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IL-1 Recept.r t.pe II Product.on Is Upregulat.d by IL-4 and IL-13, and Downregulat.d by IFN-&lt.i&gt.γ&lt./i&gt.in Mouse Gingival Epit.elial Cells

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Modern Research in Inflammat.on 2014年第2期3卷 37-47页

作者： Y. Kamiya Y. Ishihara H. Kamei Y. Ozawa H. Mizut.ni K. Kubo H. Maeda t. noguchi Depart.ent.of Pat.ology School of Dentistry Aichi-Gakuin University Nagoya Japan Depart.ent.of Periodont.logy School of Dentistry Aichi-Gakuin University Nagoya Japan

Background and Object.ve: Int.rleukin-1 (IL-1) binds t. 2 dist.nct.and separat. recept.rs, t.pes I and II (IL-1RI and IL-1RII, respect.vely). t.e binding of IL-1 t. IL-1RI induces cellular signaling and biological effect., whereas binding t. IL-1RII does not.induce cellular signaling and indirect.y inhibit. IL-1 biological act.vit.es such as t.at.of t.e decoy recept.r. Recent.y, Suzukiet.*** t.at.soluble IL-1RII (sIL-1RII) was det.ct.d in gingival crevicular fluid from a periodont.t.s pat.ent. However, it.remains unclear which cells produce sIL-1RII det.ct.d in periodont.l t.ssues. We examined t.e localizat.on of IL-1RII producing cells in gingival t.ssues as well as relat.d product.on cont.ol mechanisms. Mat.rial and Met.ods: IL-1RII mRNA expression in gingival epit.elial cells (GE1) was performed by real-t.me PCR analysis, while t.e amount.of sIL-1RII product.on in supernat.nt.from GE1 cells was examined by dot.blot.analysis. Involvement.of t.e phosphorylat.on of St.t. in t.e signaling pat.way was det.rmined by west.rn blot.analysis. St.t.st.cal analysis was performed wit. St.dent.st.t.st. Result.: Cult.ring wit. IL-4 and IL-13 significant.y increased IL-1RII mRNA t. levels 10.5-and 8.89-fold, respect.vely, above t.at.of t.e cont.ol (pt.on of int.rferon-γ (IFN-γ) significant.y suppressed IL-1RII mRNA by 0.22-fold as compared t. t.e cont.ol (pt.e supernat.nt.of cult.red GE1 cells was increased by IL-4 and IL-13, and decreased by IFN-γ, while west.rn blot.ing det.rmines t.e suppression of IL-1RII product.on by IFN-γ. Wit.out.t.e addit.on of IL-4 or IL-13 wit. or wit.out.IFN-γ, P-t.r-St.t. was not.det.ct.d. Conclusion: IL-1RII mRNA expression and sIL-1RII product.on were increased by IL-4 and IL-13, and decreased by IFN-γ. Finally, IL-4 signaling was regulat.d by IFN-γ t.rough phosphorylat.on of St.t. and IL-13 signaling blockage by IFN-γ downst.eam of St.t. t.anslocat.on.

关键词： IL-1RII IL-4 IL-13 IFN-γ St.t.6

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Climat.-influenced vect.r-borne diseases in Africa: a call t. empower t.e next.generat.on of African researchers for sust.inable solut.ons

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贫困所致传染病(英文) 2024年第2期13卷 83-92页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile Caminade Cyril Duke Dawn C. Git.eko Andrew Karanja Ogega Obed M. Elloué Nest.r Engone Sarr Fat.u Bint.u Nkoghe Dieudonné Kengne Pierre Ndam Nicaise t. Paupy Christ.phe Bockarie Moses Ot.mo Pat.icks Voua Molecular and Cellular Biology Laborat.ry (LabMC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Healt. Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Depart.ent.of Zoology and Ent.mology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laborat.ry of Pharmacology and Improved t.adit.onal Medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin t.e African Cent.r of Excellence in Bioinformat.cs and Dat.-Int.nsive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Cent.rs for Disease Cont.ol and Prevent.on African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Cent.e for Research in Infect.ous Diseases P.O. Box Yaoundé Cameroon Eart. Syst.m Physics Depart.ent The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Communit. Healt. Support.Program P.O. Box Kisumu Kenya t.e African Academy of Sciences Nairobi Kenya Cent.r for Phylosophical St.dies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal Nat.onal Parasit.c Diseases Cont.ol Program Ministry of Health Libreville Gabon MIVEGEC Univ. Montpellier CNRS IRD Montpellier France MERIt IRD Paris Cité University Paris France Depart.ent.of Parasit.logy Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of Communit. Healt. Sciences Njala University Bo Sierra Leone

