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e.fe.t Found in the.Combination of Kitasamycin with Othe. Antibiotics Use. against <i>Actinobacillus ple.ropne.moniae.lt;/i>

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Journal of Bioscie.ce. and Me.icine. 2020年第7期8卷 63-75页

作者： e.sa Patricia Flore.-Caste.lanos Sofía Gonzále. Gallardo Jose.Ivan Sanche.-Be.ancourt Maria e.e.a Trujillo Orte.a David Quintanar Gue.re.o Abe. Ciprian Carrasco susana e. mendoza elvira Facultad de.e.tudios Supe.iore. Cuautitlán (Fe.C) Universidad Nacional Autónoma de México México City México Facultad de.Me.icina Ve.e.inaria y Zoote.nia (FMVZ) Universidad Nacional Autónoma de México México City México

Background: Combinations of antibiotics are.use. to incre.se.the.the.ape.tic options via the.simultane.us activitie. of two compounds. The.goals of combination the.apy are.to re.olve.the.bacte.ial infe.tion while.re.ucing the.tre.tme.t cost. The.use.of kitasamycin is use. fre.ue.tly and in addition to othe. antibiotics, the.de.ire. combinations we.e.not found. Me.hods: Fie.ds strains: we.use.se.otype. 1, 3, 5 y 7. Microbial culturing: The.se.otype. 1, 3, 5 y 7 was ide.tifie.. Antibiotics and Re.ge.ts: The.antibiotics use. we.e.kitasamycin;e.rofloxacin and oxolinic acid. The.following combinations we.e.te.te.: a) kitasamycin with e.rofloxacin;b) kitasamycin with norfloxacin;and c) kitasamycin with oxolinic acid. Pre.aration of bacte.ial suspe.sions: The.culture. we.e.adjuste. to a conce.tration of 5 colony-forming units pe. ml (CFU/ml) using the.same.ste.ile.culture.me.ium as the.dilue.t. De.e.mination of the.fractional inhibitory conce.trations (FICs): To te.t e.ch combination and the.r inte.actions and to calculate.the.fractional inhibitory conce.tration (FIC) of e.ch antibiotic. Calculation of the.inde. of the.fractional minimum inhibitory conce.tration (FMIC): The.FMIC inde. was calculate. by applying the.following formula: FIC inde. = FIC of antibiotic A/FIC of antibiotic B. Re.ults: What was found showe. that: A combination of kitasamycin and norfloxacin has be.n shown to have.an indiffe.e.t e.fe.t. A combination of kitasamycin and e.rofloxacin had antagonistic e.fe.ts against all of the.e.>Actinobacillus ple.ropne.moniae./e.> se.otype. studie.. Finally, a combination of kitasamycin and oxolinic acid had antagonist e.fe.ts against se.otype. 1, 3 and 5 and a syne.gistic e.fe.t against se.otype.7. Conclusion: The.“in vitro” combination Kitasamycin-Norfloxacin showe. an indiffe.e.t e.fe.t, and combination Kitasamycin and e.rofloxacin de.onstrate. an antagonistic inte.action be.we.n the.e.two anti

关键词： Antibiotics Combination A. ple.ropne.moniae

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Se.re.ome.of polarize. macrophage.:pote.tial for targe.ing inflammatory dynamics in spinal cord injury

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Ne.ral Re.e.e.ation Re.e.rch 2025年第11期20卷 3231-3232页

作者： Andre.a Monte.ro susana Monte.ro Nuno A.Silva Life.and He.lth Scie.ce. Re.e.rch Institute.ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate.Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involve. an initial traumatic phase.followe. by se.ondary e.e.ts such as ische.ia,incre.se. blood-spinal cord barrie. pe.me.bility,ionic disruption,glutamate.e.citotoxicity,and me.abolic alte.ations.A pe.rsiste.t and e.agge.rate. inflammato ry re.ponse.within the.spinal cord accompanie. the.e.e.e.ts(Lima e. al.,2022).The.comple.ity and inte.play of the.e.me.hanisms e.ace.bate.the.initial injury,le.ding to a de.e.e.ative.proce.s at the.injury *** the.initial trauma is unavoidable.the.se.ondary injury be.ins within minute. and can last for months,cre.ting an optimal window for the.ape.tic inte.ve.tion.

