Corneal epithelial defects following vitreoretinal surgery:incidence and outcomes from the DISCOVER study

作     者：Kubra Sarici Daniel Petkovsek Alison Martin Alex Yuan Jeffrey M.Goshe Sunil K.Srivastava Jamie L.Reese Justis P.Ehlers 

作者机构：The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging ResearchCole Eye InstituteCleveland ClinicClevelandOH 44195USA Vitreoretinal ServiceCole Eye InstituteCleveland ClinicClevelandOH 44195USA Cornea ServiceCole Eye InstituteCleveland ClinicClevelandOH 44195USA 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第1期

页      面：83-88页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by National Institutes of Health/National Eye Institute Bethesda Maryland USA(K23-EY022947-01A1) 

主　　题：corneal epithelial defect vitreoretinal surgery intraoperative optical coherence tomography 

摘      要：AIM:To investigate the incidence,risk factors,clinical course,and outcomes of corneal epithelial defects(CED)following vitreoretinal surgery in a prospective study ***:This was a post-hoc analysis of all participants in DISCOVER intraoperative optical coherence tomography *** with CED 1 d after surgery without intraoperative corneal debridement was defined as the postoperative CED *** who underwent intraoperative debridement were defined as intraoperative debridement *** were matched 2:1 with controls(eyes without postoperative CED)for comparative *** primary outcomes were the incidence of CED on postoperative day one and the incidence of required intraoperative *** outcomes included time to defect closure,delayed healing(2 wk),visual acuity(VA)and presence of scarring at one year and cornea ***:This study included 856 eyes that underwent vitreoretinal *** corneal debridement was performed to 61(7.1%)subjects and postoperative CED developed spontaneously in 94(11.0%)*** factors associated with postoperative CED included prolonged surgical duration(P=0.003),diabetes mellitus(P=0.04),postoperative ocular hypotension(P2 wk)was associated with corneal scar formation at the end of the 1 y in all epithelial defect subjects(P0.001).The overall rate of corneal scarring for all eyes undergoing vitrectomy was 1.8%.CONCLUSION:Prolonged duration of surgery is the strongest factor associated with both intraoperative debridement and spontaneous postoperative *** defect closure is associated with a greater risk of corneal scarring at one *** overall rate of corneal scarring following vitrectomy is low at2%.