Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)

作     者：Ann J.Jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett Tim J.Anderson John C.Dalrymple-Alford 

作者机构：New Zealand Brain Research Institute66 Stewart StreetChristchurch 8011New Zealand Department of PsychologyUniversity of CanterburyChristchurchNew Zealand Department of MedicineUniversity of OtagoChristchurchNew Zealand CognadevUK Ltd.SandtonSouth Africa Department of NeurologyChristchurch HospitalChristchurchNew Zealand Brain Research New Zealand Centre of Research ExcellenceChristchurchNew Zealand 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2017年第6卷第1期

页      面：165-173页

核心收录：

学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 1009[医学-特种医学] 10[医学] 

基　　金：University of Canterbury Department of Psychology, New Zealand Neurological Foundation Canterbury Medical Research Foundation, CMRF 

主　　题：Parkinson’s disease Mild cognitive impairment Zarit caregiver burden interview Coping Depression Anxiety Positive aspects of caregiving 

摘      要：Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these ***:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD *** PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the *** ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent *** use of different coping strategies increased with worsening ***,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also ***:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with *** well-being has important implications for caregiver support,nursing home placement and disease course.