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Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na yang yongchen hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr Gregory y.h.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).the main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pt discharge,the prescription rate of OAC was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Ptivariate analysis showed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Ptronic cardioversion(adjusted OR 2.41,95%CI 1.65-3.51;Pti-arrhythmic drug use(adjusted OR 1.45,95%CI 1.38-1.53;Phospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

煤层亚临界/超临界CO_(2)吸附特征与封存模式

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天然气工业 2024年第6期44卷 152-168页

作者：王帅峰韩思杰桑树勋郭常建郭庆徐昂张金超中国矿业大学资源与地球科学学院江苏省煤基温室气体减排与资源化利用重点实验室·中国矿业大学中国矿业大学碳中和研究院

大规模高效CO_(2)地质封存是短期内快速实现CO_(2)减排的关键途径之一,以吸附特征为主要封存机制的深部不可采煤层CO_(2)封存具有规模化实施的潜力。为研究深部煤层CO_(2)封存机制,以沁水盆地无烟煤为研究对象,开展了高温高压CO_(2)吸... 详细信息

大规模高效CO_(2)地质封存是短期内快速实现CO_(2)减排的关键途径之一,以吸附特征为主要封存机制的深部不可采煤层CO_(2)封存具有规模化实施的潜力。为研究深部煤层CO_(2)封存机制,以沁水盆地无烟煤为研究对象,开展了高温高压CO_(2)吸附实验,并采用简化局部密度模型(SLD-PR)拟合,分析了温压变化下不同孔隙的吸附相密度分布特征,揭示了以吸附相密度和最大吸附层厚度协同变化为核心的煤层CO_(2)封存机理,最后通过准确划分孔内吸附空间与自由空间,预测了不同埋深下煤层CO_(2)封存量。研究结果表明:(1)不同温度下超临界CO_(2)吸附曲线均表现出典型的超临界气体吸附特征,过剩吸附量(最大值介于1·25~1·75 mmol/g)在达到最大值后下降;(2)孔隙内CO_(2)吸附层分为接触层、内层和过渡层,亚临界CO_(2)在孔内以单分子层吸附为主,而超临界CO_(2)吸附方式为多分子层吸附;(3)最大吸附层厚度随埋深增加而减小,与温度呈正相关,而与压力呈负相关;(4)CO_(2)平均吸附相密度随埋深“先增后减”,总封存量与绝对吸附量曲线在CO_(2)处于超临界状态下存在差异。结论认为:(1)在吸附空间与吸附相密度协变下,煤层CO_(2)微观封存模式随埋深可分为亚临界单分子层吸附、超临界类气态多分子层吸附型以及超临界类液态多分子层吸附3种类型,自由相封存量对总封存量的贡献随埋深增加,但吸附封存仍是煤层CO_(2)封存的主要方式;(2)研究成果揭示了原位煤层超临界CO_(2)封存机理,能够为深部煤层CO_(2)封存能力评价提供新认识。

关键词：超临界 CO_(2) 深部煤层吸附相密度分布 SLD-PR模型最大吸附层厚度封存容量吸附封存

Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

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World Journal of hepatology 2024年第7期16卷 995-1008页

作者： Nejib y Ismael Semir A Usmael Nega B Belay hailemichael Desalegn Mekonen Asgeir Johannessen Stian MS Orlien haramaya University College of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma Institute of Pathobiology Addis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for Imported and tropical Diseases Oslo University HospitalOslo 0450UllevålNorway Internal Medicine Gastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of Infectious Disease Vestfold Hospital TrustTønsberg 3103Norway Institute of Clinical Medicine Oslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway

BACKGROUND Chronic hepatitis B(ChB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of ChB will guide appropriate treatment strategies and improve the control and management of ChB in *** to investigate the characteristics of ChB in Eastern Ethiopia and assess the efficacy and safety of antiviral *** this cohort study included 193 adults who were human immunodeficiency virus-negative with ChB between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ2 tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(tDF)was initiated using treatment criteria from the Ethiopian ChB pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** this study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of tDF *** up measures to prevent and control ChB infections in Ethiopia is crucial.

关键词： Chronic hepatitis B Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa

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Fe-金属有机框架玻璃的形成过程与机理

硅酸盐学报 2024年第8期52卷 2553-2558页

作者：刘鑫宇郭超慧陶海征乔昂武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070 中山市武汉理工大学先进工程技术研究院广东中山528400

不同的中心金属离子能够赋予金属有机框架材料(MOFs)不同的性能,众多Fe基MOF材料具有优异的电、磁性能。但由于Fe元素存在变价,且Fe—N配位键难以形成,可熔融成玻Fe-MOF材料鲜有报道。使用无溶剂法成功制备Fe_(3)(C_(3)h_(2)N_(2))_6(C_... 详细信息

不同的中心金属离子能够赋予金属有机框架材料(MOFs)不同的性能,众多Fe基MOF材料具有优异的电、磁性能。但由于Fe元素存在变价,且Fe—N配位键难以形成,可熔融成玻Fe-MOF材料鲜有报道。使用无溶剂法成功制备Fe_(3)(C_(3)h_(2)N_(2))_6(C_(3)h_(4)N_(2))_(2)晶体,命名为FCIR,即Fe-MOF晶体,并且利用熔融淬冷法制成了Fe-MOF玻璃,并探究该Fe-MOF晶体在加热过程中的形态和结构演变,以及其玻璃态形成的机理。结果表明:相较于以Zn为中心离子的可熔融MOF材料,Fe离子对晶体加热过程中的熔融过程和结构演变会产生较大影响;FCIR晶体熔融淬冷后发生近程序结构变化,即由晶态时Fe离子与咪唑的6配位八面体脱去2个单配位咪唑转变为玻璃态的4配位四面体。

