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Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 29-35页

作者： O Kyu Noh Soon Sun Kim Min Jae Yang Sun Gyo Lim Jae Chul Hwang Hyo Jung cho Jae Youn Cheong sung won cho Department of Radiation Oncology Ajou University School of MedicineSuwonKorea Department of Biomedical Informatics Ajou University School of MedicineSuwonKorea Office of Biostatistics Ajou Research Institute for Innovative MedicineAjou University Medical CenterSuwonKorea Department of Gastroenterology Ajou University School of MedicineSuwonKorea

Background: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results (SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identi ed 79 patients with HEH (median age: 54.0 years;male to female ratio: 1:2.6). The initial extent of disease was local in 22 (27.8%) patients, regional metastasis in 22 (27.8%), distant metas-tasis in 31 (39.2%) and unknown in 4 (5.1%). The median size of primary tumor was 3.85 cm (interquartile range, 2.50 7.93 cm). Among 74 patients with available management data, the most common manage-ment was no treatment (29/74, 39.2%), followed by chemotherapy only (22/74, 29.7%), liver resection-based (13/74, 17.6%), and transplantation-based therapy (6/74, 8.1%). The 5-year cancer-speci c survival rate was 57.8%. Patients who underwent surgical treatment had signi cantly higher survival than those who underwent non-surgical treatment (5-year survival;88% vs. 49%, P=0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival (hazard ratio: 0.20, P=0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.

关键词： Hemangioendothelioma Epithelioid SEER program Liver transplantation Hepatectomy Liver neoplasms

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Effect of focal laser photocoagulation in eyes with mild to moderate non-proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1439-1443页

作者： Seong Hun Jeong Jung Il Han sung won cho Dong won Lee Chul Gu Kim Tae Gon Lee Jong Woo Kim Department of Ophthalmology Kim's Eye HospitalMyung-Gok Eye Research InstituteKonyang University College of Medicine

AIM：To report the effect of focal laser photocoagulation on both the severity of hard exudates（HEs） and the rate of disease progression in eyes with mild to moderate non-proliferative diabetic retinopathy（NPDR）.METHODS： We retrospectively reviewed the medical records of 33 patients（60 eyes） who had been diagnosed with mild to moderate NPDR between January 2006 and December *** patients were divided into 2 groups：Group A（38 eyes in 20 patients treated using focal laser photocoagulation） and Group B（treated without laser photocoagulation）.We also reviewed the best corrected visual acuity measurements,and the fundus photographs taken at both baseline and follow-up visits. RESULTS： In Group A,HE severity grade had decreased significantly from baseline to the final visit（P 〈0.05）,but this was not the case in Group B（P =0.662）.The cumulative probabilities of retinopathy progression at 5y were 26% in Group A and 30% in Group *** survival curves showed no significant difference between the groups with regard to retinopathy progression（P =0.805）.CONCLUSION： Focal laser photocoagulation reduced the levels of HEs in eyes with mild to moderate ***,the treatment was not able to decelerate the progression of DR.

关键词： focal laser diabetic retinopathy retina non-proliferative diabetic retinopathy

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Fatigue crack in large-scale tubular joints for offshore structures

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Science China(Technological Sciences) 2011年第3期54卷 705-714页

作者： Chul-Hee JO sung-Woo IM won-Chul cho Kwan-Kyu PARK Department of Naval Architecture and Ocean Engineering Inha University Research Institute of Industrial Science and Technology Department of Civil & Environmental Engineering Chung-Ang University Samsung Heavy Industry Inc.

Tubular members have been used for constructing offshore structures. Large-scale fatigue tests of welded tubular K-joints under the balanced in-plane bending brace were carried out to investigate the fatigue behavior of API 2W Gr.50 steel produced by POSCO. The experimental results were verified by numerical approaches and compared with the IIW, DnV RP-C203 and API RP 2A-WSD design curves. The test results based on the hot spot stress were in agreement with the design curves. The SCF factor for tubular K-joint was also obtained. The numerical parametric study of the K-joint (using the finite element program) was described and its results were compared with experimental results. The stress effects of various parameters including α, β, γ, τ and θ on the stress in the K-joint were investigated. The stress distribution for each parameter was introduced. The study showed that the maximum stress of the joint varied according to the variation of joint parameters.

