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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates Blake Nassar Ethan Littlefield Elizabeth C.Martin Adam t.Melvin Cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the MCF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKt,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKt,p-mtOR,and p-StAt3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Reviewing 40 years of artificial intelligence applied to power systems-A taxonomic perspective

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Energy and AI 2024年第1期15卷 136-150页

作者： F.Heymann H.Quest t.Lopez Garcia C.Ballif M.Galus Swiss Federal Office for Energy(SFOE) Section Geoinformation and Digital InnovationIttigenSwitzerland Ecole Polytechnique Fédérale de Lausanne(EPFL) Photovoltaics and Thin-Film Electronics Laboratory(PV-LAB)Institute of Electrical and Micro Engineering(IEM)NeuchâtelSwitzerland 3S Swiss Solar Solutions AG ThunSwitzerland Swiss Center for Electronics and Microtechnology(CSEM) Sustainable Energy CenterNeuchâtelSwitzerland Digital Energy and Electric Power Lucerne University of Applied Sciences and ArtsLucerneSwitzerland

Artificial intelligence(AI)as a multi-purpose technology is gaining increased attention and is now widely used across all sectors of the *** growing complexity of planning and operating power systems makes AI extremely valuable for the power *** now,there has been a lack of clarity regarding the specific points along the power system supply chain where AI applications demonstrate significant value,as well as which AI domains are best suited for such *** study employs an AI taxonomy and automated web search to qualitatively and quantitatively unveil the biggest potentials of AI in the power *** analysis,based on a review of 258’919 publications between 1982 and 2022,reveals where AI applications are particularly *** consider six AI domains(reasoning,planning,learning,communication,perception,integration&interaction)and 19 use cases from the power supply chain(i.e.,generation,transmission networks,distribution networks,isolated grids/microgrids,market operations and retail).Our findings indicate that,as of now,the focus is predominantly on AI applications in power retail(55%),transmission(14%)and generation(13%).Most analyzed works describe applications built on algorithms of the AI domains“learning”(45%)and“planning”(14%).Results also suggest that the current definition of AI domains is ambiguous,and they highlight missing information on the actual use and successful implementation of AI in power system use cases.

关键词： Artificial intelligence Power systems Electricity taxonomy Policy

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基于mRMR-XGBoost的水稻关键生育期识别

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农业工程学报 2024年第15期40卷 111-118页

作者：冯健昭潘永琪熊悦淞吴彻肖德琴华南农业大学数学与信息学院广州510642 华南农业大学农业农村部华南热带智慧农业技术重点实验室广州510642 广州华农大智慧农业科技有限公司广州510642

针对目前使用无人机识别水稻关键生育期时光谱数据特征维度高和冗余,导致模型准确率和泛化能力不足的问题,该研究提出一种基于最优特征组合的水稻关键生育期(分蘖期、拔节期、抽穗期、乳熟期、完熟期)识别方法。首先使用无人机采集田间... 详细信息

针对目前使用无人机识别水稻关键生育期时光谱数据特征维度高和冗余,导致模型准确率和泛化能力不足的问题,该研究提出一种基于最优特征组合的水稻关键生育期(分蘖期、拔节期、抽穗期、乳熟期、完熟期)识别方法。首先使用无人机采集田间光谱图像,基于相对植被指数和迭代自组织数据分析算法对光谱图像进行分割,以有效提取水稻冠层区域。然后对水稻生育期的关键特征进行表达,采用最小冗余特征选择算法对特征进行重要性排序,并通过增量分组法确定最优特征组合。最后基于极度梯度提升算法构建水稻生育期的识别模型。对比试验结果显示,本文模型对5个关键生育期的识别较好,混淆情况少,对水稻分蘖期、拔节期、抽穗期、乳熟期和完熟期识别精确率分别为98.08%、100.00%、99.68%、97.50%和99.29%,整体识别精确率达到98.77%,F1值为0.9891,Kappa系数为0.984,相比于SVM(支持向量机)分别提高了1.59个百分点、0.0146和0.02,相比于RF(随机森林)分别提升了1.23个百分点、0.011和0.015。研究结果可为田间作物的精准管理和决策提供重要依据。

关键词：水稻机器学习生育期光谱图像识别

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Al-Ca-Fe合金中Al_(10)CaFe_(2)化合物的形成与表征

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transactions of Nonferrous Metals Society of China 2024年第2期34卷 361-377页

作者： N.A.BELOV t.K.AKOPYAN E.A.NAUMOVA V.V.DOROSHENKO t.A.SVIRIDOVA N.O.KOROtKOVA National University of Science and technology MISIS 4 Leninsky pr.Moscow 119049Russia Baikov Institute of Metallurgy and Materials Science 49 Leninsky pr.Moscow 119991Russia

采用热力学计算和实验技术研究铝角的Al-Ca-Fe体系相图,包括液相面投影图和凝固反应。结果表明,与铝固溶体(Al)平衡的不是Al_(3)Fe相,而是一种组成符合化学式Al_(10)CaFe_(2)的三元化合物。通过包晶转变L+Al_(3)Fe→(Al)+Al_(10)CaFe_(2... 详细信息

