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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

New Optimization Method, the Algorithms of Changes, for Heat Exchanger Design

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 55-62页

作者： tam Houkuan tam Lapmou tam sikchung CHIO Chouhei GHAJAR Afshin J Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of Macao Department of Mathematics Faculty of Science and TechnologyUniversity of Macao school of Mechanical and Aerospace Engineering Oklahoma State University

Heat exchangers are widely used in the process engineering such as the chemical industries, the petroleum industries, and the HVAC applications etc. An optimally designed heat exchanger cannot only help the optimization of the equipment size but also the reduction of the power consumption. In this paper, a new optimization approach called algorithms of changes (AOC) is proposed for design and optimization of the shell-tube heat exchanger. This new optimization technique is developed based on the concept of the book of changes (I Ching) which is one of the oldest Chinese classic texts. In AOC, the hexagram operations in I Ching are generalized to binary string case and an iterative process, which imitates the I Ching inference, is defined. Before applying the AOC to the heat exchanger design problem, the new optimization method is examined by the benchmark optimization problems such as the global optimization test functions and the travelling salesman problem (TsP). Based on the TsP results, the AOC is shown to be superior to the genetic algorithms (GA). The AOC is then used in the optimal design of heat exchanger. The shell inside diameter, tube outside diameter, and baffles spacing are treated as the design (or optimized) variables. The cost of the heat exchanger is arranged as the objective function. For the heat exchanger design problem, the results show that the AOC is comparable to the GA method. Both methods can find the optimal solution in a short period of time.

关键词： optimization genetic algorithms (GA) travelling salesman problem (TsP) heat exchanger design algorithms of changes (AOC)

Public Health Control Measures for the Co-circulation of Influenza and sARs-CoV-2 During Influenza seasons

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China CDC weekly 2022年第2期4卷 22-26页

作者： John s tam Yuelong shu Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong KongChina Asia Pacific Alliance for the Control of Influenza(APACI) South MelbourneVICAustralia school of Public Health(shenzhen) Sun Yat-sen UniversityGuangzhouGuangdongChina

sEAsONAL INFLUENZA IN THE MIDsT OF COVID-19 The World Health Organization(WHO)named the disease caused by severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)as coronavirus disease 2019(COVID-19)and declared the outbreak a Public Health Emergency of International Concern(PHEIC)on January 30,2020 and a pandemic on March 11,***,there have been 239,437,517 confirmed cases of COVID-19 reported to WHO,including 4,879,235(2.1%)deaths as of October 15,2021(1).The COVID-19 pandemic continues to cause an unparalleled impact on global public health security and economic well-being in the context of previous influenza pandemics as well as other emerging infectious diseases in history(2).As the epidemiology,clinical presentations,and control measures for sARs-CoV-2 and influenza share many features,there is a need to develop strategies to address additional challenges arising in the continued surveillance,prevention,and clinical management of influenza in conjunction with COVID-19 pandemic responses.

关键词： epidemiology prevention acute

Modeling of Reversibleγ/αTransformations of Low Carbon steels in the Intercritical Temperature Range

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材料热处理学报 2004年第05B期25卷 702-705页

作者： tamás RTl Imre FELDE Hakan GR Budapest Polytechnic Budapest HungaryBay Zoltdn Institute for Materials Science and Technology Budapest HungaryMetallurgical and Materials Eng. Dept. Middle East Technical University Ankara Turkey

A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner.

关键词：奥氏体转变动力学低碳钢临界温度

On the relationship between the activity at point of interests and road traffic

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Communications in Transportation Research 2023年第1期3卷 150-160页

作者： MátéKolat tamás Tettamanti tamásBécsi Domokos Esztergár-Kiss Department of Control for Transportation and Vehicle systems Faculty of Transportation Eng.and Vehicle Eng.Budapest University of Technology and EconomicsBudapest1111PestHungary systems and Control Laboratory Institute for Computer Science and Control of the Eötvös Lorand Research NetworkBudapest1053PestHungary Department of Transport Technology and Economics Faculty of Transportation Eng.and Vehicle Eng.Budapest University of Technology and EconomicsBudapest1111PestHungary

The estimation and analysis of road traffic represent the preliminary steps towards satisfying the current needs for smooth,safe,and green ***,effective traffic monitoring is an essential topic alongside the planning of sustainable transportation systems and the development of new traffic management *** contrast to classical traffic detection solutions,this study investigates the correlation between travelers'social activities and road *** s's primary goal is to investigate the presence of the relationship between social activity and road traffic,which might allow an infrastructure-independent traffic monitoring technique as ***'s general activities at Point of Interest(POI)locations(measured as occupancy parameter)are correlated with traffic data so that,finally,proper proxys can be defined for link-level average traffic speed *** method is tested and evaluated using real-world traffic and POI occupancy data from Budapest(District XI.).The results of the correlation investigation justify an indirect relationship between activity at POIs and road traffic,which holds promise for future practical applicability.