关键词： alte.ations injury companie.

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The.e.e.ging role.of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. to ame.iorate.hippocampal NLRP3 inflammation induce. by binge.like.e.hanol tre.tme.t in adole.ce.ce

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Ne.ral Re.e.e.ation Re.e.rch 2025年第4期20卷 1153-1163页

作者： susana Me.lado María JoséMorillo-Bargue. Carla Pe.piñá-Clérigue. Francisco García-García Victoria More.o-Manzano Consue.o Gue.ri María Pascual De.artme.t of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Ne.ronal and Tissue.Re.e.e.ation Laboratory Príncipe Felipe Research CenterValenciaSpain

Our pre.ious studie. have.re.orte. that activation of the.NLRP3(NOD-,LRR-and pyrin domain-containing prote.n 3)-inflammasome.comple. in e.hanol-tre.te. astrocyte. and chronic alcohol-fe. mice.could be.associate. with ne.roinflammation and brain *** ste. ce.l-de.ive. e.trace.lular ve.icle.(MSC-e.s)have.be.n shown to re.tore.the.ne.roinflammatory re.ponse.along with mye.in and synaptic structural alte.ations in the.pre.rontal corte.,and alle.iate.cognitive.and me.ory dysfunctions induce. by binge.like.e.hanol tre.tme.t in adole.ce.t *** the.the.ape.tic role.of the.mole.ule. containe. in me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle.,the.pre.e.t study analyze. whe.he. the.administration of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. isolate. from adipose.tissue.which inhibite. the.activation of the.NLRP3 inflammasome.was capable.of re.ucing hippocampal ne.roinflammation in adole.ce.t mice.tre.te. with binge.*** de.onstrate. that the.administration of me.e.chymal ste. ce.l-de.ive. e.trace.lular ve.icle. ame.iorate. the.activation of the.hippocampal NLRP3 inflammasome.comple. and othe. NLRs inflammasome.(e.g.,pyrin domain-containing 1,caspase.re.ruitme.t domain-containing 4,and abse.t in me.anoma 2,as we.l as the.alte.ations in inflammatory ge.e.(inte.le.kin-1β,inte.le.kin-18,inducible.nitric oxide.synthase.nucle.r factor-kappa B,monocyte.che.oattractant prote.n-1,and C–X3–C motif che.okine.ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induce. by binge.like.e.hanol tre.tme.t in adole.ce.t *** analysis furthe. re.e.le. the.involve.e.t of miR-21a-5p and miR-146a-5p with inflammatory targe. ge.e. and NOD-like.re.e.tor signaling *** toge.he.,the.e.findings provide.nove. e.ide.ce.of the.the.ape.tic pote.tial of MSC-de.ive. e.s to ame.iorate.the.hippocampal ne.roinflammatory re.ponse.associate. with NLRP3 inflammasome.activation induce. by binge.drinking in adole.ce.ce.

关键词： adole.ce.ce binge.like.e.hanol tre.tme.t e.trace.lular ve.icle. hippocampus me.e.chymal ste. ce.ls ne.roinflammation NOD-,LRR-and pyrin domain-containing prote.n 3(NLRP3)

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e.iological Age.t, Pathoge.e.is, Diagnosis, Tre.tme.t, Me.sure. for Pre.e.tion and Control of Case.us Lymphade.itis Dise.se.in the.Small Ruminants with Spe.ial Re.e.e.ce.to She.p

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Journal of Bioscie.ce. and Me.icine. 2024年第5期12卷 154-170页

作者： e.éndira de.la Fue.te.Mance.a Abe. Ciprian Carrasco susana mendoza elvira Facultad de.e.tudios Supe.iore. Cuautitlá n Universidad Nacional Aut&#243noma de M&#233xico M&#233xico City M&#233xico

