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Fabrication of disk-shaped,deuterated resorcinol/formaldehyde foam target for laser-plasma experiments

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High Power Laser Science and Engineering 2021年第2期9卷 241-246页

作者： Yumi Kaneyasu Keiji Nagai Marilou Cadatal-Raduban Daniil Golovin Satoshi Shokita Akifumi Yogo takahisa jitsuno Takayoshi Norimatsu Kohei Yamanoi Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Innovative Research(IIR) Tokyo Institute of Technology–Suzukakedai CampusYokohamaJapan Centre for Theoretical Chemistry and Physics School of Natural and Computational SciencesMassey UniversityAucklandNew Zealand

Resorcinol/formaldehyde(RF)foam resin is an attractive material as a low-density target in high-power laser–plasma experiments because of its fine network structure,transparency in the visible region,and low-Z element(hydrogen,carbon,and oxygen)*** this study,we developed disk-shaped RF foam and deuterated RF foam targets with 40–200μm thickness and approximately 100 mg/cm^(3) density having a network structure from 100 nm to a few micrometers cell *** deuteration,the polymerization rate was drastically slowed down owing to kinetic isotope *** targets were used in high-power laser experiments where a megaelectronvolt proton beam was successfully generated.

关键词： deuterated material low-density material resorcinol/formaldehyde foam

Development of coal mine methane concentration technology for reduction of greenhouse gas emissions

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Science China(Technological Sciences) 2010年第1期53卷 28-32页

作者： takahisa UTAKI Engineering Department Osaka Gas Co.Ltd.1-2 Hiranomachi 4-chomeChuo-kuOsakaJapan

In coal mines in such countries as China and Russia,most of the coal mine methane(CMM) generated during mining is emitted to the atmosphere without any effective usage,because the methane concentration of CMM is relatively low and not allowed to be used as fuel for safety *** is one of the greenhouse ***,if it becomes possible to concentrate CMM to an acceptable level for use as fuel,this will greatly contribute to reduction of greenhouse gas *** the aim of gaining approval as a greenhouse gas emission reduction of the clean development mechanism(CDM) or joint implementation(JI) project,we developed a CMM concentration system to apply the vacuum pressure swing adsorption(VPSA) technology using a high methane-selective adsorbent by Osaka Gas Co.,*** pilot-scale plant of a CMM concentration system was installed in a coal mine in Fuxin City in the northeastern China and a demonstration test was commenced in December *** the result,the pilot-scale plant successfully concentrated the raw material gas with a methane concentration of 21% and a flow rate of 1000 Nm3/h to 48%,which exceeded the target of the methane concentration performance(a 25% increase).The methane recovery rate reached 93%.

关键词： methane concentration coal mine methane vacuum pressure swing adsorption greenhouse gas emissions

Safety of laparoscopic surgery in digestive diseases with special reference to antithrombotic therapy: A systematic review of the literature

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World Journal of Clinical Cases 2018年第14期6卷 767-775页

作者： takahisa Fujikawa Kenji ando Department of Surgery Kokura Memoria Hospital Department of Cardiology Kokura Memorial Hospital

AIMTo elucidate the effect of antithrombotic therapy （ATT） on bleeding and thromboembolic complications during or after laparoscopic digestive *** articles or internationally accepted abstracts between 2000 and 2017 were searched from PubMed, Cochrane Database, and Google Scholar, and studies involving laparoscopic digestive surgery and antiplatelet therapy （APT） and/or anticoagulation therapy （ACT） were included after careful review of each study. Data such as study design, type of surgical procedures, antithrombotic drugs used, and surgical outcome （both bleeding and thromboembolic complications） were extracted from each *** published articles and two internationally accepted abstracts were eligible for inclusion in the systematic review. Only one study concerning elective laparoscopic cholecystectomy in patients with peri-operative heparin bridging for ACT showed that the risk of postoperative bleeding was higher compared with those without ACT. The remaining 14 studies reported no signifcant differences in the incidence of bleeding complications between the ATT group and the group without ATT. The risk of thromboembolic events （TE） associated with laparoscopic digestive surgery in patients receiving ATT was not signifcantly higher than those with no ATT or interrupted *** T et al . Laparoscopic digestive surgery and antithrombotic therapyCONCLUSIONLaparoscopic digestive surgery in ATT-burdened patients for prevention of bleeding and TE showed satisfactory results. The risk of hemorrhagic complication during or after these procedures in patients with continued APT or heparin bridging was not signifcantly higher than in patients with no ATT or interrupted APT.