采用热力学计算和实验技术研究铝角的Al-Ca-Fe体系相图,包括液相面投影图和凝固反应。结果表明,与铝固溶体(Al)平衡的不是Al_(3)Fe相,而是一种组成符合化学式Al_(10)CaFe_(2)的三元化合物。通过包晶转变L+Al_(3)Fe→(Al)+Al_(10)CaFe_(2)(638℃,3.3%Ca和0.5%Fe,摩尔分数)发生从二元化合物到三元化合物的转变。与针状Al_(3)Fe相夹杂物不同,三元化合物的初晶和共晶具有致密的形貌。使用第一性原理计算和X射线衍射分析确定三元化合物Al_(10)CaFe_(2)的晶格结构。此外,近共晶合金Al-6%Ca-1%Fe(质量分数)在500~600℃退火后具有细晶组织,过量相的总体积分数约为25%。因此,Al-Ca-Fe体系可用于制造新的铝基复合合金。

关键词： Al-Ca合金金属间化合物相图相变显微组织铝基复合材料

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Biochemical recurrence of pathological t2+localized prostate cancer after robotic-assisted radical prostatectomy:A 10-year surveillance

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World Journal of Clinical Cases 2021年第5期9卷 1026-1036页

作者： che Hseuh Yang Yi Sheng Lin Yen Chuan Ou Wei Chun Weng Li Hua Huang Chin Heng Lu Chao Yu Hsu Min che tung Division of Urology Department of SurgeryTungs'Taichung MetroHarbor HospitalTaichung 435403Taiwan

BACKGROUND pt2+prostate cancer(PCa),a term first used in 2004,refers to organ-confined PCa characterized by a positive surgical margin(PSM)without extracapsular *** with a PSM are vulnerable to biochemical recurrence(BCR)following radical prostatectomy(RP);however,whether adjuvant radiotherapy(aRt)is imperative to PSM after RP remains *** study had the longest follow-up on pt2+PCa after robotic-assisted RP since ***,we discussed our viewpoints on pt2+PCa based on real-world *** to conclude a 10-year surveillance on pt2+PCa and compare our results with those of the published *** Forty-eight patients who underwent robotic-assisted RP between 2008 and 2011 were *** serial tests of prostate specific antigen(PSA)≥0.2 ng/mL were defined as *** designed factors were analyzed using statistical tools for BCR *** 9.4 was applied and significance was defined as Ptivariate,linear regression,and receiver operating characteristic(ROC)curve analyses were performed for statistical *** With a median follow-up period of 9 years,25(52%)patients had BCR(BCR group),and the remaining 23(48%)patients did not(non-BCR group).the median time for BCR test was 4 years from the first postoperative PSA *** PSA was significantly different between the BCR and non-BCR groups(Ptive PSA suggested a cutoff value of 19.09 ng/mL(sensitivity,0.600;specificity:0.739).the linear regression analysis showed no correlation between time to BCR and preoperative PSA(Pearson’s correlation,0.13;adjusted R2=0.026).CONCLUSION Robotic-assisted RP in pt2+PCa of worse conditions can provide better BCR-free survival.A surgical technique limiting the PSM in favorable situations is warranted to lower the pt2+PCa BCR *** PSA cut-off value of 19.09 ng/mL is a predictive factor for *** on our experiences and review of the literat

关键词： Prostatectomy/methods Robotic surgical procedures Prostatic neoplasms/pathology Prostate-specific antigen/metabolism Margins of excision Retrospective study

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Evaluation of a hepatic biomarker of nutritional imbalance in juvenile red drum(Sciaenops ocellatus) fed 60% soybean meal-based diets using NMR-based metabolomics

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Animal Nutrition 2024年第1期16卷 45-61页

作者： Fabio Casu Aaron M.Watson Justin Yost t.Gibson Gaylord Daniel W.Bearden Michael R.Denson Marine Resources Research Institute South Carolina Department of Natural Resources Bozeman Fish technology Center United States Fish and Wildlife Service Marine Biochemical Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-week feeding trial with juvenile red drum(Sciaenops ocellatus) fed high-soybean meal(SBM) diets was conducted to investigate a putative biomarker of nutritional imbalance, N-formimino-L-glutamate(FIGLU). three fishmeal-free, 60% SBM pelleted diets(named B12, Fol, and Met, respectively) were tested to evaluate the effects on growth performance and tissue metabolite profiles of supplementation of vitamin B12(0.012 mg/kg), folate(10 mg/kg), methionine(1 g/kg) respectively, above basal supplementation levels. A fourth SBM-based diet(named B12/Fol/Met) was formulated with a combination of B12, folate, and methionine to attain the above-mentioned target concentrations. A fifth 60% SBM diet(named FWS) with methionine supplementation(1 g/kg above basal supplementation levels), enriched with taurine, lysine and threonine as well as minerals, was also tested. this diet contained formulation targets and additives which have allowed for replacing fishmeal with plant proteins in rainbow trout feeds. Control diets included a fishmeal-based diet(named FM), an unsupplemented basal 60% SBM diet(named SBM60), and a “natural” diet(named N) made up of equal parts of fish(cigar minnows), squid and shrimp as a positive reference for growth performance. Formulated feeds contained approximately 37% total crude protein, approximately 14% total crude lipid and were energetically balanced. Standard growth performance metrics were measured, and tissues(liver, muscle) were collected at week 12 to evaluate diet-induced metabolic changes using nuclear magnetic resonance(NMR)-based *** results show that the FWS diet outperformed all other SBM diets and the FM diet under all performance metrics(Pt detected in fish fed the N diet but was detected in those fed the SBM diets and the FM diet. Fish fed the FWS diet and the Met diet showed lower hepatic levels of FIGLU compared with the other SBM-based diets(Pting that among the different supplementatio

