检索结果-南通市图书馆

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion:A Mini Review

Journal of Metallic Material Research 2022年第2期5卷 27-38页

作者： Abhay nanda Srivastva Nisha Saxena Netra Pal Singh Jayant kumar Department of Chemistry Nitishwar MahavidyalayaB.R.A.Bihar UniversityMuzarrafpur842002India University Department of Chemistry B.R.A.Bihar UniversityMuzaffarpur842001India Department of Chemistry M.R.M.CollegeL.N.Mithila UniversityDarbhanga846004India Department of Chemistry D.D.U.Gorakhpur UniversityGorakhpur273009India Graduate Student Department of ZoologyNitishwar MahavidyalayaB.R.A.Bihar UniversityMuzarrafpur842002India

Bacterial infections are a major cause for impulsive deaths in human *** infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden *** available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug *** growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host *** with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(***,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human *** antibiotics should also be compatible with remedies ongoing for core microbial ***,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their *** action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials *** the *** in complexes may interrupt the lipophilisity through the bacterial cell *** of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor *** structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic *** present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of th

关键词： Ligands Coordination compounds Antimicrobial activity Drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Short-Term Financial Time Series Forecasting Integrating Principal Component Analysis and Independent Component Analysis with Support Vector Regression

引用

Journal of Computer and Communications 2018年第3期6卷 51-67页

作者： Utpala nanda Chowdhury Sanjoy kumar Chakravarty Md. Tanvir Hossain Department of Computer Science and Engineering University of Rajshahi Rajshahi Bangladesh

Financial time series forecasting could be beneficial for individual as well as institutional investors. But, the high noise and complexity residing in the financial data make this job extremely challenging. Over the years, many researchers have used support vector regression (SVR) quite successfully to conquer this challenge. In this paper, an SVR based forecasting model is proposed which first uses the principal component analysis (PCA) to extract the low-dimensional and efficient feature information, and then uses the independent component analysis (ICA) to preprocess the extracted features to nullify the influence of noise in the features. Experiments were carried out based on 16 years’ historical data of three prominent stocks from three different sectors listed in Dhaka Stock Exchange (DSE), Bangladesh. The predictions were made for 1 to 4 days in advance targeting the short term prediction. For comparison, the integration of PCA with SVR (PCA-SVR), ICA with SVR (ICA-SVR) and single SVR approaches were applied to evaluate the prediction accuracy of the proposed approach. Experimental results show that the proposed model (PCA-ICA-SVR) outperforms the PCA-SVR, ICA-SVR and single SVR methods.

关键词： Financial Time Series Forecasting Support Vector Regression Principal Component Analysis Independent Component Analysis Dhaka Stock Exchange

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study

引用

World Journal of Gastroenterology 2021年第6期27卷 523-533页

作者： Jasbir Makker Hassan Tariq Kishore kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel suresh Nayudu Sridhar Chilimuri Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States KU School of Medicine-Wichita University of KansasWichitaKS 67214United States Department of Medicine BronxCare Health SystemBronxNY 10457United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional *** with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic *** still differ in their recommendations of screening for NAFLD among patients with *** To study the prevalence of NAFLD and advanced fibrosis among our patient population with *** During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited *** with known significant liver disease and alcohol use were *** data and lab parameters were *** elastography was performed in all *** In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by *** hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control *** with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography.

关键词： Advanced liver fibrosis Diabetes Steatosis Normal transaminases Fatty liver disease Metabolic syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adverse events associated with the gold probe and the injection gold probe devices used for endoscopic hemostasis:A MAUDE database analysis

引用

World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 37-43页

作者： Vishnu Charan suresh kumar Mark Aloysius Ganesh Aswath Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13202United States

