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教育和工业中的技术创新第1版

Regulation of proliferation by KCa3.1 channels is independent of channel electrophysiological function

1982年

作者：李跃滋 D·G·杰恩森 e·G·克拉瓦尔诺

书名原文:technological innovation in education and industry.

ISBN: (纸本)1524·110

书名原文:technological innovation in education and industry.

关键词：技术教育

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Regulation of proliferation by KCa3.1 channels is independen...

城市气候研究中的水、辐射和能量平衡研究现状

2008北京国际生理科学学术大会

作者： MILLeRSHIP Joanne BRUCe Jason I e DeVOR Daniel C FeARON Ian M Life Sciences the University of ManchesterManchester M13 9NTUK Department of Cell Biology and Physiology School of MedicineUniversity of PittsburghPittsburghPA 15261USA

Potassium channels regulate proliferation of a number of cell *** the potassium channel family, K3.1(IK1/SK4),is involved in the proliferation of endothelial cells(eC),t lymphocytes and several cancer cell *** respect to endothelial cells,these cells express a wide variety of ion channel types and subtypes,and the patterns of expression differ due to differences in vascular beds from which cells were isolated,passage number and culture *** this reason,it is difficult to dissect,and examine in isolation,the functional role of a specific potassium channel in eC ***,to investigate the mechanisms underlying the role of K3.1 in cell proliferation in isolation,we performed proliferation assays in HeK293 cells expressing recombinant hK3.1 *** cells stably expressing this channel,selective inhibition of hK3.1 with 10μmol/L tRAM-34 reduced proliferation,while transient expression of hK3.1 in Wt HeK293 cells increased *** mechanism by which hK3.1 stimulates cell proliferation is thought to be mediated by cell hyperpolarisation(via K efflux),which increases[Ca] by driving Ca influx through non-selective cation ***,when Wt HeK293 cells were transiently transfected with a mutant(GYG/AAA)hK3.1 channel,which neither conducts K ions nor promotes Ca entry,proliferation was increased relative to control(mock-transfected)***,when Wt HeK293 cells were transiently transfected with a trafficking mutant(L18A/L25A)hK3.1 channel,which is not expressed at the cell surface,proliferation was also increased relative to control ***,both K efflux and Ca influx are not necessary for hK 3.1-induced proliferation in HeK293 cells,and nor does hK 3.1 need to be expressed at the cell *** propose that hK 3.1-induced cell proliferation is independent of electrophysiological function and arises potentially due to direct regulation of intracellular signalling *** support of this hypothesis,in cells

关键词： KCa3.1 endothelial cells proliferation MAP kinase

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地理科学进展 1983年第2期 25-30页

作者： t.R.奥科沈建柱

1.水分平衡的研究由于城市化破坏了天然系统的水循环。城市建筑一空气系统的水平衡(图 1)满足以下方程:P+I+F=e+△r+△S+△A (1)式中:P—降水,I—从河流或水库管道供给的水,F—燃烧过程释放到空气中的

关键词：空气系统乡村反照率高频辐射电磁辐射短波辐射长波辐射

SURGeRY AND MULtI MODAL tHeRAPYIN COLON-ANGIN ReCtAL CANCeR

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实用临床医药杂志 2005年第9期9卷 9-27页

作者： K.H.Link t.A.Sagban Z.L.Ji Surgical Center and Asklepios tumortreatment Center Rhein-Main(AtC) Asklepios Paulinen Klinik(APK)Wiesbaden Germany Dept.General and Visceral Surgery Puji HospitalYangzhou UniversityChina

