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Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort

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World Journal of Gastroenterology 2021年第7期27卷 609-623页

作者： Kento Imajo Louise tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan Innovation PerspectumOxford OX42LLUnited Kingdom Centre for Inflammation Research University of EdinburghEdinburghUnited KingdomEdinburgh EH164TJUnited Kingdom Department of Cellular Pathology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Anatomic and Clinical Pathology Department Yokohoma City University HospitalYokohoma 236-0004Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver *** multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected t1(ct1)],as well as elastography techniques[vibration-controlled transient elastography(VCtE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver *** to evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH *** From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCtE,MRE and *** were subsequently biopsied,and samples were scored by three independent *** diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard *** between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa *** N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the *** identifying patients with NASH,MR liver fat and ct1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(ct1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCtE-liver stiffness measure(AU

关键词： Corrected t1 Fibro-inflammation Non-invasive imaging Non-alcoholic steatohepatitis Multiparametric magnetic resonance imaging Non-alcoholic fatty liver disease

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A Case of Secretory Carcinoma that Occurred in the Buccal Submucosa

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International Journal of Otolaryngology and Head & Neck Surgery 2019年第6期8卷 191-197页

作者： saito Yoshiro Kurasawa Yuya Moriya takashi Ikeda Kenitiro Kushihashi Yukiomi Egawa Shunya Katsuta Hideyuki Shimane toshikazu Head and Neck Oncology Center Showa UniversityTokyoJapan Department of Oral and Maxillofacial Surgery Division of Oral OncologyShowa UniversitySchool of DentistryTokyoJapan Department of Otorhinolaryngology Showa University School of MedicineTokyoJapan

Secretory carcinoma (SC) is a malignant salivary gland tumor that has been first reported by Skalova et al. in 2010. Histologically, it shows solidity infiltrated with very small cystic cavities and cribriform and papillary features and includes periodic acid-Schiff stain-positive, acid-fast secretions. the cells have oval nuclei, and vacuolated cytoplasm and foamy secretions are seen. Anaplasia is not strong and mitotic figures are rarely seen. these features closely resemble AciCC. Immunohistologically, it is thought to be positive for S-100 protein, vimentin, and mammaglobin and negative for DOG1. the presence of the EtV6-NtRK3 fusion gene is essential in diagnosing secretory carcinoma. In this report, we describe a case of SC in a 52-year-old woman. She was referred to our center because of a mass in left buccal mucosa. A soft and elastic submucosal mass measuring approximately 10 mm × 10 mm in size with a smooth surface was seen in the buccal mucosa in an area corresponding to the left mandibular canine to premolars. the imaging findings revealed that a high-intensity lesion was seen on t2-weighted images. Immunohistochemicalstaing for S-100 protein and vimentin were positive. Furthermore, genetic examination detected the presence of the EtV6-NtRK3 fusion gene. Based on these findings, the definitive diagnosis was secretory carcinoma.

关键词： Secretory Carcinoma EtV6-NtRK3 Fusion Gene Buccal Mucosa

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用空心钢锭制造的压力容器大型环段锻件

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大型铸锻件 1986年第2期 49-54页

作者： t．Imai A．Namba K．Miyata K．ASO K．Nakanishi K．saito 骆平（译）日本不详

水岛工厂把杂质含量低的熔融金属同偏析少的大型空心钢锭结合起来,已能生产重达320t的高质量钢靛。250t的实验性空心钢锭已经制造出来,目的是模拟相同尺寸空心钢锭的内部质量。1300MW压水堆压力容器零件和1100MW沸水堆压力容器零件锻造... 详细信息

水岛工厂把杂质含量低的熔融金属同偏析少的大型空心钢锭结合起来,已能生产重达320t的高质量钢靛。250t的实验性空心钢锭已经制造出来,目的是模拟相同尺寸空心钢锭的内部质量。1300MW压水堆压力容器零件和1100MW沸水堆压力容器零件锻造的环段,也已经用氧气顶吹转炉冶炼-RH脱气-空心钢锭浇注的方法制成。由于空心钢锭的均匀性,环段锻件偏析较少,而且内表面完好无缺陷。本文不仅概述了环段锻件的制造资料,而且概述了制造设备,包括4400t压力机、立车以及自动无损探伤设备。

