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New t.ends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： efstathios t Pavlidis Ioannis N Galanis t.eodoros e Pavlidis ^(nd)Propedeutic Depart.ent of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is t.e most common biliary t.ee cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** ot.er main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding t.erapeutic *** staging is based on MRI findings,t.e leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(Pet)-Ct or ^(18)F-FDG Pet-MRI to more accurately detect metastases and any ot.er occult deposits with active metabolic *** laparoscopy may detect dissemination not ot.erwise found in 20%-28.6%of *** t.eat.ent is needed,including surgical resection,targeted t.erapy by biological agents according to molecular testing gene mapping,chemot.erapy,radiation t.erapy,and *** is of great importance to understand t.e updated guidelines and current t.eat.ent *** extent of surgical intervention depends on t.e disease stage,ranging from simple cholecystectomy(t1a)to extended resections and including extended cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much at.ention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary t.ee diseases Gastrointestinal malignancies

Management of obstructed colorectal carcinoma in an emergency setting:An update

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： efstathios t Pavlidis Ioannis N Galanis t.eodoros e Pavlidis 2nd Propedeutic Depart.ent of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on t.e left *** 20%of pat.ents,obstruction and ileus may be t.e first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(Ct),Ct colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** t.e most common left-sided obstruction,t.e first choice should be eit.er emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be eit.er one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and t.e most widely used despite temporally affecting quality of *** control surgery in high-risk frail pat.ents is less frequently performed since it can be successfully substituted with endoscopic stenting or *** t.e less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficult.es in dissecting t.e distended colon and t.e risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases t.e risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemot.erapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma emergency surgery Colectomy Intraluminal metal stents

Current considerations on intraductal papillary neoplasms of t.e bile duct and pancreatic duct

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World Journal of Gastroenterology 2024年第10期30卷 1461-1465页

作者： efstathios t Pavlidis Ioannis N Galanis t.eodoros e Pavlidis 2^(nd) Propedeutic Depart.ent of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPNs)represent precursors of pancreatic cancer or bile duct cholangiocarcinoma that can be detected and *** advances in diagnostic methods,identifying t.ese premalignant lesions is still challenging for t.eat.ent *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** intervention in combination with new chemot.erapeutic agents is considered t.e optimal t.eat.ent for malignant *** balance bet.een t.e risk of malignancy and any risk of resection guides management policy;t.erefore,t.eat.ent should be individualized based on a meticulous preoperative assessment of high-risk *** of t.e bile duct is more aggressive;thus,early diagnosis and surgery are *** conservative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary t.ee diseases Pancreatic cystic neoplasms Biliary tract neoplasms extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

Decision and Coordination of an e-commerce Supply Chain Considering Returns and Network externalit.es

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Journal of Systems Science and Systems engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping Ding t.C.e.Cheng Dexia Wang School of Public Finance and taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering t.e large number of returns in online sales and t.e network externalit.es of e-platforms,we develop a decentralized model and a centralized model to explore t.e impacts of returns and network externalit.es on e-commerce supply chain(eCSC)*** show that in t.e decentralized model,t.e service level,price,market demand,and eCSC members’profits increase with t.e network externality ***,t.e service level and price increase,while t.e market demand and eCSC members’profits decrease with t.e product return *** centralized model is t.e optimal operating mode when it is properly *** design t.e“commission and return cost-sharing”contract to optimize eCSC,in which t.e proportion of t.e e-platform’s sharing of t.e return handling cost is exactly equal to t.e proportion of t.e system profit after *** on t.e decentralized model,we develop two extended models in which we endogenize t.e impacts of t.e service level and return rate on t.e network externality *** comparisons bet.een t.e extended and decentralized models,we show that high-quality service can improve eCSC’s profitability,while a high return rate hurts its economic performance.

