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Membrane tension evolution and mechanical regulation of melittin-induced membrane poration

Chinese Physics B 2024年第10期33卷 465-475页

作者： Wanting Zhang Rong Xu wendong Ma Zhao Lin Kai Yang Bing Yuan Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and technology Soochow UniversitySuzhou 215006China Songshan Lake Materials Laboratory Dongguan 523808China Biomedicine Discovery Institute Infection&Immunity ProgramMonash UniversityMelbourneAustralia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Membrane tension plays a crucial role in various fundamental cellular processes,with one notable example being the t cell-mediated elimination of tumor cells through perforin-induced membrane perforation by amplifying cellular ***,the mechanisms governing the regulation of biomolecular activities at the cell interface by membrane tension remain *** this study,we investigated the correlation between membrane tension and poration activity of melittin,a prototypical pore-forming peptide,using dynamic giant unilamellar vesicle leakage assays combined with flickering tension analysis,molecular dynamics simulations,and live cell *** results demonstrate that.an increase in membrane tension enhances the activity of melittin,particularly near its critical pore-forming ***,peptide actions such as binding,insertion,and aggregation in the membrane further influence the evolution of membrane *** cell experiments reveal that artificially enhancing membrane tension effectively enhances melittin’s ability to induce pore formation and disrupt membranes,resulting in up to a ten-fold increase in A549 cell mortality when exposed to a concentration of 2.0-μg·mL^(-1)*** findings elucidate the relationship between membrane tension and the mechanism of action as well as pore-forming efficiency of melittin,while providing a practical mechanical approach for regulating functional activity of molecules at the cell-membrane interface.

关键词： membrane tension mechanical regulation membrane poration giant unilamellar vesicle leakage assay

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Inbreeding and genetic load in a pair of sibling grouse species:tetrastes sewersowi and ***

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Avian Research 2024年第2期15卷 265-270页

作者： Kai Song tom van der Valk Bin Gao Peter Halvarsson Yun Fang wendong Xie Siegfried Klaus Zhiming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular Biology Uppsala75273Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5 JenaD-07749Germany the State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from Sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).these levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels t.an Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.

关键词： Genetic load Inbreeding Purifying selection Qinghai-tibetan Plateau ROH tetrastes

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Large-Scale Carbon Dioxide Storage in Salt Caverns:Evaluation of Operation,Safety,and Potential in China

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Engineering 2024年第9期40卷 226-246页

作者： Wei Liu Xiong Zhang Jifang Wan Chunhe Yang Liangliang Jiang Zhangxin Chen Maria Jose Jurado Xilin Shi Deyi Jiang wendong Ji Qihang Li State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China China Energy Digital technology Group Co.Ltd. Beijing 100044China Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan 430064China Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAB T2N 1N4Canada Eastern Institute of technology Ningbo 315200China Geosciences Barcelona CSIC Spanish National Research CouncilBarcelona 08028Spain

Underground salt cavern CO_(2) storage(SCCS)offers the dual benefits of enabling extensive CO_(2) storage and facilitating the utilization of CO_(2) resources while contributing the regulation of the carbon *** economic and operational advantages over traditional carbon capture,utilization,and storage(CCUS)projects make SCCS a more cost-effective and flexible *** the widespread use of salt caverns for storing various substances,differences exist between SCCS and traditional salt cavern energy storage in terms of gas-tightness,carbon injection,brine extraction control,long-term carbon storage stability,and site selection *** distinctions stem from the unique phase change characteristics of CO_(2) and the application scenarios of ***,targeted and forward-looking scientific research on SCCS is *** paper introduces the implementation principles and application scenarios of SCCS,emphasizing its connections with carbon emissions,carbon utilization,and renewable energy peak *** delves into the operational characteristics and economic advantages of SCCS compared with other CCUS methods,and addresses associated scientific *** this paper,we establish a pressure equation for carbon injection and brine extraction,that considers the phase change characteristics of CO_(2),and we analyze the pressure during carbon *** comparing the viscosities of CO_(2) and other gases,SCCS’s excellent sealing performance is *** on this,we develop a long-term stability evaluation model and associated indices,which analyze the impact of the injection speed and minimum operating pressure on *** countermeasures to ensure stability are *** selection criteria for SCCS are established,preliminary salt mine sites suitable for SCCS are identified in China,and an initial estimate of achievable carbon storage scale in China is made at over 51.8-77.7 million tons,utilizing only 20%-30%volume

关键词： Carbon-neutrality Salt cavern Large-scale CO_(2)storage Injection and withdrawal Stability analysis

