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Corneal epithelial defects following vitreoretinal surgery:incidence and outcomes from the DISCOVER study

International Journal of Ophthalmology(English edition) 2022年第1期15卷 83-88页

作者： kubra Sarici Daniel Petkovsek Alison Martin Alex Yuan Jeffrey M.Goshe sunil k.srivastava Jamie L.Reese Justis P.Ehlers The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research Cole Eye InstituteCleveland ClinicClevelandOH 44195USA Vitreoretinal Service Cole Eye InstituteCleveland ClinicClevelandOH 44195USA Cornea Service Cole Eye InstituteCleveland ClinicClevelandOH 44195USA

AIM:To investigate the incidence,risk factors,clinical course,and outcomes of corneal epithelial defects(CED)following vitreoretinal surgery in a prospective study ***:This was a post-hoc analysis of all participants in DISCOVER intraoperative optical coherence tomography *** with CED 1 d after surgery without intraoperative corneal debridement was defined as the postoperative CED *** who underwent intraoperative debridement were defined as intraoperative debridement *** were matched 2:1 with controls(eyes without postoperative CED)for comparative *** primary outcomes were the incidence of CED on postoperative day one and the incidence of required intraoperative *** outcomes included time to defect closure,delayed healing(>2 wk),visual acuity(VA)and presence of scarring at one year and cornea ***:This study included 856 eyes that underwent vitreoretinal *** corneal debridement was performed to 61(7.1%)subjects and postoperative CED developed spontaneously in 94(11.0%)*** factors associated with postoperative CED included prolonged surgical duration(P=0.003),diabetes mellitus(P=0.04),postoperative ocular hypotension(P2 wk)was associated with corneal scar formation at the end of the 1 y in all epithelial defect subjects(Pk of corneal scarring at one *** overall rate of corneal scarring following vitrectomy is low at<2%.

关键词： corneal epithelial defect vitreoretinal surgery intraoperative optical coherence tomography

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Advancement in biogas production from the solid waste by optimizing the anaerobic digestion

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Waste Disposal and Sustainable Energy 2020年第2期2卷 85-103页

作者： sunil kumar srivastava Department of Environmental Science/Chemistry Jaypee University of Engineering and TechnologyRaghogarhGunaMP 473226India

The crisis of fossil fuel and their negative impact on the environment has caused concern among the scientific communities leading them to look around for renewable sources of *** review has emphasized the efficient utilization of organic municipal solid waste as well as agriculture waste in an anaerobic digester for the production of biogas as a sustainable renewable *** advances in biogas production along with previous research work have been discussed to offer a comprehensive synopsis of the accumulated *** review also elucidates about the design of an anaerobic digester,the prospect of anaerobic digestion and opportunity in new advances in *** is one of the most accepted sustainable renewable *** characterization,elimination of contaminants,pretreatment,anaerobic diges-tion in optimum condition and utilization of energy crops enhanced the efficiency of an anaerobic *** of segregated organic solid waste increased its putrescibility and further biogas *** optimized parameters in this review were pH,temperature,loading rate,C/N ratio and solid/liquid ratio of the *** flow rate of the feedstock was optimized according to the available volume of the digester,residence time and the characteristics of the *** design of an anaerobic digester should be preferably cylindrical in shape,with a diameter ranging from 6 to 40 m,the depth ranging from 7.5 to 15 m and the conical floor having a slope around 15%.A comprehensive reform in technical,economic,and social policies is essential to accomplish a sustainable energy system considering biogas as a future renewable *** flowsheet of the biogas and methanol production has been given in Fig.1.

