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接受抗高血压药治疗的高血压患者夜间高血压的影响因素

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中华高血压杂志(中英文) 2024年第3期32卷 300-300页

作者： Maruhashi t Kinoshita Y Ozono r Nakamaru M Ninomiya M Oiwa j Kawagoe t Yoshida O Matsumoto t Fukunaga Y Sumii K Ueda H Shiode N takahari K Hayashi Y Ono Y Nakano Y takahashi M Kihara Y Higashi Y 刘青练桂丽

背景：通过家庭血压监测（home blood pressure monitoring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备...

背景：通过家庭血压监测（home blood pressure monitoring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备评估的夜间高血压的影响因素。方法：研究者使用HBPM设备连续7d测量365例接受药物治疗的高血压患者的夜间血压、早晨血压、晚上血压和睡前血压。

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GraphFlow+:Exploiting Conversation Flow in Conversational Machine Comprehension with Graph Neural Networks

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Machine Intelligence research 2024年第2期21卷 272-282页

作者： jing Hu Lingfei Wu Yu Chen Po Hu Mohammed j.Zaki School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA rensselaer Polytechnic Institute Troy 12180USA

the conversation machine comprehension(MC)task aims to answer questions in the multi-turn conversation for a single ***,recent approaches don’t exploit information from historical conversations effectively,which results in some references and ellipsis in the current question cannot be *** addition,these methods do not consider the rich semantic relationships between words when reasoning about the passage *** this paper,we propose a novel model GraphFlow+,which constructs a context graph for each conversation turn and uses a unique recurrent graph neural network(GNN)to model the temporal dependencies between the context graphs of each ***,we exploit three different ways to construct text graphs,including the dynamic graph,static graph,and hybrid graph that combines the *** experiments on CoQA,QuAC and DoQA show that the GraphFlow+model can outperform the state-of-the-art approaches.

关键词： Conversational machine comprehension(MC) reading comprehension question answering graph neural networks(GNNs) natural language processing(NLP)

On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.j.GArCíA-GArCíA P.FArI?AS-ALVArI?O Department of Naval & Industrial Engineering Polytechnic School of EngineeringUniversity of A Coru?a Campus Industrial de Ferrol Integraciones técnicas de Seguridad S.A. Pol.Ind.Espíritu Santo

the transient friction in channel mean flows is the sum of two contributions,i.e., the underlying laminar flow(ULF) and the purely turbulent component(PtC), and the contributions are analyzed separately by theoretical experiments. It is found that,the transient friction may be higher or remarkably lower than that in equal-reynolds number steady-state flows. the universal time constant for plane-parallel laminar flows is reported, and the role of the time constant in a turbulent mean flow is examined. It is shown that the time constant is related to the turbulence's frozen time. Finally, a study of the logarithmic layer during the transient flow is accomplished, which shows that the logarithmic layer is destroyed.

关键词： 76D05 76D06 76F55 O361 transient flow transient friction unsteady channel flow

Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer j.Allen Stephanie M.Ntoukas Gordon j.Bell jessica McNeil Qinggang Wang Margaret L.McNeely jeff K.Vallance Lin Yang S.Nicole Culos-reed Leanne Dickau john r.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HrF)and patient-reported symptoms in newly diagnosed breast cancer ***:this study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pr sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(ptiple symptoms(ptrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:relative VO_(2peak)appears to be a critical HrF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

the evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff rex C.Haydon Hue H.Luu Sherwin Ho Michael j.Lee jason Strelzow russell r.reid tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

the evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells targeted therapy Wnt signaling

Water and thermal conditions variation and the vegetation response at semi⁃ arid Basin

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Shengtai Xuebao 2024年第16期44卷 7198-7212页

作者： Fang Q. Zhang S. Wang G. Wang Y. Duan L. Liu t. Yao j. School of Water Conservancy and Hydropower Engineering North China Electric Power University Beijing 102206 China College of Water Sciences Beijing Normal University Beijing 100875 China the College of Water Conservancy and Civil Engineering Inner Mongolia Agricultural University Hohhot 010018 China the School of Ecology and Environment Inner Mongolia University Hohhot 010021 China