关键词：金属有机框架玻璃形成熔融结构变化

Journal of Gastroenterology and hepatology|新型分泌蛋白C6ORF120通过激活PI3K/Akt/mtOR通路活化肝星状细胞促进肝纤维化发生发展

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临床肝胆病杂志 2024年第5期40卷 1049-1049页

作者：王昕李鑫北京大学地坛医院教学医院中西医结合科

最近研究表明,活化的星状细胞可被逆转为静息状态,且在一定程度上,肝纤维化也可被逆转。然而,目前直接抗纤维化药物的缺乏是治疗肝纤维化的一大难题。因此,深入研究肝纤维化的可能机制对于临床药物研发是极其必要的。2024年3月,北京大... 详细信息

最近研究表明,活化的星状细胞可被逆转为静息状态,且在一定程度上,肝纤维化也可被逆转。然而,目前直接抗纤维化药物的缺乏是治疗肝纤维化的一大难题。因此,深入研究肝纤维化的可能机制对于临床药物研发是极其必要的。2024年3月,北京大学地坛医院教学医院王昕等在Journal of Gastroenterology and hepatology发表题为“Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mtOR pathway”的研究论文,探讨新型分泌蛋白C6ORF120在肝纤维化中的功能与机制。

关键词：星状细胞教学医院肝纤维化药物研发分泌蛋白王昕

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人工智能在废水处理领域研究的发展态势分析

安全与环境学报 2024年第5期24卷 1985-1996页

作者：王田力陈伊宁李昂孙宝平首都经济贸易大学财政税务学院北京100070 首都经济贸易大学安全工程系北京100070

为深入了解人工智能技术在废水处理领域应用研究的发展态势,对1990—2023年Web of Science数据库中990篇人工智能与废水处理交叉领域文献进行了计量分析。研究结果显示,本地引用次数(total Local Citation Score,tCLS)排名前4的期刊分别... 详细信息

为深入了解人工智能技术在废水处理领域应用研究的发展态势,对1990—2023年Web of Science数据库中990篇人工智能与废水处理交叉领域文献进行了计量分析。研究结果显示,本地引用次数(total Local Citation Score,tCLS)排名前4的期刊分别是Process Safety and Environmental Protection、Engineering Applications of Artificial Intelligence、Water Science and technology和Journal of Environmental Sciences;本地引用次数(total Local Citation Score,tLCS)排名前10的期刊中有6个期刊来自于英国,其他期刊分别来自于中国、意大利、德国和美国。中国学者在该领域的发文量、tLCS全球排名第一,全球引用次数(total Global Citation Score,tGCS)全球排名第一,体现了中国学者对人工智能与废水处理交叉领域的关注度较高。在发文量排名前10的机构中有4所来自中国,分别是北京工业大学、中国科学院、哈尔滨工业大学和清华大学,合计的发文量占前10总数的25.1%。有4名中国学者进入了发文量前10,分别为北京工业大学的Qiao J F、Wang D、han h G以及哈尔滨工业大学的Ren N Q。通过关键词分析发现,人工神经网络是本领域的研究热点之一,利用神经网络来预测废水处理的效果是当前的热点话题。

关键词：环境工程学废水处理人工智能

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用于诊断肝细胞癌的肝脏影像报告及数据系统2018版5类：一项最新Meta分析

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国际医学放射学杂志 2024年第3期 373-374页

作者： S.Lee y.y.Kim J.Shin y.h.Roh J.y.Choi V.Chernyak 吴玉平

摘要目的该项更新的Meta分析旨在确定使用肝脏影像报告和数据系统（LI-RADS）2018版本（v2018）的LI-RADS LR-5类对肝细胞癌（hCC）的诊断能力，并通过评估成像方

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Electron tomography for sintered ceramic materials by a neural network algebraic reconstruction technique

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Journal of Materials Science & technology 2022年第5期100卷 75-81页

作者： R.h.Shen y.t.he W.Q.Ming y.Zhang X.D.Xu J.h.Chen Centre for high Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China

the missing wedge effect in electron tomography introduces various types of artifacts in the tomograms and lowers the reconstruction resolution and *** artifacts produced in tomographic reconstruction of bulk materials can be very severe,particularly for sintered bulk ceramic materials in which there are often nano-pores or pore-like microstructure ***,we report a neural network algebraic reconstruction algorithm with no prior knowledge to perform electron tomography for a sintered SiC material with nano carbon *** results show that the proposed algorithm has a great suppressive effect on the missing wedge artifacts and a high tolerance for *** information in the missing wedge can be partly recovered by this ***,both the shape of the bulk SiC specimen and its irregular inner pore-like features are correctly retrieved in the obtained 3D *** study shows the effectiveness of the neural network algorithm for improving the reconstruction accuracy of electron tomography,in order to reveal sophisticated 3D microstructures generally existing in sintered ceramic materials.

关键词： Neural network Missing wedge Electron tomography Sintered ceramics

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning yeh John y Chiang hsin-Ju Chiang Pei-Lin Shao Pei-hsun Sung hon-Kan yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND the treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** to investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Pthe protein levels of inflammation[interleukin(IL)-1β/tumor necrosis factor(tNF)-α/nuclear factor-κB/toll-like receptor(tLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Phereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-h2AX)displayed an identical pattern of SaO2%among the groups(all Pthe pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation