** complex architecture and massive parameters bring BERT competitive performance but also result in slow speed at model inference *** speed up BERT inference,FastBERT realizes adaptive inference with an acceptable drop in accuracy based on knowledge distillation and the early-exit ***,many factors may limit the performance of FastBERT,such as the teacher classifier that is not knowledgeable enough,the batch size shrinkage and the redundant computation of student *** overcome these limitations,we propose a new BERT inference method with GPU-Efficient Exit Prediction(GEEP).GEEP leverages the shared exit loss to simplify the training process of FastBERT from two steps into only one step and makes the teacher classifier more knowledgeable by feeding diverse Transformer outputs to the teacher *** addition,the exit layer prediction technique is proposed to utilize a GPU hash table to handle the token-level exit layer distribution and to sort test samples by predicted exit *** this way,GEEP can avoid batch size shrinkage and redundant computation of student *** results on twelve public English and Chinese NLP datasets prove the effectiveness of the proposed *** source codes of GEEP will be released to the public upon paper acceptance.

关键词： BERT FastBERT inference acceleration model distillation early exit text classification

LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

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Science China(Life Sciences) 2024年第3期67卷 488-503页

作者： Xiao Fan Fangzhou Liu Xiang Wang Ying Wang Yu Chen chengyu Shi Xinwan Su Manman tan Qingfeng Yan Jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Key Laboratoryof Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Department of Central Laboratory the First People's Hospital of HuzhouHuzhou 313000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of MedicineThe 4th Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer.

关键词： long non-coding RNA peroxiredoxin liquid-liquid phase separation ferroptosis breast cancer