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Multi-layer perceptron-based data-driven multiscale modelling of granular materials with a novel Frobenius norm-based internal variable

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi wang Y.t.Feng Shaoheng Guan tongming Qu Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK Institute of theoretical and Computational Physics Graz University of TechnologyGraz8010Austria Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One objective of developing machine learning(ML)-based material models is to integrate them with well-established numerical methods to solve boundary value problems(BVPs).In the family of ML models,recurrent neural networks(RNNs)have been extensively applied to capture history-dependent constitutive responses of granular materials,but these multiple-step-based neural networks are neither sufficiently efficient nor aligned with the standard finite element method(FEM).Single-step-based neural networks like the multi-layer perceptron(MLP)are an alternative to bypass the above issues but have to introduce some internal variables to encode complex loading *** this work,one novel Frobenius norm-based internal variable,together with the Fourier layer and residual architectureenhanced MLP model,is crafted to replicate the history-dependent constitutive features of representative volume element(RVE)for granular *** obtained ML models are then seamlessly embedded into the FEM to solve the BVP of a biaxial compression case and a rigid strip footing *** obtained solutions are comparable to results from the FEM-DEM multiscale modelling but achieve significantly improved *** results demonstrate the applicability of the proposed internal variable in enabling MLP to capture highly nonlinear constitutive responses of granular materials.

关键词： Granular materials History-dependence Multi-layer perceptron(MLP) Discrete element method FEM-DEM Machine learning

Effective protective agents against the organ toxicity of t-2 toxin and corresponding detoxification mechanisms:A narrative review

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Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju wang Lv-hui Sun Xu wang Qinghua Wu Aimei Liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan430070China College of Life Science Yangtze UniversityJingzhou 434025China

t-2 toxin is one of the most widespread and toxic fungal toxins in food and *** can cause gastrointestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxicity in humans and animals.t-2 toxin is physicochemically stable and does not readily degrade during food and feed ***,suppressing t-2 toxin-induced organ toxicity through antidotes is an urgent *** agents against the organ toxicity of t-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively *** this review,we provide an overview of the various protective agents to t-2 toxin and the molecular mechanisms underlying the detoxification *** appropriate targets to antagonize t-2 toxin toxicity is also an important *** review will provide essential guidance and strategies for the better application and development of t-2 toxin antidotes specific for organ toxicity in the future.

关键词： t-2 toxin Organ toxicity Protective agent Detoxification mechanism

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Relationship between seismic structures and the diverse rupture processes of the 2023 türkiye earthquake doublet

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Science China Earth Sciences 2024年第9期67卷 2810-2823页

作者： Zhi wang Yi FU Shunping PEI CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Key Laboratory of tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Recent geodetic and seismological observations of two major earthquakes in southeastern türkiye in February 2023 have revealed complex rupture initiation,propagation,and segmentation along the East Anatolian Fault Zone(EAFZ)and surrounding ***,the role of upper crust structures along the EAFZ in determining the diverse rupture processes of this earthquake doublet remains *** further investigate this,we employed double-difference location and seismic tomography techniques to determine high-resolution seismic velocities(V_(P),V_(S))and Poisson’s ratio(σ)structures using a multiparameter joint tomographic *** dataset includes 100,833 high-quality source-receiver travel-time pairs of P-and *** find that the unique rupture processes of this earthquake doublet were primarily influenced by contrasting crustal seismic structures and localized geological *** M_(w)7.8 mainshock was initiated within a transitional edge zone characterized by a rigid part(asperity)of the seismogenic zone with sharp contrast variations in rock strength ranging from low to high along the *** comparison,the M_(w)7.6 rupture originated in a ductile belt featuring fluid saturation with low-VP,low-VS,and high-σvalues that extended parallel to the Cardak *** pronounced contrast structures observed along the former rupture can be attributed to the oblique collision system between the weakened section of the east Anatolian plateau and the brittle Arabian platform,while the latter rupture was initiated within the ductile structure associated with fluid intrusion caused by the northward subduction of the Cyprus slab and subsequent ***,the occurrence of the first earthquake(E1)serves to alleviate shear stress on the second earthquake(E2)fault,potentially impeding the initiation of an E2 *** the contrary,this event also significantly reduces the normal stress acting on the E2 fault due to a double left-lateral strike-slip system

