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Semantic Segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v v Shiloah Elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

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Genetic Algorithm with variable Length Chromosomes for Network Intrusion Detection

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International Journal of Automation and computing 2015年第3期12卷 337-342页

作者： sunil Nilkanth pawar Rajankumar Sadashivrao Bichkar Jawaharlal Nehru Engineering College G.H.Raisoni College of Engineering & Management

Genetic algorithm(GA) has received significant attention for the design and implementation of intrusion detection systems. In this paper, it is proposed to use variable length chromosomes(vLCs) in a GA-based network intrusion detection *** chromosomes with relevant features are used for rule generation. An effective fitness function is used to define the fitness of each rule. Each chromosome will have one or more rules in it. As each chromosome is a complete solution to the problem, fewer chromosomes are sufficient for effective intrusion detection. This reduces the computational time. The proposed approach is tested using Defense Advanced Research Project Agency(DARPA) 1998 data. The experimental results show that the proposed approach is efficient in network intrusion detection.

关键词： Genetic algorithms intrusion detection variable length chromosome network security evolutionary optimization.

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Lithium bromide catalyzed solvent free method for synthesis of 2-substituted benzimidazoles and imidazopyridines

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Chinese Chemical Letters 2010年第5期21卷 519-523页

作者： Deepak v.Dekhane Shivaji S.pawar sunil v.Gupta Murlidhar S.Shingare Shivaji N.Thore Department of Chemistry Vinyakrao Patil Mahavidyala VaijapurAurangabad 423701MSIndia Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004MSIndia

The first successful lithium bromide mediated solvent free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields is described.

关键词： Benzimidazoles Arylenediamine Aliphatic esters Lithium bromide Imidazopyridines

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Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-αin high-fat diet-induced obese rats

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 698-702页

作者： Sayyed Nadeem Pradeep Dhore Mohsin Quazi sunil pawar Navin Raj Technocarts Institute of Technology Pharmacy Anand NagarBhopalMadhypradeshIndia Agnihotri College of Pharmacy Bapuji WadiSindhi(Meghe)Wardha-442 001MaharashtraIndia

Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese ***:The high fat diet induced obese rals were orally treated with orlistat(50 mg/kg) and ELSF(100,200.300 mg/kg/day) to the respective treatment *** body weight,lasting blood glucose level,lipid profile, serum levels of tumor necrosis factor-α(TNF-α) in rats were measured after 30 days of treatment adn compared to the obese control ***:ELSF significantly(P vent fat amassment.

关键词： Lagenaria sicera Cucurbitaceae Fat amassment High fat diet

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La_2O_3/TFE: An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines

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Chinese Chemical Letters 2014年第8期25卷 1149-1152页

作者： sunil U. Tekale vijay P. Pagore Sushama S. Kauthale Rajendra P. pawar Department of Chemistry Shri Muktanand College Department of Chemistry Deogiri College

Lanthanum oxide（La2O3） in combination with 2,2,2-trifluoroethanol（TFE） was found to be an efficient system for the one-pot, four-component synthesis of Hantzsch polyhydroquinoline derivatives from aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature. The catalyst is heterogeneous and reusable, hence can be separated easily and reused. The present method is featured by mild reaction conditions, use of heterogeneous catalyst, non-chromatographic purification,short reaction time and high yields, which make it an attractive route for the synthesis of polyhydroquinolines.

关键词： Hantzsch polyhydroquinolines La2O3 TFE

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Influence of cerium ions on structure-dependent magnetic properties of Ba-Sr M-type hexaferrite nanocrystals

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Journal of Rare Earths 2024年第2期42卷 364-372,I0005页

作者： Ram A.pawar sunil M.Patange P.M.Dighe Sher Singh Meena Abdullah GAl-Sehemi Mehboobali Pannipara Santosh S.Jadhav Department of Physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Department of Physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia Padmashri vikhe Patil College of Arts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid State Physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Department of Chemistry King Khalid UniversityAbha61413Saudi Arabia Department of Physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a systematic effort to investigate the structure-sensitive magnetic parameters of Ce^(3+) substituted Ba-Sr hexaferrite nanocrystals chemically formulated as Ba_(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexaferrite powders were prepared using the sol-gel self-ignition route and structurally characterized by means of powder X-ray diffraction and Fourier transform infrared *** creation of the M-type hexaferrite phase within the synthesized samples was revealed from the Rietveld refinement of the X-ray *** occurrence of a secondary phase of CeO_(2) was revealed within the hexaferrites for the substitution,x> *** refined X-ray diffraction data were utilized to compute the lattice parameters,X-ray density,and lattice parameter *** crystal structure plotted from the refined XRD data reveals the occupancy of the ions at different lattice *** XPS data of the hexaferrite were analyzed to confirm the oxidation states of the constituent *** nanocrystalline nature of the hexaferrites was revealed from the crystallite sizes calculated using Scherer's *** analysis of FTIR spectra confirms that only a fraction of Ce^(3+)accommodated in the lattice and the remaining Ce content reside in the form of the CeO_(2) *** morphology of the hexaferrites was analyzed from the FESEM profiles of the ferrite *** magnetic behavior study was performed by analyzing the Curie temperature,hysteresis loops,and hyperfine interactions by means of susceptibility,v.S.M,and Mossbauer spectroscopy,*** hexaferrites with increasing coercivity,decreasing saturation magnetization,and decreasing Curie temperature are reported in the *** substituted Ce^(3+)ions inhibit the grain growth and create lattice imperfections giving rise to hexaferrites with tuned magnetic parameters suitable for different applications.

