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“Passive-bending colonoscope”significantly improves cecal intubation in difficult cases

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World Journal of Gastroenterology 2012年第32期18卷 4454-4456页

作者： takeshi Mizukami Haruhiko Ogata Toshihumi Hibi Endoscopy Center NHO Kurihama Medical and Addiction CenterKanagawa 239-0841Japan Endoscopy Center Keio UniversityTokyo 160-0016Japan Department of Gastroenterology Keio UniversityTokyo 160-0016Japan

Colonoscopy sometimes causes pain during insertion,especially in difficult ***-insufflation of air causes elongation or acute angulations of the colon,making passage of the scope difficult and causing *** previously reported a sedative-risk-free colonoscopy insertion technique,namely,"Water Navigation Colonoscopy".Complete air suction after water infusion not only improves the vision,but also makes water flow down to the descending colon,while the sigmoid colon collapses and *** non-sedative colonoscopy can be carried out without pain in most cases,some patients do complain of *** of these patients have abnormal colon morphology,and the pain is caused while negotiating the "hairpin" bends of the *** "hairpin" bends of the colon should be negotiated by gently pushing the full-angled *** proximal 10-20 cm from the angulated part of the conventional colonoscope is stiff,with a wide turning radius,therefore,a conventional colonoscope cannot be negotiated through the "hairpin" bends of the colon without stretching them and causing *** "passive-bending colonoscope" has a flexible tip with a narrow turning radius,so that the scope can be negotiated through the "hairpin" bends of the colon with a minimum turning radius and minimal ***,the intubation and pain-reducing performance of the "passive-bending colonoscope" was assessed in difficult cases.

关键词： Computed tomographic colonography Water navigation colonoscopy Passive-bending colonoscope Cecal intubation

Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines

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World Journal of Gastroenterology 2001年第6期7卷 855-859页

作者： Edgar Staren takeshi lwamura HubertAppert JohnHoward Department of Surgery Medical College of OhioToledoOhioUSA Department of Surgery Miyazaki Medical CollegeMiyazakiJapan

AIM: To investigate the specific mechanisms of intrinsic and acquired resistance to taxotere (TXT) in pancreatic adenocarcinoma (PAC). METHODS: MTT assay was used to detect the sensitivity of PAC cell line SUIT-2 and its sublines (S-007, S-013, S-020, S-028 and TXT selected SUIT-2 cell line, S2/TXT) to TXT. Mdr1 (P-gp), multidrug resistance associated protein (MRP), lung resistance protein (LRP) and beta-tubulin isotype gene expressions were detected by RT-PCR. The functionality of P-gp and MRP was tested using their specific blocker verapamil (Ver) and indomethacin (IMC), respectively. The transporter activity of P-gp was also confirmed by Rhodamine 123 accumulation assay. RESULTS: S-020 and S2/TXT were found to be significantly resistant to TXT(19 and 9.5-fold to their parental cell line SUIT-2, respectively). RT-PCR demonstrated strong expression of Mdr1 in these two cell lines, but weaker expression or no expression in other cells lines. MRP and LRP expressions were found in most of these cell lines. The TXT-resistance in S2-020 and S2/TXT could be reversed almost completely by Ver, but not by IMC. Flow cytometry showed that Ver increased the accumulation of Rhodamine-123 in these two cell lines. Compared with S-020 and SUIT-2, the levels of beta-tubulin isotype II, III expressions in S-2/TXT were increased remarkably. CONCLUSION: The both intrinsic and acquired TXT-related drug resistance in these PAC cell lines is mainly mediated by P-gp, but had no relationship to MRP and LRP expressions. The increases of beta-tubulin isotype II, III might be collateral changes that occur when the SUIT-2 cells are treated with TXT.

关键词： Drug Resistance, Neoplasm Taxoids Antineoplastic Agents, Phytogenic Carcinoma Humans Paclitaxel derivatives Pancreatic Neoplasms Research Support, Non-U.S. Gov't Tumor Cells, Cultured

Information gathering and evaluation of data quality for safety assessment of chemicals-2013 abstract

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中国药理学与毒理学杂志 2013年第3期 508-509页

作者： takeshi Morita Division of Safety Information on Drug Food and ChemicalsNational Institute of Health SciencesTokyo 158-8501Japan

It is important to review existing toxicity data of chemicals as well as conduct of toxicity *** provides toxicological information on similar class of chemicals,and avoids unnecessary tests.A critical first step is to assemble all of the available information on the *** are many information sources of data on physic-chemical properties or mammalian toxicity(e.g.,human data,in vivo or in vitro studies,in silico outputs).The sources include review docu-ments,databanks / databases,published literature,in house company data,or output from internet search *** vary in many aspects,including quality,covering fields,extent of peer review,the time-spans of covered,number of chemicals addressed and the extent of ***,the second step is to evaluate data quality including reliability,relevance and *** of GLP studies in accordance with standardtest guideline are considered to be reliable and *** judgment in a weight of evidence approach will be needed for determination of toxicity of *** quality and consistency of the data,study design,mechanism or mode of action,dose-effect relationships and biological relevance should be taken into *** of useful information sources and key points of data quality will be presented and discussed.