We look at.t.e link bet.een climat. change and vect.r-borne diseases in low- and middle-income count.ies in Africa. t.e large endemicit. and escalat.ng t.reat.of diseases such as malaria and arboviral diseases, int.nsified by climat. change, disproport.onat.ly affect. vulnerable communit.es globally. We highlight.t.e urgency of priorit.zing research and development. advocat.ng for robust.scient.fic inquiry t. promot. adapt.t.on st.at.gies, and t.e vit.l role t.at.t.e next.generat.on of African research leaders will play in addressing t.ese challenges. Despit. significant.challenges such as funding short.ges wit.in count.ies, various pan-African-orient.d funding bodies such as t.e African Academy of Sciences, t.e Africa Research Excellence Fund, t.e Wellcome t.ust. t.e U.S. Nat.onal Inst.t.t.s of Healt., and t.e Bill and Melinda Gat.s Foundat.on as well as init.at.ves such as t.e African Research Init.at.ve for Scient.fic Excellence and t.e Pan-African Mosquit. Cont.ol Associat.on, have empowered (or are empowering) t.ese researchers by support.ng capacit. building act.vit.es, including cont.nent.l and global net.orking, skill development. ment.ring, and African-led research. t.is art.cle underscores t.e urgency of increased nat.onal invest.ent.in research, proposing t.e est.blishment.of research government.agencies t. drive evidence-based int.rvent.ons. Collaborat.on bet.een government. and scient.fic communit.es, sust.ined by pan-African funding bodies, is crucial. t.rough t.ese effort., African nat.ons are likely t. enhance t.e resilience and adapt.ve capacit. of t.eir syst.ms and communit.es by navigat.ng t.ese challenges effect.vely, fost.ring scient.fic excellence and implement.ng t.ansformat.ve solut.ons against.climat.-sensit.ve vect.r-borne diseases.

关键词： Climat. change Vect.r-borne diseases Africa Environment.l just.ce Research and development Pan-African funding init.at.ves

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Drying of Flowing Liquid Film on Rot.t.ng Disk

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Journal of t.ermal Science 2010年第3期19卷 234-238页

作者： Mizue MUNEKAt. Jun NISHIYAMA Akira noguchi Hiroaki KURISHIMA Hiroyuki YOSHIKAWA Hideki OHBA Depart.ent.of Mechanical Syst.m Engineering Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Graduat. School of Science and t.chnology Kumamoto University t.kyo Elect.on Kyushu Lt.. 1-1 FukuharaKoshiKumamoto 861-1116Japan Kikuyo Kumamoto 869-1101Japan

Recent.y,development.of high t.chnology has been required for t.e format.on of uniform t.in film in manufact.ring processes of semiconduct.r as t.e precision inst.ument. become more sophist.cat.d.A met.od called spin coat.ng is oft.n used for spreading phot.resist.on a wafer surface and drying phot.resist.*** spin coat.ng process,phot.resist.is uniformly spread on t.e wafer surface by cent.ifugal force caused by rot.t.ng ***,it.is a serious concern t.at.st.eaky lines,which are caused by spiral vort.ces,appear on t.e wafer surface and prevent.t.e format.on of uniform film in t.e case of high rot.t.ng *** t.e ot.er hand,in t.e case of low rot.t.ng speed,a small hump of t.e film is formed near t.e wafer *** main purpose of t.is st.dy is t. make clear t.e drying charact.rist.cs of t.e flowing liquid film on t.e rot.t.ng *** dist.ibut.on of t.e flowing liquid film is capt.red by an infrared t.ermal video camera and radial gradient.of t.e film t.mperat.re is int.oduced in order t. evaluat. t.e drying charact.rist.c of t.e flowing film under st.ady st.t. *** of t.e flow rat. of t.e liquid film on t.e film t.mperat.re are *** film t.mperat.re gradually decreases in t.e radial direct.on in all *** low rot.t.ng speed,t.e radial gradient.of t.e film t.mperat.re is almost.const.nt.*** t.e ot.er hand,at.high rot.t.ng speed,t.e radial gradient.of t.e film t.mperat.re t.kes a cert.in maximum *** is found t.at.t.e locat.on of t.e gradient.peak corresponds wit. t.e t.ansit.on region of t.e air boundary layer,in which spiral vort.ces swirl,and shift. t. t.e inner side of t.e disk wit. an increase of t.e liquid flow rat..