关键词： tubular K-joint API 2W Gr.50 hot spot stress SCF fatigue through-thickness crack S-N curve numerical parametric study

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Robust digital receiver for EPC sensor network

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Journal of Systems Engineering and Electronics 2013年第1期24卷 44-51页

作者： Cheng Jin sung Ho cho Department of Electronics and Computer Engineering Hanyang University

A robust digital receiver based on a matched filter （MF） is proposed for the radio frequency identification （RFID） reader system to enhance the reliability of signal processing in the electronic product code （EPC） sensor network （ESN）. The performance of the proposed receiver is investigated by examining the anti-collision algorithm in the EPC global Class1 Generation2 protocol. The validity and usefulness are demonstrated by both computer simulations and experiments. Based on the verification results, comparing with the conventional zero crossing detector （ZCD） based receiver, the proposed receiver is very robust against strong amplitude distortions and considerable frequency deviations happening on the backscattered signal from a passive tag.

关键词： electronic product code (EPC) sensor network (ESN) signal distortion matched filter radio frequency identification (RFID) receiver.

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NaF-FeF2 nanocomposite： New type of Na-ion battery cathode material

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Nano Research 2017年第12期10卷 4388-4397页

作者： Insang Hwang sung-Kyun Jung Eun-Suk Jeong Hyunchul Kim sung-Pyo cho Kyojin Ku Hyungsub Kim won-Sub Yoon Kisuk Kang Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Seoul 08826 Republic of Korea Department of Energy Science (DOES) Sungkyunkwan University Suwon 16419 Republic of Korea National Center for Inter-University Research Facilities Seoul National University Seou108826 Republic of Korea Neutron Science Division HANARO Korea Atomic Energy Research Institute Daejeon 34057 Republic of Korea Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul National University Seou108826 Republic of Korea

Na-ion batteries （NIBs） are considered one of the most attractive alternatives for Li-ion batteries （LIBs） because of the natural abundance of Na and the similarities between the NIB technology and the well-established LIB technology. However, the discovery of high-performance electrode materials remains a key factor in the success of NIBs. Herein, we propose a new type of cathode material for NIBs based on a nanocomposite of an alkali metal fluoride （NaF） and a transition metal fluoride （FeF2）. Although neither of these components is electrochemically active with Na, the nanoscale mixture of the two can deliver a reversible capacity of -125 mAh/g in the voltage range of 1.2--4.8 V vs. Na/Na＋ via an Fe2＋/Fe3＋ redox couple. X-ray absorption spectroscopy reveals that the reversible Na storage is aided by the F-ions due to the decomposition of NaF, which are absorbed on the surface of FeF2, promoting the redox reaction of Fe and triggering the gradual transformation of the mother structure （FeF2） into a new （FeFB-like） host structure for the Na ions. This unique Na-ion storage phenomenon, which is reported for the first time, will introduce an avenue for designing novel cathode materials for NIBs.

关键词： nanocomposite Na-ion batteries NaF FeF2 cathode

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Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy

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World Journal of Gastroenterology 2013年第38期19卷 6494-6499页

作者： In-Chul Park Yang-Hyun Baek Sang-Young Han sung-Wook Lee won-Tae Chung sung-won Lee Sang-Hyeon Kang Duk-Song cho Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of MedicineDong-A University

Warfarin is a widely used *** differences in drug response,a narrow therapeutic range and the risk of bleeding render warfarin difficult to use *** 18-year-old woman with antiphospholipid syndrome received long-term warfarin therapy for a recurrent deep vein *** years later,she developed right flank *** diagnosed intrahepatic and subgaleal hemorrhages secondary to anticoagulation *** stopping oral anticoagulation,a follow-up computed tomography showed improvement in the *** restarting warfarin because of a recurrent thrombosis,the intrahepatic hemorrhage *** decided to start clopidogrel and hydroxychloroquine instead of *** patient has not developed further recurrent thrombotic or bleeding *** hemorrhage is a very rare complication of warfarin,and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control.

关键词： Warfarin Liver Subgaleal Hemorrhage Antiphospholipid syndrome

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Progress of Materials and Devices for Neuromorphic Vision Sensors

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Nano-Micro Letters 2022年第12期14卷 239-271页

作者： sung Woon cho Chanho Jo Yong-Hoon Kim sung Kyu Park Department of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National UniversitySunchŏnJeonnam 57922Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea

The latest developments in bio-inspired neuromorphic vision sensors can be summarized in 3 keywords:smaller,faster,and smarter.(1)Smaller:Devices are becoming more compact by integrating previously separated components such as sensors,memory,and processing *** a prime example,the transition from traditional sensory vision computing to in-sensor vision computing has shown clear benefits,such as simpler circuitry,lower power consumption,and less data redundancy.(2)Swifter:Owing to the nature of physics,smaller and more integrated devices can detect,process,and react to input more *** addition,the methods for sensing and processing optical information using various materials(such as oxide semiconductors)are evolving.(3)Smarter:Owing to these two main research directions,we can expect advanced applications such as adaptive vision sensors,collision sensors,and nociceptive *** review mainly focuses on the recent progress,working mechanisms,image pre-processing techniques,and advanced features of two types of neuromorphic vision sensors based on near-sensor and in-sensor vision computing methodologies.

