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Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

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World journal of Gastroenterology 2006年第41期12卷 6693-6698页

作者： Jung Woo Shin Neung Hwa Park Seok Won Jung Byung Chul Kim sung Ho Kwon Jae Serk Park In Du Jeong sung-jo bang Do Ha Kim Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine Ulsan University HospitalUlsanKorea

AIM： To determine the changes of quantitative hepatitis B e antigen （HBeAg） that predicts early detection of non-response or breakthrough to long-term lamivudine （LAM） therapy. METHODS： Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 too, we retrospectively analyzed 220 patients who had received LAM more than 24 too. RESULTS： The mean duration of LAM therapy was 36 （range, 24-72） mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 （24.1%） patients. Viral breakthrough was observed in 105 （47.7%） patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg： decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non-response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 （92.5%） of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four （7.5%） had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 too, 95.2% （negative predictive value） failed to achieve HBeAg seroconversion. CONCLUSION： Almost all patients who failed to show a continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough.

关键词： Hepatitis B e antigen positive chronic hepatitis B lamivudine Quantitative HBeAg levels Non- response Breakthrough

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A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor

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World journal of Gastroenterology 2007年第24期13卷 3396-3399页

作者： sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong jong Hwa Lee Yang Won Nah sung jo bang Jung Woo Shin Neung Hwa Park Do Ha Kim Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Ulsan University Hospital Ulsan Korea Department of Pathology University of Ulsan College of Medicine Ulsan University Hospital Ulsan Korea Department of Radiology University of Ulsan College of Medicine Ulsan University Hospital Ulsan Korea Department of Surgery University of Ulsan College of Medicine Ulsan University Hospital Ulsan Korea

Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively.

关键词： Gastrointestinal stromall tumor Duodenum Pancreas head tumor

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Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception

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World journal of Gastroenterology 2006年第12期12卷 1969-1971页

作者： Hyun Soo Kim Jung WooShin In Du Jeong sung-jo bang Do Ha Kim Neung Hwa Park Gyu Yeol Kim Young Min Kim Hee Jeong Cha Yoong Ki Jeong Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Surgery University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Pathology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Radiology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea

Hepatocellular carcinoma （HCC） is a so highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal （GI） tract is rare, and most common site is stomach. Metastasis to the small intestine is extremely rare. Moreover, metastatic HCC of the small bowel causing intussusception has not been reported until now. Here, we report a case of metastasis of HCC to the small bowel manifested by intussusception.

关键词： Hepatocelluar carcinoma Small bowel metastasis Intussusception

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Learning models for endoscopic ultrasonography in gastrointestinal endoscopy

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World journal of Gastroenterology 2015年第17期21卷 5176-5182页

作者： Gwang Ha Kim sung jo bang joo Ha Hwang Department of Internal Medicine Pusan National University School of Medicine Biomedical Research Institute Pusan National University HospitalBusan 602-739South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 682-714South Korea Division of Gastroenterology Department of MedicineUniversity of WashingtonSeattleWA 98104United States

Endoscopic ultrasonography(EUS) has become a useful diagnostic and therapeutic modality in gastrointestinal ***,EUS requires additional training since it requires simultaneous endoscopic manipulation and ultrasonographic *** adequate EUS training can be challenging since EUS is highly operator-dependent and training on actual patients can be associated with an increased risk of complications including inaccurate ***,several models have been developed to help facilitate training of *** models currently available for EUS training include computer-based simulators,phantoms,ex vivo models,and live animal *** each model has its own merits and limitations,the value of these different models is rather complementary than ***,there is a lack of objective data regarding the efficacy of each model with recommendations on the use of various training models based on expert opinion ***,objective studies evaluating the efficacy of various EUS training models on technical and clinical outcomes are still needed.

关键词： Endoscopic ultrasonography Training Phantom Computer simulation Animal model

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Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon jong Ho Moon sung Jae Park Chan Guk Park sung-jo bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

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Modelling charge transport and electro-optical characteristics of quantum dot light-emitting diodes

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npj Computational Materials 2021年第1期7卷 1116-1126页

作者： sung-Min Jung Tae Hoon Lee Sang Yun bang Soo Deok Han Dong-Wook Shin Sanghyo Lee Hyung Woo Choi Yo-Han Suh Xiang-Bing Fan Jeong-Wan jo Shijie Zhan Jiajie Yang Chatura Samarakoon Yoonwoo Kim Luigi GOcchipinti Gehan Amaratunga jong Min Kim Electrical Engineering Division Department of EngineeringUniversity of CambridgeCambridgeUnited Kingdom

Quantum dot light-emitting diodes(QD-LEDs)are considered as competitive candidate for next-generation displays or *** advances in the synthesis of core/shell quantum dots(QDs)and tailoring procedures for achieving their high quantum yield have facilitated the emergence of high-performance ***,the charge-carrier dynamics in QD-LED devices,which constitutes the remaining core research area for further improvement of QD-LEDs,is,however,poorly understood ***,we propose a charge transport model in which the charge-carrier dynamics in QD-LEDs are comprehensively described by computer *** charge-carrier injection is modelled by the carrier-capturing process,while the effect of electric fields at their interfaces is *** simulated electro-optical characteristics of QD-LEDs,such as the luminance,current density and external quantum efficiency(EQE)curves with varying voltages,show excellent agreement with ***,our computational method proposed here provides a useful means for designing and optimising high-performance QD-LED devices.

