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Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana

Journal of Integrative Plant Biology 2016年第3期58卷 254-265页

作者： Takao Araya takuya kubo Nicolaus von Wiren Hideki Takahashi Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingM148824USA Molecular Plant Nutrition Leibniz Institute of Plant Genetics and Crop Plant ResearchD-06466 GaterslebenGermany Graduate School of Environmental Science Hokkaido UniversitySapporo 060-0810Japan

Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with：（i） inhibition of primary root growth under nitrogen limitation or on ammonium;（ii） rapid progression of lateral root emergence in response to ammonium; and（iii） inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies.

关键词： Ammonium mathematical modeling nitrate nitrogen root system architecture

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Practical BRDF reconstruction using reliable geometric regions from multi-view stereo

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Computational Visual Media 2019年第4期5卷 325-336页

作者： Taishi Ono Hiroyuki kubo Kenichiro Tanaka takuya Funatomi Yasuhiro Mukaigawa Nara Institute of Science and Technology IkomaNara 630-0192Japan

In this paper,we present a practical method for reconstructing the bidirectional reflectance distribution function(BRDF)from multiple images of a real object composed of a homogeneous *** key idea is that the BRDF can be sampled after geometry estimation using multi-view stereo(MVS)*** contribution is selection of reliable samples of lighting,surface normal,and viewing directions for robustness against estimation errors of *** method is quantitatively evaluated using synthesized images and its effectiveness is shown via real-world experiments.

关键词： BRDF reconstruction multi-view stereo(MVS) photogrammetry rendering

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Acquiring non-parametric scattering phase function from a single image

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Computational Visual Media 2018年第4期4卷 323-331页

作者： Yuki Minetomo Hiroyuki kubo takuya Funatomi Mikio Shinya Yasuhiro Mukaigawa Nara Institute of Science and Technology 8916-5 Takayama-choIkomaNara630-0192Japan. Toho University 2-2-1 MiyamaFunabashiChiba274- 8510Japan. Dwango CG Research KADOKAWA Hongo Bldg.5-24-5 HongoBunkyo-kuTokyo113-0033Japan.

Acquiring accurate scattering properties is important for rendering translucent materials. In particular, the phase function, which determines the distribution of scattering directions, plays a significant role in the appearance of a material. We propose a distinctive scattering theory that approximates the effect of single scattering to acquire the non-parametric phase function from a single image. Furthermore, in various experiments, we measured the phase functions from several real diluted media and rendered images of these materials to evaluate the effectiveness of our theory.

关键词： scattering phase function measurement rendering

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Synthesis and Properties of a Through-Space Interacting Diradicaloid

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Precision Chemistry 2023年第3期1卷 183-191页

作者： takuya Kodama Yasukazu Hirao Takashi kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICSOTRI)Osaka UniversitySuitaOsaka 565-0871Japan

Knowledge about electronic structures is important to gain an understanding of the unique functional properties of *** this study,we synthesized and characterized a diradicaloid in which two phenalenyl radical sites are coupled antiferromagnetically via a through-space *** results of quantum chemical,physicochemical(^(1)H NMR,electronic absorption,cyclic voltammetry,SQUID,ESR),and chemical reactivity studies show that this diradicaloid has singlet diradical *** assessment of the nature of the bonding interaction between two radical sites in this species using DFT calculations demonstrates that a small spatial overlap between the two SOMOs in this diradicaloid provides an efficient electron exchange path for the singlet state to be substantially lower in energy than the triplet state.

关键词： through-space interaction phenalenyl radical singlet diradical diradicaloid antiferromagnetic interaction

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An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture

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World Journal of Gastroenterology 2008年第7期14卷 1091-1096页

作者： Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido takuya Miura Norihito kubo Mutsuo Sasaki Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic ***: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa ***: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely ***: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas.

关键词： Pancreaticojejunostomy Duct-to-mucosa contact method Fast-absorbable suture Irradiated polyglactin 910 Pancreatic fistula

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Study of High Power ICRF Antenna Design in LHD

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Plasma Science and Technology 2010年第1期12卷 15-19页

作者： Hiroshi KASAHARA Tetsuo SEKI Kenji SAITO Ryuhei KUMAZAWA Takashi MUTOH Goro NOMURA Fujio SHIMPO Shin kubo Takashi SHIMOZUMA Yasuo YOSHIMURA Hiroe IGAMI Hiromi TAKAHASHI 赵燕平 takuya OOSAKO Yuichi TAKASE National Institute for Fusion Science Institute of Plasma Physics Chinese Academy of Sciences University of Tokyo

In large helical device （LHD）, antenna loadings are different for minority ion cyclotron heating （MICH with 38.47 MHz） and mode-converted ion Bernstein wave heating （MC-IBW with 28.4 MHz）, and it is necessary to improve antenna loading with low heating efficiency to avoid arching on transmission line. To design a new ion cyclotron range of frequencies （ICRF） antenna in LHD, calculation for a simple antenna model is conducted using three-dimensional electrical magnetic code （high frequency structure simulator, HFSS） for an water loading as an imaginary plasma with low heating efficiency. At resonant frequencies, antenna loading is sensitive to strap width, and resonant frequencies are strongly related to strap height. There is no differences of RF current profile on the strap surface between resonant frequency and non-resonant frequency. The strap should be perpendicularly placed against the magnetic field line, since Faraday-shield angle will lead to a decrease in the effective antenna height.

关键词： ICRF minority heating mode conversion heating antenna design LHD

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Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2076-2087页

作者： takuya Sho Kenichi Morikawa Akinori kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638HokkaidoJapan

The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall ***,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major *** on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate *** provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade *** patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver *** initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be *** also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this ***,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in *** suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve.

关键词： Hepatocellular carcinoma Lenvatinib Molecular targeted agent TACE refractory TACE-unsuitable Barcelona Clinic Liver Cancer intermediate stage

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Resection of a locally advanced hilar tumor and the hepatic artery after stepwise hepatic arterial embolization: A case report

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World Journal of Gastroenterology 2008年第22期14卷 3587-3590页

作者： takuya Miura Kenichi Hakamada Takashi Ohata Shunji Narumi Yoshikazu Toyoki Masaki Nara Keinosuke Ishido Motonari Ohashi Harue Akasaka Hiroyuki Jin Norihito kubo Shuichi Ono Hiroshi Kijima Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Radiology and Radiation Oncology Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Pathology and Bioscience Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan Department of Pathology and Bioscience Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan

We herein report a case of a hilar tumor with extensive invasion to the proper hepatic artery, which was successfully treated with a radical resection in a 57-year-old female patient after a stepwise hepatic arterial embolization. She underwent right colectomy and partial hepatectomy for advanced colon cancer two years ago and radiofrequency ablation therapy for a liver metastasis one year ago, respectively. A recurrent tumor was noted around the proper hepatic artery with invasion to the left hepatic duct and right hepatic artery 7 mo previously. We planned a radical resection for the patient 5 mo after the absence of tumor progression was confirmed while he was undergoing chemotherapy. To avoid surgery-related liver failure, we tried to promote the formation of collateral hepatic arteries after stepwise arterial embolizationof the posterior and anterior hepatic arteries two weeks apart. Finally, the proper hepatic artery was occluded after formation of collateral flow from the inferior phrenic and superior mesenteric arteries was confirmed. One month later, a left hepatectomy with hepatic arterial resection was successfully performed without any major complications.

关键词： Hepatic arterial embolization Stepwise Hilar tumor Arterial resection Collateral artery

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Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

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