1 Summarythe 5-year-survival rates of surgically treated patients are varying and depend on UICC stages/substages with remarkable variations in between published reports, surgical hospital units, individual surgeons, and continents. these variations may be due to surgical techniques, training status, hospital and individual case volume, but also on referral patterns, and statistical evaluation methods. Survival time and cure rates are significantly improved by modern adjuvant chemotherapy in colon cancers UICC Ⅲ and in substages of UICC Ⅱ (e.g. UICC Ⅱ B) by 5%-16%, and adjuvant radiochemotherapy in rectal cancer by 10%-14% when compared to surgical controls. In three modern colon cancer trials standard adjuvant chemotherapy was further improved by increasing the survival rates, e.g. from 59% to 71% in stage Ⅲ and IIB patients. In rectal cancer neoadjuvant radio(chemo)therapy decreases local relapse rates vs. postoperative adjuvant radio(chemo)therapy. Since surgery in rectal cancer has also been significantly improved by total mesorectal excision (tMe) and better surgical training, the indications and methods for multimodal therapy have changed from UICC Ⅱ+Ⅲ to more individual criteria. Molecular and genetic factors, such as thymidylate synthase (tS), microsatellite instability (MSI) or loss of chromosome 18q/DCC might have an independent impact on prognosis in the spontaneous course, but could also help to individually select colon and rectal cancer patients and treatment protocols for multimodal therapy. thus, surgery and multimodal therapy has become very complex, needs regularly be updated in competent reviews, and should be conducted in specialized centers of multi-and interdisciplinary excellence.

关键词：结肠癌直肠癌手术治疗综合治疗

针对热带飓风的风场、波浪和风暴潮的NOPP实时预报系统

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人民珠江 2006年第6期27卷 4-9页

作者： Scott C.HAGeN Hans C.GRABeR Vincent J.CARDONe Andrew t.COX Robert e.JeNSeN Donald N.SLINN Mark D.POWeLL 耿兵绪中佛罗里达州大学迈阿密大学海洋气象公司美国陆军工程兵团佛罗里达州大学美国国家海洋大气局大西洋海洋气象实验室飓风研究所

介绍针对热带气旋的风场、波浪、风暴潮的NOPP(国家海洋合作项目)实时预报系统。这个系统的低分辨率模式曾被用于2004年和2005年的飓风季节预测,国家飓风中心每6 h在内部网上发布飓风路径、极限半径与特征浪高的预测值。这个预测系统通... 详细信息

介绍针对热带气旋的风场、波浪、风暴潮的NOPP(国家海洋合作项目)实时预报系统。这个系统的低分辨率模式曾被用于2004年和2005年的飓风季节预测,国家飓风中心每6 h在内部网上发布飓风路径、极限半径与特征浪高的预测值。这个预测系统通过输入来自H*WIND的高精度初始风场数据来预测以后每半小时的风场预测数据。改进后的风场数据被用于追踪飓风路径以及驱动三阶的波浪模块和风暴潮模块。而波浪模块得出的辐射压力场则被耦合于飓风登陆时的海岸风暴潮位预测中。此系统正在采用低分辨率与高分辨率模式模拟2006年飓风季节情况。

关键词：实时预测波浪模拟潮汐模拟风暴潮模拟热带气旋飓风

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南非严重耐多药结核基因型的多样性

国际结核病与肺部疾病杂志 2008年第3期3卷 106-111页

作者： C.K.Mlambo R.M.Warren X.Poswa t.C.Victor A.G.Duse e.Marais 郑晓静（译）张宗德（译）何广学（审校） Clinical Microbiology and Infectious Disease National Health Laboratory Services and University of the Witwatersrand Johannesburg Gauteng Department of Science and technology/National Research Foundation Centre of excellence in Biomedical tuberculosis Research Medical Research Centre （MRC） Centre for Molecular and Cellular Biology Stellenbosch University Western Cape tuberculosis Referral Laboratory National Health Laboratory Services Johannesburg Gauteng South Africa 不详

背景:严重耐多药结核(XDR-tB)已成为结核病控制的新威胁,但对其流行病学尚不十分了解。目的:采用分子手段研究南非XDR-tB菌株基因型的人群结构组成,从而确定XDR-tB主要是获得性还是原发感染。方法:收集耐多药结核(MDR-tB)患者的痰菌分离... 详细信息