关键词： In-sensor computing Near-sensor computing Neuromorphic vision sensor Optoelectronic synaptic circuit Optoelectronic synapse

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Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： sung Bum Park Hye-Jin cho Sang Rin Moon Kyoung Jin choi won Hoon Jung Ki Young Kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

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Middle Paleozoic metamorphic and sedimentary events in the central Korean Peninsula and their geological implications

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Geoscience Frontiers 2024年第5期15卷 136-161页

作者： Byung choon Lee sung won Kim Bo Young Lee Chang Whan Oh Deung-Lyong cho Weon-Seo Kee Department of Earth and Environmental Sciences Chonnam National University77Yongbong-roBuk-guGwangju 61186Republic of Korea Geology and Space Division Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Department of Earth and Environmental Sciences Jeonbuk National UniversityJeonju 561-756Republic of Korea

The Middle Paleozoic tectonic evolution of the central Korean Peninsula(Gyeonggi Massif,Hongseong-Imjingang,and Okcheon zone of Okcheon Belts)remains ***,the occurrence of high-grade metamorphism and sedimentation need further *** this study,we conducted zircon U-Pb-rare earth element analyses from in the ultramafic-mafic complex in the central Korean Peninsula(Cheonan and Gapyeong areas)and the Paleozoic metasedimentary rocks in the Okcheon Zone of the Okcheon Belt to constrain the timing of maximum depositional and metamorphic *** also examined the metamorphic P-T-t path from garnet-bearing amphibolite in the central Korean Peninsula by pseudosection modeling and *** results show that(i)some of the ultramafic-mafic complex and metasedimentary rocks in the central Korean Peninsula formed during the Middle Paleozoic(ca.450–374 Ma);(ii)garnet-bearing amphibolite underwent successive metamorphism from amphibolite facies condition(7.5–8.0 kbar and 540–630℃)at pre-peak stage to granulite facies condition(10.9–11.8 kbar and 740–820℃)at peak stage,and then retrograded into amphibolite facies condition(5.7–7.7 kbar and 530–670℃)along the clockwise P–T path during ca.403–362 *** and previous studies suggest that the central Korean Peninsula underwent subduction-related orogenic events during the Middle Paleozoic era,and it is well correlated to those of the orogenic events in the North Qinling belt.

关键词： Central Korean Peninsula Middle Paleozoic Orogenic event Pressure-temperature estimation Zircon U-Pb-REE analysis

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Evaluation of the relationship between two different methods for enumeration fecal indicator bacteria: Colony-forming unit and most probable number

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Journal of Environmental Sciences 2010年第6期22卷 846-850页

作者： Kyung Hwa cho Dukki Han Yongeun Park Seung won Lee sung Min Cha Joo-Hyon Kang Joon Ha Kim Department of Environmental Science and Engineering Gwangju Institute of Science and Technology Deparment of Civil and Environmental Engineering Dongguk University-Seoul Sustainable Water Resource Technology Center Gwangju Institute of Science and Technology

Most probable number （MPN） and colony-forming unit （CFU） estimates of fecal indicator bacteria （FIB） concentration are common measures of water quality in aquatic environments. Thus, FIB intensively monitored in Yeongsan Watershed in an attempt to compare two different methods and to develop a statistical model to convert from CFU to MPN estimates or vice versa. As a result, the significant difference was found in the MPN and CFU estimates. The enumerated Escherichia coli concentrations in MPN are greater than those in CFU, except for the measurement in winter. Especially in fall, E. coli concentrations in MPN are one order of magnitude greater than that in CFU. Contrarily, enterococci bacteria in MPN are lower than those in CFU. However, in general, a strongly positive relationship are found between MPN and CFU estimates. Therefore, the statistical models were developed, and showed the reasonable converting FIB concentrations from CFU estimates to MPN estimates. We expect this study will provide preliminary information towards future research on whether different analysis methods may result in different water quality standard violation frequencies for the same water sample.

关键词： most probable number colony-forming unit fecal indicator bacteria Escherichia coli enterococci

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