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The Effect of Sleep and Cognition Enhancement Multimodal Intervention for Mild Cognitive Impairment with Sleep Disturbance in the Community-Dwelling Elderly

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International Journal of Mental Health Promotion 2023年第11期25卷 1197-1208页

作者： Eun Kyoung Han Hae Kyoung son Department of Nursing Eulji UniversitySeongnam13135South Korea

Dementia prevalence has soared due to population aging. In Mild Cognitive Impairment (MCI) as a pre-dementia stage, sleepdisturbances have raised much interest as a factor in a bidirectional relationship with cognitive decline. Thus, this studydeveloped the Sleep and Cognition Enhancement Multimodal Intervention (SCEMI) based on Lazarus’ multimodal approachand conducted a randomized controlled experiment to investigate the effects of the novel program on sleep and cognition inMCI elderly. The participants were 55 MCI elderly with sleep disturbances at two dementia care centers located in S-city,Gyeonggi-do, South Korea (n = 25 in the experimental group and n = 30 in the control group). The study period was fromNovember 01 to December 27, 2022. The experimental group received 8 sessions of SCEMI, 60 min per session once a *** control group received general education and guidance using a simplified booklet on the sleep and cognitive *** data collection, a self-reported questionnaire was used to investigate sleep quality, presleep arousal, cognitive function,stress, and depression. The results showed that, compared to the control group, the experimental group had significantlyimproved across all variables: sleep quality (U = 109.50, p < 0.001), presleep arousal (U = 11.50, p < 0.001), cognitive function(U = 72.00, p < 0.001), stress (U = 139.00, p < 0.001), and depression (U = 231.50, p = 0.015). Thus, the SCEMI appears topositively affect symptomatic improvement and delays the progression to dementia as an integrated intervention to enhancesleep and cognition in community-dwelling MCI elderly with sleep disturbances.

关键词： Depression elderly mild cognitive impairment sleep disturbance stress

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A Case of Ankle Osteomyelitis Caused by <i>Mycobacterium abscessus</i>

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Journal of Tuberculosis Research 2015年第3期3卷 107-112页

作者： Hyun Je Seo Jung Hwan son Ji Young Park Jong min Kim Department of Orthopaedic Surgery Kosin University Hospital Busan South Korea Department of Internal Medicine Kosin University Hospital Busan South Korea

The proportion of non-tuberculous mycobacteria to Mycobacterium tuberculosis cultivated in the laboratory has been recently increasing. Numerous skin and soft tissue infections have been reported, while osteomyelitis is reported very rarely. A delayed diagnosis can cause a wide range of bone destruction and joint contracture, which highlights the importance of early recognition of osteomyelitis. Here we report a case of ankle osteomyelitis caused by Mycobacterium abscessus and treatment failure due to delayed diagnosis.

关键词： Ankle Osteomyelitis Mycobacterium abscessus

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Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau Yoon-Hee Park Kyu-Hwan Shim Sang-Wook son Seong-Soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea Laboratory of Cell Signaling and Nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

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Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy

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World Journal of Gastroenterology 2008年第6期14卷 948-950页

作者： Youn son Chung Yong Woo Chung Sun You Moon Su Mi Yoon min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park Department of Gastroenterology Hallym University College of Medicine Anyang Korea Department of Radiology Hallym University College of Medicine Anyang Korea

Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically.

关键词： Toothpick Colon Colonoscopy Pseudodiverticulum

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关于女性的中韩谚语比较研究

关于女性的中韩谚语比较研究

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作者：孙贞敏（son Jeong min）浙江大学

学位级别：硕士

中韩两国的语言中都存在大量的谚语,谚语是在语言习惯中最具代表性的语言表现形式之一,而在这众多谚语中又有许多涉及女性形象的内容。本文从语言与文化相结合的角度,通过对有关反映女性问题谚语的定量分析描写,揭示关于女性的两国谚语... 详细信息

中韩两国的语言中都存在大量的谚语,谚语是在语言习惯中最具代表性的语言表现形式之一,而在这众多谚语中又有许多涉及女性形象的内容。本文从语言与文化相结合的角度,通过对有关反映女性问题谚语的定量分析描写,揭示关于女性的两国谚语的共同点及不同点,并进一步考察中韩两个民族文化之间的关系。本文共分五部分。第一章,介绍了中韩谚语的界定及语言特点。论述谚语的界定、谚语的来源和中韩谚语的关系及研究目的、研究现状和本文的研究方法。第二章,关于“女性美”的中韩谚语比较。把相关谚语分为“外在美”、“内在美”两类,再进行综合比较,分为赞美女性美与抨击女性美,并描写两国女性美文化的特点。第三章,关于“女性言行禁忌”的中韩谚语比较。按照谚语内容的不同主要分为四大类:多言、嫉妒、善交、懒惰,分别举例并归纳特点。第四章,关于“女性地位”的中韩谚语比较,女儿、婆婆、媳妇、妻子、寡妇、妾等在家庭及社会里的不同角色特点与地位。第五章,中韩女性文化背景讨论,探讨形成两国古代女性文化特点的原因。通过对涉及女性形象的谚语的分析,考察谚语中蕴涵的中韩女性文化及关系,希望能为中韩两国的汉语和韩语教学提供一些有价值的参考与借鉴。

