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Techniques and strategies for regional anesthesia in acute burn care—a narrative review

Burns & Trauma 2021年第1期9卷 383-392页

作者： Clifford C.Sheckter Barclay T.Stewart Christopher Barnes Andrew Walters Paul I.Bhalla tam n.pham Department of Surgery UWMedicine Regional Burn Center at Harborview Medical CenterUniversity ofWashington3259th Ave.SeattleWA 98104USA Harborview Injury Prevention and Research Center University ofWashington401 Broadway.SeattleWA 98122USA Department of Anesthesia and Pain Medicine Harborview Medical Center.University ofWashington3259th Ave.SeattleWA 98104USA

Burn injuries and their treatments result in severe *** traumatic injuries that are characterized by a discrete episode of pain followed by recovery,burn-injured patients endure pain for a prolonged period that lasts through wound closure(*** pain,procedural pain,breakthrough pain,neuropathic pain and itch).Regional anesthesia,including peripheral nerve blocks and neuraxial/epidural anesthesia,offers significant benefits to a multimodal approach in pain treatment.A‘regional-first’approach to pain management can be incorporated into the workflow of burn centers through engaging regional anesthesiologists and pain medicine practitioners in the care of burn patients.A detailed understanding of peripheral nerve anatomy frames the burn clinician’s perspective when considering a peripheral nerve block/*** infra/supraclavicular nerve block provides excellent coverage for the upper extremity,while the trunk can be covered with a variety of blocks including erector spinae plane and quadratus lumborum plane *** lower extremity is targeted with fascia iliaca plane and sciatic nerve blocks for both donor and recipient *** centers that adopt regional anesthesia should be aware of potential complications and contraindications to prevent adverse events,including management of local anesthetic toxicity and epidural *** of anticoagulation around regional anesthesia placement is crucial to prevent hematoma and nerve ***,regional anesthesia can facilitate a better patient experience and allow for early therapy and mobility goals that are hallmarks of burn care and rehabilitation.

关键词： Burn Regional anesthesia nerve block Epidural nerve catheter Pain

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EP Aquarii:A new Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： pham T.nhung Do T.Hoai Pierre Darriulat pham Tuan-Anh pham n.Diep nguyen B.ngoc Tran T.Thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

new analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

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A concise review on surface and structural modification of porous zeolite scaffold for enhanced hydrogen storage

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Chinese Journal of Chemical Engineering 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir R.S.R.Mohd Zaki A.T.Abd Wahab S.n.Miskan Anh-tam nguyen Dai-Viet n.Vo H.D.Setiabudi Centre for Research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center of Excellence for Green Energy and Environmental nanomaterials(CE@GrEEn) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Investigating zeolites as hydrogen storage scaffolds is imperative due to their porous nature and favorable physicochemical ***,the storage capacity of the unmodified zeolites has been rather unsatisfactory(0.224%-1.082%(mass))compared to its modified ***,the contemporary focus on enhancing hydrogen storage capacities has led to significant attention towards the utilization of modified zeolites,with studies exploring surface modifications through physical and chemical treatments,as well as the integration of various active *** enhanced hydrogen storage properties of zeolites are attributed to the presence of aluminosilicates from alkaline and alkaline-earth metals,resulting in increased storage capacity through interactions with the charge density of these ***,there is a great demand to critically review their role such as well-defined topology,pore structure,good thermal stability,and tunable hydrophilicity in enhanced hydrogen *** article aimed to critically review the recent research findings based on modified zeolite performance for enhanced hydrogen *** of the factors affecting the hydrogen storage capacities of zeolites that can affect the rate of reaction and the stability of the adsorbent,like pressure,structure,and morphology were studied,and ***,future perspectives,recommendations,and directions for modified zeolites were discussed.

关键词： Zeolites Hydrogen storage Surface modification Adsorption Active metal

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Effective parameters on polydimethylsiloxane/graphene composite-based triboelectric nanogenerator performance

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International Journal of Smart and nano Materials 2024年第2期15卷 365-386页

作者： Fattaneh Salemi Fathallah Karimzadeh Mohammad-Hasan Abbasi Fatemeh Moradi Duc Hoa pham Jaehwan Kim Department of Materials Engineering Isfahan University of Technology(IUT)IsfahanIran CRC for nanocellulose Future Composites Department of Mechanical EngineeringInha UniversityIncheonRepublic of Korea

This paper systematically investigates the effective parameter ontheperformanceof polydimethylsiloxane/graphene(PDMS@Gr)-based triboelectric nanogenerators(TEnGs)as well as their ***@Gr films containing 0,0.05,0.5,1,and 1.5 wt.%graphene are synthesized,and their sur-face characteristics,mechanical behavior,and electrical prop-erties are *** contact-separation mode TEnGs are fabricated,and their performance is *** results demonstrate that the surface roughness and sur-face charge density are the most critical parameters for the performance of PDMS@Gr-based TEnGs compared to the elec-trical and mechanical properties of the friction *** PDMS@Gr-based TEnG with 1 wt.%graphene shows the high-est power output of 2.6 W/m?at an optimized working con-dition(5 Hz and 15 n).It also exhibits stable power output until 15,oo0 working cycles and displays battery-free applica-tions by powering a light-emitting diode(LED)array,a calculator,a digital watch,and a digital thermometer.

