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npj Flexible Electronics 2021年第1期5卷 276-276页

作者： Subimal Majee Mikael C.F.Karlsson Pawel Jerzy Wojcik Anurak Sawatdee Mohammad Yusuf Mulla Naveed ul hassan Alvi Peter Dyreklev Valerio Beni David Nilsson Published in partnership with Nanjing Tech University

The original version of this Article omitted from the author list the 3rd author Pawel Jerzy Wojcik from redoxme AB,Research&Development Department,Norrköping,Sweden(Affiliation#3)and 7th author Peter Dyreklev from RI... 详细信息

关键词： ping Nor Sweden

High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

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World Journal of Gastroenterology 2022年第35期28卷 5217-5229页

作者： Essa A Mohamed Nasra H Giama Abubaker O Abdalla hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States Center for Clinical and Translational Science Mayo ClinicRochesterMN 55905United States School of Nursing University of MinnesotaMinneapolisMN 55455United States Division of Digestive Diseases Emory School of MedicineAtlantaGA 30322United States Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine NewYork-Presbyterian QueensFlushingNY 11355United States Department of Pediatrics University of Nevada Las VegasLas VegasNV 89154United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Medicine Gargar Urgent Care and ClinicMinneapolisMN 55406United States Office of the Director Shire ScientificMinneapolisMN 55405United States Department of Neurology Washington University School of Medicine in St LouisSt LouisMO 63130United States Knight Alzheimer Disease Research Center Washington University School of MedicineSt LouisMO 63130United States

BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and *** previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in *** To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening *** We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV *** Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV *** age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,*** participants developed incident HCC during follow *** Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States ***-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.

关键词： Viral hepatitis Liver disease Community engagement African Immigrant health

Association of gene variants with susceptibility to type 2 diabetes among Omanis

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World Journal of Diabetes 2015年第2期6卷 358-366页

作者： Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed rizvi Yengo Loic Philippe Froguel Riad Bayoumi Department of Biochemistry College of Medicine and Health SciencesSultan Qaboos University Genomics and Metabolic Disease Institute Pasteur of Lille Lille2 University

AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among ***:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,*** control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical *** difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this *** all volunteers questioned had a relativewith diabetes *** of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%*** was collected from June 2010 to February ***:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an as

关键词： Type 2 diabetes Genetics Oman Casecontrol Association Gene Variants

Race and colorectal cancer screening compliance among persons with a family history of cancer

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1300-1305页

作者： Adeyinka O Laiyemo Nicole Thompson Carla D Williams Kolapo A Idowu Kathy Bull-Henry Zaki A Sherif Edward L Lee hassan Brim hassan Ashktorab Elizabeth A Platz Duane T Smoot Division of Gastro-enterology Department of Medicine Howard University College of Medicine Howard University Cancer Center Department of Medicine Georgetown Univer-sity Department of Biochemistry and Molecular Biology Howard University College of Medicine Department of Pathology Howard University Department of Epidemiology Johns Hopkins Bloomberg School of Public Health the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Medicine Meharry Medical Center

AIM: To determine compliance to colorectal cancer(CRC) screening guidelines among persons with a family history of any type of cancer and investigate racial differences in screening ***: We used the 2007 Health Information National Trends Survey and identified 1094(27.4%)respondents(weighted population size = 21959672) without a family history of cancer and 3138(72.6%) respondents(weighted population size = 58201479) with a family history of cancer who were 50 years and older. We defined compliance with CRC screening as the use of fecal occult blood testing within 1 year, sigmoidoscopy within 5 years, or colonoscopy within 10 years. We compared compliance with CRC screening among those with and without a family member with a history of cancer. RESulTS: Overall, those with a family member with cancer were more likely to be compliant with CRC screening(64.9% vs 55.1%; OR = 1.45; 95%CI: 1.20-1.74). The absolute increase in screening rates associated with family history of cancer was 8.2% among whites. Hispanics had lowest screening rates among those without family history of cancer 41.9% but had highest absolute increase(14.7%) in CRC screening rate when they have a family member with cancer. Blacks had the lowest absolute increase in CRC screening(5.3%) when a family member has a known history of cancer. However, the noted increase in screening rates among blacks and Hispanics when they have a family member with cancer were not higher than whites without a family history of cancer:(54.5% vs 58.7%; OR = 1.16; 95%CI: 0.72-1.88) for blacks and(56.7% vs 58.7%; OR = 1.25; 95%CI: 0.72-2.18) for ***: While adults with a family history of any cancer were more likely to be compliant with CRC screening guidelines irrespective of race/ethnicity, blacks and Hispanics with a family history of cancer were less likely to be compliant than whites without a family history. Increased burden from CRC among blacks may be related to poor uptake of screening

关键词： Colon cancer Health disparities Screening Fecal bl

Beverage intake preference and bowel preparation laxative taste preference for colonoscopy

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第3期6卷 84-88页

作者： Adeyinka O Laiyemo Clinton Burnside Maryam A Laiyemo John Kwagyan Carla D Williams Kolapo A Idowu hassan Ashktorab Angesom Kibreab Victor F Scott Andrew K Sanderson Department of Medicine Howard University College of Medicine Howard University Cancer Center Department of Biological Sciences College of Arts and Sciences Howard University Georgetown-Howard Universities Center for Clinical and Translations Science

AIM: To examine whether non-alcoholic beverage intake preferences can guide polyethylene glycol(PEG)-based bowel laxative preparation selection for ***: We conducted eight public taste test sessions using commercially procured(A) unflavored PEG,(B) citrus flavored PEG and(C) PEG with ascorbate(Moviprep). We collected characteristics of volunteers including their beverage intake preferences. The volunteers tasted the laxatives in randomly assigned orders and ranked the laxatives as 1st, 2nd, and 3rd based on their taste preferences. Our primary outcome is the number of 1st place rankings for each preparation. RESulTS: A total of 777 volunteers completed the study. Unflavored PEG was ranked as 1st by 70(9.0%), flavored PEG by 534(68.7%) and PEG with ascorbate by173(22.3%) volunteers. Demographic, lifestyle characteristics and beverage intake patterns for coffee, tea, and carbonated drinks did not predict PEG-based laxative ***: Beverage intake pattern was not a useful guide for PEG-based laxative preference. It is important to develop more tolerable and affordable bowel preparation laxatives for colonoscopy. Also, patients should taste their PEG solution with and without flavoring before flavoring the entire gallon as this may give them more opportunity to pick a pattern that may be more tolerable.

关键词： Bowel preparation Laxatives Colonoscopy Taste tests Colon cancer Screening