关键词： Thromboembolic complication Bleeding complication Laparoscopic surgery Anticoagulation therapy Digestive surgery Antithrombotic therapy Antiplatelet therapy

Safety of pancreatic surgery with special reference to antithrombotic therapy:A systematic review of the literature

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World Journal of Clinical Cases 2021年第23期9卷 6747-6758页

作者： takahisa Fujikawa Shigetoshi Naito Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555Japan

BACKGROUND Postpancreatectomy hemorrhage(PPH)is the most severe type of complication after pancreatic surgery,although the effect of antithrombotic therapy(ATT)on PPH is largely *** safety and efficacy of chemical thromboprophylaxis for venous thromboembolism(VTE)remains *** To elucidate the effect of ATT on *** Published articles between 2013 and 2020 were searched from PubMed and Google Scholar,and after careful reviewing of all studies,studies concerning ATT and pancreatic surgery were *** such as study design,type of surgical procedures,type of antithrombotic drugs,and surgical outcome were extracted from the *** Nineteen published articles with a total of 37863 patients who underwent pancreatic surgery were included in the systematic *** were cohort studies,with only three being prospective in *** studies demonstrated that in patients receiving chronic ATT,which were mostly managed by heparin bridging,the risk of PPH was higher compared with those without ATT,and one study showed that patients with direct-acting oral anticoagulants managed by heparin bridging had significantly higher postoperative bleeding rates than *** remaining six studies reported that pancreatic surgery can be safely performed in patients receiving chronic ATT,even under preoperative aspirin *** chemical thromboprophylaxis for VTE,most studies have shown a potentially high risk of PPH in patients undergoing chemical thromboprophylaxis;however,its effectiveness against VTE has not been statistically demonstrated,particularly among Asian *** Pancreatic surgery in chronically ATT-received patients can be safely performed without an increase in the occurrence of PPH,although the safety and efficacy of chemical thromboprophylaxis for VTE during pancreatic surgery is still *** investigation using reliable studies with good design is required to establish definite pr

关键词： Antithrombotic therapy Pancreatic surgery Perioperative management Antiplatelet therapy Anticoagulation therapy Pancreaticoduodenectomy

Efficacy of tailored Helicobacter pylori eradication therapy based on antibiotic susceptibility and CYP2C19 genotype

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World Journal of Gastroenterology 2014年第21期20卷 6400-6411页

作者： Mitsushige Sugimoto takahisa Furuta First Department of Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan

The cure rates of Helicobacter pylori (H. pylori) eradication therapy using a proton pump inhibitor (PPI) and antimicrobial agents such as amoxicillin, clarithromycin, and metronidazole are mainly influenced by bacterial susceptibility to antimicrobial agents and the magnitude of the inhibition of acid secretion. Annual cure rates have gradually decreased because of the increased prevalence of H. pylori strains resistant to antimicrobial agents, especially to clarithromycin. Alternative regimens have therefore been developed incorporating different antimicrobial agents. Further, standard PPI therapy (twice-daily dosing) often fails to induce a long-term increase in intragastric pH > 4.0. Increasing the eradication rate requires more frequent and higher doses of PPIs. Therapeutic efficacy related to acid secretion is influenced by genetic factors such as variants of the genes encoding drug-metabolizing enzymes (e.g., cytochrome P450 2C19, CYP2C19), drug transporters (e.g., multidrug resistance protein-1; ABCB1), and inflammatory cytokines (e.g., interleukin-1β). For example, quadruple daily administration of PPI therapy potently inhibits acid secretion within 24 h, irrespective of CYP2C19 genotype. Therefore, tailored H. pylori eradication regimens that address acid secretion and employ optimal antimicrobial agents based on results of antimicrobial agent-susceptibility testing may prove effective in attaining higher eradication rates.

关键词： Helicobacter pylori Tailored eradication therapy Proton pomp inhibitor Cytochrome P450 2C19 Clarithromycin

Hazard Mitigation Planning for Debris flow Based on Numerical Simulation Using Kanako Simulator

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Journal of Mountain Science 2012年第4期9卷 529-537页

作者： LIU Jinfeng NAKATANI Kana MIZUYAMA takahisa Key Laboratory of Mountain Surface Process and Hazards Institute of Mountain Hazards and EnvironmentChineseAcademy of SciencesChengdu 610041China Department of Erosion Control Engineering Kyoto UniversityKyoto 6068502Japan

Debris flow often causes enormous loss to life and property,especially on alluvial *** structures such as retention check dams are essential to reduce the *** hazard mitigation evaluation and planning it is of significance to determine the location,size and type of dam and the effects of damage *** present a numerical simulation method using Kanako simulator for hazard mitigation planning of debris flow disaster in Tanjutani Gully,Kyoto City,*** simulations were carried out for three situations:1) the simulations of erosion,deposition,hydrograph changing and inundation when there were no mitigation measures;2) the simulations of check dams in four locations(470 m,810 m,1,210 m and 1,610 m from the upstream end) to identify the best location;3) the simulations of check dams of three types(closed,slit and grid) to analyze their effects on sediment trapping and discharge *** on the simulations,it was concluded that two closed check dams(located at 470 m and 1,610 m from the upstream end) in the channel and a drainage channel on the alluvial fan can reduce the risk on the alluvial fan to an acceptable level.