关键词：中韩谚语女性比较文化

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Synthesis of TiO_2 visible light catalysts with controllable crystalline phase and morphology from Ti-bearing electric arc furnace molten slag

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Journal of Environmental Sciences 2016年第9期28卷 14-22页

作者： Yang Li Lulu Liu min Guo Mei Zhang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing The State Key Laboratory for Refractories and Metallurgy School of Materials and MetallurgyWuhan University of Science and Technology

TiO_2 visible light catalysts with different crystalline phases and morphologies were synthesized from titanium-bearing electric arc furnace molten slag（Ti-bearing EAF slag）by using a simple acidolysis *** effects of the p H of the HCl solution,liquid to solid ratio（RL/S,HCl solution to the residue ratio,m L/g） and acidolysis time on the micro-morphology and crystalline phase of as-prepared TiO_2 photocatalysts were systematically *** results indicated that with decreasing p H in the HCl solution and increasing RL/S,the crystalline phase and micro-morphology of the obtained TiO_2 nanostructures tended to transform from anatase type TiO_2 with spherical nanoparticle structures to rutile type TiO_2 with needle-like nanorod *** acidolysis time had little influence on the crystalline phase but great impact on the size of the obtained TiO_*** growth mechanism of TiO_2 from Ti-bearing EAF slag during the acidolysis process was also *** addition,the influence of RL/son the photocatalytic properties of the synthesized nanostructured TiO_2 was *** results showed that the photodegradation efficiency for Rhodamine B solution could reach 91.00% in 120 min when the RL/Swas controlled at 50：1.

关键词： Ti-bearing electric arc furnace molten slag Crystalline phase Morphology TiO_2

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高血压脑出血患者影像学特征与认知功能障碍的相关性研究

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医药论坛杂志 2024年第4期45卷 433-436,440页

作者：李舟姜艳涛朱敏平煤神马医疗集团总医院神经内科河南平顶山467000 台州市中医院神经外科浙江台州318000

目的研究高血压脑出血患者影像学特征与认知功能障碍的相关性。方法选取2020年10月—2021年12月平煤神马医疗集团总医院收治的100例高血压脑出血并发认知功能障碍患者(设为观察组)和100例高血压脑出血无认知障碍患者(设为对照组)作为此... 详细信息

目的研究高血压脑出血患者影像学特征与认知功能障碍的相关性。方法选取2020年10月—2021年12月平煤神马医疗集团总医院收治的100例高血压脑出血并发认知功能障碍患者(设为观察组)和100例高血压脑出血无认知障碍患者(设为对照组)作为此次研究对象,收集两组患者一般临床资料、神经影像学资料,并采用蒙特利尔认知评估表(MoCA)和简易精神状态评价量表(MMSE)评估患者的认知功能,痴呆评分量表(CDR)评估患者的痴呆病情严重程度。采用Person相关性分析上述因素与高血压脑出血认知功能障碍的相关性。结果观察组的脑白质病变发生率、脑内微出血数目多于对照组(Pson相关性分析显示,高血压脑出血患者的脑白质病变、脑内微出血数目与MoCA、MMSE评分、CDR分级呈正相关(P<0.05)。结论高血压脑出血患者的认知功能障碍发生与脑白质病变、脑内微出血数目密切相关。

关键词：高血压脑出血影像学特征认知功能障碍相关性

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Novel monoclonal antibody against beta 1 integrin enhances cisplatin efficacy in human lung adenocarcinoma cells

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The Journal of Biomedical Research 2016年第3期30卷 217-224页

作者： min-Young Kim Woon-Dong Cho Kwon Pyo Hong Da Bin Choi Jeong won Hong Soseul Kim Yoo Ri Moon Seung-Myoung son Ok-Jun Lee Ho-Chang Lee Hyung Geun song Department of Pathology Chungbuk National University College of MedicineCheongju28644Republic of Korea Research Institute Chungbuk National University College of MedicineCheongju28644Republic of Korea

The use of anti-beta 1 integrin monoclonal antibody in lung cancer treatment has proven beneficial. Here, we developed a novel monoclonal antibody （mAb）, called P5, by immunizing mice with human peripheral blood mononuclear cells （PBMC）. Its anti-tumor effect is now being tested, in a clinical phase Ⅲ trial, in combinato- rial treatments with various chemical drugs. To confirm that P5 indeed binds to beta 1 integrin, cell lysates were immunoprecipitated with commercial anti-beta 1 integrin mAb （TS2/16） and immunoblotted against P5 to reveal a 140 kDa molecular weight band, as expected. Immunoprecipitation with P5 followed by LC/MS protein sequence analysis further verified P5 antigen to be beta 1 integrin. Cisplatin treatment upregulated cell surface expression of beta 1 integrin in A549 cells, while causing inhibition of cell growth. When cells were co-treated with different concentrations of P5 mAb, the cisplatin-mediated inhibitory effect was enhanced in a dose-dependent manner. Our findings show that a combinatorial treatment of P5 mAb and cisplatin in A549 cells resulted in a 30% increase in apoptosis, compared to baseline, and significantly more when compared to either the cisplatin or P5 alone group. The entire peptide sequences in CDR from variable region of Ig heavy and light chain gene for P5 mAb are also disclosed. Together, these results provide evidence of the beneficial effect of P5 mAb in combinatorial treatment of human lung adenocarcinoma.