BACKGROUND Gastrointestinal(GI)bleeding accounts for over half a million admissions annually and is the most common GI diagnosis requiring hospitalization in the United *** electrocoagulation devices are used for the management of gastrointestinal *** is no data on device-related adverse events for gold probe(GP)and injection gold probe(IGP).AIM To analyze this using the Food and Drug Administration(FDA’s)Manufacturer and User Facility Device Experience(MAUDE)database from 2013 to *** We examined post-marketing surveillance data on GP and IGP from the FDA MAUDE database to report devicerelated and patient-related adverse events between *** MAUDE database is a publicly available resource providing over 4 million records relating to medical device *** analyses were performed using IBM SPSS Statistics V.27.0(IBM Corp.,Armonk,NY,United States).RESULTS Our search elicited 140 reports for GP and 202 reports for IGP,respec-tively,during the study period from January 2013 to August *** reportedly occurred in 130 cases for GP,and actual patient injury or event occurred in 10 patients.A total of 149 patients(74%)reported with Injection GP events suffered no significant consequences due to the device failure,but 53 patients(26%)were affected by an *** GP and IGP are critical in managing gastrointestinal *** study of the FDA MAUDE database revealed the type,number,and trends of reported device-related adverse *** endoscopist and support staff must be aware of these device-related events and be equipped to manage them if they occur.

关键词： Hemostasis Gastrointestinal bleeding Endoscopy Device failure Bipolar coagulation Cautery Risks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Catalytic Cracking of Waste Polypropylene in a Nitrogen Fluidized Bed Reactor

引用

Journal of Geoscience and Environment Protection 2016年第4期4卷 20-25页

作者： Anil Vyas suresh kumar Singh Komal Sharma Sukhwant Singh Chemical Engineering Department Jai Narain Vyas University Jodhpur India Civil Engineering Department Jai Narain Vyas University Jodhpur India Chemical Engineering Department MNIT Jaipur India

Polypropylene (PP) is rated first as volume leader in the plastic sector. Its non-biodegradable property poses serious environmental problem in case of disposal. The catalytic cracking of PP was performed with various catalysts i.e. ZSM-5, Zeolite, RB and SPS. The cracking was observed under different feed to catalyst ratio i.e. 1:1 to 5:1. The fluidized bed reactor was fabricated with arrangement to measure the temperature ranging from 100。C to 800。C. The effective of feed to catalyst ratio was found 3:1 at a temperature range of 420。C - 510。C and catalyst ZSM-5 gives maximum liquid conversion of waste PP. Conversion of PP to liquid fuel will not only resolve the problem of disposal of waste polypropylene plastic but also give a value aided product.

关键词： Waste PP Pyrolysis Catalytic Cracking ZSM-5 Zeolite Liquid Fuel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway

引用

Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 337-345页

作者： VGM.Naidu Bandari Uma Mahesh Ashwini kumar Giddam Kuppan Rajendran Dinesh Babu Jian Ding K suresh babu B Ramesh Rajeswara Rao Pragada Gopalakrishnakone P Venom & Toxin Research Programme Department of AnatomyYong Loo Lin School of Medicine4 Medical DriveNational University of SingaporeSingapore-117597 Currently affiliated to Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research(NIPER)BalanagarHyderabadA.PIndia-500037 Department of pharmacology A.U.College of pharmaceutical SciencesAndhra universityVishakhapatnamAndhra PradeshIndia-530003 Natural Products Laboratory Indian Institute of Chemical TechnologyUppal RoadHyderabad 500 607India

Objective:To evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule(EtAc-LME) in MKN-74,NUGC gastric cancer cells and non cancerous gastric mucous cells(GES-1),and to explore the mechanism of EtAc-LME induced ***:The mechanism of EtAc-LME induced apoptosis was explored by analysing the activation of pro-caspases,PARP cleavage,expression of cytochrome-c (Cyt-c) was determined by western blotting,mRNA expression of Bcl-2,Bax by RT-PCR,loss of mitochondrial potential using DiOC6 dye,annexin binding assay and its influence on cell cycle arrest by flow ***:The results indicated that EtAc-LME inhibited the gastric cancer cell growth in dose-dependent manner and cytotoxicity was more towards the gastric cancer cells(NUCC and MKN-74) compared to normal gastric cells(GES-1),suggesting more specific cytotoxicity to the malignant *** expression of Cyt-c and subsequent activation of caspases-3 and down regulation of Bcl-2 and loss in mitochondrial potential in EtAc-LME treated MKN-74 and NUGC cells suggested that EtAc-LME induced apoptosis by mitochondrial dependent ***:The present findings suggest that ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells emphasizing the importance of this traditional medicine for its potential in the treatment of gastric cancer.

