Lovastatin as a supplement to mitigate rumen methanogenesis:an overview

作     者：Amaury Ábrego-Gacía Héctor M.Poggi-Varaldo Vania Robles-González Teresa Ponce-Noyola Graciano Calva-Calva Elvira Ríos-Leal Daniel Estrada-Bárcenas Alfredo Mendoza-Vargas Amauryábrego-Gacía;Héctor M.Poggi-Varaldo;Vania Robles-González;Teresa Ponce-Noyola;Graciano Calva-Calva;Elvira Ríos-Leal;Daniel Estrada-Bárcenas;Alfredo Mendoza-Vargas

作者机构：Department of Biotechnology and BioengineeringCINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Environmental Biotechnology and Renewable Energies GroupCINVESTAV-IPNP.O.Box 17-74007000 Mexico CityMexico Instituto de HidrologíaUniversidad Tecnológica de la MixtecaOaxaca 69000 Huajuapan de LeónMexico National Collection of Microbial and Cellular CulturesCINVESTAV-IPNP.O.Box17-74007000 Mexico CityMexico Unidad de Secuenciación e Identificación de PolimorfismosInstituto Nacional de Medicina Genómica14610 Mexico CityMexico 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2022年第13卷第2期

页      面：353-364页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：This research was funded by Basic Science Project SEP-CONACYT(grant number A1-S-26901) Partial funding from a personal grant of Dr.Héctor M.Poggi-Varaldo to the Environmental Biotechnology and Renewable Energies through CINVESTAV is appreciated 

主　　题：Fermentation Lovastatin Methanogenesis Microbiota Rumen 

摘      要：Methane from enteric fermentation is the gas with the greatest environmental impact emitted by ***(Lv)addition to feedstocks could be a strategy to mitigate rumen methane emissions via decreasing the population of methanogenic archaea(MA).Thus,this paper provides the first overview of the effects of Lv supplementation,focusing on the inhibition of methane production,rumen microbiota,and ruminal *** indicated that Lv treatment had a strong anti-methanogenic effect on pure strains of ***,there are uncertainties from in vitro rumen fermentation trials with complex substrates and rumen ***-state fermentation(SSF)has emerged as a cost-effective option to produce *** this way,SSF of agricultural residues as an Lv-carrier supplement in sheep and goats demonstrated a consistent decrease in ruminal methane *** experimental evidence for in vitro conditions showed that Lv did not affect the volatile fatty acids(VFA).However,in vivo experiments demonstrated that the production of VFA was *** did not negatively affect the digestibility of dry matter during in vitro and in vivo methods,and there is even evidence that it can induce an increase in *** the rumen microbiota,populations of MA were reduced,and no differences were detected in alpha and beta diversity associated with Lv ***,some changes in the relative abundance of the microbiota were *** studies are recommended on:(i)Lv biodegradation products and stability,as well as its adsorption onto the solid matter in the rumen,to gain more insight on the“availableor effective Lv concentration;and(ii)to determine whether the effect of Lv on ruminal fermentation also depends on the feed composition and different ruminants.