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2型糖尿病基础上的1型糖尿病：自身免疫性1型糖尿病叠加于原有2型糖尿病

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药品评价 2008年第6期5卷 282-282页

作者： suzukiLtakahashiK，MiyamotoS， suzuki t takahashi K Miyamoto S

回顾性地分析了126名在2000年7月～2005年12月间2次或多次入院的2型糖尿病患者资料。这些患者重复筛查了胰岛素自身抗体（IAA），评价了胰岛素分泌功能。结果发现，2位患者的ICA、GADAb、IA-2Ab等自身抗体最初为阴性，但其中至少一类抗... 详细信息

回顾性地分析了126名在2000年7月～2005年12月间2次或多次入院的2型糖尿病患者资料。这些患者重复筛查了胰岛素自身抗体（IAA），评价了胰岛素分泌功能。结果发现，2位患者的ICA、GADAb、IA-2Ab等自身抗体最初为阴性，但其中至少一类抗体随后转为阳性，内源性胰岛素分泌减少，最终进入胰岛素依赖阶段。血清自身抗体转变时，患者已有15～23年的糖尿病病史和糖尿病特有的微血管并发症，

关键词： 2型糖尿病 1型糖尿病自身免疫性胰岛素自身抗体胰岛素分泌功能微血管并发症 GADAb 胰岛素依赖

Extraction of resonance parameters from meson production reaction

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Chinese Physics C 2009年第12期33卷 1140-1145页

作者： t. Sato N. suzuki t. -S. H. Lee Department of Physics Osaka University Toyonaka Osaka 560-0043 Japan Excited Baryon Analysis Center(EBAC) Thomas Jefferson National Accelerator Facility Newport News Virginia 23606 USA Physics Division Argonne National Laboratory Argonne IL 60439 USA

We have developed an analytic continuation method for extracting parameters of nucleon resonances within a Hamiltonian formulation of meson-nucleon reactions. the method was tested for simple solvable models and then applied for our recent coupled channels model （πN, ηN, π△, ρN, and σN ） of the π＊N and γ＊N reactions. the resonance pole positions and their properties are studied for P11and P11 channels.

关键词： baryon resonance meson production reaction resonance pole

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伴睑板腺炎的疱性角膜炎青年患者

世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 10-10页

作者： suzuki t Mitsuishi Y Sano Y 陈立军 Department of Ophthalmology Kyoto Prefectural University of Medicine Kajii-cho Kamigyo-ku Kyoto City 602- 0841 JapanDr

PURPOSE: to describe the unique clinical features of phlyctenular keratitis, including the association with meibomitis, in young patients. DESIGN: Observational case series. MEtHODS: the study population consisted of 23 Japanese patients aged under 35 years with phlyctenular keratitis. We examined their clinical history, signs and symptoms, human leukocyte antigen (HLA), bacterial cultures of meibum, and the efficacy of antibiotics. the minimal diagnostic criteria included corneal nodules consisting of cellular infiltrates and superficial neovascularization. RESULtS: Of the 23 patients, 20 (87% )- were women, and 13 (56.5% ) had a history of chalazia. In all cases, the lesions and the severity of corneal nodules and neovascularization corresponded well with the location and the severity of meibomitis. the frequency of HLA- A26 and HLA- B35 was significantly increased in our patients (P=.003 and .016, respectively). Propionibacterium acnes in bacterial cultures of pure meibum in 12 of the 20 patients (60% ) was statistically more highly positive than those in four of the 17 age-matched normal control subjects (23.5% ; P=.028). CONCLUSION: the characteristics of phlyctenular keratitis in our cases include significantly higher prevalence in female patients, severity variation of ocular surface manifestation corresponding to meibomitis, specific HLA association, and possible P. acnes involvement.

关键词：睑板腺炎小疱棒状杆菌霰粒肿人白细胞抗原研究人群严重度病例研究观察性

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA the Bin talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological targeting Diagnosis and the

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

StUDY ON tHE tEXtURE OF A FRICtION StIR WELDED Mg-Al-Ca ALLOY

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Acta Metallurgica Sinica(English Letters) 2006年第5期19卷 335-340页

作者： D. t. Zhang M. suzuki K. Maruyama Graduate School of Environmental Studies Tohoku University 6-6-02 Aoba-yamaAoba-ku Sendai 980-8579 Japan College of Mechanical Engineering South China University of TechnologyGuangzhou 510640 China

Macro-texture of an Mg-Al-Ca alloy prepared by friction stir welding （FSW） was investigated through pole figure measurement and X-ray diffraction （XRD） pattern analysis. It was found that at the top and bottom surfaces of friction stir zone （FSZ）, （0002） basal planes of magnesium tend to be arranged parallel to the plate surface. In the cross section of FSZ, no obvious texture had evolved and （0002） basal planes showed a random distribution.

关键词： friction stir welding (FSW) Mg-Al-Ca alloy texture microstructure

Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Design Method of Guide Vane for Wells turbine

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Journal of thermal Science 2006年第2期15卷 126-131页

作者： Masami suzuki Department of Mechanical Engineering Graduate School of Engineering The University of Tokyo

Guide vanes are installed in the Wells turbine in order to improve its efficiency, self-rotating characteristics and off design performance with stall. this work attempts to explain the role of these guide vanes on the basis of momentum theory. It is shown that the upstream vanes are more effective in enhancing efficiency than the downstream ones. A design method for guide vanes is suggested based on experimental data and potential theory. Experimental studies carried out by the author confirm the theory proposed.

关键词： wells turbine guide vane cascade potential flow wave energy converter ocean engineering

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu tomotari Inami Eri Nakajima Shiho tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa tanaka Makoto suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki takami takayuki Komatsu tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

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锥虫早老素蛋白亲水区的克隆和表达纯化

中国比较医学杂志 2008年第6期18卷 5-8,12页

作者：赵锦太田伸生铃木高史铃木光子薮义贞大岛茂羽藤真理子张仁利深圳市疾病预防控制中心深圳518020 日本名古屋市立大学医学院日本名古屋

目的体外表达锥虫早老素蛋白亲水区肽段,以制备抗血清用于功能研究。方法根据锥虫早老素蛋白二级结构特性,设计引物分别扩增N端及C端片段的亲水区肽段基因,装入原核表达载体进行表达,并通过变性纯化方法获得足够量表达蛋白,制备兔抗血... 详细信息

目的体外表达锥虫早老素蛋白亲水区肽段,以制备抗血清用于功能研究。方法根据锥虫早老素蛋白二级结构特性,设计引物分别扩增N端及C端片段的亲水区肽段基因,装入原核表达载体进行表达,并通过变性纯化方法获得足够量表达蛋白,制备兔抗血清。结果成功扩增并克隆锥虫早老素蛋白亲水区片段L2及L7,并分别采用变性磁珠法和变性树脂法进行大量蛋白产物纯化,浓缩纯化产物制备兔抗血清经Western blot杂交验证,出现目的蛋白大小阳性条带。结论成功表达锥虫早老素蛋推测N端及C端亲水肽段,并成功制备抗血清,可用于锥虫早老素蛋白功能分析。

关键词：早老素蛋白阿尔茨海默病布氏锥虫蛋白表达