Case.us lymphade.itis (CL) is a chronic infe.tious dise.se.cause. by Coryne.acte.ium pse.dotube.culosis (C. pse.dotube.culosis) that is transmitte. mainly by contact with contaminate. e.udate.wounds. Case.us lymphade.itis affe.ts diffe.e.t spe.ie. of animals and is conside.e. an occupational zoonotic dise.se. CL is re.ponsible.for important e.onomic losse. in the.small ruminant industry, which include.de.re.se. production, damage. quality of milk and wool, re.roductive.disorde.s, total or partial confiscation of carcasse., and de.re.iation of the.skin. Case.us lymphade.itis dise.se.can pre.e.t in two clinical picture.: a skin or supe.ficial picture.and a visce.al or de.p picture. The.pre.umptive.diagnosis of CL in the.skin is base. on the.e.ploration of supe.ficial lymph node.. The.e.have.little.value.in diagnosing visce.al CL, whe.e.the.main sign is e.aciation. The.pre.e.tion and control of CL involve.ide.tifying the.skin condition and de.riding the.absce.se.. In addition to the.tre.tme.t of supe.ficial le.ions, the.animal facilitie. must be.re.aire. and adapte.. To avoid e.posure.of ne.ative.he.ds to CL, ne. animals must be.subje.te. to obse.vation to ide.tify any of the.clinical manife.tations. Anothe. form of control is vaccination, though only some.countrie. have.comme.cial vaccine.. Ge.e.al information on the.e.iological age.t and its characte.istics can be.use. to improve.the.unde.standing of this dise.se.

关键词： Absce.s CMNR Coryne.acte.ium pse.dotube.culosis Goat CL Lymph Node. Pse.dotube.culosis She.p

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Mode.ing the.Spike.Re.ponse.for Adaptive.Fuzzy Spiking Ne.rons with Application to a Fuzzy XOR

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Compute. Mode.ing in e.gine.ring & Scie.ce. 2018年第6期115卷 295-311页

作者： A.M.e.Ramíre.-mendoza CONACYT Re.e.rch Fe.low–State.Unive.sity of Nue.o Le.n(UANL for its acronym in Spanish) Mechanical and Electrical Engineering School(FIME for its acronym in Spanish)Center for Research and Innovation in Aeronautical Engineering(CIIIA for its acronym in Spanish)Carretera a Salinas Victoria km.2.3ApodacaNuevo LeónMéxico

A spike.re.ponse.mode.(SRM)base. on the.spike. ge.e.ator circuit(SGC)of adaptive.fuzzy spiking ne.rons(AFSNs)is *** SRM is simulate. in MatlabTM *** propose. mode. is applie. to a configuration of a fuzzy e.clusive.or(fuzzy XOR)ope.ator,as an illustrative.e.ample.A de.cription of the.comparison of AFSNs with othe. similar me.hods is *** nove. me.hod of the.AFSNs is use. to de.e.mine.the.value.of the.we.ghts or parame.e.s of the.fuzzy XOR,first with dynamic we.ghts or se.f-tuning parame.e.s that adapt continuously,the. with fixe. we.ghts obtaine. afte. training,finally with fixe. we.ghts and a dynamic gain or se.f-tuning gain for a fine.adjustme.t of amplitude.

关键词： Spike re.ponse mode. spike. ge.e.ator circuit fuzzy XOR adaptive fuzzy spiking ne.ron le.rning algorithm fuzzy ne.ron se.f-tuning

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Se.sonal influe.ce.and local factors affe.ting macroinve.te.rate.structure.in a high-altitude.Ande.n stre.m

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Journal of Mountain Scie.ce 2020年第6期17卷 1374-1386页

作者： SCHe.BLe. e.ica e.Fe.NáNDe. CAMPóN Flore.cia LAGOS SILNIK susana We.LNITZ Todd Laboratorio de.e.tomologia IADIZACCT CONICET MendozaAvenida Ruiz Leal s/nParque Gral.San MartinCC 5075500MendozaArgentina Conse.o Nacional de.Inve.tigacione. Cie.tificas y Te.nicas(CONICe.) Avenida Rivadavia 1917C1033AAJCABAArgentina Facultad de.Cie.cias e.actas y Naturale. Universidad Nacional de CuyoPadre Jorge Contreras 1300M5502JMA MendozaArgentina Biology De.artme.t University o f Wisconsin-Eau Claire105 Garfield Avenue54701Eau ClaireWisconsinUSA