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异速轧制和常规轧制对7075铝板力学性能的影响

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有色金属科学与工程 2024年第3期15卷 400-406页

作者：武磊何兵覃文东覃铭运城职业技术大学智能制造与数智矿山学院山西运城044000 广西壮族自治区铝基新材料工程研究中心广西百色533000 百色学院材料科学与工程学院广西百色533000 吉利百矿研究院有限公司广西百色533000

为进一步开发更高效的7075铝板轧制工艺,本文围绕异速轧制和常规轧制对7075铝板力学性能的影响开展了研究,并采用了4个不同的轧制累积变形率。实验分2步进行,第1步为轧板弯曲程度随异速比变化实验,将轧板弯曲内面朝向水平底面放置,测量... 详细信息

为进一步开发更高效的7075铝板轧制工艺,本文围绕异速轧制和常规轧制对7075铝板力学性能的影响开展了研究,并采用了4个不同的轧制累积变形率。实验分2步进行,第1步为轧板弯曲程度随异速比变化实验,将轧板弯曲内面朝向水平底面放置,测量弯曲内面最高点距离水平底面距离y,以及弯曲内面与水平底面的两接触点距离x,用y/x值表征轧板的弯曲程度;第2步为异速和常规轧制实验。实验结果表明:当异速比为1.12时,轧板弯曲程度最大,y/x值最高达到0.22218;虽然采用了相同的设计累积变形率,但异速轧制和常规轧制的轧板实际累积变形率相差1%~2%;两种方式轧制的轧板在实际累积变形率达到76%时,t6热处理过程中再结晶进行得更加充分,再结晶生成的中小尺寸晶粒增多;经过6道次异速轧制和常规轧制的7075铝板,t6热处理后,断口中可见大量尺寸小于1μm的韧窝,并且在韧窝底部出现弥散析出的尺寸小于100 nm的微小第二相粒子,异速轧制7075铝板中韧窝尺寸较常规轧制7075铝板中更细小;与常规轧制相比,采用异速轧制的7075铝板的强度有一定提高,但提高幅度不大;常规轧制的7075铝板在达到一定变形量时会出现强度峰值,而异速轧制的7075铝板的强度随轧制累积变形率升高而持续提高。

关键词：异速轧制 7075铝板变形率异速比力学性能

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基于机器学习的体外循环后心肌缺血-再灌注损伤中m6A相关基因聚类分析和免疫浸润分析

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中国胸心血管外科临床杂志 2024年第10期31卷 1475-1485页

作者：唐垚陈文栋王燕琼杨伟昆明医科大学第一附属医院麻醉科昆明650032

目的通过机器学习的方法确定体外循环后心肌缺血-再灌注损伤(myocardial ischemia-reperfusion injury,MI/RI)中N6-甲基腺苷(N6-methyladenosine,m6A)相关的特征基因并对其进行聚类分析及免疫浸润分析。方法通过GEO中数据集GSE132176,筛选m6A甲基化相关的差异基因,基于差异基因表达谱对该数据集样本进行聚类分析。并对聚类后m6A簇的差异基因进行基因本体论(GO)和京都基因与基因组百科全书(KEGG)富集分析以确定m6A簇基因功能。通过R软件从支持向量机(SVM)模型和随机森林(RF)模型中确定更优模型,用于筛选MI/RI中m6A相关的特征基因,并构建特征基因列线图以预测疾病的发病率。运用R软件分析特征基因与免疫细胞的相关性,并运用在线网站构建特征基因调控网络。结果该数据集中共筛选出5个m6A相关的差异基因,对其进行聚类分析将基因表达谱分为两簇。对m6A簇进行富集分析,结果显示这些基因主要参与调节单核细胞分化、对脂多糖的反应、对细菌来源分子的反应、细胞对氧气水平下降的反应、DNA转录因子结合、DNA结合转录激活剂活性、RNA聚合酶Ⅱ特异性、NOD样受体信号通路、流体剪切应力与动脉粥样硬化、肿瘤坏死因子(tNF)信号通路、白介素(IL)-17信号通路等。利用R软件确定RF模型为更优模型,该模型确定MEttL3、YtHDF1、RBM15B、MEttL14为MI/RI的特征基因,免疫浸润分析发现肥大细胞、1型辅助性t淋巴细胞(th1)、17型辅助性t淋巴细胞(th17)、巨噬细胞与体外循环后MI/RI相关。结论机器学习获得4个特征基因MEttL3、YtHDF1、RBM15B、MEttL14,同时聚类分析和免疫细胞浸润分析更好地揭示体外循环后MI/RI可能存在的病理生理过程。

