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Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

The Influence of Significant Public Health Events on Offline Consumption and Its Pathways

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 627-648页

作者： Baile Lu Kewei Zhou Shuai Hao la ta Hongyan Dai Weihua Zhou College of Systems Engineering National University of Defense TechnologyChangsha 410073China Business School Central University of Finance and EconomicsBeijing 100081China Department of Marketing and Operations Management College of BusinessSouthern University of Science and TechnologyShenzhen 518055China School of Management Zhejiang UniversityHangzhou 310058China

In the face of a significant public health event,consumers may either increase their panic buying or decrease their willingness to make *** study focuses on the impact of a significant public health event on offline store sales and consumer consumption,utilizing data from chain convenience stores in Hefei and Wuhu during early 2019 and early 2020 in *** a difference-in-differences model,the study investigates the effect of the significant public health event outbreak on weekly store sales,order numbers,and consumer consumption in terms of product quantities,transaction amount,average amount per order,and transaction *** from prior literature that finds hoarding behavior of consumers online,the findings of this paper indicate a significant reduction in stores’offline weekly sales and order numbers,as well as consumers’offline weekly consumption across the four dimensions,as a result of the significant public health event ***,employing a mediation model,the study explores the pathway of population mobility through which the significant public health event adversely affects offline ***,subset analysis is conducted for stores located in different areas and consumers with varying characteristics,revealing that the aforementioned conclusions predominantly apply to stores situated in office areas and residential areas,as well as consumers with either no apparent preference for different product categories or a noticeable preference for food.

关键词： Significant public health event offline consumption population mobility mediating effect

Deformation-strain field in Sichuan and its surrounding areas based on GPS data

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Geodesy and Geodynamics 2015年第3期6卷 203-209页

作者： Chen Fuchao ta.la Chen Juzhong School of Geodesy and Geomatics Wuhan University First Crust Monitoring and Application Center China Earthquake Administration

The strain rate in Sichuan and its surrounding areas, and the activity rate and strain rate in two block boundary fault zones were calculated according to the block movement parameters estimated using the station speed obtained from regional GPS station observation data in these areas for 2009e2011 and GPS continuous station data for 2011e2013. The movement field characteristics in these areas were analyzed with the Sichuan Basin as the reference. Results show that the principal strain rate and maximum shear strain rate of the Bayan Har block were the largest, followed by those of the Sichuane Yunnan block and Sichuan Basin. The deep normal strain rate in the Longmenshan fault zone was compressive and large over the study period. The normal strain rate in the Xianshuihe fault zone was tensile.

关键词： Sichuan and its surrounding areas Displacement vec

Highly dispersed NiMo@rGO nanocomposite catalysts fabricated by a two-step hydrothermal method for hydrogen evolution

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2432-2440页

作者： Duanhao Cao Xiaofeng Ma Yipeng Zhang la ta Yakun Yang Chao Xu Feng Ye Jianguo Liu School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

Exploring and designing a high-performance non-noble metal catalyst for hydrogen evolution reaction(HER)are crucial for the large-scale application of H2 by water ***,novel catalysts with NiMo nanoparticles decorated on reduced graphene oxide(NiMo@r GO)synthesized by a two-step hydrothermal method were *** characterization results showed that the prepared NiMo@r GO-1 had an irregular lamellar structure,and the NiMo nanoparticles were uniformly dispersed on the ***@rGO-1 exhibited outstanding HER performance in an alkaline environment and required only 93 and 180 mV overpotential for HER in 1.0 M KOH solution to obtain current densities of-10 and-50 mA·cm^(-2),*** tests showed that NiMo@rGO-1 had a certain operating stability for32 *** the same condition,the performance of NiMo@rGO-1 can be comparable with that of commercial Pt/C catalysts at high current *** synergistic effect between NiMo particles and lamellate graphene can remarkably promote charge transfer in electrocatalytic *** a result,NiMo@rGO-1 presented the advantages of high intrinsic activity,large specific surface area,and small electrical *** lamellar graphene played a role in dispersion to prevent the aggregation of *** prepared NiMo@rGO-1 can be used in anion exchange membrane water electrolysis to produce *** study provides a simple preparation method for efficient and low-cost water electrolysis to produce hydrogen in the future.

关键词： hydrogen evolution reaction NiMo nanocomposite reduced graphene oxide synergistic effect

Current Vertical Motion Analysis of Northwestern Margin of Ordos Based on Precise Leveling

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Earthquake Research in China 2018年第1期32卷 113-118页

作者： Guo Baozhen ta.la Zhou Haitao Su Guangli The First Monitoring and Application Center CEA

Ordos block was squeezed by the Qinghai-Tibetan block and North China block,and the tectonic activity was intense. In the periphery of Ordos block,there was a series of folds zones and compressed faults with complicate structures. This paper used three-phase data of 1980,1990 and 2014 to calculate vertical velocity of Northwestern margin of Ordos and the analytical results indicated that(1) the Hetao basin between the rise of Yinshan fault block and Ordos fault block showed relatively subsidence,in which Linhe basin was the most evident and the subsidence rate was about 2-4 mm/a. The subsidence rate of Jartai-Yinchuan rift zone on the western margin of Ordos block was about 2 mm/a;(2) the whole testing zone exhibited the evident inherited movement characterized by mountain rise and basin subsidence;(3) the two leveling section through the northern margin fault and Dengkou-Benjing fault showed that the difference between vertical velocities on two sides of the fault was less than 0. 5 mm/a.

