C-硝基吡唑类和C-硝基吡咯类对局部缺血损伤后眼血流量和视网膜功能恢复的作用(英文)
Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult作者机构：Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology Texas A&M University System Health Science Center College Station 美国 Texas 77843 ND Zelinsky Institute of Organic Chemistry Russian Academy of Sciences Leninsky Prospect 47 俄罗斯 Moscow 119992 Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology Texas A&M University System Health Science Center College Station 美国 Texas 88743
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2002年第23卷第8期
页 面：35-42页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：AIM: Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal .function recovery after ischemia have been studied. METHODS: The compounds were tested on ocular blood flow of ocular hyperten-sive (40 mmHg) rabbit eyes with colored microsphere technique. They were also tested on the retinal function recovery after ischemia of rat eyes with electroretinography. RESULTS: All compounds (DC-1 through DC-17) showed significant increase in retinal function recovery after ischemia in the range of 26 % to 120 % (P0.05). Among five compounds (DC-1 through DC-5) studied, four compounds (DC-2 through DC-5) in-creased the blood flow in choroid, iris, and ciliary body, but not in retina. DC-1 did not show significant increase of blood flow in any of these ocular tissues. CONCLUSION: C-Nitropyrazoles can facilitate significant retinal function recovery after ischemic insult through the increase of ocular blood flow. Since rabbit s retina is scarce in vasculature, it did not show significant chang
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