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被骗风波

空中英语教室（初级版．大家说英语） 2024年第3期 21-22,52,53页

作者： Garrett hart 不详

Bill和他的朋友们经常外出吃饭。他们是大学生,总是喜欢在一起消磨时间。“嘿,Katrina!你今天晚上要不要去一家新餐厅吃饭?那里有现场音乐演奏哦。”Bill对他的朋友Katrina说。“听起来很好玩,可是我没办法去。我作业太多了,我必须待在... 详细信息

Bill和他的朋友们经常外出吃饭。他们是大学生,总是喜欢在一起消磨时间。“嘿,Katrina!你今天晚上要不要去一家新餐厅吃饭?那里有现场音乐演奏哦。”Bill对他的朋友Katrina说。“听起来很好玩,可是我没办法去。我作业太多了,我必须待在家里看书。”她说。

关键词：大学生音乐演奏吃饭好玩

Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian Pacific Journal of tropical Biomedicine 2024年第5期14卷 199-206页

作者： Lucelina s.Araújo Bruno B.silva Eduarda N.F.N.santos Arnaldo s.Bezerra samuel s.Frota Assis R.Montenegro Eridan O.P.t.Florean Maurício Fvan tilburg Maria Izabel F.Guedes Laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:to evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete Freund’s adjuvant;(2)Inactivated Escherichia coli(BL21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of tNF,IFN-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:the inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a th2 profile response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response th1 th2 Leishmania infantum

EP Aquarii:A New Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： Pham t.Nhung Do t.Hoai Pierre Darriulat Pham tuan-Anh Pham N.Diep Nguyen B.Ngoc tran t.thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

RARREs2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi t.H.shubhra Institute of Chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARREs2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(tAGs),by RARREs2 through the modulation of phosphatase and tensin homologue(PtEN)-mammalian target of rapamycin(mtOR)-sterol regulatory element-binding protein 1(sREBP1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARREs2) Lipid metabolism Cancer PtEN-mtOR-sREBP1 signaling Metabolic reprogramming Brain metastasis

Basis for the diversity and extent in loss of digestible nutrients created by dietary phytin: Emphasis on fowl and swine

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Animal Nutrition 2024年第1期16卷 422-428页

作者： Edwin t.Moran Michael R.Bedford Poultry science Department Auburn University AB Vista Woodstock Court Blenheim Road

Phytin is the Ca2+-Mg2+-K+salt of phytic acid that is created and deposited in the aleurone layer and/or germ of grains and legumes. Its high presence in feedstuffs for fowl and swine diets results in it being a universal and significant impediment to optimum performance. Phytin impairs gastrointestinal recovery of a wide array of nutrients, the effect varying with the nutrient concerned. On exposure to low pH during gastric digestion, phytin dissociates into phytic acid and solubilized Ca2+. Even at low gastric pH,phytic acid is negatively charged which forms the basis of its anti-nutritive behavior. Pepsinogen has extensive basic amino acids on its activation peptide that are presented as cations at low pH which are targeted by pepsin for activation. Partially crystalized Ca2+near the enzyme?s active site further stabilizes its newly formed structure. thus, phytic acid appears to interfere with gastric digestion by several mechanisms; interfering with pepsinogen activation by binding to the polypeptide?s basic amino acids;coordinating free Ca2+, destabilizing pepsin; binding some dietary proteins directly, further compromising gastric proteolysis. Upon digesta attaining neutrality in the duodenum, Ca2+and other cations rebind with accessible anions, phytic acid being a significant contender. Phytate not only binds free cations but can also strip them from enzymes(e.g. Ca2+, Zn2+) which reduces their structural resistance to autolysis and ability as co-factors(e.g. Zn2+) to increase enzyme activity. Goblet cells initially employ Ca2+as an electronic shield between mucin layers enabling granule formation and cell storage. After mucin granule release, Ca2+is progressively displaced by Na+to free the viscous mucins enabling its translocation. Mucin entangles with the glycocalyx of adjacent enterocytes thereby constructing the unstirred water layer（UsWL）. Excessive removal of Ca2+from mucin by phytic acid increases its fluidity facilitating its loss from the UsWL with