关键词： Memecylon edule Anti-cancer Gastric cancer Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoprotection: A Hallmark of <i>Citrullus colocynthis</i>L. against Paracetamol Induced Hepatotoxicity in Swiss Albino Rats

引用

American Journal of Plant Sciences 2012年第7期3卷 1022-1027页

作者： Arshed Iqbal Dar Ramesh Chandra Saxena suresh kumar Bansal Pest Control & Ayurvedic Drug Research Lab. S.S.L Jain P.G College Vidisha India

Objective: To demonstrate the in-vivo hepatoprotective effect of the ethanolic extracts of Citrullus colocynthis (Linn.) against paracetamol induced hepatotoxicity in albino rats. Animal Model: Swiss Albino rats of either sex were used, divided into six groups with six in each group. Group 1-Normal control: The animals were maintained under normal control, which were given distilled water only. Group 2-Induction of hepatotoxicity: The animals received paracetamol 500 mg/kg b.w. (p.o) every 72 h for 10 Days. Groups 3 to 5: Animals received ethanolic extract of Citrullus colocynthis L. at 50, 100 & 200 mg/kg bw/day for 7 days (p.o). Group 6: The animals were treated with Silymarin (100 mg/kg p.o) which served as standard. Groups 3 to 6 were intoxicated with paracetamol (500 mg/kg bw) 1 h before the administration of extract or Silymarin for 10 days. Histopathological findings, different hepatic biochemical parameters viz. AST, ALT, ALP, Total bilirubin, Total cholesterol, Triglycerides, & the body weight before & after treatment were evaluated to investigate the hepatoprotective activity. Results: Paracetamol induced a significant rise in AST, ALT, ALP, Total Bilirubin, Total Cholesterol, Triglycerides. Administration of 200 mg/kg bw of ethanolic extract of Citrullus colocynthis L. effectively reduced these pathological damages caused by paracetamol intoxication. In addition to serum parameters treatment of 200 mg/kg bw of ethanolic extract of Citrulus colocynthis L. also promotes the body weight in albino rats as shown in Figure 6 respectively. Histopathological changes of the liver samples were compared with the normal control as shown in Figures 2-5 respectively. Conclusion: From our results we may infer that the mode of action of 90% ethanolic extract of Citrullus colocynthis L. (200 mg/kg bw) in affording the in-vivo hepatoprotective activity against paracetamol may be due to the cell membrane stabilization, hepatic cell regeneration & normalizing the serum param

关键词： Citrullus colocynthis L. Hepatoprotective Paracetamol Silymarin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lean Management Based Sustainable Transport System for Surat Metropolitan Area in the Context of Industrial Development

引用

Journal of Traffic and Transportation Engineering 2017年第3期5卷 147-156页

作者： suresh Sharma Pankaj J. Gandhi Anil kumar Roy Doctoral student Faculty of Business and Management Himalayan University Surat 395009 India Ph.D. Guide Visiting Faculty at Veer Narmad South Gujarat University Surat 395009 lndia Faculty of Planning CEPT University Ahmedabad 380009 lndia

Surat city is continuously expanding with industrial development. Despite several flyovers, traffic congestion continues in the heart of city. Therefore, fresh transportation planning is at anvil. Simultaneously, further expansion plan is under consideration to create yet another, the 10th industrial zone. Purpose of this paper is to explore lean management based sustainable transport system for meeting the increasing needs of people and supply-chain. The research examines different mode of transportation like; vehicles on road, rail on the land, and steamers through the sea route to provide connectivity. This study may support the planners of the smart city. The study intends to find how lean management can be integrated to sustainable transport system meeting objectives of lean and sustainability both. Lean management system claims to be capable of eliminating all type of wastes including those associated with transport system. On the other hand, sustainable transport claims to meet the needs of people in personal economic lives, importantly respecting the need of future generations. Therefore, this applied research aims to find a lean and sustainable transport solution. This research work can be seen as descriptive type as it includes survey of location and fact finding enquiries.

