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MicroRNAs in hepatocellular carcinoma treatment:Charting the path forward

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World Journal of gastroenterology 2024年第11期30卷 1470-1474页

作者： Hong t lin Antonio F Alvarez Castaneda Somashekar g Krishna Khalid Mumtaz Division of gastroenterology Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recognized for their involvement in the regulation of gene expression and exhibit significant potential in both the prognostic assessment and treatment of hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;instead,it evolves within a microenvironment featuring oncogenic and tumor-suppressive *** combined with suitable delivery vehicles,miRNA technology provides the capability to directly engage with these elements,thereby hindering tumor formation and *** research in this domain holds the promise of enabling a more efficacious and multi-modal treatment approach for HCC in the near future.

关键词： Hepatocellular carcinoma tumor microenvironment MicroRNA Mesenchymal stem cell Exosome

Creep-induced redistribution of alloying elements in CZ1 zirconium alloys

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Journal of Materials Science & technology 2024年第6期173卷 31-44页

作者： W.t.lin Q.Y.Lv D.Jiao L.B.Zhang J.tan g.Sha J.Hu China Nuclear Power technology Research Institute Shenzhen 518026China School of Material Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Introducing minor alloying elements is an effective strategy to improve the corrosion and mechanical properties of zirconium alloys for nuclear *** in-reactor service,external environment and stress can affect the distribution of alloying elements,substantially changing the degradation process of zirconium *** date,there is a lack of in-depth understanding of the interaction between creep and microchemistry ***,we conducted systematic transmission electron microscopy(tEM)and atom probe tomography(APt)investigations to address creep-induced redistribution of alloying elements in CZ1(Zr-Sn-Nb-Fe-Cr-Cu)zirconium alloy with different initial ***,Fe,Sn,and Cu are found to co-segregate at grain *** higher the intermediate annealing temperature,the larger the gibbsian interfacial excesses of solute elements *** further demonstrate that creep can reduce the excess value of Fe at grain boundaries due to the coarsening of Zr-Fe-Cr second phase particles via grain boundary and dislocation pipe *** the same time,the excess value of Sn is increased by diffusing from the matrix to grain ***,Cu as a minor element in the concentration range of 0.05-0.3 wt.%is found to segregate at dislocations to form the Cottrell atmosphere and develop Cu-rich nanoclusters for suppressing dislocation *** new understanding of the segregation and clustering of minor alloying elements provides guidance for developing zirconium alloys with enhanced creep resistance.

关键词： Zirconium alloy thermal creep grain boundary segregation Dislocation segregation Cu-rich nanoclusters

Nomograms and prognosis for superficial esophageal squamous cell carcinoma

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World Journal of gastroenterology 2024年第10期30卷 1291-1294页

作者： Hong tao lin Ahmed Abdelbaki Somashekar g Krishna Department of Internal Medicine Division of GastroenterologyHepatology and NutritionThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

In recent years,endoscopic resection,particularly endoscopic submucosal dis-section,has become increasingly popular in treating non-metastatic superficial esophageal squamous cell carcinoma(ESCC).In this evolving paradigm,it is crucial to identify factors that predict higher rates of lymphatic invasion and poorer *** tumor size,deeper invasion,poorer differentiation,more infiltrative growth patterns(INF-c),higher-grade tumor budding,positive lymphovascular invasion,and certain biomarkers have been associated with lymph node metastasis and increased morbidity through retrospective reviews,leading to the construction of comprehensive nomograms for outcome *** validated by future prospective studies,these nomograms would prove highly applicable in guiding the selection of treatment for superficial ESCC.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal resection Endoscopic mucosal resection Endoscopic submucosal dissection Lymph node metastasis

A fast forward computational method for nuclear measurement using volumetric detection constraints

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Nuclear Science and techniques 2024年第2期35卷 47-63页

作者： Qiong Zhang lin-Lv lin University of Electronic Science and technology of China Chengdu 610000China

Owing to the complex lithology of unconventional reservoirs,field interpreters usually need to provide a basis for interpretation using logging simulation *** the various detection tools that use nuclear sources,the detector response can reflect various types of information of the *** Monte Carlo method is one of the primary methods used to obtain nuclear detection responses in complex ***,this requires a computational process with extensive random sampling,consumes considerable resources,and does not provide real-time response ***,a novel fast forward computational method(FFCM)for nuclear measurement that uses volumetric detection constraints to rapidly calculate the detector response in various complex environments is ***,the data library required for the FFCM is built by collecting the detection volume,detector counts,and flux sensitivity functions through a Monte Carlo ***,based on perturbation theory and the Rytov approximation,a model for the detector response is derived using the flux sensitivity function method and a one-group diffusion *** environmental perturbation is constrained to optimize the model according to the tool structure and the impact of the formation and borehole within the effective detection ***,the method is applied to a neutron porosity tool for *** various complex simulation environments,the maximum relative error between the calculated porosity results of Monte Carlo and FFCM was 6.80%,with a rootmean-square error of 0.62 *** field well applications,the formation porosity model obtained using FFCM was in good agreement with the model obtained by interpreters,which demonstrates the validity and accuracy of the proposed method.

关键词： Nuclear measurement Fast forward computation Volumetric constraints

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Féeton(B-L gauge boson)dark matter for the 511-keV gamma-ray excess and the prediction of low-energy neutrino flux

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Chinese Physics C 2024年第8期48卷 76-82页

作者： Jie Sheng Yu Cheng Weikang lin tsutomu t.Yanagida tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityChina Key Laboratory for Particle Astrophysics and Cosmology(MOE)&Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai Jiao Tong UniversityShanghai 200240China South-Western Institute For Astronomy Research Yunnan UniversityKunming 650500China Kavli IPMU(WPI) UTIASUniversity of TokyoKashiwa277-8583Japan

the féeton is the gauge boson of the U(1)_(B−L) gauge *** the gauge coupling constant is extremely small,the féeton becomes a candidate for dark *** show that its decay to a pair of an electron and a positron explains the observed galactic 511-keV gamma-ray excess in a consistent *** féeton dark matter decays mainly into pairs neutrino and *** low-energy experiments with improved directional capability will enable capturing these neutrino *** seesaw-motivated parameter space predicts a relatively short féeton lifetime that is comparable to the current cosmological constraint.

关键词： feeton 511-keV gamma-ray excess low-energy neutrino

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Decision and Coordination of an E-commerce Supply Chain Considering Returns and Network Externalities

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei lin Yuyan Wang Luping Ding t.C.E.Cheng Dexia Wang School of Public Finance and taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and Engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering the large number of returns in online sales and the network externalities of e-platforms,we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain(ECSC)*** show that in the decentralized model,the service level,price,market demand,and ECSC members’profits increase with the network externality ***,the service level and price increase,while the market demand and ECSC members’profits decrease with the product return *** centralized model is the optimal operating mode when it is properly *** design the“commission and return cost-sharing”contract to optimize ECSC,in which the proportion of the e-platform’s sharing of the return handling cost is exactly equal to the proportion of the system profit after *** on the decentralized model,we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality *** comparisons between the extended and decentralized models,we show that high-quality service can improve ECSC’s profitability,while a high return rate hurts its economic performance.

关键词： E-commerce supply chain coordination mechanism network externalities return products

the Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2024年

作者： Lawrence g.Brown Huaxin lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon

We show that when A is a separable C*-algebra, every countably generated Hilbert A-module is projective(with bounded module maps as morphisms). We also study the approximate extensions of bounded module maps. In the case where A is a σ-unital simple C*-algebra with strict comparison, and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup, we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： Shih-lin lin Bo-Chen lin graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

this paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)