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Comprehensive Analysis of Estrogen Receptor 1 Dysregulation in Liver Hepatocellular Carcinoma: Implications for Prognosis and Therapeutic Targeting - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 51-59页

作者： syed hussain raza Yasir Hameed Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investigates the expression pattern and regulatory mechanisms of estrogen receptor 1 (ESR1) in liver hepatocellular carcinoma (LIHC) through comprehensive bioinformatics analysis. Utilizing UALCAN and GEPIA2 databases, significant down-regulation of ESR1 expression is observed in LIHC samples compared to normal controls, indicating its potential role in tumor progression. Further analysis reveals consistent down-regulation across different clinical variables including patient age, gender, race, and various stages of LIHC, affirming the regulatory role of ESR1 in tumor development and progression. Additionally, promoter methylation analysis demonstrates hypermethylation of ESR1 in LIHC samples, negatively correlating with its expression. This association persists across different clinical parameters, emphasizing the inverse relationship between ESR1 methylation and expression levels. Survival analysis indicates that up- regulation of ESR1 is associated with better overall survival, suggesting its potential as a prognostic biomarker in LIHC. Furthermore, genetic mutation analysis using cBioPortal reveals a spectrum of alterations in ESR1, including amplification, missense mutation, deep deletion, splice mutation, and truncating mutation, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a deeper understanding of ESR1 dysregulation in LIHC and its clinical implications as a potential therapeutic target and prognostic marker.

关键词： Estrogen receptor 1 Liver hepatocellular carcinoma Biomarker Prognosis

Edge-Computing with Graph Computation:A Novel Mechanism to Handle Network Intrusion and Address Spoofing in SDN

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Computers, Materials & Continua 2020年第12期65卷 1869-1890页

作者： Rashid Amin Mudassar hussain Mohammed Alhameed syed Mohsan raza Fathe Jeribi Ali Tahir University of Engineering and Technology TaxilaPakistan University of Wah Wah CanttPakistan Jazan University JazanSaudi Arabia Abasyn University Islamabad IslamabadPakistan

Software Defined Networking(SDN)being an emerging network control model is widely recognized as a control and management *** model provides efficient techniques to control and manage the enterprise *** emerging paradigm is edge computing in which data processing is performed at the edges of the network instead of a central *** data processing at the edge nodes reduces the latency and bandwidth *** SDN,the controller is a single point of *** security issues related to the traditional network can be solved by using SDN central management and *** Spoofing and Network Intrusion are the most common *** attacks severely degrade performance and *** propose an edge computing-based mechanism that automatically detects and mitigates those *** this mechanism,an edge system gets the network topology from the controller and the Address Resolution Protocol(ARP)traffic is directed to it for further *** such,the controller is saved from unnecessary processing related to addressing *** propose a graph computation based method to identify the location of an attacker or intruder by implementing a graph difference *** using the correct location information,the exact attacker or intruder is blocked,while the legitimate users get access to the network *** proposed mechanism is evaluated in a Mininet simulator and a POX *** results show that it improves system performance in terms of attack mitigation time,attack detection time,and bandwidth requirements.

关键词： Software Defined Networking(SDN) edge computing Address Resolution Protocol(ARP) ARP inspection security graph difference

MECHANICALLY AND THERMALLY STABLE BLENDS OF POLY(STYRENE-BUTADIENE-STYRENE) WITH CONDUCTING POLY(THIOUREA-AZO-NAPHTHYL)

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Chinese Journal of Polymer Science 2013年第12期31卷 1623-1631页

作者： Ayesha Kausar syed Tajammul hussain Nanosciences and Catalysis Division National Centre for PhysicsQuaid-i-Azam University Campus

A new aromatic azo-polymer, poly（thiourea-azo-naphthyl）（PTAN）, has been synthesized using 1-（5- thiocarbamoylaminonaphthyl）thiourea and diazonium salt solution of 2,6-diaminopyridine. PTAN was easily processable using polar solvents and had high molar mass 57 × 10^3 g/mol. Electrically conducting, mechanically and thermally stable rubbery blends of poly（styrene-butadiene-styrene）（SBS） triblock copolymer and PTAN were produced by solution blending technique. FESEM of SBS/PTAN blends revealed nano-scale dispersion of the conducting filler showing good adhesion between the matrix and PTAN. Remarkable effects of azo-content on the conductivity of SBS-based blends have been observed. Accordingly, PTAN loading from 10 to 60 wt% increased the conductivity from 1.24 to 1.66 S/cm. Relationship between PTAN loading and thermal stability of the materials was also investigated. With increasing the PTAN content, 10% gravimetric loss was increased from 484 to 500 ℃, while glass transition was enhanced from 119 to 126 ℃. Thermal and conducting data of the blend showed better results relative to pure elastomer but were lower than those of the conducting filler. Similarly, the tensile strength （57.35-62.33 MPa） of SBS/PTAN was improved relative to there of SBS. Fine balance of properties renders new materials fairly better than the existing elastomeric blends used in a number of applications.