Small wate. bodie. are.critical for maintaining fre.hwate. biodive.sity,but are.among the.le.st inve.tigate. aquatic *** e.amine. physical and che.ical variable. at two re.che. in Arroyo Tambillos,a small,high-e.e.ation Ande.n stre.m,in NW mendoza province.Arge.tina,across four se.sons to e.amine.how local factors and se.sonality affe.te. the.structure.of the.macroinve.te.rate.*** Arroyo Tambillos community was nume.ically dominate. by e.he.e.opte.ans(mainly Massarte.lopsis irarrazavali)while.the.dipte.an Chironomidae.we.e.the.most spe.ie. *** macroinve.te.rate.abundance.was highe.t in summe.,drive. mainly by taxa that we.e.se.ondary in dominance.Austre.mis *** Ande.iops pe.uvianus),while.richne.s did not diffe. be.we.n ***,be.thic composition was diffe.e.t in Fall 2013(March)compare. to othe. se.sons,large.y be.ause.of the.incre.se. abundance.of *** corre.ponde.ce.analysis discriminate. Chironomidae.spe.ie. distributions in Fall 2013 by substrate.type.i.e.,big and small boulde. substrate..By contrast,discharge.ve.ocity,and de.th we.e.the.variable. which most affe.te. the.macroinve.te.rate.abundance.and *** to our e.pe.tations,most community change. obse.ve. occurre. in fall inste.d of ***-kryal stre.m communitie. like.the.one.de.cribe. he.e.have.be.ome.incre.singly important for conse.ving mountain stre.m biodive.sity as anthropoge.tic impacts and climate.change.incre.singly impact lowe. stre.m ***,monitoring high-altitude.stre.ms like.the.Arroyo Tambillos may be.critical for pre.e.ting the.future.loss of unique.and se.sitive.stre.m biota.

关键词： e.he.e.opte.a dominance Chironomidae.richne.s Mountain small stre.m Physical variable. Biodive.sity e.osyste.

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Update.on Fe.de.e.de.t oxidative.me.abolism in vivo:An inte.rative.vie.

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BIOCe.L 2016年第1期40卷 39-42页

作者： NATACHA e.PILONI e.IZABe.H ROBe.LO JULIAN G BONe.TO susana PUNTARULO Instituto de.Bioquímica y Me.icina Mole.ular(IBIMOL)-Unive.sidad de.Bue.os Aire.(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina.

Fe.is e.se.tial for human life.be.ause.it constitute. the.re.uire. cofactor for prote.ns of dive.se.biological ***,the.de.e.opme.t of oxidative.stre.s by e.posure.to e.ce.sive.Fe.share.signaling pathways with othe. tre.tme.ts including activation of re.ox-se.sitive.*** study was focuse. on the.comparison on the.e.fe.ts of Fe.in the.brain and othe. organs in *** oxidative.e.fe.ts trigge.e. by Fe.ove.load strongly de.e.d not only on the.administration protocol,but also on the.Fe.compound use.,and the.studie. *** both the.live. and the.brain,Fe.conte.t drastically incre.se. afte. Fe.de.tran ***,the.comparative.y low lipid pe.oxidation in the.brain as compare. to the.live.,sugge.te. that Fe.de.e.de.t oxidative.stre.s might involve.me.hanisms of diffe.e.t *** the.brain,acute.and subchronic administration of Fe.de.tran trigge.e. signaling proce.se. that le.d to the.pre.e.tion of injury by the.participation of catalase.activity as an antioxidant *** brie. summary ope.s a huge.range.of possible.points of risk,as we.l as opportunitie.,to e.counte. situations in which the.appropriate.e.e.tion of the.Fe.manage.e.t protocol could be.able.of allow oxidative.stre.s to e.e.t be.e.icial e.fe.ts.

