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Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)

translational Neurodegeneration 2017年第1期6卷 165-173页

作者： Ann J.Jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill toni Pitcher Paul t.barrett tim J.Anderson John C.Dalrymple-Alford New Zealand Brain Research Institute 66 Stewart StreetChristchurch 8011New Zealand Department of Psychology University of CanterburyChristchurchNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand Cognadev UK Ltd.SandtonSouth Africa Department of Neurology Christchurch HospitalChristchurchNew Zealand Brain Research New Zealand Centre of Research Excellence ChristchurchNew Zealand

Background:there is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these ***:to investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD *** PD patients were classified using MDS-task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the *** ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent *** use of different coping strategies increased with worsening ***,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also ***:the study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with *** well-being has important implications for caregiver support,nursing home placement and disease course.

关键词： Parkinson’s disease Mild cognitive impairment Zarit caregiver burden interview Coping Depression Anxiety Positive aspects of caregiving

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使用生物素标记cDNA探针对RP和PPR进行鉴别诊断

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生物技术通报 1993年第12期9卷 8-9页

作者： K.D.Pandey M.D.Baron t.barrett 李春华

在东南亚的大反刍动物中,牛瘟(RP)仍然是一个主要问题。1986年以来在印度一些州 RP 的发病记录一直呈上升趋势,它也是引起牛死亡的第三大地方病。山羊与绵羊的 RP 发病率也不断增加。而这些小反刍动物通常是牛的传染源。1980年在印度 ta... 详细信息

在东南亚的大反刍动物中,牛瘟(RP)仍然是一个主要问题。1986年以来在印度一些州 RP 的发病记录一直呈上升趋势,它也是引起牛死亡的第三大地方病。山羊与绵羊的 RP 发病率也不断增加。而这些小反刍动物通常是牛的传染源。1980年在印度 tamilnadu 地区,首次报道在绵羊中发生一种类似 RP 的病,"小反刍动物兽疫" (PP8)。该病的发病区似乎限制在西非和中东。PPR 引起坏死性口炎及牙龈和舌背面损害,鼻眼有卡他性的分泌物和腹泻,可导致死亡。

关键词：坏死性口炎 cDNA探针生物素标记鉴别诊断 RP PPR 卡他性发病区临床样品分子诊断技术

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tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry timothy barrett Sovan Sarkar I-StEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

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射精对精囊液的体积和前列腺ADC纵向影响研究

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国际医学放射学杂志 2018年第1期 123-123页

作者： t.barrett J.tanner A.B.Gill R.A.Slough J.Wason F.A.Gallagher 于文娟 Department of Radiology Addenbrooke ’s Hospital and University of Cambridge

摘要目的采用MRI前瞻性连续研究射精对精囊(SV)体积和前列腺表观扩散系数(ADC)值的纵向影响。方法 15名健康男性志愿者(年龄27～53岁,平均35.9岁)接受基线及

关键词：前列腺 ADC

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验证PI-RADS 2.0版本中的主要序列和动态对比增强成像的作用

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国际医学放射学杂志 2018年第1期 102-102页

作者： M.D.Greer J.H.Shih N.Lay t.barrett L.K.Bittencourt S.Borofsky 周波 Molecular Imaging National Cancer InstituteNational Institutes of Health

摘要目的采用多阅片者间研究数据验证前列腺成像报告和数据系统(PI-RADS)2.0版中主要脉冲序列和动态对比增强(DCE)MRI的有限作用。材料与方法本回顾性研究

关键词：动态对比增强 DCE 检出率 PI-RADS 2.0 DWI

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t2W和DW-MRI评分对MR-tRUS融合引导下经会阴模板定位的前列腺癌再活检术定位的指导意义

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国际医学放射学杂志 2014年第5期 492-492页

作者： E.M.1.Lawrence S.Y.tang t.barrett B.Koo D.A.Goldman A.Y.Warren 苏云燕 Department of Radiology University of Cambridge

摘要目的评估MR t2加权和DW-MRI预测评分系统检测经MR-经直肠超声(tRUS)融合引导下经会阴模板定位(ttP)的前列腺再穿刺证实的前列腺癌的性能。方法回顾性

关键词：前列腺癌模板定位 t2W MR-tRUS MRI 经会阴活检术

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Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Abate B Shewaye Abel t tasamma Zekarias S Ayalew Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of Internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and Hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

