Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-αin high-fat diet-induced obese rats

作     者：Sayyed Nadeem Pradeep Dhore Mohsin Quazi Sunil Pawar Navin Raj 

作者机构：Technocarts Institute of Technology PharmacyAnand NagarBhopalMadhypradeshIndia Agnihotri College of PharmacyBapuji WadiSindhi(Meghe)Wardha-442 001MaharashtraIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第9期

页      面：698-702页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Lagenaria sicera Cucurbitaceae Fat amassment High fat diet 

摘      要：Objective:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit(ELSF) on fat amassment and serum TNF-αin high-fat diet-induced obese ***:The high fat diet induced obese rals were orally treated with orlistat(50 mg/kg) and ELSF(100,200.300 mg/kg/day) to the respective treatment *** body weight,lasting blood glucose level,lipid profile, serum levels of tumor necrosis factor-α(TNF-α) in rats were measured after 30 days of treatment adn compared to the obese control ***:ELSF significantly(P 0.001) reduced the body weight gain,fasting blood glucose,total cholesterol,triglyceride,total protein and TNF-α.Conclusions:These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.