关键词： Renewable energy Anaerobic digestion Biomass Biogas Energy crops Solid waste

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Disaster Preparedness:Looking through the Lens of Hospitals in Japan

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International Journal of Disaster Risk Science 2013年第2期4卷 89-100页

作者： Farah Mulyasari Satomi Inoue sunil Prashar kenji Isayama Mrittika Basu Nitin srivastava Rajib Shaw Graduate School of Global Environmental Studies Kyoto University Kyoto 606-8501 Japan

Critical facilities, such as hospitals, play a crucial role in the socioeconomic and psychological recovery of the population after a disaster. Hospitals are considered important due to their roles in saving lives in the affected population and must be able to withstand hazards and remain functioning during and after a disaster. This article assesses earthquake preparedness of hospitals in eight Japanese cities using a questionnaire survey. The questionnaire consists of six parameters and 21 indicators from the “four pillars of hospital preparedness” including structural, nonstructural, functional, and human resources. The results show that the majority of the respondent hospitals fulfill the functional preparedness, which is useful during the emergency period of a disaster, while the other three pillars—structural, nonstructural, and human resources—need to be strengthened. This study helps to assess the status of disaster preparedness as well as the gaps for these hospitals in the Tohoku and Nankai Trough regions, drawing lessons from the Great East Japan Earthquake and Tsunami of the Tohoku area. This status and the gaps are used as a departure point to indicate how to enhance preparedness and resilience to future disaster risks.

关键词： disaster Japan strengthened

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Biomedical Perspective of Electrochemical Nanobiosensor

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Nano-Micro Letters 2016年第3期8卷 193-203页

作者： Priti Singh Shailendra kumar Pandey Jyoti Singh Sameer srivastava Sadhana Sachan sunil kumar Singh Department of Biotechnology Motilal Nehru National Institute of Technology Department of Chemical Engineering Motilal Nehru National Institute of Technology

Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. key challenges associated with the electrochemical sensor and its future perspectives are also addressed.

关键词： Biomarkers Point-of-care detection Nanomaterials Electroactive species Potentiometric Amperometric Implantable

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Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry

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Journal of Pharmaceutical Analysis 2016年第6期6卷 363-373页

作者： sunil kumar Awantika Singh Vikas Bajpai Mukesh srivastava Bhim Pratap Singh Brijesh kumar Sophisticated Analytical Instrument Facility CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Academy of Scientific and Innovative Research (AcSIR) New Delhi 110025 India Biometry and Statistics Division CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Department of Biotechnology Mizoram University Tanharil 796004 Aizawl Mizoram India

Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and ***,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in *** is an aphrodisiac used in dietary *** there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion *** identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and *** MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS ***,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia *** of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species.

关键词： Rauwolfia species Monoterpene indole alkaloids (MIAs) HPLC–ESI–QTOF–MS/MS Principal component analysis (PCA)

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Rhododendrons in Indian Himalayan Region: Diversity and Conservation

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American Journal of Plant Sciences 2010年第2期1卷 131-137页

作者： k. Chandra Sekar sunil kumar srivastava 不详

The genus Rhododendron of Indian Himalayan Region (IHR) has been enumerated in the present paper. A total of 87 species, 12 subspecies and 8 varieties of Rhododendrons recorded in IHR, among these 6 species and one subspecies are reported from Western Himalaya. The maximum concentration of 86% observed in Arunachal Pradesh (75 species). The species of Rhododendrons exhibit significant diversity in habit and broad range of distribution from the altitude of 800-6000 m. and the best range is observed in 3001-3500 m altitudes. In analysis revealed 20 taxa are endemic, 30 are rare, 24 are threatened / endangered, 3 are vulnerable and 47 taxa have to be assessed. The major threats to rhododendrons are deforestation and unsustainable extraction for firewood and incense by local people has been discussed.

关键词： Rhododendrons Indian Himalayan Region Ericaceae India

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Expression of multidrug resistance proteins in retinoblastoma

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1655-1661页

作者： Swati Shukla Arpna srivastava sunil kumar Usha Singh Sandeep Goswami Bhavna Chawla Mandeep Singh Bajaj Seema kashyap Jasbir kaur Department of Ocular Biochemistry Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Oculoplasty & Pediatric Opthalmology Services Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Department of Ocular Pathology Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India

AIM： To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug ***： Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy（PCNC） were also prepared. Their chemosensitivity to chemotherapeutic agents（vincristine, etoposide and carboplatin） were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma ***： Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein（P-gp） was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1（Mrp-1） expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associatedprotein（Lrp） was observed in the drug resistant Y79 cells as well as in ***： Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