关键词： CD29 beta 1 integrin lung adenocarcinoma monoclonal antibody cisplatin

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Pre-existing diabetes mellitus increases the risk of gastric cancer:A meta-analysis

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World Journal of Gastroenterology 2013年第6期19卷 936-945页

作者： Jae Moon Yoon Ki Young son Chun Sick Eom Daniel Durrance Sang min Park Department of Family Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110-744South Korea Center for Health Promotion Seoul National University HospitalSeoul 110-744South Korea Department of Family Medicine Hallym UniversityChuncheon Sacred Heart HospitalChunCheon 200-704South Korea Family Medicine Graduate School of Korea University College of MedicineSeoul 110-799South Korea

AIM:To systematically assess the association between diabetes and incidence of gastric ***:We searched MedLine (PubMed),EMBASE,and the Cochrane Library without any limitations with respect to publication date or language,we also searched the references of qualifying *** studies and cohort studies comparing the risk of gastric cancer between diabetic patients and control subjects were *** excluded studies reporting only standardized incidence ratios without control groups and those that investigated only mortality but not *** studies met our criteria,and the qualities of these studies were assessed using theNewcastle-Ottawa Quality Assessment *** performed a meta-analysis of pre-existing diabetes and gastric cancer incidence using the DerSimonian-Laird method for *** subgroup analyses,we separated the studies by study type,region,sex and method to determine confounding factors and *** also conducted subgroup analyses to examine the effects of smoking,Helicobacter pylori (***) infection,and cancer *** bias was evaluated using Begg's ***:A random-effects model meta-analysis showed an increased gastric cancer risk in diabetic patients [relative risk (RR)=1.19;95%CI:1.08-1.31].Subgroup analyses indicated that this result persisted in cohort studies (RR=1.20;95%CI:1.08-1.34),in studies on populations of both Western (RR=1.18;95%CI:1.03-1.36) and Eastern countries (RR=1.19;95%CI:1.02-1.38),in a female subgroup (RR=1.24;95%CI:1.01-1.52),and in highly qualified studies (RR=1.17;95%CI:1.05-1.31).Moreover,these results persisted when the analysis was confined to studies adjusted for well-known gastric cancer risk factors such as smoking (RR=1.17;95%CI:1.01-1.34) and *** infection (RR=2.35;95%CI:1.24-4.46).CONCLUSION:Pre-existing diabetes mellitus may increase the risk of gastric cancer by approximately 19%.This effect seems to be unrelated to geographical region.

关键词： Disease association Diabetes mellitus Gastric cancer Incidence Risk Meta-analysis

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Analysis of High-Resolution QTL Markers Associated with Rice Yields Using Data for Two Consecutive Years in Different Environmental Conditions

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Natural Science 2014年第11期6卷 818-827页

作者： Ye-Jin son Gyu-Ho Lee Hyun-Suk Lee Tri Handoyo Byung-Wook Yun Kyung-min Kim Division of Plant Biosciences School of Plant Biosciences Kyungpook National University Daegu Korea Division of Plant Biosciences School of Plant Biosciences Kyungpook National University Daegu Korea Department of Agronomy Faculty of Agriculture Jember University Jember Indonesia

Previously we reported the identification of seven quantitative trait loci (QTLs) associated with the rice yield measuring five parameters including panicles per plant (PPP), spikelets per panicle (SPP), seed set percentage (SSP), 1000-grain weight (TGW) and yield in 2012. Here we report the analysis of QTLs using the same trait parameters data of the mapping population in 2013 for detecting highly conserved QTL markers. A total of 6 QTLs were identified from chromosomes 1, 7, 8, 10, 11, and 12, which were contrasted with our previous results (chromosomes 1, 2, 4, 5, 6, 8, and 11). In this comparison, three QTLs from chromosome 1, 8, and 11 were only found to be associated with the components of yield over two consecutive years indicating high sensitivity of QTL markers to the environment. Of those three QTLs, SPP-associated marker RM12285 was found to be dominantly expressed by real-time PCR (qPCR). In addition, compared to our previous report the numbers of mapping population and markers were significantly increased for higher resolution markers from 70 to 120, and from 143 to 217, respectively. We also found that the parameter SPP was dominantly correlated with the rice yield. Furthermore, the double haploid (DH) population facilitated to analyze the epistatic effects for yield and yield components in rice. Taken together, combining multiple mapping population data over years possibly enables narrowing down to the highly conserved QTL markers against diverse environmental fluctuation caused by such as drought and high temperature. Thus, these data would be critically exploited to improve for the crop breeding strategy.

关键词： QTL Rice Yield Component Epistatic Interaction qPCR

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