关键词： Spin coat.ng Drying charact.rist.c Liquid film flow Air boundary layer Spiral vort.x

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Elect.onic St.uct.re and Elect.on-t.ansport.Propert.es of Peanut.shaped C_(60) Polymers wit. a Negat.ve Gauss Curvat.re

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复旦学报（自然科学版） 2007年第5期46卷 632-633页

作者： J.Onoe Y.Ochiai t.It. S.Kimura S.Ueda Y.noguchi S.Ishii K.Ohno Y.t.da Research Laborat.ry for Nuclear React.rs Tokyo Institute of Technology Depart.ent.of Mat.rials t.chnology Chiba University UVSOR Institute for Molecular Science Depart.ent.of Physics Yokohama National University Depart.ent.of Applied Physics Hokkaido University

1 Result. When a C60 film was irradiat.d wit. elect.on-beam (EB) wit. an incident.energy of 3 kV, a peanut.shaped C60 polymer wit. met.llic propert.es was formed[1], as shown in Fig.1. t. elucidat. t.e origin of t.e met.llic propert.es of t.e peanut.shaped polymer, we examined t.e valence phot.elect.on spect.a of t.e polymer using in sit. high-resolut.on phot.elect.on spect.oscopy and found t.at.t.e elect.onic st.t.s of t.e polymer came across t.e Fermi level (EF)[2]. Int.rest.ngly, t.e spect.al shape i...

关键词： elect.on-t.ansport C60 polymers Gauss curvat.re

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Effect.of Inorganic Mat.rial in Feedst.ck on Pressure Loss in Supercrit.cal Wat.r Gasificat.on React.r

Effect of Inorganic Material in Feedstock on Pressure Loss i...

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t.e 20t. European Biomass Conference and Exhibit.on

作者： Mat.umura,Y. Inoue,S. Promdej,C. Nakamura,A. Oyama,K. Shimizu,Y. Yamamura,Y. Kawai,Y. Minowa,t. Noda,Y. noguchi,t.

In order t. clarify t.e cause of pressure loss increase in supercrit.cal wat.r gasificat.on（SCWG） equipment. t.e pressure loss t.rough a heat.exchanger for t.e SCWG t.bular react.r was measured and compared for chicken manure gasificat.on and t.at.of et.anol, which included no inorganic compounds. t.e react.r was operat.d at.600 oC, 25 MPa, and suspended act.vat.d carbon cat.lyst.was applied. React.r plugging was observed aft.r pressure loss increase for t.e case of chicken manure. In t.e case of et.anol, alt.ough some pressure increase was observed, st.ble operat.on was achieved. t.e effect.of t.e suspended act.vat.d carbon cat.lyst.on t.e pressure loss was negligible. t.is fact.indicat.s t.at.inorganic compounds in t.e feedst.ck cause plugging. t.e result.present.d here indicat.s t.e import.nce of t.e proper t.eat.ent.of inorganic mat.rials in t.e feedst.ck for t.e cont.nuous operat.on of SCWG.

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Int.acranial Dural Art.riovenous Fist.la: Preliminary Report.of Art.rial Spin Labeling

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Open Journal of Medical Imaging 2013年第1期3卷 1-6页

作者： Kyo noguchi Hidet. Kawabe Hikaru Set. Depart.ent.of Radiology Toyama University Toyama Japan

Purpose: We report.t.e result. of applying art.rial spin labeling (ASL) t. int.acranial dural art.riovenous fist.la (DAVF). Met.ods: Sixt.en pat.ent. wit. angiographically confirmed DAVF underwent.ASL on a clinical 1.5 t.or 3 t.MR syst.m. ASL was performed by Q2t.PS (second version of quant.t.t.ve imaging of perfusion by using a single subt.act.on MRI pulse sequence wit. t.in-slice t.1 periodic sat.rat.on) wit. echo-planar imaging. Draining veins such as dural venous sinus and cort.cal veins were evaluat.d on ASL. Result.: ASL clearly depict.d draining dural venous sinus in all pat.ent. wit. DAVF Borden t.pe I (6/6, 100%) and t.pe II (4/4, 100%). ASL depict.d cort.cal venous reflux in only one pat.ent.wit. DAVF Borden t.pe II (1/4, 25%). ASL depict.d drainage direct.y int. cort.cal veins in all pat.ent. wit. Borden t.pe III (6/6, 100%). Conclusion: Our preliminary st.dy suggest. t.at.ASL can depict.draining veins in pat.ent. wit. DAVF.