关键词： Information gathering and evaluation of data quality for safety assessment of chemicals-2013 abstract data

Role of osteoclasts in regulating hematopoietic stem and progenitor cells

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World Journal of Orthopedics 2013年第4期4卷 198-206页

作者： takeshi Miyamoto Department of Orthopedic Surgery Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Keio Kanrinmaru Project Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Department of Integrated Bone Metabolism and Immunology Keio University School of Medicine 35 Shina-no-machi Shinjuku-ku Tokyo 160-8582 Japan

Bone marrow(BM) cavities are utilized for hematopoiesis and to maintain hematopoietic stem cells(HSCs). HSCs have the ability to self-renew as well as to differentiate into multiple different hematopoietic lineage cells. HSCs produce their daughter cells throughout the lifespan of individuals and thus, maintaining HSCs is crucial for individual life. BM cavities provide a specialized microenvironment termed "niche" to support HSCs. Niches are composed of various types of cells such as osteoblasts, endothelial cells and reticular cells. Osteoclasts are unique cells which resorb bones and are required for BM cavity formation. Loss of osteoclast function or differentiation results in inhibition of BM cavity formation, an osteopetrotic phenotype. Osteoclasts are also reportedly required for hematopoietic stem and progenitor cell(HSPC) mobilization to the periphery from BM cavities. Thus, lack of osteoclasts likely results in inhibition of HSC maintenance and HSPC mobilization. However, we found that osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization by using three independent osteoclast-less animal models. In this review, I will discuss the roles of osteoclasts in hematopoietic stem cell maintenance and mobilization.

关键词： Osteoclasts Hematopoietic stem and progenitor cell Mobilization Receptor activator of nuclear factor kappa B ligand Osteomac Osteopetrosis op/op C-Fos Osteoprotegerin

New,Unexpected Pyranose-Furanose Rearrangement Towards the Synthetic Studies on Rare Sugars and Nucleosides

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复旦学报（自然科学版） 2005年第5期44卷 794-795页

作者： takeshi Sugai Deparment of Chemistry Keio University Yokohama 223-8522 Japan

Preparation of rare aminosugars such as N-acetylgalactosamine (GalNAc) in large quantities is of importance for the chemo-enzymatic synthesis of oligosaccharides. Starting from naturally abundant N-acetylglucosamine (GlcNAc), the regio- and stereoselective and new functional group transformation play important roles as the key reactions.

关键词：吡喃糖五环糖氨基糖核苷区域选择性

Asymmetric Hydrogenation of Ketones——Design of Chiral Catalysts

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复旦学报（自然科学版） 2005年第5期44卷 762-763页

作者： takeshi Ohkuma Division of Chemical Process Engineering Graduate School of Engineering Hokkaido University Sapporo 060-8628 Japan

Asymmetric hydrogenation of ketones is one of the most reliable methods for obtaining chiral secondary alcohols. This transformation is not only of academic interest, but also of industrial significance because of its simplicity, environmental friendliness, and economic viability. Chiral RuXY(binap)(1,2-diamine) complexes (BINAP = 2,2'-bis(diphenyl-phosphino)-1, 1'-binaphthyl,X = Y = C1 or X = H, Y = BH4) with[1] or without[2] a strong base catalyze rapid, highly productive asymmetric hydrogenation of various simple ketones in 2-propanol. This reaction, unlike conventional hydrogenation, proceeds selectively at a C = O bond leaving coexisting C = C linkages intact. A range of chiral alcohols are accessible in high enantiomeric purity from aromatic,heteroaromatic, olefinic, and amino ketones by this method[1,2]. However, no universal chiral catalysts exist due to the structural diversity of ketonic substrates. Thus, tert-alkyl ketones and 1-tetralones have remained difficult to be hydrogenated with high reactivity and enantioselectivity. We here report that this problem can be resolved by the use of BINAP/PICA-Ru (PICA = α-picolylamine)[3] or BINAP/1,4-diamine-Ru[4] complexes as catalysts.