关键词： 2023 turkiye earthquake doublet Joint seismic tomography tomographic transition edge Seismic rupture process Strong fault coupling

An isolated symmetrical 2t2R cell enabling high precision and high density for RRAM-based in-memory computing

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Science China(Information Sciences) 2024年第5期67卷 287-294页

作者： Yaotian LING Zongwei wang Yuhang YANG Lin BAO Shengyu BAO Qishen wang Yimao CAI Ru HUANG School of Integrated Circuits Beijing Advanced Innovation Center for Integrated Circuits Peking University State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

In-memory computing(IMC), leveraging emerging memories, holds significant promise in overcoming memory limitations and improving energy efficiency. However, the prevailing IMC array structure based on serially connected transistors and memory cells(1t1R/2t2R), along with the signed weight mapping scheme, can lead to asymmetrical weight sensing issues(AWS) due to electrical asymmetry within the1t1R/2t2R structure, particularly in highly scaled cells where the transistor's resistance becomes significant. In this paper, we propose and fabricate an electrically symmetric memory cell based on a physically isolated 2t2R structure for IMC. this design aims to enhance the precision and density of RRAM-based IMC arrays. the 2t2R cells are manufactured using the back-end-of-line(BEOL) process of a commercial40 nm technology platform. the feasibility of this design is verified through measured and simulated results,showcasing its capability to address the issue of AWS. Compared to conventional 2t2R cells, this design achieves a considerably smaller transistor footprint without compromising accuracy, while also improving integration density by 42.2%. these innovative memory cell advancements have the potential to further advance high-energy-efficient IMC technology.

关键词： RRAM 2t2R multi-level storage weight asymmetry in-memory computing

Aggregation-induced t_(1)/t_(2) contrast enhancement for magnetic resonance imaging-guided intraoperative surgery

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Science China Chemistry 2024年第6期67卷 2046-2055页

作者： Wenbo Sun Bin Yu Dianshuai Huang Chunhuan Jiang Wei wang Jianhua Liu Zonghua wang Lehui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsQingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and TreatmentQingdao UniversityQingdao266071China Department of Radiology Second Hospital of Jilin UniversityChangchun130041China

Magnetic resonance imaging(MRI)plays an important role in precision medicine that is hampered by the lack of contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic ***,we demonstrate a DNA-based MRI probe that overcomes previous single-mode enhancement and provides a mechanism of action for aggregationinduced dual-modal MRI signal enhancement.A facile method is developed to produce aggregated t_(1)/t_(2)dual-modal NaGdF_(4):Dy@PDA-DNA(PDA=polydopamine)MRI *** aggregated,this probe can further amplify MRI signal intensity and exhibit improved geometrical and positional stability in *** performance of the NaGdF_(4):Dy@PDA-DNA MRI probe toward MRI-guided preoperative planning and visualization-guided surgery is verified using an orthotopic tumor-bearing mouse *** result shows that the rapid metabolism of the degraded probe leads to the mitigation of long-term toxic ***,the developed high-performance MRI probe is of great significance for enhancing MRI diagnostic accuracy into precision medical therapeutic interventions.

关键词： MRI probe DNA aggregation-induced t_(1)/t_(2)contrast enhancement precision medicine degradable probe

Photoluminescence and ratiometric thermo-response of Eu^(2+)and Eu^(3+)in BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor materials

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Journal of Rare Earths 2024年第7期42卷 1240-1249,I0002页

作者： Ziyao wang Haitao Fu Xiufeng Zhan Bo tong Guofeng Ma H.t.(Bert)Hintzen Institute of Innovative Science and technology Shenyang UniversityShenyang110044China College of Mechanical Engineering Shenyang UniversityShenyang110044China Faculty of Applied Sciences Delft University of Technology2629 JBDelftthe Netherlands