关键词： e-commerce supply chain coordination mechanism network externalit.es return products

Strong coupling and catenary field enhancement in t.e hybrid plasmonic metamaterial cavity and tMDC monolayers

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Opto-electronic Advances 2024年第5期7卷 20-32页

作者： Andergachew Mekonnen Berhe Khalil As’ham Ibrahim Al-Ani Haroldo t.Hattori Andrey e.Miroshnichenko School of engineering and technology University of New South Wales at CanberraNorthcott DriveCanberra ACT 2610Australia

Strong coupling bet.een resonantly matched surface plasmons of metals and excitons of quantum emit.ers results in t.e formation of new plasmon-exciton hybridized energy *** plasmon-exciton strong coupling,plasmonic nanocavit.es play a significant role due to t.eir ability to confine light in an ultrasmall ***,two-dimensional transition metal dichalcogenides(tMDCs) have a significant.exciton binding energy and remain stable at.ambient conditions,making t.em an excellent alternative for investigating light-mat.er *** a result,strong plasmon-exciton coupling has been reported by introducing a single metallic ***,single nanoparticles have lower spatial confinement of electromagnetic fields and limited tunability to match t.e excitonic ***,we introduce t.e concept of catenary-shaped optical fields induced by plasmonic metamaterial cavit.es to scale t.e st.ength of plasmon-exciton *** demonstrated plasmon modes of metallic metamaterial cavit.es offer high confinement and tunability and can match with t.e excitons of tMDCs to exhibit a strong coupling regime by tuning eit.er t.e size of t.e cavity gap or *** calculated Rabi splitting of Au-MoSe_2 and Au-WSe_2 heterostructures strongly depends on t.e catenary-like field enhancement induced by t.e Au cavity,resulting in room-temperature Rabi splitting ranging bet.een 77.86 and 320 me *** plasmonic metamaterial cavit.es can pave t.e way for manipulating excitons in tMDCs and operating active nanophotonic devices at.ambient temperature.

关键词： catenary-shaped field enhancement strong coupling plasmon exciton Rabi splitting

Current considerations for t.e surgical management of gallbladder adenomas

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1507-1512页

作者： efstathios t Pavlidis Ioannis N Galanis t.eodoros e Pavlidis t.e Second Depart.ent of Propaedeutic Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder adenomas are rare lesions(0.5%)associated with potential malignant transformation,particularly with gallbladder adenomas that are≥1 cm in *** detection and management are crucial for preventing lethal carcinoma *** polyps can often be distinguished from t.e more often nonneo-plastic cholesterol pseudopolyps(5%-10%),which are *** is t.e first-line tool for initial diagnosis and follow-up when *** question is whet.er cholecystectomy is always necessary for all *** manage-ment of gallbladder adenomas is determined according to t.e size of t.e tumor,t.e growth rate of t.e tumor,t.e pat.ent’s symptoms and whet.er risk factors for malignancy are ***≥1 cm in size,an age>50 years and a familial history of gallbladder carcinoma are indications for immediate laparoscopic ***,ultrasound follow-up is *** adenomas 6-9 mm in size,t.e absence of≥2 mm growth at 6 months,one year,and two years,as well as an adenoma sizedthout.existing risk factors indicates that no furt.er surveillance is ***,it would be preferable to individualize t.e management in doubtful *** interventional modalit.es for preserving t.e gallbladder need furt.er evaluation,especially to determine t.e long-term outcomes.

关键词： Biliary diseases true neoplastic polyps Gallbladder adenomas Benign bi-liary tumors Gallbladder polyps extrahepatic biliary neoplasms

eco-toxicity and health risk assessment of polycyclic aromatic hydrocarbons in surface sediments of Burullus Lake in egypt

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China Geology 2024年第3期7卷 460-468页

作者： Hanan e Osman Mohamed H e el-Morsy Hazem t Abd el-Hamid Depart.ent of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMecca 24382Saudi Arabia Deanship of Scientific Research Umm Al-Qura UniversityMakkah 24372Saudi Arabia National Institute of Oceanography and Fisheries(NIOF) Cairo 11865Egypt Botany and Microbiology Depart.ent Faculty of ScienceAl-Azhar UniversityCairo 11651Egypt