关键词：氢化酮不均匀性手性催化联萘

H^1-ESTIMATES OF LITTLEWOOD-PALEY AND LUSIN FUNCTIONS FOR JACOBI ANALYSIS

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Analysis in Theory and Applications 2009年第3期25卷 201-229页

作者： takeshi Kawazoe Department of Mathematics Keio University at Fujisawa 5322 Endo FujisawaKanagawa 252-8520 Japan

For a ≥β≥ -1/2 let △（x） = （2shx）^2α＋1 （2chx）2β＋1 denote the weight function on R＋ and L^1 （△） the space of integrable functions on R＋ with respect to △（x）dx, equipped with a convolution structure. For a suitable Ф ∈ L^1 （△）, we put Фt（x） = t^-1 △（x）^-1 △（x/t）Ф（x/t） for t 〉 0 and define the radial maximal operator MФ, as usual manner. We introduce a real Hardy space H^1 （△） as the set of all locally integrable functions f on R＋ whose radial maximal function MФ （f） belongs to L^1 （△）. In this paper we obtain a relation between H^1 （△） and H^1 （R）. Indeed, we characterize H^1 （△） in terms of weighted H^1 Hardy spaces on R via the Abel transform of f. As applications of H^1 （△） and its characterization, we shall consider （H^1 （△）,L^1 （△））-boundedness of some operators associated to the Poisson kernel for Jacobi analysis： the Poisson maximal operator Me, the Littlewood-Paley g-function and the Lusin area function S. They are bounded on L^p（△） for p 〉 1, but not true for p = 1. Instead, Mp, g and a modified Sa,r are bounded from H^1 （△） to L^1 （△）.

关键词： Hardy space Jacobi analysis Littlewood-Paleyfunction Lusinfunction

Biogeographical note on Antarctic microforae: Endemism and cosmopolitanism

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Geoscience Frontiers 2013年第6期4卷 633-646页

作者： Waqar Azeem Jadoon Ryosuke Nakai takeshi Naganuma Graduate School of Biosphere Science Hiroshima University1-4-4 KagamiyamaHigashi-HiroshimaHiroshima 739-8528Japan National Institute of Genetics 1111 YataMishimaShizuoka 411-8540Japan Research Fellow of the Japan Society for the Promotion of Science Chiyoda-kuTokyo 102-8471Japan

This study deals with the biogeography of Antarctic microflora （Antarctica acts as best model to study microbial biogeography） such as cyanobacteria and selected halophiles with special emphasis on Halomonas variabilis and Bacillus *** are known to be resistant not only to salt stress,but also to extreme temperature,pressure,and aridity and they are capable of surviving in harsh environments such as polar regions,deep-sea habitats,and *** microbes are known to be resistant to hostile environmental conditions,and are capable of surviving in harsh *** group has isolated 444 strains belonging to 28 genera of halophiles from various environments around the *** 16S rRNA gene sequences revealed that many of the isolated strains from geographically distant habitats having different environmental conditions,were closely related to each other,with some strains possessing 100％ identical *** possessing survival mechanism such as spore formation are usually *** genus Halomonas is represented by potentially endemic strains and the ubiquitous ***,while spore-forming *** showed cosmopolitan *** potentially endemic （moderate endemicity that is regional and/or continental distribution） strain was reported from Syowa station,East Antarctica,and Mario Zucchelli station,West Antarctica,which are geographically separated by 3000 ***,15 strains having 100％ similarity with *** were considered *** results of this work provide support for the middle-ground model that some microbes have moderate endemicity and others have cosmopolitan *** results will contribute to a greater understanding of microbial biogeography with special emphasis on Antarctica.

关键词： Biogeography Cyanobacteria Halophilic bacteria 16S rRNA Molecular phylogeny

A Study on High Subsonic Airfoil Flows in Relatively High Reynolds Number by Using OpenFOAM

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Journal of Thermal Science 2014年第2期23卷 133-137页

作者： Shinichiro NAKAO Masashi KASHITANI takeshi Miyaguni Yutaka YAMAGUCHI Department of Mechanical Engineering Nagasaki Institute of Applied Science536 Aba-MachiNagasaki851-0193JAPAN Department of Aerospace Engineering National Defense Academy1-10-20 HashirimizuYokosuka239-8686JAPAN

In the present study,numerical calculations of the flow-field around the airfoil model are performed by using the OpenFOAM in high subsonic *** airfoil model is NACA *** maximum thickness is 10 % of the chord *** SonicFOAM and the RhoCentralFOAM are selected as the solver in high subsonic *** grid point is 158,000 and the Mach numbers are 0.277 and 0.569 *** CFD data are compared with the experimental data performed by the cryogenic wind tunnel in the *** results are as *** numerical results of the pressure coefficient distribution on the model surface calculated by the SonicFOAM solver showed good agreement with the experimental data measured by the cryogenic wind *** the data calculated by the SonicFOAM have the capability for the quantitative comparison of the experimental data at low angle of attack.

关键词： OpenFOAM High Subsonic Flows Cryogenic Wind Tunnel Airfoil