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EARLY PTOLEMAIC COINS FROM THE COLLECTION OF THE STATE HISTORICAL MUSEUM (MOSCOW)

Journal of Ancient Civilizations 2023年第2期38卷 191-235,250页

作者： svyatoslav V.Smirnov Eugenii V.Zakharov Institute of World History Russian Academy of SciencesMoscowRussia The State Historical Museum MoscowRussia

In 2018,the work of one of the leading experts in numismatics of Hellenistic Egypt Catharine ***’s Coins of the Ptolemaic Empire was out of *** work significantly complements and,in some ways,revises the fundamental ... 详细信息

关键词： details Egypt some

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Manifestation of Key Molecular Genetic Markers in Pharmacocorrection of Endogenous Iron Metabolism in MCF-7 and MCF-7/DDP Human Breast Cancer Cells

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CellBio 2013年第4期2卷 217-227页

作者： Vasyl’ Chekhun Natalia Lukianova Dmytro Demash Tetiana Borikun svyatoslav Chekhun Yulia Shvets Department of Mechanisms of Antitumor Therapy R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology NAS of Ukraine Kyiv Ukraine

Effects of the nanocomposite and its components (magnetic fluid, cisplatin) on the level of endogenous iron exchange and the key links of genetic and epigenetic regulation of apoptotic program of sensitive and resistant MCF-7 cells were examined. We showed genetic and epigenetic mechanisms of action of nanocomposite of magnetic fluid and cisplatin. Nanocomposite caused elevation of number of cells in apoptosis in sensitive and especially resistant MCF-7 cells compared to cisplatin alone. It was proved that impact of nanocomposite on MCF-7/S and MCF-7/DDP cells caused more significant changes in expression of apoptosis regulators p53, Bcl-2 and Bax. We also suggested that changes in endogenous iron homeostasis and activation of free radical processes caused significant impact on apoptosis. Those changes included changes in methylation and expression of transferrin, its receptors, ferritin heavy and light chains (predominantly in resistant cell line), which caused activation of free radical synthesis and development of oxidative stress. We also showed that nanocomposite impact resulted into significant changes in expression of miRNA-34a and miRNA-200b, which regulated apoptosis, cell adhesion, invasion and activity of ferritin heavy chains gene. Thus, use of nanocomposite containing cisplatin and ferromagnetic as exogenous source of Fe ions caused changes of endogenous iron levels in sensitive and resistant cells allowing to increase specific activity of cytostatics and overcome factors, which promoted MDR development. Pharmacocorrection of endogenous iron metabolism allowed increasing antitumor activity of cisplatin and overcoming drug resistance.

关键词： Nanocomposite Iron Metabolism Apoptosis ROS Drug Resistance Breast Cancer Cells

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Entropy of Measurements of Electric and Non-eleCtric Systems Fluctuating Parameters

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Journal of Electronic Research and Application 2018年第3期2卷 26-30页

作者： Zenoviy Kolodiy svyatoslav yatsyshyn Institute of Computer Technologies Automatics and MetrologyNational Lviv Polytechnic UniversityLvivUkraine

Fluctuations of the measured parameters of the investigated electric and non-electric systems are considered on the thermodynamics *** have defined that entropy of the investigated system in relation to environment depends on the correlation between measuring durationТmeas of the system’s fluctuation parameter and the system’s relaxation timeτ.Decrement of the energy spectrum of fluctuations with the decrease of frequency is explained byТmeas>τ.WhenТmeas≈Nmaxτ(where Nmax is the number of possible ways to create the balanced state of the system),entropy of investigated system tends to zero in relation to the environment,and the measurement error caused by fluctuations becomes the minimal.

关键词： Entropy fluctuations measurement time relaxation time.

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C-硝基吡唑类和C-硝基吡咯类对局部缺血损伤后眼血流量和视网膜功能恢复的作用(英文)

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Acta Pharmacologica Sinica 2002年第8期23卷 35-42页

作者： Bo XUAN, Tao WANG, George CY CHIOU, Igor L'vovich DALINGER, Tatyana Konstantinovna SHKINEVA, svyatoslav Arkadievich SHEVELEVInstitute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology,Texas A&M University System Health Science Center, College Station, Texas 77843, USA ND Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119992, Moscow, Russia Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology Texas A&M University System Health Science Center College Station 美国 Texas 77843 ND Zelinsky Institute of Organic Chemistry Russian Academy of Sciences Leninsky Prospect 47 俄罗斯 Moscow 119992 Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology Texas A&M University System Health Science Center College Station 美国 Texas 88743

AIM: Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal .function recovery after ischemia have been studied. METHODS: The compounds were tested on ocular blood flow of ocular hyperten-sive (40 mmHg) rabbit eyes with colored microsphere technique. They were also tested on the retinal function recovery after ischemia of rat eyes with electroretinography. RESULTS: All compounds (DC-1 through DC-17) showed significant increase in retinal function recovery after ischemia in the range of 26 % to 120 % (P<0.05). Among five compounds (DC-1 through DC-5) studied, four compounds (DC-2 through DC-5) in-creased the blood flow in choroid, iris, and ciliary body, but not in retina. DC-1 did not show significant increase of blood flow in any of these ocular tissues. CONCLUSION: C-Nitropyrazoles can facilitate significant retinal function recovery after ischemic insult through the increase of ocular blood flow. Since rabbit's retina is scarce in vasculature, it did not show significant chang

关键词：吡唑类吡咯类眼高压视网膜电描记术局部缺血

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