关键词： Precise leveling Ordos Fault Vertical velocity

Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease

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World Journal of Gastroenterology 2006年第34期12卷 5550-5553页

作者： Judit Bene Lili Magyari Gábor talián Katalin Komlósi Beáta Gasztonyi Beáta tari gnes Várkonyi Gyula Mózsik Béla Melegh Mta PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Pécs Hungary Department of Medical Genetics and Child Development University of Pécs Pécs Hungary Department of Medical Genetics and Child Development University of Pécs Pécs Hungary 1~(st) Department of Medicine School of Medicine University of Pécs Pécs Hungary Department of Pediatrics and Child Health Center University of Szeged Szeged Hungary

AIM： To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn＇s disease （CD）. METHODS： A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn＇s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants （Arg702Trp, Gly908Arg and 2007finsC changes） with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specific regions of these genes. RESULTS： At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profile was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls （9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls）. No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION： The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD.

关键词： OCTN1 OCTN2 NOD2/CARD15 Crohn's disease

Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet

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World Journal of Gastroenterology 2005年第42期11卷 6671-6675页

作者： Judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Hungary Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary 1st Department of Medicine School of Medicine University of Pécs Hungary 2nd Department of Medicine Semmelweis University Budapest Hungary

AIM： To determine the fasting plasma carnitine ester in patients with celiac disease. METHODS： We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet. RESULTS： The level of free camibine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced （4.703± 0.205 vs 10.227 ± 0.368 nmol/mL, P〈0.01）. The level of propionylcarnitine was 61.5%, butyrylcarnitine 56.9%, hexanoylcarnitine 75%, octanoylcarnitine 71.1%, octenoylcarnitine 52.1%, decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%, lauroylcarnitine 61.5%, miristoylcarnitine 66.7%, miristoleylcarnitine 62.5% and oleylcarnitine 81.1% in the celiac disease patients compared to the control values, respectively （P〈0.01）. CONCLUSION： The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis.

关键词： Plasma carnitine ester profile Celiac disease

Cutaneous lesions and disorders in healthy neonates and their relationships with maternal-neonatal factors: a cross-sectional study

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World Journal of Pediatrics 2017年第6期13卷 571-576页

作者： Rita(A)brahám Angéla Meszes Zita Gyurkovits Judit Bakki Hajnalka Orvos Zsanett Renáta Csoma Department of Dermatology and Allergology University of SzegedSzegedHungary Department of Obstetrics and Gynecology University of SzegedSzegedHungary

Background:Cutaneous lesions are very common in *** a number of studies have reported on their incidence,very little is known about the factors that influence *** set out to investigate a large population of neonates with the aims of achieving an overall picture of neonatal skin manifestations,and examining their relationships with various maternal,neonatal and perinatal ***:This study was conducted on neonates born at the Department of Obstetrics and Gynaecology at the University of Szeged between June 2013 and July 2015.A total of 4658 consecutive infants underwent a whole-body skin examination within the first 72 hours of extrauterine *** official neonatal medical charts were used to collect data on the history of the participating neonates and on maternal ***:74.35% of the neonates exhibited at least one skin *** major diagnosis groups were transient,benign cutaneous lesions;vascular lesions;traumatic,iatrogenic,congenital or acquired disorders with skin injuries;pigmented lesions;and developmental abnormalities or benign skin *** relationships between the skin findings and six neonatal or maternal factors were examined:gender,gestational age and birth weight of the neonates;maternal age and the number of previous pregnancies of the mothers,and mode and circumstances of the ***:We found several significant correlations between the examined maternal/neonatal factors and the occurrence of birthmarks and neonatal skin *** course,further studies are required to confirm and better understand these associations.

关键词： cutaneous lesions dermatology epidemiology neonates

Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis

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World Journal of Gastroenterology 2006年第1期12卷 110-113页

作者： Judit Bene Katalin Komlósi Viktória Havasi Gábor talián Beáta Gasztonyi Krisztina Horváth Gyula Mózsik Béla Hunyady Béla Melegh Mária Figler Mta PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs PécsHungary Department of Medical Genetics and Child DevelopmentUniversity of PécsPécsHungary Department of Medical Genetics and Child Development University of PécsPécsHungary Department of Medicine School of MedicineUniversity of PécsPécsHungary

AIM： To determine the plasma carnitine ester profile in adult patients with ulcerative culitis （UC） and compared with healthy control subjects. METHOD： Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age- and sex-matched healthy controls. RESULTS： There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl- （0.331 ± 0.019 vs 0.392 ± 0.017 μmol/L）, butyryl- （0.219 ± 0.014 vs 0.265 ± 0.012）, and isovalerylcarniUne （0.111 ± 0.008 vs 0.134 ± 0.008） levels were decreased in the UC patients. By contrast, the level of octanoyl- （0.147 ± 0.009 vs 0.114 ± 0.008）, decanoyl- （0.180 ± 0.012 vs 0.137 ± 0.008）, myristoyl- （0.048 ± 0.003 vs 0.039 ± 0.003）, palmitoyl- （0.128 ± 0.006 vs 0.109 ± 0.004）, palmitoleyl- （0.042±0.003 vs 0.031 ± 0.002） and oleylcarnitine （0.183 ± 0.007 vs 0.163 ± 0.007; P 〈 0.05 in all comparisons） were increased in the patients with UC. CONCLUSION： Our data suggest selective involvement of the carnitine esters in UC patients, probably due to their altered metabolism.

关键词： Carnitine Carnitine ester profile Ulcerativecolitis