Polycyclic aromatic hydrocarbons(PAHs)are ubiquitous environmental contaminants of growing concern due to t.eir potential ecological and human health *** study presents a comprehensive assessment of PAHs contamination in t.e surface sediments of Burullus Lake,a vital and second largest delta lake in *** aim was to evaluate t.e eco-toxicity and potential health risks associated with t.e presence of t.ese *** seven sediment samples were collected from various drains in t.e sout.ern part of Burullus *** extraction method was employed to extract PAHs(16PAHs)from t.e sediment ***,target compounds were located using *** results showed that samples contained PAHs levels ranging from 0.038×10^(-6)to 0.459×10^(-6),which is considered heavily polluted by t.e european standard for PAHs ***,t.ere was no apparent source of PAHs in t.e elKhashah drain or t.e Brinbal Canal,as HPLC found none of t.e *** most prevalent compound in sediment samples along t.e study area was *** diagnostic indices in t.e present study indicated that t.e hydrocarbons in t.e region originated from pyrolytic and man-made sources along t.e drains of Burullus *** principal component analysis(PCA)and diagnostic ratios revealed that coal combustion and pyrolytic sources were responsible for t.e PAHs contamination in t.e surface *** non-carcinogenic risk(HI),which is t.e product of t.e HQs for t.e adult and child populations,respectively,was *** values under 1,t.erefore,demonstrated that t.ey had no carcinogenic effects on human *** and MeQs in t.e sediments of Burullus Lake do not have a cancer-causing impact on *** t.e safety of nearby wildlife,aquatic life,and people,all activit.es that raise petroleum hydrocarbon levels in Burullus Lake must be adequately regulated and *** to t.e ecological risk assessment,t.ere is litt.e chance that PAHs will be found

关键词： Polycyclic aromatic hydrocarbons Diagnostic indices toxicity Delta lake sediment Burullus Lake Human health risk Aquatic ecosystem HPLC Coal combustion

Facile synt.esis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian t.Scarpitti Zhewen Luo Abigail e.Smith Jian Ye Zachary D.Schultz Depart.ent of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot.engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scat.ering(SeRS)for bioanalysis and cell ***,creating stable,reproducible,and strong SeRS signals remains challenging due to t.e potential interference from surrounding chemicals and locating SeRS-active analytes into hot-spot ***,we developed a straightforward approach to synt.esize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBt)as a reporter molecule within t.ese gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which t.e nanorods based intra-gap nanoparticles exhibit t.e highest SeRS *** advantage of our method is t.e ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBt and quick synt.esis without requiring an additional step to centrifuge for t.e purification of core *** intense localized field in t.e synt.esized hot spots of t.ese plasmonic gap nanostructures holds great promise as a SeRS substrate for a broad range of quantitative optical applications.

关键词： hot spot.engineering surface enhanced Raman scat.ering intra-gap nanoparticles 4-nitrobenzenethiol

Instance Segmentation of Characters Recognized in Palmyrene Aramaic Inscriptions

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Computer Modeling in engineering & Sciences 2024年第9期140卷 2869-2889页

作者： Adéla Hamplová Alexey Lyavdansky tomášNovák Ondrej Svojše David Franc Arnošt Veselý Czech University of Life Sciences in Prague(CULS) Faculty of Economics and ManagementDepartment of Information EngineeringPrague16500Czech Republic National Research University Higher School of economics(HSe) Faculty of HumanitiesInstitute for Oriental and Classical StudiesMoscow101000The Russian Federation

this study presents a single-class and multi-class instance segmentation approach applied to ancient Palmyrene inscriptions,employing two state-of-t.e-art deep learning algorithms,namely YOLOv8 and Roboflow *** goal is to contribute to t.e preservation and understanding of historical texts,showcasing t.e potential of modern deep learning methods in archaeological *** research culminates in several key findings and scientific *** comprehensively compare t.e performance of YOLOv8 and Roboflow 3.0 in t.e context of Palmyrene character segmentation—this comparative analysis mainly focuses on t.e st.engths and weaknesses of each algorithm in this *** also created and annotated an extensive dataset of Palmyrene inscriptions,a crucial resource for furt.er research in t.e *** dataset serves for training and evaluating t.e segmentation *** employ comparative evaluation metrics to quantitatively assess t.e segmentation results,ensuring t.e reliability and reproducibility of our findings and we present custom visualization tools for predicted segmentation *** study advances t.e state of t.e art in semi-automatic reading of Palmyrene inscriptions and establishes a benchmark for future *** availability of t.e Palmyrene dataset and t.e insights into algorithm performance contribute to t.e broader understanding of historical text analysis.

关键词： Optical character recognition instance segmentation Palmyrene ancient languages computer vision