recently, most semi⁃arid basins in China have experienced vegetation greening under significant water and thermal conditions changes, which has exacerbated the shortage of water resources despite the positive effect of increasing carbon sinks and reducing carbon emissions. the study of vegetation response under variations of water and thermal conditions can help to understand the mechanism of the balance between the hydrological processes and vegetation pattern and is of great significance for the sustainable utilization of water resources and ecological protection. However, few studies have focused on the time⁃periodic and segmented response mechanisms of vegetation dynamics to variations of water and thermal conditions, resulting in unclear mechanisms of trade⁃off between vegetation greening and water resources. this study analyzed the varied trends of water and thermal conditions and discussed the spatio⁃temporal response of vegetation from two points: overall trends and varied processes at the upper and middle Hailar river Basin from 1980 to 2012 by using trends and wavelet period analysis. the results show that: (1) spatially, the average annual precipitation increased and the temperature decreased from west (grassland) to east (forest). Compared with the grassland area, the runoff and the Normalized Difference Vegetation Index (NDVI) in the forest area showed larger, and indicated slower warming and larger precipitation declining. (2) temporally, the average annual precipitation and the runoff slightly decreased with a trend of 10 mm/ 10 a and 19.3 mm/ 10 a, respectively; the average annual temperature and NDVI in the growing season increased significantly with a trend of 0.65 ℃ / 10 a and 0.003—0.006/ 10 a, respectively. the results suggested that warming and drying inhibited the runoff and increased the vegetation growth, even in the context of precipitation increased and smooth increasing trend of temperature after 1998, showing the accumulative effect of w

关键词： runoff variations vegetation response water and thermal conditions water stress

recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： jeremy P.tervo Patricia t.jacobson Brandon j.Vilarello tiana M.Saak Francesco F.Caruana Liam W.Gallagher joseph B.Gary David A.Gudis Paule V.joseph D.P.Devanand terry E.Goldberg jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SArS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(tDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

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the proximity between hydroxyl and single atom determines the catalytic reactivity of rh1/CeO_(2) single-atom catalysts

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Nano research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou Congcong Du juan Li jianyu Huang Hong-xia Shen Abhaya K.Datye Shan jiang jeffrey t.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China College of Biology and Chemical Engineering Jiaxing UniversityJiaxing 314000China Department of Chemical&Biological Engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Fujian Key Laboratory of rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

the local structure of the metal single-atom site is closely related to the catalytic activity of metal single-atom catalysts(SACs).However,constructing SACs with homogeneous metal active sites is a challenge due to the surface heterogeneity of the conventional ***,we prepared two rh1/CeO_(2)SACs(0.5rh1/r-CeO_(2)and 0.5rh1/c-CeO_(2),respectively)using two shaped CeO_(2)(rod and cube)exposing different facets,i.e.,CeO_(2)(111)and CeO_(2)(100).In CO oxidation reaction,the t100 of 0.5rh1/r-CeO_(2)SACs is 120°C,while the t100 of 0.5rh1/c-CeO_(2)SACs is as high as 200°*** in-situ CO diffuse reflectance infrared Fourier transform spectroscopy(CO-DrIFtS),we found that the proximity between OH group and rh single atom on the plane surface plays an important role in the catalytic activity of rh1/CeO_(2)SAC system in CO *** rh single atom trapped at the CeO_(2)(111)crystal surface forms the rh1(OH)adjacent species,which is not found on the CeO_(2)(100)crystal surface at room ***,during CO oxidation,the OH group far from rh single atom on the 0.5rh1/c-CeO_(2)disappears and forms rh1(OH)adjacent species when the temperature is above 150°*** formation of rh1(OH)adjacentCO intermediate in the reaction is pivotal for the excellent catalytic activity,which explains the difference in the catalytic activity of rh single atoms on two different CeO_(2)*** formed rh1(OH)adjacent-O-Ce structure exhibits good stability in the reducing atmosphere,maintaining the rh atomic dispersion after CO oxidation even when pre-reduced at high temperature of 500°*** functional theory(DFt)calculations validate the unique activity and reaction path of the intermediate rh1(OH)adjacentCO species *** work demonstrates that the proximity between metal single atom and hydroxyl can determine the formation of active intermediates to affect the catalytic performances in catalysis.

关键词： crystal plane rh1/CeO_(2)single-atom catalyst proximity of rh and hydroxyl coordination structure CO oxidation

remarkably high fracture toughness of HfNbtatiZr refractory high-entropy alloy

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journal of Materials Science & technology 2022年第28期123卷 70-77页

作者： X.j.Fan r.t.Qu Z.F.Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nano Science and technology Institute University of Science and Technology of ChinaSuzhou 215132China

High-entropy alloys(HEAs)with face-centered cubic(FCC)phase such as CoCrFeMnNi or CoCrNi generally exhibit ultra-high fracture toughness but relatively low *** contrast,body-centered cubic(BCC)HEAs often display higher strengths,but the few reports on fracture toughness measurement demonstrate low toughness *** we show that the BCC HfNbtatiZr refractory HEA,which possesses a combination of high strength,good tensile ductility and excellent high-temperature properties,also exhibits a remarkably high fracture *** using the"single specimen"compliance method for j-integral measurement according to the AStM E1820–17 standard,its fracture toughness K_(jIC)was experimentally determined to be 210 MPa m^(1/2),which renders this HEA among the toughest metallic *** excellent damage tolerance makes the HEA promising for applications as high-temperature structural materials such as in aerospace field.

关键词： High-entropy alloys BCC structure Fracture toughness j-integral

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