关键词： Energy harvester triboelectric nanogenerator graphene polydimethylsiloxane composite

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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECn1 interaction

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen ningning Li Shan Sun nana Wang Yang Chen Chunsheng Dong Kin Yip tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics and FUTURE-nEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RnA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCL2 and BECn1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECn1 and BCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECn1/Beclin 1 Dipeptide repeat neurodegeneration

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Exploring a targeted approach for public health capacity restrictions during COVID-19 using a new computational model

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Infectious Disease Modelling 2024年第1期9卷 234-244页

作者： Ashley n.Micuda Mark R.Anderson Irina Babayan Erin Bolger Logan Cantin Gillian Groth Ry Pressman-Cyna Charlotte Z.Reed noah J.Rowe Mehdi Shafiee Benjamin tam Marie C.Vidal Tianai Ye Ryan D.Martin Department of Physics Engineering Physics&AstronomyQueen's UniversityKingstonONCanada Department of Medical Biophysics Western UniversityLondonONCanada Department of Mathematics and Statistics Queen's UniversityKingstonONCanada Department of Biology Queen's UniversityKingstonONCanada Department of Electrical and Computer Engineering Nazarbayev UniversityNur-SultanKazakhstan Energetic Cosmos Laboratory Nazarbayev UniversityNur-SultanKazakhstan School of Computing Queen's UniversityKingstonONCanada Department of Biomedical and Molecular Sciences Queen's UniversityKingstonONCanada Department of Physics University of OxfordOxfordUnited Kingdom Department of Physics Stanford UniversityStanfordCAUnited States

This work introduces the Queen's University Agent-Based Outbreak Outcome Model(QUABOOM).This tool is an agent-based Monte Carlo simulation for modelling epidemics and informing public health *** illustrate the use of the model by examining capacity restrictions during a *** find that public health measures should focus on the few locations where many people interact,such as grocery stores,rather than the many locations where few people interact,such as small *** also discuss a case where the results of the simulation can be scaled to larger population sizes,thereby improving computational efficiency.

关键词： Monte-carlo Agent-based epidemic modelling COVID-19 Small business capacity restrictions Public health Basic reproductive number

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A High-order Coupled Compact Integrated RBF Approximation Based Domain Decomposition Algorithm for Second-order Differential Problems

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Computer Modeling in Engineering & Sciences 2015年第4期104卷 251-304页

作者： C.M.T.Tien n.pham-Sy n.Mai-Duy C.-D.Tran T.Tran-Cong Computational Engineering and Science Research Centre Faculty of HealthEngineering and SciencesThe University of Southern QueenslandToowoombaQueensland 4350Australia

This paper presents a high-order coupled compact integrated RBF(CC IRBF)approximation based domain decomposition(DD)algorithm for the discretisation of second-order differential *** Schwarz DD algorithms,including one-level additive/multiplicative and two-level additive/multiplicative/hybrid,are *** CCIRBF based DD algorithms are analysed with different mesh sizes,numbers of subdomains and overlap sizes for Poisson *** convergence analysis shows that the CCIRBF two-level multiplicative version is the most effective algorithm among various schemes employed ***,the present CCIRBF two-level method converges quite rapidly even when the domain is divided into many subdomains,which shows great promise for either serial or parallel *** practical tests,we then incorporate the CCIRBF into serial and parallel two-level multiplicative *** numerical examples,including those governed by Poisson and navier-Stokes equations are analysed to demonstrate the accuracy and efficiency of the serial and parallel algorithms implemented with the *** results show:(i)the CCIRBF-Serial and-Parallel algorithms have the capability to reach almost the same solution accuracy level of the CCIRBF-Single domain,which is ideal in terms of computational calculations;(ii)the CCIRBF-Serial and-Parallel algorithms are highly accurate in comparison with standard finite difference,compact finite difference and some other schemes;(iii)the proposed CCIRBF-Serial and-Parallel algorithms may be used as alternatives to solve large-size problems which the CCIRBF-Single domain may not be able to deal *** ability of producing stable and highly accurate results of the proposed serial and parallel schemes is believed to be the contribution of the coarse mesh of the two-level domain decomposition and the CCIRBF *** is noted that the focus of this paper is on the derivation of highly accurate serial and parallel algorithms

关键词： Coupled compact integrated RBF (CCIRBF) Schwarz domain decomposition one-level two-level coarse meshes additive multiplicative hybrid serial parallel colouring technique Poisson equation naiver-Stokes equation liddriven cavity

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Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata Judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka tamás Resál tamás Molnár Zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ Translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

BACKGROUnD Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** To evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps T1 tumor Endoscopic removal Outcomes Long-term Surveillance

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排卵期女性用自然周期、改良自然周期或人工子宫内膜制剂进行一次冷冻胚胎移植后活产率的临床研究

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中国临床药理学杂志 2024年第16期40卷 2456-2456页

作者： HO V n A pham T D nGUYEn n T 孟海峰

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促... 详细信息

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促性腺激素(hCG);改良自然周期组使用hCG来触发排卵;人工周期组使用口服戊酸雌二醇(从月经第2~4天开始,每天8mg)和阴道孕酮(从子宫内膜厚度≥7mm开始,每天800mg)。

关键词：人工周期戊酸雌二醇子宫内膜厚度活产率自然周期冷冻胚胎移植排卵期孕酮

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