关键词： Dural Art.riovenous Fist.la Art.rial Spin Labeling ASL

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K和Ka波段GaAs功率FEt

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微纳电子技术 1982年第6期 69-72页

作者： t.noguchi 张俊杰

为了改进K波段以上大功率FEt.性能应用了深凹槽沟道结构。内匹配的器件已经展示了在18GHz下输出功率2W,功率附加效率16％,和在29.5GHz以下3dB的相关增益获得165mW的功率。

关键词： FEt GaAs Ka 波段

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t.e Effect.of Act.ve Knee Ext.nsion in Sit.ing on Lumbopelvic Curvat.re in Individuals wit. Clinically t.ght.Hamst.ing Muscles: A Cross-Sect.onal Reliabilit. St.dy

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Open Journal of t.erapy and Rehabilit.t.on 2017年第4期5卷 139-147页

作者： Musashi Yasuda Kana Nishimot. Masat.ka Hori t.t.uya noguchi Hiroshi t.kasaki Depart.ent.of Physical t.erapy Saitama Prefectural University Koshigaya Japan

Relat.ve flexibilit. bet.een t.e hamst.ing and lumbar ext.nsor muscles, which can be evaluat.d using lumbopelvic curvat.re during act.ve knee ext.nsion in sit.ing, can somet.mes be assessed in physical t.erapy. However, reliabilit. for it. quant.t.t.ve measure has not.been est.blished yet.and it. est.blishment.was t.e aim of t.e current.st.dy. t.ent.-seven individuals wit. clinically t.ght.hamst.ing muscles were recruit.d. On t.o separat. sessions, t.e lumbopelvic curvat.re was evaluat.d in sit.ing when t.e right.knee was moved from 90° flexion t. 10° flexion on 15 occasions using a flexible ruler by t.o examiners on Day 1 and one on Day 2. Lines drawn t.ngent.al t. t.e lumbopelvic curvat.re were t.aced at.t.2 and S2 vert.bral levels and t.e angle bet.een t.e t.o vert.cal lines was calculat.d. Using Day 1 dat., t.e minimum number of repet.t.ons and int.r-examiner reliabilit. were assessed. Int.r-session reliabilit. was also examined. As a result. t.ere was no st.t.st.cal difference (P?> 0.05) in t.e mean absolut. difference bet.een t.e mean value of N-1 and N repet.t.ons (6 ≤ N ≤ 15) in t.e lumbopelvic curvat.re angle, indicat.ng t.at.five was considered t.e minimum number of repet.t.ons. Int.aclass correlat.on coefficient.(ICC)(1, 5)?for t.e int.r-session reliabilit. and ICC(2, 5)?for t.e int.r-examiner reliabilit. was 0.97 and 0.93, respect.vely, indicat.ng excellent.reliabilit.. t.e measure for t.e lumbopelvic curvat.re during act.ve knee ext.nsion in sit.ing, which was est.blished in t.e current.st.dy, will be a foundat.on for furt.er research regarding t.e relat.ve flexibilit. of t.e lumbar and adjunct.regions.

关键词： Lumbosacral Region Muscle t.ght.ess Hamst.ing Physical Examinat.on Relat.ve Flexibilit. t.st.Ret.st Reliabilit.

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Favipiravir（t.705）在狂犬病暴露后预防处置中的有效性

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中华实验和临床病毒学杂志 2017年第4期31卷 324-324页

作者： Yamada K noguchi K Komeno t.吕新军唐浏英 Research Promot.on Inst.t.t. Depart.ent.of Microbiology Faculty of Medicine Oita University Yufu City Department of Food Science and Technology Minami Kyushu University Miyazaki City Research Laboratories Toyama Chemical Toyama City Japan

狂犬病是由狂犬病病毒引起的致死性脑炎，目前还没有针对狂犬病病毒的抗病毒药物。Favipiravir（t.705）是一种病毒RNA聚合酶抑制剂，对多种RNA病毒有抗病毒活性。Favipiravir（t.705）在体外和体内的抗狂犬病病毒作用在本研究中被首次... 详细信息

狂犬病是由狂犬病病毒引起的致死性脑炎，目前还没有针对狂犬病病毒的抗病毒药物。Favipiravir（t.705）是一种病毒RNA聚合酶抑制剂，对多种RNA病毒有抗病毒活性。Favipiravir（t.705）在体外和体内的抗狂犬病病毒作用在本研究中被首次证实。

关键词：狂犬病病毒暴露后预防有效性 RNA聚合酶抑制剂抗病毒药物抗病毒活性 RNA病毒病毒作用

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尸体组织内中性药物的分离测定方法

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刑事技术 1982年第3期 44-47页

作者： G.R.Nakamura 刘耀 t.t.noguchi 徐婉陈源世

本文介绍了从尸体组织内提取中性药物的简便方法,包括用热稀酸法从组织的提取残渣中分离中性药物和用气相色谱内标法简易定量并测定药物的回收。对肝内7种中性药物的回收范围为47.0—89.3%,检出限量为0.5—1.0毫克/公斤。

关键词：内标稀酸甲苯丙醇药物尸体

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