关键词：空心钢锭制造设备压力容器锻件无损探伤设备内部质量熔融金属杂质含量

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Role of t-box transcription factor 3 in gastric cancers

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 12-20页

作者： Naoki Asano Akira Imatani Akio takeuchi Masashi saito Xiao-Yi Jin Waku Hatta Kaname Uno tomoyuki Koike Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

the expression of t-box transcription factor 3(tBX3)has been identified in various cancers,including gastric *** role in breast cancers and melanomas has been intensively studied,and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been *** reports on the role of tBX3 in gastric cancers have implied its involvement in gastric *** its pivotal role in the initiation and progression of cancers,tBX3 could be a promising therapeutic target for gastric cancers.

关键词： Aging Wnt β-catenin transforming growth factor-β Stomach Carcinogenesis

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7.在新型五辊式成型轧机上连轧异形金属带材的变形及受力特点

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钢管 1989年第2期18卷 37-43页

作者： Yoshihiro saito toshinari Watanabe 王国平日本大阪大学材料学与工程系

布置紧凑的新型成型连轧机的开发旨在用于轧制异形金属带材。该轧机由一个中心平面辊和在其四周配置的五个“卫星式”带孔型的轧辊组成。平薄板在中心辊和卫星辊间依次轧成异形金属带材。巳建造一台试验性连轧机,并且用平铝板几次试轧成... 详细信息

布置紧凑的新型成型连轧机的开发旨在用于轧制异形金属带材。该轧机由一个中心平面辊和在其四周配置的五个“卫星式”带孔型的轧辊组成。平薄板在中心辊和卫星辊间依次轧成异形金属带材。巳建造一台试验性连轧机,并且用平铝板几次试轧成t形和U形断面异形金属带材,还对该轧机的轧制特点进行了明确的阐述。试验表明这种新型轧机适合于轧制异形金属带材。

关键词：带材辊式连轧卫星式金属带铝板侧导板压下量轧制力轧制道次

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肝细胞癌动脉性富血供对比剂增强超声与钆塞酸二纳增强MRI评价的对照性研究

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国际医学放射学杂志 2012年第4期 401-402页

作者： K. Sugimoto F. Moriyasu J . Shiraishi K. saito J. taira t. Saguchi 唐光健 Department of Gastroenterology and Hepatology Tokyo Medical University6 -7 -1 Nishishinjuku Shinjuku-ku Tokyo 160 - 0023 Japan

摘要目的以Ct肝动脉增强(CtHA)影像为参照标准,对照对比剂增强(CE)超声与钆塞酸二钠增强MRI对肝细胞癌(HCC)与发育不良性结节(DN)动脉性富血管程度的评估。方法54例连续病人纳入研究,其中组织学证实HCC57个,DN(高分级)3个。所有病例均... 详细信息

摘要目的以Ct肝动脉增强(CtHA)影像为参照标准,对照对比剂增强(CE)超声与钆塞酸二钠增强MRI对肝细胞癌(HCC)与发育不良性结节(DN)动脉性富血管程度的评估。方法54例连续病人纳入研究,其中组织学证实HCC57个,DN(高分级)3个。所有病例均接受了CE超声、钆塞酸二钠增强MRI与CtHA检

关键词：超声对比剂 MRI 钆塞酸肝细胞癌

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Small undifferentiated intramucosal gastric cancer with lymph-node metastasis:Case report

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World Journal of Gastroenterology 2013年第20期19卷 3157-3160页

作者： tomoyuki Odagaki Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Hitoshi Katai Hirokazu taniguchi Ryoji Kushima Yutaka saito Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Gastric Surgery Division National Cancer Center HospitalTokyo 104-0045Japan Pathology Division National Cancer Center HospitalTokyo 104-0045Japan

It has been reported recently that small undifferentiated intramucosal early gastric cancer(EGC) < 20 mm in size without any lymphovascular involvement or ulcerative findings had virtually no risk of lymph-node(LN) **... 详细信息

