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Doping engineering of iron oxide nanoparticles towards high performance and biocompatible t_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu Ping-Li Dong Yu-Yun Chai Run Yang Zhen-hui Ma chi-Chong Lu Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the t_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical t_(1) contrast agents(Gd-DtPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR t_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

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Diagnostic significance of serum levels of serum amyloid A,procalcitonin,and high-mobility group box 1 in identifying necrotising enterocolitis in newborns

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2003-2011页

作者： Li-Ming Guo Zhi-hui Jiang hong-Zhen Liu Lei Zhang Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Qilu Hospital of Shandong University(Qingdao)Qingdao 260010Shandong ProvinceChina

BACKGROUND Necrotising enterocolitis(NEC)is a critical gastrointestinal emergency affecting premature and low-birth-weight *** amyloid A(SAA),procalcitonin(PCt),and high-mobility group box 1(HMGB1)have emerged as potential biomarkers for NEC due to their roles in inflammatory response,tissue damage,and immune *** to evaluate the diagnostic value of SAA,PCt,and HMGB1 in the context of NEC in *** the study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the ***,radiological,and laboratory findings,including serum SAA,PCt,and HMGB1 Levels,were collected,and specific detection methods were *** diagnostic value of the biomarkers was evaluated through statistical analysis,which was performed using chi-square test,t-test,correlation analysis,and receiver operating characteristic(ROC)*** the study demonstrated significantly elevated levels of serum SAA,PCt,and HMGB1 Levels in newborns diagnosed with NEC compared with healthy *** correlation analysis indicated strong positive correlations among serum SAA,PCt,and HMGB1 Levels and the presence of *** analysis revealed promising sensitivity and specificity for serum SAA,PCt,and HMGB1 Levels as potential diagnostic *** combined model of the three biomarkers demonstrating an extremely high area under the curve(0.908).CONCLUSION the diagnostic value of serum SAA,PCt,and HMGB1 Levels in NEC was *** biomarkers potentially improve the early detection,risk stratification,and clinical management of critical *** findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.

关键词： Serum amyloid A Procalcitonin High-mobility group box 1 Necrotising enterocolitis in newborns Serum biomarkers

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Numerical simulation for the initial state of avalanche in polydisperse particle systems

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chinese Physics B 2024年第2期33卷 405-412页

作者：韩韧李亭迟志鹏杨晖李然 School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Numerical simulation is employed to investigate the initial state of avalanche in polydisperse particle *** and propagation processes are illustrated for pentadisperse and triadisperse particle systems,*** these processes,particles involved in the avalanche grow slowly in the early stage and explosively in the later stage,which is clearly different from the continuous and steady growth trend in the monodisperse *** examining the avalanche propagation,the number growth of particles involved in the avalanche and the slope of the number growth,the initial state can be divided into three stages:t1(nucleation stage),t2(propagation stage),t3(overall avalanche stage).We focus on the characteristics of the avalanche in the t2 stage,and find that propagation distances increase almost linearly in both axial and radial directions in polydisperse *** also consider the distribution characteristics of the average coordination number and average velocity for the moving *** results support that the polydisperse particle systems are more stable in the t2 stage.

关键词： avalanche initial state polydisperse particle systems propagation

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Network pharmacology investigation of the mechanism underlying the therapeutic action of Shikang granules in retinal ischemia-reperfusion injuries

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Integrative Medicine Discovery 2024年第17期8卷 1-8页

作者： Xiao-Xuan Wang Cong-Ying Wang chi Zhang Fang-Yuan Zheng Long-hui Han Ming-Lian Zhang Hebei Eye Hospital Hebei Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054000China

Background:Retinal ischemia/reperfusion(I/R)injury often results in vision loss,and effective clinical management options are currently *** granules(SKG)are traditional chinese medicine-based preparations commonly used in clinical practice for treating optic ***:Despite decades of clinical use,the precise mechanism of action(MoA)of SKG remains ***,we employ a network pharmacological approach to elucidate its MoA by identifying active ingredients and relevant targets using the traditional chinese Medicine System Pharmacology Database and Analytical *** associated with retinal I/R injury were sourced from GeneCards,Online Mendelian Inheritance in Man,and *** software facilitated the identification of intersecting targets,which were then subjected to gene ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway *** validate the protective effect and explore the MoA of SKG in retinal I/R injuries,we conducted experiments using rat ***:Our animal experiments demonstrated that SKG mitigated apoptosis following retinal I/R injury by upregulating the expression of the anti-apoptotic protein Bcl-2 and downregulating the expression of BAX,Caspase-9,Caspase-3,PARP,and cytochrome ***,SKG was found to increase the expression of PI3K and ***:SKG may exert its protective effects by inhibiting apoptosis through modulation of pro-apoptotic and anti-apoptotic protein expression,as well as activation of the PI3K/AKt pathway.