关键词： Hazard mitigation planning Debrisflow Numerical simulation Kanako Simulator

Safety of liver resection in patients receiving antithrombotic therapy:A systematic review of the literature

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World Journal of Hepatology 2021年第7期13卷 804-814页

作者： takahisa Fujikawa Department of Surgery Kokura Memorial HospitalFukuoka 802-8555Japan

BACKGROUND Little is unknown about the effect of chronic antithrombotic therapy(ATT)on bleeding complication during or after *** addition,the safety and effectiveness of chemical prevention for venous thromboembolism(VTE)is still *** To clarify the effect of ATT on thromboembolism and bleeding after liver *** Articles published between 2011 and 2020 were searched from Google Scholar and PubMed,and after careful reviewing of all studies,studies concerning ATT and liver resection were *** such as study design,type of surgery,type of antithrombotic agents,and surgical outcome were extracted from the *** Sixteen published articles,including a total of 8300 patients who underwent hepatectomy,were eligible for inclusion in the current *** studies regarding patients undergoing chronic ATT showed that hepatectomy can be performed safely,and three studies have also shown the safety and efficacy of preoperative continuation of *** chemical prevention for VTE,some studies have shown a potentially high risk of bleeding complications in patients undergoing chemical thromboprophylaxis;however,its efficacy against VTE has not been shown statistically,especially among Asian *** Hepatectomy in patients with chronic ATT can be performed safely without increasing the incidence of bleeding complications,but the safety and effectiveness of chemical thromboprophylaxis against VTE during liver resection is still controversial,especially in the Asian *** a clear protocol or guideline requires further research using reliable studies with good design.

关键词： Liver resection Bleeding complication Antithrombotic therapy Thromboembolic complication Thromboprophylaxis

Case study of debris flow disaster scenario caused by torrential rain on Kiyomizu-dera, Kyoto, Japan - using Hyper KANAKO system

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Journal of Mountain Science 2016年第2期13卷 193-202页

作者： Kana NAKATANI Satoshi HAYAMI Yoshifumi SATOFUKA takahisa MIZUYAMA Department of Erosion Control Engineering Kyoto University Kyoto 606-8502 Japan CTI Engineering Co. Ltd. Osaka 541-0045 Japan Department of Civil Engineering Ritsumeikan University Shiga 606-8502 Japan National Graduate Institute for Policy Studies Tokyo106-8677 Japan

This paper presents debris-flow numerical simulations using the Hyper KANAKO system,developed by the *** system uses the debris flow simulator KANAKO 2D equipped with a graphical user interface(GUI);hence,a user can easily produce appropriate landform data for simulations using standard laser profiler data,and visualize the results using a *** KANAKO was applied to the streams around Kiyomizu-dera in Kyoto,***-dera is a famous temple in Japan which is visited by numerous tourists throughout the *** simulated a disaster scenario of debris flow caused by torrential *** set the hydrograph using rainfall intensity data,and set the landform data using information from the Geospatial Information Authority of Japan(GSI) and a digital elevation model(DEM).We evaluated different mesh sizes and also used a digital surface model(DSM) to consider the building *** simulation results showed that with small mesh size,the debris flowmoved through the roads,which seems realistic for a disaster *** buildings were considered,the flow direction changed,and a 1-m flow depth,which was deeper than in other cases,appeared in the flow *** may pose a dangerous situation for evacuations.

关键词： Debris flow Simulation GIS Hyper KANAKO system Torrential rain Kiyomizu-dera

Hydraulic model tests for evaluating sediment control function with a grid-type Sabo dam in mountainous torrents

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International Journal of Sediment Research 2013年第4期28卷 511-522页

作者： Takahiro ITOH Shigeo HORIUCHI takahisa MIZUYAMA Kazuhiko KAITSUKA NIPPON KOEI Co. Ltd Pasco Corporation Graduate School of Agriculture Kyoto University NIPPON KOEI Co. Ltd.

There are two kinds of Sabo dams in order to control sediment transport by debris flow and flash floods in mountainous area,which arc closed and open-type’s *** Japan,open-type’s Sabo dams are constructed taking into account the continuity of sediment routing from upstream to downstream reach in a basin.A plan to construct a 20 m high grid-type Sabo dam which can capture a sediment volume of 400,000 nr is proposed in the Amahata river basin in *** model tests are conducted to decide on the section for a dam(Section A,B) and the grid size such as clearance of vertical/horizontal bars for evaluating the *** runs of flume tests are conducted and the sediment control function of the Sabo dam is discussed using several experimental data such as dimensionlcss sediment runoff rate from Sabo dam,temporal changes of bed profile and mean diameter and so *** was found that sediment deposition in sediment storage area of Sabo dam was affected by curved channel,and that next the grid size of steel bars and thirdly the section of a dam was able to capture sediment in storage area of Sabo *** was controlled well in the section B and in the grid size of l.0×d95,and the problems related to sediment runoff after sediment capturing in Sabo dam are pointed out.

关键词： Hydraulic model tests Debris flow Grid-type Sabo dam Sediment storage