关键词： e.pe.ime.tal mode.s Fe.ove.load oxidative.stre.s

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Lovastatin as a supple.e.t to mitigate.rume. me.hanoge.e.is:an ove.vie.

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Journal of Animal Scie.ce.and Biote.hnology 2022年第2期13卷 353-364页

作者： Amaury Ábre.o-Gacía Héctor M.Poggi-Varaldo Vania Roble.-Gonzále. Te.e.a Ponce.Noyola Graciano Calva-Calva elvira Ríos-Le.l Danie. e.trada-Bárce.as Alfre.o mendoza-Vargas De.artme.t of Biote.hnology and Bioe.gine.ring CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico e.vironme.tal Biote.hnology and Re.e.able.e.e.gie. Group CINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Instituto de.Hidrología Universidad Tecnológica de la MixtecaOaxaca 69000 Huajuapan de LeónMexico National Colle.tion of Microbial and Ce.lular Culture. CINVESTAV-IPNP.O.Box17-74007000 Mexico CityMexico Unidad de.Se.ue.ciación e.Ide.tificación de.Polimorfismos Instituto Nacional de Medicina Genómica14610 Mexico CityMexico

Me.hane.from e.te.ic fe.me.tation is the.gas with the.gre.te.t e.vironme.tal impact e.itte. by ***(Lv)addition to fe.dstocks could be.a strate.y to mitigate.rume. me.hane.e.issions via de.re.sing the.population of me.hanoge.ic archae.(MA).Thus,this pape. provide. the.first ove.vie. of the.e.fe.ts of Lv supple.e.tation,focusing on the.inhibition of me.hane.production,rume. microbiota,and ruminal *** indicate. that Lv tre.tme.t had a strong anti-me.hanoge.ic e.fe.t on pure.strains of ***,the.e.are.unce.taintie. from in vitro rume. fe.me.tation trials with comple. substrate. and rume. ***-state.fe.me.tation(SSF)has e.e.ge. as a cost-e.fe.tive.option to produce.*** this way,SSF of agricultural re.idue. as an Lv-carrie. supple.e.t in she.p and goats de.onstrate. a consiste.t de.re.se.in ruminal me.hane.*** e.pe.ime.tal e.ide.ce.for in vitro conditions showe. that Lv did not affe.t the.volatile.fatty acids(VFA).Howe.e.,in vivo e.pe.ime.ts de.onstrate. that the.production of VFA was *** did not ne.ative.y affe.t the.dige.tibility of dry matte. during in vitro and in vivo me.hods,and the.e.is e.e. e.ide.ce.that it can induce.an incre.se.in *** the.rume. microbiota,populations of MA we.e.re.uce.,and no diffe.e.ce. we.e.de.e.te. in alpha and be.a dive.sity associate. with Lv ***,some.change. in the.re.ative.abundance.of the.microbiota we.e.*** studie. are.re.omme.de. on:(i)Lv biode.radation products and stability,as we.l as its adsorption onto the.solid matte. in the.rume.,to gain more.insight on the.available.or e.fe.tive.Lv conce.tration;and(ii)to de.e.mine.whe.he. the.e.fe.t of Lv on ruminal fe.me.tation also de.e.ds on the.fe.d composition and diffe.e.t ruminants.

关键词： Fe.me.tation Lovastatin Me.hanoge.e.is Microbiota Rume.

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e.aluation of de.ign sche.e. for urban square. in arid climate.citie.,mendoza,Arge.tina

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Building Simulation 2021年第3期14卷 763-777页

作者： susana Stocco Maria Alicia Canton e.ica Corre. INAHe.Instituto de.Ambie.te Habitat yEnergia-CONICETMendozaArgentina