关键词： Aquaculture Metabolomics Nuclear magnetic resonance Red drum Soybean meal N-Formimino-L-glutamate

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Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： B.Li D.Vretenar t.Nikšić J.Zhao P.W.Zhao J.Meng State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Physics Department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

the generalized time-dependent generator coordinate method(tD-GCM)is extended to include pairing *** correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and weight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,while pairing is treated dynamically in the standard BCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** model is applied to the description of saddle-to-scission dynamics of induced *** generalized tD-GCM charge yields and total kinetic energy distribution for the fission of 240Pu,are compared to those obtained using the standard time-dependent density functional theory(tD-DFt)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics

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Marine yeast Rhodotorula paludigena VA 242 a pigment enhancing feed additive for the Ornamental Fish Koi Carp

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Aquaculture and Fisheries 2024年第1期9卷 66-70页

作者： R.Rekha K.A.Nimsi K.Manjusha t.K.Sirajudheen Faculty of Ocean Science&technology Kerala University of Fisheries and Ocean Studies(KUFOS)CochinKerala682506India

Skin colour is an important criterion in determining the aesthetic appeal of ornamental fishes,and thus their market *** the pigment enhancement in ornamental fishes has been the subject of extensive research by using various synthetic as well as natural pigment *** composition is one of the most important elements that influence the development of pigmentation in *** study is an attempt to assess the possibility of using carotenogenic marine yeast as pigment enhancer in fish diet for Koi carp,Cyprinus *** 60 days feeding experiment was done by using feed incorporated with mangrove associated marine yeast Rhodotorula paludigena *** pigmentation in the scales of fishes fed with experimental feed was observed than that fed with the control diet(normal pellet feed).Furthermore the improved growth rate and general wellbeing in fishes fed with experimental feed provides scope for further studies in this field with respect to the growth and survival of fishes.

关键词： Marine yeasts Carotenoids Ornamental fishes Pigment enhancer Feed additive Rhodotorula sp

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Mechanism of action, benefits, and research gap in fermented soybean meal utilization as a high-quality protein source for livestock and poultry

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Animal Nutrition 2024年第1期16卷 130-146页

作者： Modinat t.Lambo Haokai Ma Haosheng Zhang Peng Song Hongxiang Mao Guowen Cui Baisheng Dai Yang Li Yonggen Zhang College of Animal Science and technology Northeast Agricultural University Wilmar (Shanghai) Biotechnology Research and Development Center Co. Ltd College of Electrical Engineering and Information Northeast Agricultural University

Animal nutritionists have incessantly worked towards providing livestock with high-quality plant protein feed *** meal (SBM) has been an essential and predominantly adopted vegetable protein source in livestock feeding for a long time;however,several SBM antinutrients could potentially impair the animal's performance and growth,limiting its *** processing methods have been employed to remove SBM antinutrients,including fermentation with fungal or bacterial *** to the literature,fermentation,a traditional food processing method,could improve SBM's nutritional and functional properties,making it more suitable and beneficial to *** current interest in health-promoting functional feed,which can enhance the growth of animals,improve their immune system,and promote physiological benefits more than conventional feed,coupled with the ban on the use of antimicrobial growth promoters,has caused a renewed interest in the use of fermented SBM (FSBM) in livestock *** review details the mechanism of SBM fermentation and its impacts on animal health and discusses the recent trend in the application and emerging advantages to livestock while shedding light on the research gap that needs to be critically addressed in future *** appears to be a multifunctional high-quality plant protein source for *** removing soybean antinutrients,beneficial bioactive peptides and digestive enzymes are produced during fermentation,providing probiotics,antioxidants,and immunomodulatory *** aspects regarding FSBM feeding to animals remain uncharted,such as the duration of fermentation,the influence of feeding on digestive tissue development,choice of microbial strain,and possible environmental impact.

关键词： Soybean meal Protein feed Fermentation Microorganism Livestock

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Satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael t.Resende Lee Hickey Cibele H.Amaral Lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil theCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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