关键词： retinal ischemia-reperfusion injury Shikang granules apoptosis PI3K/AKt pathway

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A glycine-rich nuclear effector VdCE51 of Verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhtRXH2

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the Crop Journal 2024年第4期12卷 1137-1149页

作者： chi Li Yingqi Huang Wenjing Shang Jieyin Chen Steven J.Klosterman Krishna V.Subbarao Jun Qin Xiaoping Hu State Key Laboratory of Crop Stress Resistance and High-Efficiency Production Key Laboratory of Plant Protection Resources and Pest Management of Ministry of EducationKey Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangji 831100XinjiangChina Agricultural Research Service United States Department of AgricultureSalinasCA 93905USA Department of Plant Pathology University of CaliforniaDavisc/o United States Agricultural Research StationSalinasCA 93905USA

Verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash *** of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,VdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia *** effector was a required factor for full virulence of ***,and its nuclear localization was a requisite for suppressing plant *** thioredoxin GhtRXH2,identified as a positive regulator of plant immunity,was a host target of *** findings show a virulence regulating mechanism whereby the secreted nuclear effector VdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhtRXH2,thus suppressing plant immunity.

关键词： Verticillium dahliae Plant immunity Effector thioredoxin

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休耕对抚仙湖周边农田土壤剖面和浅层地下水中氮累积的影响

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环境科学 2024年第6期45卷 3225-3233页

作者：叶远行陈安强李林闵金恒王炽闫辉张丹云南农业大学资源与环境学院昆明650201 云南省农业科学院农业环境资源研究所昆明650201

减少外源氮投入能有效降低农田土壤氮累积和地下水氮污染,休耕是减少外源氮投入的重要措施之一.为探讨农田休耕对土壤剖面和浅层地下水中氮累积的影响,以抚仙湖周边农田土壤剖面和浅层地下水为研究对象,分析了休耕前(2017年12月)和休耕... 详细信息

减少外源氮投入能有效降低农田土壤氮累积和地下水氮污染,休耕是减少外源氮投入的重要措施之一.为探讨农田休耕对土壤剖面和浅层地下水中氮累积的影响,以抚仙湖周边农田土壤剖面和浅层地下水为研究对象,分析了休耕前(2017年12月)和休耕后(2020年8月和2021年4月)农田0~100 cm土壤剖面氮累积和浅层地下水中氮浓度的变化及其两者的关系.结果表明:休耕显著降低了土壤剖面氮含量和储量,休耕后0~30、30~60和60~100 cm土壤剖面tN、ON、DtN、NO_(3)^(-)-N和NH_(4)^(+)-N含量分别降低18.4%~36.5%、16.1%~26.8%、54.0%~130.2%、59.5%~90.8%和60.1%~110.6%.休耕前0~100 cm土壤tN、ON、DtN、NO_(3)^(-)-N和NH_(4)^(+)-N储量分别为(17.20±0.97)t·hm^(-2)、(15.50±1.23)t·hm^(-2)、(0.68±0.06)t·hm^(-2)、(266.8±31.17)kg·hm^(-2)和(18.7±3.04)kg·hm^(-2),休耕后各形态氮储量分别下降了25.5%、23.3%、44.7%、80.1%和59.9%.休耕也改变了浅层地下水中氮浓度和形态构成,休耕后地下水中tN、ON、NO_(3)^(-)-N和NH_(4)^(+)-N浓度分别下降了88.4%、82.7%、92.1%、65.8%,ON/tN和NH_(4)^(+)-N/tN从休耕前的26%和6%升高至休耕后的39%和17%,而NO_(3)^(-)-N/tN从休耕前的61%降至休耕后的41%.地下水氮浓度和形态变化与休耕前后土壤中DtN、NH_(4)^(+)-N、NO_(3)^(-)-N和地下水中p H、ORP、DO等因素密切相关.可见,休耕有效降低了农田土壤剖面氮累积,缓解了浅层地下水氮污染,有利于防止高原湖泊的水质恶化.

关键词：休耕氮储量浅层地下水土壤剖面抚仙湖

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On-Demand Photon Storage and Retrieval with a Solid-State Photon Molecule at Room temperature

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Electromagnetic Science 2024年第3期2卷 42-51页

作者： Ze-Yu Luo tong Zhang Yi-teng Ye Yun-Fei Wang Cheng-Cheng Yu Zhi-Cong Luo Yi-Jie Zhang Mo-chi Xu Barry CSanders hui Wang Chao-Yang Lu Jian-Wei Pan Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Institute for Quantum Science and technology University of CalgaryCalgary T2N 1N4Canada

Deterministically achieving on-chip photon storage and retrieval is a fundamental challenge for integrated ***,this requirement is increasingly urgent as photon storage and retrieval is crucial to realize truly scalable room-temperature quantum ***,most of existing quantum memories integrated on chips must either work at cryogenic temperature or else are strongly coupled with the environment,which hugely reduces the ***,we propose an on-chip room-temperature quantum memory comprising three coupled microcavities,which presents an ideal dark state decoupled by a waveguide,thereby allowing on-demand photon storage and retrieval with high efficiency and high fidelity ***,we demonstrate that the single-photon temporal duration can be increased or decreased by a factor of 10^(3),thereby enabling many crucial quantum *** error-robust approach highlights the potential for a solid-state photonic molecule for use as on-chip quantum memory and for optical quantum computing.