关键词：体外循环 N6-甲基腺苷RNA甲基化心肌缺血-再灌注损伤机器学习

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Blow-up of critical norms for the 3-D Navier-Stokes equations

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Science China Mathematics 2017年第4期60卷 637-650页

作者： WANG wendong ZHANG ZhiFei School of Mathematical Sciences Dalian University of Technology School of Mathematical Sciences Peking University

Let u = （Uh,U3） be a smooth solution of the 3-D Navier-Stokes equations in R3 × [0, t）. It was proved that if u3 ∈ L^∞（0,t;Bp,q-1＋3/p（R3）） for 3 〈 p,q 〈 oe and uh ∈ L^∞（0, t;BMO-1（R3）） with uh（t） ∈ VMO-1（R3）, then u can be extended beyond t. this result generalizes the recent result proved by Gallagher et al. （2016）, which requires u ∈ L^∞（O,t;Bp,^-11＋3/P（R3））. Our proof is based on a new interior regularity criterion in terms of one velocity component, which is independent of interest.

关键词： Navier-Stokes equations interior regularity criterion BMO space Besov space

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Process Study and Exergy Analysis of a Novel Air Separation Process Cooled by LNG Cold Energy

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Journal of thermal Science 2014年第1期23卷 77-84页

作者： XU wendong DUAN Jiao MAO Wenjun Key Laboratory of Enhanced Heat t.ansfer & Energy Conservation of the Ministry of Education School of Chemistry and Chemical EngineeringSouth China University of Technology Zhongshan ling niao Gas Co.Ltd.

In order to resolve the problems of the current air separation process such as the complex process, cumbersome operation and high operating costs, a novel air separation process cooled by LNG cold energy is proposed in this paper, which is based on high-efficiency heat exchanger network and chemical packing separation technology. the operating temperature range of LNG cold energy is widened from 133K-203K to l13K-283K by high- efficiency heat exchanger network and air separation pressure is declined from 0.5MPa to about 0.35MPa due to packing separation technology, thereby greatly improve the energy efficiency. Both the traditional and novel air separation processes are simulated with air handling capacity of 20t＇h-1. Comparing with the traditional process, the LNG consumption is reduced by 44.2%, power consumption decrease is 211.5 kWh per hour, which means the annual benefit will be up to 1.218 million CNY. And the exergy efficiency is also improved by 42.5%.

关键词： LNGs air separation cold energy exergy analysis heat exchanger.

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可双向钻土自升降式喷灌装置技术工程示范应用研究

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水利发展研究 2024年第6期24卷 44-48页

作者：吴琼王文冬北京市水务规划研究院北京100048 北京市水利规划设计研究院北京100048

水资源短缺问题日趋严重,开展农田节水灌溉设施研究及应用日益重要。本研究将一种可双向钻土自升降式喷灌装置应用于农业蔬菜种植示范区。通过分析其喷头流量、喷洒半径、喷洒均匀性等性能参数随试验压力的变化规律,得出该装置的最佳运... 详细信息

水资源短缺问题日趋严重,开展农田节水灌溉设施研究及应用日益重要。本研究将一种可双向钻土自升降式喷灌装置应用于农业蔬菜种植示范区。通过分析其喷头流量、喷洒半径、喷洒均匀性等性能参数随试验压力的变化规律,得出该装置的最佳运行压力为0.3 MPa;在此压力条件下,该装置实现了研究区域内土壤墒情由轻旱向适墒的转变,灌溉用水定额从3200 m^(3)/hm^(2)下降到2800 m 3/hm^(2),水资源利用率提高了10%以上,具有良好的节水效果;同时通过引进可双向钻土自升降式喷灌装置,对整个研究区域开展节水灌溉,将区域土壤有效控制在适墒范围,使得研究区域内年作物总产量增加了43.4 t,估算经济产值增量高达34.73万元/年,取得了显著的经济效益。

关键词：可双向钻土自升降式喷灌工程示范运行工况节水效果

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添加油橄榄果渣对玉米秸秆青贮品质的影响

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草业科学 2024年第3期41卷 762-769页

作者：何玉鹏叶文斌苏满春陈文东王让军王昱陇南师范高等专科学校农林技术学院/陇南特色农业生物资源研究开发中心甘肃陇南742500

本研究旨在探究添加油橄榄(Olea europaea)果渣对玉米(Zea may)秸秆青贮品质的影响,设玉米秸秆(C)、5%油橄榄果渣+95%玉米秸秆(t_(5))、10%油橄榄果渣+90%玉米秸秆(t_(10))、20%油橄榄果渣+80%玉米秸秆(t_(20))、30%油橄榄果渣+70%玉米... 详细信息