关键词： Poly(thiourea-azo-naphthyl) SBS Electrical conduction Thermal stability Tensile strength.

Interaction properties of solitons for a couple of nonlinear evolution equations

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Chinese Physics B 2021年第1期30卷 185-190页

作者： syed Tahir raza Rizvi Ishrat Bibi Muhammad Younis Ahmet Bekir Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Punjab University College of Information Technology University of the PunjabLahorePakistan Neighbourhood of Akcaglan Imarli Street Number 28/426030EskisehirTurkey

We study one-and two-soliton solutions for the Cahn–Allen(CA) equation and the Brethorton equation. The CA equation has broad spectrum of applications especially in anti-phase boundary motion and it is used in phase-field *** the Brethorton equation is a model for dispersive wave systems, it is used to find the resonant nonlinear interaction among three linear modes. We use the Hirota bilinear method to obtain one-and two-soliton solutions to the CA equation and the Brethorton equation.

关键词： Hirota bilinear method soliton interaction evolution equations

NUMERICAL SIMULATION OF AN OSCILLATING FLOW PAST A CIRCULAR CYLINDER IN THE VICINITY OF A PLANE WALL

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Journal of Hydrodynamics 2008年第5期20卷 547-552页

作者： SHAH syed Bilal hussain Department of Modern Mechanics University of Science and Technology of China

Oscillating flow around a circular cylinder in the vicinity of a plane wall was investigated by solving the two-dimensional incompressible Navier-Stokes equations with a finite element Galarkin residual method. The effect of the gap G/D between the cylinder surface and the wall on the flow behavior was studied. For the case of G/D 〈 0.25, the periodicity in the flow is attributed to both the outer shear layer instability and the oscillating frequency. As G/D 〉 0.25, vortex shedding occurs and the periodicity in the flow is mainly due to the competition of the oscillating frcqucncy and the vortex shedding frequency from an isolated stationary cylinder.

关键词： finite element method vortex shedding oscillating flow circular cylinder

A Secure NDN Framework for Internet of Things Enabled Healthcare

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Computers, Materials & Continua 2021年第4期67卷 223-240页

作者： syed Sajid Ullah Saddam hussain Abdu Gumaei hussain AlSalman IT Department Hazara UniversityMansehra21120Pakistan Research Chair of Pervasive and Mobile Computing Department of Information SystemsCollege of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Computer Science Taiz UniversityTaizYemen Department of Computer Science College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia

Healthcare is a binding domain for the Internet of Things(IoT)to automate healthcare services for sharing and accumulation patient records at anytime from anywhere through the *** current IP-based Internet architecture suffers from latency,mobility,location dependency,and *** Named Data Networking(NDN)has been projected as a future internet architecture to cope with the limitations of IP-based ***,the NDN infrastructure does not have a secure framework for IoT healthcare *** this paper,we proposed a secure NDN framework for IoTenabled Healthcare(IoTEH).In the proposed work,we adopt the services of Identity-Based Signcryption(IBS)cryptography under the security hardness Hyperelliptic Curve Cryptosystem(HCC)to secure the IoTEH information in *** HCC provides the corresponding level of security using minimal computational and communicational resources as compared to bilinear pairing and Elliptic Curve Cryptosystem(ECC).For the efficiency of the proposed scheme,we simulated the security of the proposed solution using Automated Validation of Internet Security Protocols and Applications(AVISPA).Besides,we deployed the proposed scheme on the IoTEH in NDN infrastructure and compared it with the recent IBS schemes in terms of computation and communication *** simulation results showed the superiority and improvement of the proposed framework against contemporary related works.