关键词： quantum charge competitive

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KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 62-66页

作者： Jung Hyun jo Huapyong Kang Hee Seung Lee Moon Jae Chung Jeong Youp Park Seungmin bang Seung Woo Park Si Young Song Division of Gastroenterology Department of Internal Medicine Severance Hospital Yonsei University College of Medicine

Background: Sodium meta-arsenite(NaAsO_2, KML001) is a potential oral anticancer agent acting on telomerase and telomere length. This prospective study evaluated its safety, tolerability, and effectiveness as salvage chemotherapy in patients with advanced biliary tract cancer(BTC) resistant to gemcitabinebased chemotherapy. Methods: Forty-four patients(21 women and 23 men) with advanced BTC and failure history of gemcitabine-based chemotherapy, performance status(PS) 0–2, normal cardiac, hepatic, and renal function were enrolled. Daily dose of KML001(7.5 mg. p.o.) was administered to eligible subjects for 24 weeks divided into six treatment cycles. Response was evaluated bimonthly using CT. Results: After an average of 1.5 months of treatment(range: 0.5–10.0), 3 patients(6.8%) obtained progression-free status, 23 patients(52.3%) had disease progression, and 18 patients(40.9%) dropped out before evaluation. One patient(2.3%) completed six treatment cycles without progression. During the treatment, morphine dosage kept the same or decreased in 20 patients(47.6%). Nine patients(20.5%) experienced grade-3 adverse events(AEs), while no patient experienced grade-4 AEs. The most common AEs were liver enzyme elevation(11/44, 25%) and anemia(10/44, 22.7%). KML001 was discontinued in six patients(13.6%) due to AEs, including liver toxicity( n = 3), QTc prolongation( n = 2), and abdominal pain( n = 1). Conclusions: KML001 did not have enough anticancer effect on patients with advanced BTC resistant to gemcitabine. However, KML001 was safe and well-tolerable in terms of AEs and pain control when used as salvage therapy. Further studies are needed to establish arsenic agents as a reliable treatment option in patients with BTC.

关键词： Biliary tract neoplasms Cholangiocarcinoma Gallbladder neoplasms KML001 Sodium meta-arsenite

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Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer

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World journal of Gastrointestinal Oncology 2018年第11期10卷 421-430页

作者： Huapyong Kang Jung Hyun jo Hee Seung Lee Moon Jae Chung Seungmin bang Seung Woo Park Si Young Song Jeong Youp Park Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine

AIM To directly compare the efficacy and toxicity of standarddose FOLFIRINOX(sFOLFIRINOX) and modified-dose FOLFIRINOX(mFOLFIRINOX, 75% of standard-dose) for pancreatic *** One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX(n = 88) or mFOLFIRINOX(n = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate(ORR),disease control rate(DCR), progression-free survival(PFS), and overall survival(OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. The adverse events(AEs) were evaluated, and severe(≥ grade 3) AEs rates of the two groups were compared for toxicity *** The mFOLFIRINOX group included more female patients(30.7% vs 57.1%; P = 0.004) and older patients [age(median), 57 vs 63.5; P = 0.018] than the sFOLFIRINOX group. In the efficacy analysis, the ORR and DCR were not significantly different between the two groups(ORR: 39.8% vs 35.7%; P = 0.656; DCR: 80.7% vs 83.3%; P = 0.716). The median PFS and OS were also not different between the groups(PFS: 8.7 mo vs 8.1 mo, P = 0.272; OS: 13.9 mo vs 13.7 mo, P = 0.476). In the safety analysis with severe AEs, the rates of neutropenia(83.0% vs 66.7%; P = 0.044), anorexia(48.9% vs 28.6%; P = 0.029) and diarrhea(13.6% vs 0.0%; P = 0.009) were markedly lower in the mFOLFIRINOX *** m FOLFIRINOX showed comparable efficacy but better safety compared to sFOLFIRINOX. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy.

关键词： Dose modification Adverse event Pancreatic cancer Adenocarcinoma FOLFIRINOX Chemotherapy

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FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study

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World journal of Gastrointestinal Oncology 2020年第2期12卷 182-194页

作者： In Rae Cho Huapyong Kang Jung Hyun jo Hee Seung Lee Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-Suk Park Seungmin bang Department of Internal Medicine International Saint Mary’s HospitalCatholic Kwandong University College of MedicineIncheon 22711South Korea Department of Medicine Yonsei University Graduate School50-1 Yonsei-roSeoul 03722South Korea Division of Gastroenterology Department of Internal MedicineYonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea Department of Radiology Yonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea

BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer ***,studies that compared these two regimens and studies in Asian populations are *** To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean *** Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort *** efficacy,treatment-related adverse events and economic aspects were *** Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at *** median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX ***≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX *** drug costs of both regimens were *** Treatment efficacy and economic burdens were comparable between the two ***,the details of adverse event were ***+nabPTX regimen might be considered preferentially in certain conditions.

关键词： Pancreatic cancer Chemotherapy FOLFIRINOX Gemcitabine Nabpaclitaxel Survival

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Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma

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World journal of Gastroenterology 2017年第18期23卷 3301-3308页

作者： Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin bang Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Division of Gastroenterology Department of Internal Medicine and Yonsei Institute of Gastroenterology Yonsei University College of Medicine

To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).METHODSWe retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative *** median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (P = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (P = 0.01).CONCLUSIONNACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.

关键词： Klatskin tumor Locally advanced Survival rate Neoadjuvant therapy Chemoradiotherapy

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