It has been reported recently that small undifferentiated intramucosal early gastric cancer(EGC) thout any lymphovascular involvement or ulcerative findings had virtually no risk of lymph-node(LN) ***,the indications for endoscopic resection were expanded to include such undifferentiated EGC *** describe herein a case of a small undifferentiated intramucosal EGC thout lymphovascular involvement or ulcerative findings that involved lymph-node metastasis.A 57-year-old female underwent pylorus preserving gastrectomy as standard treatment for an undifferentiated EGC 15 mm in size without any ulcerative *** surgical specimen revealed a signet-ring cell carcinoma with a moderately to poorly differentiated adenocarcinoma limited to the mucosa that was 15 mm in size with no lymphovascular involvement or ulcerative *** case involved LN metastasis,however,and the lesion was diagnosed as pathological stage ⅡA(t1N2M0) according to the Japanese Classification of Gastric Carcinoma.

关键词： Early gastric cancer Endoscopic submucosal dissection Expanded indications Lymph-node metastasis Undifferentiated type

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利用低时间分辨力Gd-EOB-DtPA动态对比增强MRI测量肝储备功能:与半乳糖人血清白蛋白核素显像和吲哚氰绿滞留的初步对比研究

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国际医学放射学杂志 2014年第2期 185-186页

作者： K.saito J.Ledsam S.Sourbron t.Hashimoto Y.Araki S.Akata 滕泽 Department of Radiology Tokyo Medical University 67-1 Nishi-Shinjuku Shinjuku-ku TokyoJapan

目的本研究旨在探讨利用低时间分辨力GdEOB-DtPA动态对比增强(DCE)MRI的示踪动力学模型取代99tcm-半乳糖人血清白蛋白(GSA)单光子发射计算机体层

关键词：示踪动力学模型肝脏储备功能 GD-EOB-DtPA 半乳糖人血清白蛋白显像吲哚氰绿滞留

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先进涂层三元催化器的开发

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汽车与新动力 2021年第2期4卷 64-69页

作者： [日]Y.saito [日]I.CHINZEI [日]A.MORIKAWA [日]M.ItO [日]S.OISHI [日]t.OKUDA 陈佳(译) 不详

提高催化器性能可以改善排放,从而进一步保护环境。然而,从资源可利用的角度来看,也有进一步减少催化器活性组分中的贵金属含量的需求。为此开发了1款高性能的催化器,其采用了先进的涂层技术,减少了贵金属含量。发动机高压缩比和高废气... 详细信息

提高催化器性能可以改善排放,从而进一步保护环境。然而,从资源可利用的角度来看,也有进一步减少催化器活性组分中的贵金属含量的需求。为此开发了1款高性能的催化器,其采用了先进的涂层技术,减少了贵金属含量。发动机高压缩比和高废气再循环(EGR)率等降低燃油耗技术的应用通常会提高尾气中的碳氢(HC)/氮氧化物(NOx)比。研究了Pd在涂层中的涂覆位置,以提高催化器的HC催化活性。Pd对HC催化活性有较大影响,通过调整其在涂层中的涂覆位置可以改善其与尾气的接触程度。即使在空速较高的情况下也可以有效提高转化效率。对涂层结构进行了研究,尽可能提高其催化活性和储氧能力,以及提高涂层中的气体扩散性。通过控制每种涂层材料的颗粒尺寸可以提高催化剂的耐热性和储氧能力。通过细化氧化铝材料及构筑连接通道,以控制涂层厚度。这种涂层结构在不影响排气背压的情况下保证了气体扩散性。新开发的催化器具有较高的催化活性,贵金属含量减少了约20%。

关键词：催化剂碳氢涂层贵金属

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神经生长因子增加成年豚鼠气道和神经节P物质的含量

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中华结核和呼吸杂志 1997年第Z1期20卷 91-91页

作者： saito H tsukiji J Fu L Nishikawa M Ikeda H Okubo t 曾小明(译) FirstDepartmentofInternalMedicine YokohamaCityUniversitySchoolofMedicineYokohamaJapan

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