关键词： Named data networking healthcare identity-based signcryption

Influence of Cu doping in Magnesium Hydroxide Nanoparticles for Bandgap Engineering

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Journal of Wuhan University of Technology(Materials Science) 2023年第3期38卷 485-489页

作者： syed Masood raza S NASEEM Shah ADEEL Tahir YASMEEN Bibi Department of Physics Federal Urdu University of ArtsScience&TechnologyKarachiPakistan Department of Chemistry Federal Urdu University of ArtsScience&TechnologyKarachiPakistan

Cu doped Mg(OH)_(2) nanoparticles were synthesized with varying concentrations from 0 to 10%by a chemical synthesis technique of coprecipitation.X-rays diffraction (XRD) of the samples confirms that all the samples acquire the hexagonal crystal *** results indicated the solubility limit of dopant in the host material and the secondary phase of CuO was observed beyond 3%Cu doping in Mg(OH)_(2).The reduction in the size of nanoparticles was observed from 166 to 103 nm for Mg(OH)_(2) and 10% Cu doped Mg(OH)_(2)samples,*** shift in absorption spectra exhibited the systematical enhancement in optical bandgap from 5.25 to 6.085 eV.A good correlation was observed between the bandgap energy and crystallite size of the nanocrystals which confirmed the size induced effect in the *** transformation in the sample morphology was observed from irregular spherical particles to sepals like shapes with increasing the Cu concentration in the host *** energy dispersive X-Ray (EDX) analysis confirmed the purity of mass percentage composition of the elements present in the samples.

关键词： Cu doped Mg(OH)_(2) nanoparticles phase purity optical band gap morphologies

Invariant of Enhanced AES Algorithm Implementations Against Power Analysis Attacks

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Computers, Materials & Continua 2022年第7期72卷 1861-1875页

作者： Nadia Mustaqim Ansari Rashid hussain Sheeraz Arif syed Sajjad hussain Department of Electronic Engineering Dawood University of Engineering&TechnologyKarachiPakistan Faculty of Engineering Sciences and Technology Hamdard UniversityKarachiPakistan Faculty of Information Technology Salim Habib UniversityKarachiPakistan Faculty of Computer Sciences SZABISTKarachiPakistan

The security of Internet of Things(IoT)is a challenging task for researchers due to plethora of IoT *** Channel Attacks(SCA)are one of the major *** prime objective of SCA is to acquire the information by observing the power consumption,electromagnetic(EM)field,timing analysis,and acoustics of the ***,the attackers perform statistical functions to recover the *** Encryption Standard(AES)algorithm has proved to be a good security solution for constrained IoT *** paper implements a simulation model which is used to modify theAES algorithm using logicalmasking *** invariant of the AES algorithm hides the array of bits during substitution byte transformation of *** model is used against SCAand particularly Power Analysis Attacks(PAAs).Simulation model is designed on MATLAB *** will give better solution by hiding power profiles of the IoT devices against *** future,the lightweight AES algorithm with false key mechanisms and power reduction techniques such as wave dynamic differential logic(WDDL)will be used to safeguard IoT devices against side channel attacks by using Arduino and field programmable gate array(FPGA).

关键词： Side channel attacks power analysis attacks network security masking advance encryption standard

Morphological Variations,Distribution and Population Estimation of Indian Spiny Tailed Liza rd(Uromastyx hardwickii Gray,1827)from District Bahawalnagar,Punjab,Pakistan

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Asian Herpetological Research 2020年第3期11卷 257-262页

作者： Waqas ALI Arshad JAVID Saddam hussain Ali hussain syed Mohsin BUKHARI Department of Wildlife and Ecology University of Veterinary and Animal SciencesLahorePakistan

This study was conducted in selected sites of District Bahawalnagar namely,Shaheed Chowk,Chak40/F,Chak 163/7 R and Fareedkot Tiba between March 2019 and August *** techniques included recording of burrows,flooding,burrow exaction,noose traps and pit fall traps were used to capture Uromast yx *** this survey150 individuals were captured from study area for morphological measurement and population *** average snout to vent length(SVL)of male,female and juveniles were(172.50±19.71)mm,(155.50±18.72)mm and(86.25±11.72)mm *** average weight of male,female and juvenile was(93.06±8.56)g,(88.16±7.95)g and(40.16±4.30)g *** relative abundance(Pi)of males,females and juveniles were 0.53,0.33 and *** spiny tailed lizard(***)has been listed in the IUCN Red list and *** threats to the species in the study area are increase in urbanization,habitat fragmentation,illegal hunting for meat and *** this regard strict implementation of the Wildlife act is needed to protect the wildlife of ***,comprehensive surveys are required in throughout Punjab to declare conservation status of ***.

关键词： habitat morphological characters population Uromastyx hardwickii