本研究旨在探究添加油橄榄(Olea europaea)果渣对玉米(Zea may)秸秆青贮品质的影响,设玉米秸秆(C)、5%油橄榄果渣+95%玉米秸秆(t_(5))、10%油橄榄果渣+90%玉米秸秆(t_(10))、20%油橄榄果渣+80%玉米秸秆(t_(20))、30%油橄榄果渣+70%玉米秸秆(t_(30))5个处理,每个处理4个重复,每个重复300 g。经青贮调制室温避光保存45 d后测定青贮发酵指标和营养成分。结果表明:在感官评分上,C、t_(5)和t_(10)的评分等级为优,而t_(20)和t_(30)的评分等级为良。在发酵品质上,t_(30)的pH显著高于其余处理(Pt_(10)和t_(20)的pH显著高于C和t_(5)(Pt_(5)、t_(10)、t_(20)、t_(30)的乳酸含量显著低于C(Pt_(5)的乳酸꞉乙酸显著(Pt_(10)、t_(20)和t_(30),t_(10)和t_(20)的乳酸꞉乙酸显著高于t_(30)(Pt_(20)和t_(30)的氨态氮꞉总氮显著低于C(P<0.05)。在营养价值上,随着油橄榄果渣添加量的提高,混合青贮饲料的干物质、中性洗涤纤维、酸性洗涤纤维含量显著增加(P<0.05),而水溶性碳水化合物含量显著降低(P<0.05)。综合分析感官评分、发酵指标和营养价值,油橄榄果渣与玉米秸秆的混合青贮,油橄榄果渣的最高添加比例为20%,为油橄榄果渣的饲料化利用提供了策略。

关键词：油橄榄果渣玉米秸秆青贮感官评分发酵品质营养价值添加比例

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Effects of Groundwater with Various Salinities on Evaporation and Redistribution of Water and Salt in Saline-sodic Soils in Songnen Plain,Northeast China

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Chinese Geographical Science 2023年第6期33卷 1141-1152页

作者： ZHU wendong ZHAO Dandan YANG Fan WANG Zhichun DONG Shide AN Fenghua MA Hongyuan ZHANG Lu tIBOR tóth Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun130012China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Shandong Key Laboratory of Eco-environmental Science for Yellow Rriver Delta Binzhou UniversityBinzhou256603China Research Institute for Soil Science and Agricultural Chemistry of the Hungarian Academy of Sciences(MtA tAKI-RISSAC) BudapestII.Herman O.út 151025Hungary

Groundwater mineralization is one of the main factors affecting the t.ansport of soil water and salt in saline-sodic *** investigate the effects of groundwater with different levels of salinity on evaporation and distributions of soil water and salt in Songnen Plain,Northeast China,five levels of groundwater sodium adsorption ration of water(SARw)and total salt content(tSC mmol/L)were conducted in an oil column *** five treated groundwater labeled as St0:0,St0:10,St5:40,St10:70 and St20:100,were prepared with NaCl and CaCl2 in proportion,*** results showed the groundwater evaporation(GWE)and soil evaporation(SE)increased firstly and then decreased with the increase of groundwater *** values of GWE and SE in St10:70 treatment were the highest,which were 2.09 and 1.84 times the values in the St0:0 treatment with the lowest GWE and *** was a positive linear correlation between GWE and the Ca^(2+)content in groundwater,with R^(2)=*** soil water content(SWC)of St0:0 treatment was significantly(Pt.an those of other treatments during the *** SWC of the St0:0 and St0:10 treatments increased with the increase of soil depth,while the other treatments showed the opposite *** analysis indicated the SWC in the 0–60 cm soil layer was positively correlated with the groundwater tSC and its ion contents during the *** accumulation occurred in the topsoil and the salt accumulation in the 0–20 cm soil layer was significantly(Pter t.an that in the *** study revealed the effects of the salinity level of groundwater,especially the Ca^(2+)content.and tSC of groundwater,on the GWE and distributions of soil water and salt,which provided important support for the prevention and reclamation of soil salinization and sodificaton in shallow groundwater regions.

关键词： groundwater evaporation sodium adsorption ratio total salt content ion composition soil salinization water and salt dynamics Songnen Plain,China

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