关键词： Ba-Sr hexaferrite Ce^(3+)substitution XPS Saturation magnetization Coercivity M?ssbauer spectroscopy

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Primary hepatic amyloidosis:A case report and review ofliterature

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World Journal of Hepatology 2016年第6期8卷 340-344页

作者： Nikhil Sonthalia Samit Jain sunil pawar vinay Zanwar Ravindra Surude Praveen M Rathi Department of Gastroenterology Topiwala National Medical College and BYL Ch HospitalMumbai 400008MaharashtraIndia

We describe a case of 42-year-old female presenting with abdominal pain associated with loss of weight and fever for 8 mo. On evaluation she had gross hepatomegaly with raised alkaline phosphatase and raised GGT levels with normal transaminases and bilirubin. On imaging she had diffuse enlargement of liver with heterogeneous contrast uptake in liver. Her viral marker and autoimmune markers were negative. Liver biopsy depicted massive deposition of amyloid in peri-sinusoidal spaces which revealed apple green birefringence on polarizing microscopy after Congo red staining. Cardiac and renal evaluation was unremarkable. Abdominal fat pad and rectum biopsy was negative for amyloid deposit. There was no evidence of primary amyloidosis as bone marrow examination was normal. Serum and urine immunofixation electrophoresis were normal. Immunoperoxidase staining for serum amyloid associated protein for secondary amyloidosis was negative from liver biopsy. We present this rare case of primary hepatic amyloidosis and review the literature regarding varied presentations of hepatic involvement in amyloidosis.

关键词： Amyloidosis Congo red staining Isolatedhepatic amyloidosis Amyloid associated protein Immunofixation electrophoresis

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LC-Uv and LC-MS evaluation of stress degradation behavior of desvenlafaxine

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Journal of Pharmaceutical Analysis 2012年第4期2卷 264-271页

作者： Shubhangi M.pawar Laxman D.Khatal Satish Y.Gabhe sunil R.Dhaneshwar Research and Development Centre in Pharmaceutical Sciences and Applied Chemistry Poona College of PharmacyBharati Vidyapeeth University Bioanalytical Research Department BioAnalytical Technologies Pvt.Ltd.

The objective of current study was to develop a validated specific stability indicating reversed-phase liquid chromatographic method for the quantitative determination of desvenlafaxine in bulk sample and pharmaceutical dosage form in the presence of degradation products. Forced degradation studies were performed on bulk sample of desvenlafaxine as per ICH prescribed stress conditions using acid, base, oxidative and photolytic degradation to show the stability indicating power of the method. Significant degradation was observed under acidic stress condition and the degradation product formed was identified by LC-MS and a degradation pathway for drug has been proposed. Successful separation of drug from degradation products formed under stress conditions was achieved on a SymmetryShield column C 18 (5 mm, 250 mm 4.6 mm, i.d.) using the mobile phase consisting of a mixture of 0.2% (v/v) triethylamine in ammonium acetate (0.05 M; pH 6.5) and methanol using isocratic gradient.

关键词： Reversed-phase liquid chromatography Liquid chromatography mass spectrometer (LC/MS) Desvenlafaxine Stress studies validation Degradation

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Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices

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Journal of Rare Earths 2013年第5期31卷 441-448页

作者： Arun Kumar K v Revathy K P Prathibha vasudevan sunil Thomas Biju P R Unnikrishnan N v School of Pure & Applied Physics Mahatma Gandhi University

We reported here the structural and optical characterisation of silver nanocrystallites/Eu3＋：SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy （EDX）, X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, atomic force microscope （AFM） and transmission electron microscopy （TEM） measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3＋ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3＋ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate.

关键词： sol-gel luminescence SiO2-TiO2 silver nanoparticles rare earths

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Establishment of inherent stability of pramipexole and development of validated stability indicating LC-Uv and LC-MS method

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Journal of Pharmaceutical Analysis 2013年第2期3卷 109-117页

作者： Shubhangi M.pawar Laxman D.Khatal Satish Y.Gabhe sunil R.Dhaneshwar Department of Pharmaceutical Chemistry Poona College of PharmacyBharati Vidyapeeth UniversityPuneMaharashtra 411038India Bioanalytical Research Department BioAnalytical Technologies Pvt.Ltd.PuneMaharashtra 411030India Department of Pharmaceutical Chemistry RAK Medical and Health Sciences UniversityCollege of Pharmaceutical SciencesRas Al Khaimah 11172United Arab Emirates

Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson＇s disease.A validated specific stability indicating reversed-phase liquid chromatographic method has been developed for the quantitative determination of pramipexole in bulk as well as in pharmaceutical dosage forms in the presence of degradation *** degradation studies were performed by exposition of drug to hydrolytic（acidic and basic）,oxidative and photolytic stress conditions,as defined under ICH guideline Q1A（R2）.Significant degradation was observed under hydrolytic,oxidative and photolytic conditions and the degradation products formed were identified by LC-MS.

关键词： Degradation products Forced degradation/stress studies Liquid chromatography mass spectrometry Pramipexole Reversed-phase liquid chromatography

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