背景:严重耐多药结核(XDR-tB)已成为结核病控制的新威胁,但对其流行病学尚不十分了解。目的:采用分子手段研究南非XDR-tB菌株基因型的人群结构组成,从而确定XDR-tB主要是获得性还是原发感染。方法:收集耐多药结核(MDR-tB)患者的痰菌分离株,送至国家参比实验室进行二线抗结核药物的药敏试验。对XDR-tB的分离株进行Spoligotyping分型,并与该分离株的地理来源相匹配。结果:自2005年6月至2006年12月共获得699例MDR-tB患者的分离株,其中101例(17%)菌株耐氧氟沙星(OFX)或卡那霉素(KAN),41例(6%)对二者均耐药(XDR-tB)。Spoligotyping法将XDR-tB分离株共分为17个基因型。结果表现为高度的基因型多样性和地理分布多样性,所以我们估计63%～75%的XDR-tB患者为获得性耐药。结论:获得性严重耐多药可能是导致南非XDR-tB流行的主要机制。因此结核病控制的迫切问题是必须致力于阻止这种潜在的不治之症的传播。

关键词：分枝杆菌,结核 MDR—tB XDR—tB

Diarrheic escherichia coli: A Predominant etiological Agent of Gastroenteritis, a Case Study in Douala, Cameroon

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Journal of Biosciences and Medicines 2023年第6期11卷 1-17页

作者： Amandine Plidikoua Olivier Ziem Justice t. Ngom Afsa Mamboune Balbine Adande Clémence Francioli Koro Koro Rosalie Annie Ngono Ngane Department of Biochemistry Faculty of Sciences University of Douala Douala Cameroon Hygiene and environment Department-Microbiology Section Pasteur Center of Cameroon Yaoundé Cameroon

Context: Gastroenteritis remains an infectious disease with high morbidity and mortality particularly in low incomes countries, where the capacity to search all etiological agents, especially pathogenic escherichia coli, is very limited. We investigated the contribution of pathogenic escherichia coli and their antibiotic resistance profiles in cases of gastroenteritis. Methods: A cross-sectional study was carried out on human stool samples from October 2021 to June 2022 at Laquintinie Hospital. Samples were received from patients of all age groups and screened for bacteriological and parasitological identification by microscopy, bacterial culture, biochemical identification, and antimicrobial susceptibility tests. Results: A total of 296 patients with gastroenteritis complaints, were enrolled in the study with ages ranging from 5 months to 90 years old (Median = 35.5;SD = 20.8). Among the samples analyzed, 1.7% (n = 5/296) were positive for parasites and 27% (n = 80/296) were positive for bacterial pathogens. Parasites were found in mono parasitism, mainly entamoeba histolytica (60%;n = 3/5), followed by trichomonas intestinalis (20%;n = 1/5), and Giardia intestinalis (20%;n = 1/5). three species of bacterial pathogens were identified with no co-infection: diarrheic escherichia coli (DeC), Salmonella sp, and Shigella sp with respective proportions of 90% (n = 72/80), 6.3% (n = 5/80), and 3.7% (n = 3/80). For antibiotic resistance profiles (ARPs) of the 72 isolates of DeC, high levels of resistance were observed globally with amoxicillin (93.1%;n = 67/72), followed by ciprofloxacin (75%;n = 54/72), and to trimethoprim + sulfamethazole (73.6%;n = 53/72). In contrast, DeC showed low resistance rates with nitrofurans (6.9%;n = 5/72) and imipenem (2.8%;n = 2/72). the strains had 56 distinct ARPs, of which 88.9% (n = 64/72) were MDR. Salmonella sp and Shigella sp showed high levels of resistance to amoxicillin and trimethoprim + sulfamethazole. Conclusion: these results e

关键词： Gastroenteritis enteropathogens Pathogenic escherichia coli Antibiotic Resistance Multidrug-Resistance

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成人钢琴集体课教程学生用书 1

2015年

作者： e.L.兰卡斯特坎农·D.蓝甫洛编

本系列由***博士亲自编写。学生用书由26个单元组成，每单元包括读谱练习、技巧讲解、拓展曲目、和声训练、合奏训练等内容，课程设计非常合理，能帮助学生全面提高音乐技能和素养。本书适合高校中非钢琴专业的学生使用。

ISBN: (纸本)9787552306248

关键词：奏法教材钢琴

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高情商管理者的6个习惯 1版