A Bioinformatics Analysis of FAM3A to Identify its Potential Role as a Biomarker in Liver Hepatocellular Cancer

作     者：Syed Hussain Raza 

作者机构：Department of Biochemistry and BiotechnologyThe Islamia University of BahawalpurBahawalpurPakistan 

出 版 物：《Proceedings of Anticancer Research》 (抗癌研究)

年 卷 期：2024年第8卷第4期

页      面：87-97页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Liver hepatocellular cancer(LIHC) FAM3A expression Bioinformatics analysis Biomarker 

摘      要：Liver hepatocellular cancer(LIHC)is positioned as the third cancer with the highest mortalities worldwide,and high mortalities are associated with late diagnosis and *** study advances bioinformatics analysis of FAM3A expression in LIHC to evaluate its potential as a prognostic,diagnostic and therapeutic *** tools such as UALCAN,GEPIA2,KM plotter,TIMER2 and cBioPortal are employed to conduct ***,the expression analysis revealed up-regulation of FAM3A in LIHC based on various ***,the study observed that FAM3A methylation regulates expression as variation in methylation level of FAM3A was assessed in ***,this over-expression of FAM3A results in poor overall survival(OS)in LIHC *** of these proposed that FAM3A has a role in the progression and development of *** examined association of FAM3A expression and infiltration level of CD8+T cells in LIHC patients using TIMER2 revealed that FAM3A has a positive correlation with purity in LIHC that highlights the molecular *** of genetic alteration revealed minute role of FAM3A in LIHC still provides valuable ***,our findings reveal that FAM3A has potential as diagnostic,therapeutic and prognostic biomarkers in LIHC.