关键词： Road traffic estimation Google popular times(GPT) Point of interest(POI) POI occupancy Genetic algorithm(GA)

Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population

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World Journal of Gastroenterology 2011年第48期17卷 5317-5323页

作者： Xiao-Ming Zhou Paul Ks Chan John s tam Department of Epidemiology Shanghai Public Health Clinical Center Fudan University Shanghai 201508China Department of Microbiology The Chinese University ofHong Kong Shatin Hong Kong China World Health Organization Geneva 1200 Switzerland

AIM： To explore mutations around the interferon sensitivity-determining region （IsDR） which are associated with the resistance of hepatitis C virus lb （HCV-lb） to interferon-α treatment. METHODs： Thirty-seven HCV-lb samples were obtained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended IsDR （eIsDR） covering 64 amino acids upstream and 67 amino acids downstream from the previously reported IsDR were analyzed. REsULTs： One amino acid variation （I2268V, P = 0.023） was significantly correlated with treatment outcome in this pilot study with a limited number of patients, while two amino acid variations （R2260H, P = 0.05 and $2278T, P = 0.05） were weakly associated with treat- ment outcome. The extent of amino acid variations within the IsDR or eIsDR was not correlated with treat- ment outcome as previously reported. CONCLUsION： Three amino acid mutations near but outside of IsDR may associate with interferon treatment resistance of HCV-lb patients in Hong Kong.

关键词： Hepatitis C virus lb Extended interferon sen-sitivity-determining region Interferon-R Resistance HongKong Mutation

Polymeric micelle nanocarriers in cancer research

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Frontiers of Chemical science and Engineering 2016年第3期10卷 348-359页

作者： Dae Hwan shin Yu Tong tam Glen s. Kwon school of Pharmacy University of Wisconsin Madison WI 53705 USA

Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.

关键词： nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation

Complications in children with percutaneous endoscopic gastrostomy (PEG) placement

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World Journal of Pediatrics 2019年第1期15卷 12-16页

作者： Brigitta Balogh tamás Kovács Amulya Kumar saxena Division of Pediatric surgery Department of PediatricsUniversity of SzegedKorányi fasor 14-15Szeged 6725Hungary Department of Pediatric surgery Chelsea Children's HospitalChelsea and Westminster NHS Fdn TrustImperial College LondonLondonUK

Introduction The aim of this study was to analyze the complication rates and mortality in association with different operative techniques of percutaneous endoscopic gastrostomy (PEG),age,underlying diseases and other risk ***,analysis of the indications of PEG insertion and the underlying comorbidities was also *** This study performs a literature analysis of PEG-related complications in *** was searched on PubMed(R) (1994-2017) using terms 'percutaneous endoscopic gastrostomy','complications','mortality' and 'children'.Results Eighteen articles with 4631 patients were *** mean age was 3 years (0-26 years).Operative techniques were:pull technique in 3507 (75.7%),1 stage PEG insertion in 449 (9.7%),introducer technique in 435 (9.4%),image-guided technique in 195 (4.2%) and laparoscopic-assisted PEG in 45 (1.6%).Most frequent indications for PEG insertion were dysphagia (n =859,32.6%),failure to thrive (n =723,27.5%) and feeding difficulties (n =459,17.4%).Minor complications developed in n 1518 patients (33%),including granulation (n =478,10.3%),local infection (n =384,8.3%) and leakage (n =279,6%).In 464 (10%) patients,major complications occurred;the most common were systemic infection (n =163,3.5%)and cellulitis (n =47,1%).severe complication like perforation occurred in less than 0.3%.Patients with lethal outcomes (n =7,0.15%) had severe comorbidities;and the cause of mortality was sepsis in all *** or young age did not affect complication *** with ventriculoperitoneal (VP) shunt had higher risk of major *** high-risk patients,laparoscopic-assisted PEG insertion had less major and severe complication than traditional pull *** PEG is a safe operative technique;although minor complications are relatively common and occur in up to 1/3 of patients,there is a fairly low rate of severe ***-thirds of PEG patients have at least one ***

关键词： Children Complications Percutaneous endoscopic gastrostomy

The Impact of Topography on social Factors,a Case study of Montenegro

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Journal of Mountain science 2014年第1期11卷 131-141页

作者： TELBIsZ tamás BOTTLIK Zsolt MARI László KOsZEGI Margit Department of Physical Geography Eotvos University Department of Regional science Eotvos University

Relationships between environmental and social factors have long been studied by ***,GIs-aided statistical analysis provides new tools to explore these *** order to detect the impact of topography on social factors,we selected the country of Montenegro as a case example due to its high topographic *** compared the spatial pattern of population,settlements and ethnic minorities to physical geographic factors,especially to topography,but lithology and land cover data were also taken into *** found that certain factors are closely correlated,*** settlement density linearly decreases with elevation,while the characteristic settlement area shows an exponential increase *** population density is not related to absolute elevation,but it is in close correlation with height(*** relative to the local minimum).Population change and illiteracy are also topography-related social *** the contrary,the variable ethnic pattern of Montenegro is influenced by historical,political and economic effects rather than by environmental factors or topographic *** a conclusion we state that in the scale of a country or a region,the environment can strongly impact some social factors.

关键词： Human-environment relations Dinarides GIs settlements Population Ethnic groups