A novel Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphor was developed and synthesized by solid-state *** valence state of Eu,photoluminescence and thermo-sensitive performance of the phosphor prepared either in ambient air or carbothermally were investigated and *** phosphor shows high sensitivity(Sa=0.0173 K^(-1),S_(r)=0.461%/K)and superior signal discriminability(Δν∼10380 cm^(−1)).the thermo-sensitive performance is subject to the dual effects of different thermo-responses by Eu^(2+)versus Eu^(3+)combined with energy transfer from Eu^(2+)to Eu^(3+),so that the sensitivity of the phosphor in the temperature range presents a non-monotonic *** development of the BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor is not only expected to be relevant for application in the field of temperature sensing,but also of reference significance for improving the sensitivity by means of energy transfer between co-activator ions over a wider temperature range of Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphors.

关键词： Photoluminescence Ratiometric thermo-response Phosphor Eu^(2+)/Eu^(3+) Rare earths

Boeravinone B ameliorates allergic nasal inflammation by modulating the GAtA-3/t-bet signaling pathway in a mouse model of allergic rhinitis

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Asian Pacific Journal of tropical Biomedicine 2024年第6期14卷 245-252页

作者： Ben Ye Ji-Zhe wang Department of Otorhinolaryngology Second Hospital of Dalian Medical UniversityDalian116000China Department of Otorhinolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objective:to evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible ***:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone *** mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LtC-4,myeloperoxidase,Nrf2,HO-1,GAtA-3,ROR-γ,t-bet,antioxidant parameters,and allergen-specific cytokines were ***:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(Pt also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GAtA-3,and ROR-γwhile enhancing the level of ***:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关键词： Allergic reaction Boeravinone B Oxidative stress Inflammation Ovalbumin

Realization of Low in-Band Harmonic for Compact 6–18-GHz t/R Module Under tX-Mode Operation

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Chinese Journal of Electronics 2024年第2期33卷 380-384页

作者： Jinming LAI Zhiyou LI Chaojie wang Hailong wang Xiaohua MA School of Microelectronics Xidian University CEtC 29th Research Institute

Wideband high power amplifier(PA) with poor harmonic suppression will degrade the performance of the active electronically scanned array(AESA) due to its harmonic products falling into the operating bandwidth of a wideband t/R module. In view of this, a compact reconfigurable harmonic suppress circuit(HSC) is proposed to achieve low in-band harmonic for compact t/R module with multiple octaves under tX-mode operation. the HSC consists of eight microstrip resonant stubs with high impedance and multiple p-i-n switches. By controlling the p-i-n switches, the HSC can work in three states. When six of the used p-i-n switches are “ON” state, the corresponding microstrip resonant stubs are loaded onto the 50 Ω transmission line, which performs a bandstop filter(BSF). For verification, the HSC with bandwidth of 12–15 GHz/15–18 GHz is designed to apply to a 6–18 GHz t/R module. As a result, the second harmonic of 6–9 GHz transmitting signal can be suppressed below 32 d Bc when compared to the PA's fundamental output. While the p-i-n switches are “OFF” state, the HSC is almost the same as a 50 Ω transmission line, which will have a little effect on the 9–18 GHz transmitting signal. the measurement results approximately agree with the calculated results and simulated results, which demonstrate the validity of the proposed HSC.

关键词： Microstrip filters Harmonics suppression Power transmission lines PIN photodiodes Switches Harmonic analysis transmission line measurements

ti_(3)C_(2)t_(x)/SnO_(2)P–N heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： Yue Zhang Ming-Yue wang Xiao-Guang San Yan-Bai Shen Guo-Sheng wang Lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily ***,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical ***,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important *** this study,ti_(3)C_(2)tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good longterm *** functional theory(DFt)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with ***,ti_(3)C_(2)t_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room ***,the formation of p-n heterostructures between SnO_(2)and ti_(3)C_(2)t_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde *** perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： ti_(3)C_(2)t_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFt calculations