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Neuroprotective potential of cannabidiol:Molecular mechanisms and clinical implications

Journal of Integrative Medicine 2023年第3期21卷 236-244页

作者： Srushti M.Tambe suraj mali Purnima D.Amin Mozaniel Oliveira Department of Pharmaceutical Sciences and Technology Institute of Chemical TechnologyMatunga EastMumbai 400019India Department of Pharmaceutical Sciences and Technology Birla Institute of TechnologyRanchi 835215India Adolpho Ducke Laboratory Emilio Goeldi MuseumPara 66077-830Brazil

Cannabidiol(CBD),a nonpsychotropic phytocannabinoid that was once largely disregarded,is currently the subject of significant medicinal *** is found in Cannabis sativa,and has a myriad of neuropharmacological impacts on the central nervous system,including the capacity to reduce neuroinflammation,protein misfolding and oxidative *** the other hand,it is well established that CBD generates its biological effects without exerting a large amount of intrinsic activity upon cannabinoid *** of this,CBD does not produce undesirable psychotropic effects that are typical of marijuana ***,CBD displays the exceptional potential to become a supplementary medicine in various neurological ***,many clinical trials are being conducted to investigate this *** review focuses on the therapeutic effects of CBD in managing neurological disorders like Alzheimer's disease,Parkinson's disease and ***,this review aims to build a stronger understanding of CBD and provide guidance for future fundamental scientific and clinical investigations,opening a new therapeutic window for neuroprotection.

关键词： Cannabis sativa Cannabidiol Natural products Bioactive compounds Anti-neurodegenerative diseases

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Identification of Anxiolytic Potential of Niranthin:In-vivo and Computational Investigations

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Natural Products and Bioprospecting 2021年第2期11卷 223-233页

作者： Atul R.Chopade Prakash M.Somade Pratik P.Somade suraj N.mali Department of Pharmacology Rajarambapu College of PharmacyKasegaonSangliMaharashtra 415404India Dept.of Physiology Krishna Institute of Medical SciencesKaradMaharashtraIndia Government College of Pharmacy KaradMaharashtraIndia

Anxiety is an unpleasant state,which can critically decrease the quality of life is often accompanied by nervous behaviour and *** is a lignan isolated from various Phyllanthus *** literature survey on niranthin highlights wide ranges of the therapeutic *** a present study,based on our previous investigations,we evaluated pure,isolated and characterized niranthin as an anxiolytic *** niranthin[6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole]was purchased from commercial source and further subjected for assessment of its anxiolytic potentials using popular animal models including Elevated plus-maze model/test(EPM)and Light&Dark Exploration test(L&D).GABA-A receptor mediation was evaluated by pretreating the mice with the GABA-A receptor antagonist Flumazenil before the EPM *** docking simulation studies(pdb id:4COF)carried out by Vlife QSAR software showed that niranthin(docking score:−62.1714 kcal/mol)have shown comparatively best docking score compared to the standard drug Diazepam(docking score:−63.1568 kcal/mol).To conclude,Niranthin has probable potential in the management of anxiety *** in-silico and in-vivo analysis(indirectly)indicated the plausible role of GABA mediation for anxiolytic ***,these studies are preliminary,future in depth experimental explorations will be required to use Niranthin as anti-anxiety drug in near future.

关键词： Pharmacology Phytoconstituents Niranthin Lignan Anxiolytic activity EPM models

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