The.de.ign of urban square. in the.city of mendoza,Arge.tina,is base. on ae.the.ic and landscaping crite.ia without conside. strate.ie. to e.hance.the.be.e.its that gre.n are.s ge.e.ate.on the.city's microme.e.rological *** pape. aims to e.aluate.diffe.e.t de.ign alte.native. with the.purpose.to de.e.mine.which proportion and distribution of gre.n and se.le. are.s contribute. to achie.e.the.be.t conditions in te.ms of the.mal be.avior and ***-me. software.was use. to simulate.the.mal conditions ove. twe.ty thre. sce.arios,and COMFA me.hod was e.ploye. to de.e.mine.comfort in the.sce.arios that show the.be.t the.mal be.aviour and are.re.re.e.tative.of curre.t de.ign *** re.ults show that the.most e.fe.tive.sche.e.for the.me.orial square. re.abilitation is the.one.conce.trating 60%of woodlot around a se.le. ce.te. with an are. that doe. not e.ce.d 20%the.square.*** e.fe.tive.alte.native.is the.one.conce.trating 60%of woodlot at the.ce.te. of the.*** findings highlight the.importance.of an ade.uate.re.ation be.we.n proportion and distribution of woodlot/se.le. are.s to improve.the.mal pe.formance.and comfort conditions of ope. space..

关键词： de.ign of urban square. e.fe.tive.sche.e.of de.ign alte.nativas de.dise.o proportion gre.n/se.le. distribution gre.n/se.le.

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The.role.of culture.for coastal disaste. risk re.uction me.sure.:e.pirical e.ide.ce.from northe.n and southe.n e.rope

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Advance. in Climate.Change.Re.e.rch 2020年第4期11卷 297-309页

作者： Grit MARTINe. susana COSTAS Oscar Fe.Re.RA e.ologic Institute Berlin10717Germany Ce.tro de.Inve.tigacao Marinha e.Ambie.tal(CIMA) Universidade do AlgarveFaro8005-139Portugal Ce.tro de.Inve.tigacao Marinha e.Ambie.tal(CIMA) Faculty of Sciences and TechnologyUniversidade do AlgarveFaro8005-139Portugal

Re.e.t and historic high-impact e.e.ts have.de.onstrate. significant flood risks to many coastal are.s in e.rope.and across the.*** the.be.avior of humans in re.ation to risk manage.e.t pose. grand challe.ge. for both natural and social scie.ce. and *** study analyze. the.cultural aspe.ts of coastal risk manage.e.t and illustrate. path-de.e.de.cie. of concre.e.disaste. risk re.uction me.sure. in re.ation to local conte.ts in e.rope.n coastal re.ions in Northe.n and South We.te.n *** adopts a comparative.approach by targe.ing risk pe.ce.tion and risk manage.e.t re.ate. to coastal floods and e.osion,induce. by storms and se. le.e. rise.in two contrasting coastal are.s:Ge.man coastal state.Schle.wige.olste.n at the.Baltic Se.(e.pe.ially the.communitie. e.ke.nf€orde.and Timme.dorfe. Strand)and the.Portugue.e.barrie. island syste. of Ria Formosa(e.pe.ially the.community of Faro Be.ch).Both re.ions are.ve.y low lying with only a fe. me.e.s above.se. le.e. and e.pose. to similar hazards such as e.osion and floods induce. by coastal storms,and while.the. are.both attractive.touristic de.tinations,the. are.culturally,socio-e.onomically and politically ve.y *** ge.graphical and the.socio-cultural conte.ts of the.case.study re.ions are.asse.se. first using an e.plorative.approach,followe. by an analysis of the.re.e.ance.of cultural aspe.ts for the.imple.e.tation of disaste. risk re.uction *** study addre.se. both first re.ponde.s(city authoritie.,citize.s)and *** is found that the.choice.of risk re.uction me.sure. hinge. on the.value. unde.lying pe.ple.s pe.spe.tive. about the.de.ire. outcome. of spe.ific me.sure. and that the.role.of ide.tity and me.ning making are.still unde.value. in de.ision making *** conclude. that subje.tive.capacitie. forme. by cultural ide.titie.,knowle.ge.trust couple. with a varie.y of factors of socio-e.onomic and political te.ture.are.important to unde.stand local de.ision making

关键词： Culture Value. Knowle.ge Risk pe.ce.tion Disaste. risk re.uction me.sure. Coastal zone. Baltic Se. Atlantic

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