关键词： retinoblastoma chemotherapy multidrug resistance multidrug resistance associated proteins

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Growth of Boron Nitride Nanotubes Having Large Surface Area Using Mechanothermal Process

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World Journal of Nano Science and Engineering 2011年第4期1卷 119-128页

作者： sunil k. Singhal Avanish k. srivastava Rakesh B. Mathur 不详

Nanostructures of boron nitride (BN) including nanotubes, nanofibers and nanosheets having a large surface area are very useful in storing hydrogen and other gases. In the present paper we report the synthesis and characterization of these nanostructures of BN using mechanothermal process. Under this process elemental boron powder is first ball milled to about 50 h in an inert atmosphere and then annealed at 1100℃ - 1250℃ for 6 h in the presence of NH3 gas. By this treatment nanotubes and other nanostructures of BN were synthesized. The diameter of BN nanotubes varied from 20 to 50 nm and most of them exhibited spindle or bamboo like morphology. Because of the large surface area, these nanotubes may be explored for a better hydrogen gas storage device as compared to the crystallized nanotubes. The main advantage of this technique is that the nanotubes can be grown in large quantity. A possible growth mechanism towards the evolution of such fascinating nano-objects of boron nitride has been discussed employing high-resolution transmission electron microscopy and photoluminescence.

关键词： Boron Nitride Nanotubes Mechanothermal Process Morphology Photo Luminescence

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Revision of <i>Genus Crescentia</i>L. (Bignoniaceae) in India

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American Journal of Plant Sciences 2013年第6期4卷 1164-1168页

作者： Virendra k. Madhukar sunil kumar srivastava Nawal kishor Dubey Banaras Hindu University Varanasi India. Botanical Survey of India NRC Dehradun India

The genus Crescentia L. in India is taxonomically revised. A key to the species, nomenclatural citation of each species, their synonyms, type details, taxonomic description, phenology, distribution in India and worldwide, exsiccata, ecological and taxonomical notes if any, have been provided. Line drawing of the habit and dissected parts of each species have been given.

关键词： Crescentia Bignoniaceae Revision Taxonomic India

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氨化碳纳米管接枝生物分子(蛋白质和DNA)(英文)

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新型炭材料 2009年第4期24卷 301-306页

作者： kalpana Awasthi D.P. Singh sunil Singh D. Dash O.N. srivastava Department of Physics Banaras Hindu University Varanasi-221005 INDIA Department of Physics Southern Illinois University Carbondale Lincoln Carbondale-629014401 USA Department of Biochemistry Institute of Medical Sciences Banaras Hindu University Varanasi-221005 INDIA

报告-种氨基功能化处理的多壁碳纳米管(f-MWCNTs)用于生物分子〔如牛血浆蛋白素(BSA)蛋白质及脱氧核醣核酸(DNA)〕的接枝处理高效方法。以苯—二茂铁喷入氩氛炉于～850℃裂解制得MWCNTs,,而后向纳米管表面导入羧基化合物,再以氨基基团对... 详细信息

报告-种氨基功能化处理的多壁碳纳米管(f-MWCNTs)用于生物分子〔如牛血浆蛋白素(BSA)蛋白质及脱氧核醣核酸(DNA)〕的接枝处理高效方法。以苯—二茂铁喷入氩氛炉于～850℃裂解制得MWCNTs,,而后向纳米管表面导入羧基化合物,再以氨基基团对MWCNTs,进行功能化处理。该过程包括:乙二胺与羧基基团直接结合,经酰胺化引入胺基基团。对制得的MWCNTs、f-MWCNTs以及由BSA蛋白质和DNA接枝的氨化f-MWCNTs等样品,采用SEM、TEM、FTIR进行表征。结果表明:生物分子(BSA蛋白质和DNA)接枝于氨化的f-MWCNTs。

关键词：碳纳米管功能化处理蛋白质 DNA

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