关键词： Digestive enzyme Calcium Endogenous protein Mucin Phytin

the Radcliffe Wave Parameters from Data on Open star Clusters

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Research in Astronomy and Astrophysics 2024年第3期24卷 106-109页

作者： V.V.Bobylev A.t.Bajkova Pulkovo Astronomical Observatory St-Petersburg 196140Russia

A spectral analysis of the vertical positions and velocities of 374 open star clusters(OsCs)was carried *** took these OsCs from the Hunt and Reffert catalog;they have an average age of about 10 million years,and are located on the galactic plane XY in a narrow zone inclined by 25°to the galactic axis *** following estimates of the parameters of the Radcliffe wave were obtained:(a)the maximum value in periodic perturbations of vertical coordinates Z_(max)=92±10pc with the wavelength of these perturbations λ_(z)=4.82±0.09 kpc;(b)the maximum value of the velocity of vertical disturbances Wmax=4.36±0.12km s^(-1) with disturbance wavelengthλ_(W)=1.78±0.02 *** that the results of the vertical velocity analysis are first-class in accuracy and completely new.

关键词： (Galaxy) local interstellar matter-Galaxy structure-(Galaxy) solar neighborhood

the soft X-ray Imager(sXI)on the sMILE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： s.sembay A.L.Alme D.Agnolon t.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont t.Crawford J.P.Breuer t.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor t.Crawford N.Eaton C.Feldman C.Forsyth t.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland s-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones t.Kennedy K.Koch-Mehrin s.Kögl s.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani s.Parsons P.Patel J.Pearson G.Peikert F.s.Porter t.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman s.sachdev A.samsonov M.soman D.sibeck s.smit J.søndergaard R.speight s.stavland M.steller tianRan sun J.thornhill W.thomas K.Ullaland B.Walsh D.Walton C.Wang s.Yang school of Physics and Astronomy University of LeicesterLeicesterLE17RHUK space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard space science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for space science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace technology MadridSpain EstEC European Space Agency2201 AZ NoordwijkNetherlands state Key Laboratory of space Weather National Space Science CentreBeijing 100190China University of Applied sciences and Arts Northwestern switzerland CH-5210 WindischSwitzerland Koegl space GmbH CH-8157 DielsdorfSwitzerland space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied sciences 8400 WinterhurSwitzerland Genov solutions N-5172 LoddefjordNorway stM Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NAsA/Goddard space Flight Centre MD 20771USA Center for space Physics Boston UniversityBostonMA 02215USA Department of theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

the soft X-ray Imager(sXI)is part of the scientific payload of the solar wind Magnetosphere Ionosphere Link Explorer(sMILE)*** is a joint science mission between the European space Agency(EsA)and the Chinese Academy of sciences(CAs)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the sMILE *** is sensitive to the soft X-rays produced by the solar Wind Charge eXchange(sWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the sXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of sMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United states.

关键词： soft X-ray Imaging micropore optics large area CCD

Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along NH-1A from Ramban to Banihal, North Western Himalayas

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： Amit Jaiswal A.K.Verma t.N.singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

the network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connecting road networks is significant in safely executing these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the NH-1A of Ramban district of North Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluating the stability of these slopes,kinematic analysis was performed along with geological strength index(GsI),rock mass rating(RMR),continuous slope mass rating(CosMR),slope mass rating(sMR),and Q-slope in the present *** sMR gives three slopes as completely unstable while CosMR suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rating(ssR)for the factor of safety(Fos)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and ssR design chart based on the *** value ranges given by different empirical classifications were RMR(37-74),GsI(27.3-58.5),sMR(11-59),and CosMR(3.39-74.56).Good relationship was found among RMR&ssR and RMR&GsI with correlation coefficient(R 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： Rock mass classification Kinematic analysis slope stability Himalayan road static and dynamic conditions