关键词： Photon storage and retrieval On-chip quantum memory Photon temporal shaping

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Energetics characteristics of the super magnetic storm on November 20,2003 based on 3D global MHD simulation

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Science china Earth Sciences 2014年第12期57卷 3035-3046页

作者： HAN JinPeng WANG chi LI hui State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of Sciences College of Earth Science University of the Chinese Academy of Sciences

the three-dimensional global magnetohydrodynamic model(PPM-LR MHD)is employed to investigate the energy budget in the solar wind-magnetosphere system during the super magnetic storm on November 20,2003,one of the biggest storms during the last decade with Dst^-500 n *** this event,about 23%solar wind kinetic energy is transferred into the *** total energy input is estimated to be about 9.50×1017 J,about 14 times of a moderate *** energy dissipation via the inner magnetosphere is less than the energy input with the coupling efficiency of^63.3%.the energy dissipated via ring current injection is less than that via high-latitude ionosphere at the initial stage of the super ***,both the simulation results and the empirical results indicate that the ratio of ring current injection to the total energy output increases with the enhancement of the magnetospheric activity *** are consistent with the statistical results we have got *** empirical equations underestimate the solar wind kinetic energy,the energy input,and the energy dissipation via high-latitude ionosphere compared with the simulation results;however,the coupling efficiency of the high-latitude ionosphere(23.4%)is close to the simulation result(23.1%)during the entire storm time period.

关键词： MHD simulation energy budget super storm energy coupling function

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A newly discovered active contact binary in the field of NGC 1348

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Research in Astronomy and Astrophysics 2012年第1期12卷 93-103页

作者： Xiang-Song Fang Sheng-hong Gu Ho-Keung hui chi-tai Kwok Bill Yeung Kam-Cheung Leung National Astronomical Observatories / Yunnan Observatory Chinese Academy of SciencesKunming 650011 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650011 China Graduate University of chinese Academy of Sciences Beijing 100049 China Hokoon Nature Education cum Astronomical Centre Sik Sik-Yuen Hong Kong China hong Kong Astronomical Society Hong Kong China

We present a CCD photometry study of a newly discovered active eclipsing binary in the field of open cluster NGC 1348 based on the first time-series photometric observation. From the minimum times, we determined an orbital period of P = 0.691363 d. Among our datasets, the BV（.RI）c light curves obtained in November 2008 were analyzed using the Wilson-Devinney light curve modeling tech- nique. Because of the uncertainty of the membership of this binary in open cluster NGC 1348, we have analyzed the photometric data in two cases with different primary effective temperatures： Case A （t1 = 7750K） and Case B （t1 = 5250K）. Our anal- yses reveal that, for Case A, it is a deep （f 〉 70%）, very low mass ratio （q - 0.096） binary system, indicating that it is now in the late evolution stage of a contact binary; while for Case B, it is a red system with extraordinarily long orbital period with respect to the period-color relation for normal contact binaries, which suggests that this binary has evolved off the main sequence. the well known O＇Connell effect （e.g., AB 0.03 mag） was found in the dataset obtained in November 2008, which could be due to the existence of starspots on the components, therefore the corresponding spot properties （for Case A： hot spot; for Case B： dark spot） were determined using the Wilson-Devinney code. With the purpose of analyzing the dark spot activity for Case B, we compared the light curves derived in different observing runs, and found that a slight change appeared from November to December, 2008, which indicates the evolution of spot activity on at least one component over a time scale of about one month.

关键词： stars: binaries: close -- stars: binaries: eclipsing -- stars: spots

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7075铝合金接触固溶工艺参数优化

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塑性工程学报 2024年第8期31卷 100-106页

作者：刘持振安保芹解焕阳杨茴茴朱伟东张志强凌云吉恩斯科技有限公司热成形技术研究分院山东烟台264000 上海凌云工业科技有限公司凌云中央研究院上海201708 吉林大学材料科学与工程学院吉林长春130015

为探索接触固溶过程中实验参数对7075铝合金成形件性能的影响,以7075-t6铝合金板材为研究对象,首先进行了接触固溶成形实验,获得了不同实验参数下的成形件并分别进行性能测定。然后采用响应面法分析了接触固溶温度、固溶时间和接触压强... 详细信息

为探索接触固溶过程中实验参数对7075铝合金成形件性能的影响,以7075-t6铝合金板材为研究对象,首先进行了接触固溶成形实验,获得了不同实验参数下的成形件并分别进行性能测定。然后采用响应面法分析了接触固溶温度、固溶时间和接触压强对零件洛氏硬度、抗拉强度和断后伸长率的影响,并根据实验数据,采用遗传算法进行多目标优化,得到满足多性能要求的工艺参数,确定了符合要求的优化解。结果表明,在接触固溶温度为475℃、固溶时间为32 s,接触压强为13 MPa时,可以获得同时保证多个综合性能的最优解。

关键词： 7075铝合金热冲压接触固溶响应面法多目标优化

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