BACKGROUND Gastroesophageal reflux disease(GERD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Ethiopia have investigated the clinical characteristics,risk factors,and severity of GERD using esophagogastroduodenoscopy(EGD).AIM to assess the clinical features of GERD in Ethiopian patients who underwent EGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GERD and endoscopic findings of EE at trauma Associated Severe Hemorrhage and Amniotic Membrane Stem Cell between January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and binary logistic regression analysis with SPSS version 26 to identify the association between variables with a statistical significance set at P valuethe mean±SD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:*** most commonly reported symptom was epigastric pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed by LA-B(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(Ptricture and barrett’s esophagus were observed in 4.5%and 1.36%of patients with EE,*** Most of the patients had milder EE with fewer ***,severe EE was more prevalent in older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease Erosive esophagitis Hiatal hernia Esophagogastroduodenoscopy Heart burn

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Modernity@Zero Hour:three Women(Lee Miller,Hannah Hoch,Anonyma)

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Journal of Foreign Languages and Cultures 2020年第1期4卷 40-64页

作者： barrett Watten Wayne State University

this essay is a part of a longer work on literary and visual modernism at the“moment”of destruction in 1945:Stunde Null or Zero ***,I focus on the t4constructedness,'of universals via the material,psychological,and political destruction in Germany at war's *** this moment,destruction and universals interconnect in three temporal modes:anticipatory,punctual,and ***“punctual”universals,I read Lee Miller’s war journalism,published in Vogue,in relation to her war and Holocaust photography,as uniting modernist aesthetic values and the“event”of *** the construction of“anticipatory”universals,I discuss the work of Hannah Hoch,dada painter and collagist,who emerged from internal exile in Berlin to participate in the first modernist exhibitions in the destroyed city after Stunde ***,the anonymously authored A Woman in Berlin,documenting the survival strategies to mass sexual predation by Soviet troops immediately at and after Stunde Null,extends from punctual accounts of destruction to a retrospective *** each case,modernist visual and verbal forms-and an ethical imperative to keep interpretive horizons open-negotiates between the“radical particularity”of the lived experience of destruction and universal *** constructedness of universals in modernist works anticipates the construction of political,ethical,and aesthetic universals in the global order after 1945.

关键词： modernism World War II feminism art history destruction universals

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Rock mechanics for design of Brisbane tunnels and implications of recent thinking in relation to rock mass strength

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 676-683页

作者： L.B.McQueen A.Purwodihardjo S.V.L.barrett Golder Associates Pty Ltd. 124 Pacific HighwaySt.LeonardsNSW2065Australia Golder Associates Pty Ltd. 147 Coronation DriveMiltonQueensland4064Australia Golder Associates Pty Ltd. Building 7Botanicca Corporate Park570 e 588 Swan StreetRichmondVictoria3121Australia

this paper explores the potential implications of recent thinking in relation to rock mass strength for future tunnelling projects in Brisbane,Australia,particularly as they are constructed within deep horizons where the in situ stress magnitudes is *** mass failure mechanisms for the current tunnels in Brisbane are generally discontinuity controlled and the potential for stress-induced failure is relatively *** the road tunnels which have been constructed in Brisbane over the last 12 years,the strength of the more massive rock masses for continuum analysis has been estimated by the application of the Hoek-Brown(H-B)failure criterion using the geological strength index(GSI)to determine the H-B parameters mb,s and *** the last few years,alternative approaches to estimating rock mass strength for‘massive to moderately jointed hard rock masses’have been proposed by others,which are built on the work completed by *** and *** in this area over their joint *** paper explores one of these alternative approaches to estimating rock mass strength for one of the geological units(the Brisbane tuff),which is often encountered in tunnelling projects in *** potential implications of these strength forecasts for future tunnelling projects are discussed along with the additional work which will need to be undertaken to confirm the applicability of such alternative strength criteria for this rock mass.

关键词： Rock mass strength Hoek-Brown(H-B)failure criterion triaxial testing Brittle failure Brisbane tuff

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Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review

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World Journal of Gastrointestinal Oncology 2015年第9期7卷 132-140页

作者： Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael t.barrett Derek Cridebring Daniel D Von Hoff Honor Health Research Institute Virginia G. Piper Cancer Center translational Genomics Research Institute Caris Life Sciences Imaging Endpoints Mayo Clinic

Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of *** characterization revealed overexpression in MRP1(80%), MGMt(79%), tOP2A(75), RRM1(42%),tOPO1(42%), PtEN(45%), CMEt(40%), and C-KIt(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. this analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease.

关键词： Adenosquamous carcinoma of the pancreas Molecular

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