关键词： Lean management sustainable development environment health and safety people-planet-profit.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Large Scale Multiplication of Casuarina junghuhniana Miq. Clonal Plants through Mini-cutting Technique

引用

Journal of Agricultural Science and Technology(B) 2020年第2期10卷 98-105页

作者： Chezhian Palanisamy Seenivasan Ramanathan Selvakrishnan Palanisamy suresh kumar Ganesan Department of Plantation Tamil Nadu Newsprint and Papers LimitedKagithapurmKarurTamil Nadu 639136India

The modern concept of meeting the customer’s requirements in better products at low costs in a sustainable manner is possible only through innovative *** nodal cutting technique is the most widely used method for large scale propagation of Casuarina,Eucalyptus and other pulpwood species in *** Nadu Newsprint and Papers Limited(TNPL)has started large scale multiplication of Casuarina junghuhniana *** mini-cutting technique from indoor clonal mini hedges raised in sand *** compared to stem/nodal cuttings,indoor clonal mini hedges raised in sand beds improve the rooting potential,quality of root systems and are time-and *** productivity of cuttings is increased five times in indoor clonal hedge orchard than conventional stem/nodal *** rooting percentage also improved to 90%without rooting hormone whereas the same is only 50%in stem *** plant developed through mini-cutting technique has more lateral root system which helps the plants/trees to withstand during heavy *** such stump derived stock plants by intensively managing indoor sand bed clonal mini hedges resulted in a noticeable enhancement of cutting capacity for adventitious rooting as well as the overall quality of the plants produced in much shorter period with easier and cheaper *** study reveals that mini-cutting method is ideal propagation technique for large scale propagation of *** clones in India.

关键词： Casuarina junghuhniana mini-cutting stem cutting sand bed and propagation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteomic Alterations in Human Dermal Fibroblasts under Photo-Induced Pollution Caused by Excessive Solar Irradiations such as Infra-Red, Blue Light, UVA and UVB

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2023年第1期13卷 16-32页

作者： Balu Muthaiyah suresh kumar Ramadoss Yellapantula Sree Gouri Balaji Bandyopadhyay ITC Life Sciences and Technology Center (ITC LSTC) Bangalore India

Background: The skin serves as the first line of defense for the human body. Direct sunlight contains damaging radiations that can speed up the ageing process of the skin, resulting in wrinkles, leathery skin, dark patches, and solar elastosis. Objectives: To evaluate the effect of multiple solar irradiation related factors at the protein level in human dermal fibroblast (HDF). The overall effect of individual solar irradiations such as Infrared A (IRA), blue light (BL), UVA, and UVB on HDF cells and the extent of molecular level aberrations to be assessed and compared against each. Methods: Label-free quantitative proteomics (MS/MS) approach has been adopted in this study to observe the protein level changes induced in the HDF cells through various exposures of full light sources. Following that, downstream insilico analysis has been carried out. Results: In this study, it is demonstrated all the four different solar irradiations significantly contribute to the molecular degeneration of skin cells through various mechanisms. This study confirms that BL down-regulates DNA repair proteins and the skin cells-HDF stimulate the histone proteins as a response mechanism to maintain the chromosomal integrity. Conclusions: The proteomics experiment carried out in the current study intends to support the future sun care products based on full light protection technology that can be custom designed to provide complete protection from the solar radiation. Similar technology could enhance the further investigations for deeper understanding of induction, mode of action, and prevention of skin damage from extensive solar irradiation.

关键词： Full Light Technology Solar Irradiation Cellular Damage DNA Repair & Damage HDF Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：